scholarly journals Effects of ethanolic extracts of Quercus , Cirsium vulgare , and Falcaria vulgaris on gastric ulcer, antioxidant and inflammatory indices, and gene expression in rats

2021 ◽  
Vol 9 (16) ◽  
Author(s):  
Ali Mohammad Basatinya ◽  
Javad Sajedianfard ◽  
Saeed Nazifi ◽  
Saied Hosseinzadeh ◽  
Mahbobeh Kamrani Mehni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Ulcer ◽  
Cirsium Vulgare ◽  
Falcaria Vulgaris ◽  
Ethanolic Extracts

Microscopical Evaluation of Healing Effect of Falcaria vulgaris Extract on Aspirin-Induced Gastric Ulcer in Rats

2015 ◽  
Vol 22 (3) ◽  
pp. 29
Author(s):  
Maryam Yadegari ◽  
Mozafar Khazaei ◽  
Mehri Mirhoseini
Keyword(s):  
Gastric Ulcer ◽  
Healing Effect ◽  
Falcaria Vulgaris

scholarly journals The potential effects of Centella asiatica ethanolic extracts as an anti-inflammatory agent through decreasing TNF-α expression in indomethacin-induced gastric ulcer model rats

2021 ◽  
Author(s):  
Priscilla Maiselina Sriepindonnta ◽  
Fatimah Nur Fitriani ◽  
Savannah Quila Thirza ◽  
Made Dinda Pratiwi ◽  
Dwi Evan Prima Putra Noviardi ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Centella Asiatica ◽  
Inflammatory Agent ◽  
Tnf Α ◽  
Ethanolic Extracts ◽  
Ulcer Model ◽  
Anti Inflammatory

Frequency of virulence factor of Helicobacter pylori and IL17 gene expression related with gastric ulcer patient

2021 ◽  
Author(s):  
Raed Obaid Saleh ◽  
Najwa Shihab Ahmed ◽  
Emad A. Ewais ◽  
Aqeel Shakir Mahmood ◽  
Ahmed R. Sofy
Keyword(s):  
Gene Expression ◽  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Virulence Factor ◽  
Ulcer Patient ◽  
Gastric Ulcer Patient

scholarly journals Protective Effects of Dioscorea batatas Flesh and Peel Extracts against Ethanol-Induced Gastric Ulcer in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1680 ◽  
Author(s):  
Siyul Byeon ◽  
Jisun Oh ◽  
Ji Lim ◽  
Jeong Lee ◽  
Jong-Sang Kim
Keyword(s):  
Gastric Ulcer ◽  
Alcohol Consumption ◽  
Plasma Levels ◽  
Gastric Mucosal Damage ◽  
Heme Oxygenase 1 ◽  
Excessive Alcohol Consumption ◽  
Oral Supplementation ◽  
Ethanolic Extracts ◽  
Excessive Alcohol ◽  
Dioscorea Batatas

Gastric ulcer is a major digestive disorder and provoked by multifactorial etiologies, including excessive alcohol consumption. In this study, we examined the gastroprotective effect of aqueous and ethanolic extracts of Dioscorea batatas Decne (DBD; commonly called Chinese yam) flesh or peel against acidified ethanol-induced acute gastric damage in mice. Our findings demonstrated that oral supplementation of aqueous or ethanolic extracts of DBD flesh or peel before ulcer induction was significantly effective in macroscopically and histologically alleviating ethanol-induced pathological lesions in gastric mucosa, decreasing the plasma levels of inflammatory mediators, such as nitric oxide and interleukin-6, attenuating the gastric expression of cyclooxygenase-2, and increasing the gastric content of prostaglandin E2. In particular, pretreatment with the flesh extract prepared in 60% ethanol prominently decreased the expression of biomarkers of oxidative stress, including the plasma levels of 8-hydroxy-2-guanosine and malondialdehyde, and restored heme oxygenase-1 expression and superoxide dismutase activity in the stomach. Overall, these findings suggest that the oral supplementation with DBD extract, especially flesh ethanol extract, prior to excessive alcohol consumption, may exert a protective effect against ethanol-induced gastric mucosal damage in vivo, presumably through the activation of the antioxidant system and suppression of the inflammatory response.

Elevation of TFF1 gene expression during healing of gastric ulcer at non‐ulcerated sites in the stomach: Semiquantification using the single tube method of polymerase chain reaction

2000 ◽  
Vol 15 (6) ◽  
pp. 604-609 ◽  
Author(s):  
Takashi Saitoh ◽  
Tsutomu Mochizuki ◽  
Takeshi Suda ◽  
Yutaka Aoyagi ◽  
Yoshihisa Tsukada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Polymerase Chain Reaction ◽  
Gastric Ulcer ◽  
Chain Reaction ◽  
Single Tube ◽  
Polymerase Chain

scholarly journals Anti-inflammatory effects of Centella asiatica ethanolic extracts towards indomethacin-induced gastric ulcer model in rats by altering COX-2 expression

2021 ◽  
Author(s):  
Savannah Quila Thirza ◽  
Made Dinda Pratiwi ◽  
Dwi Evan Prima Putra Noviardi ◽  
Priscilla Maiselina Sriepinndonta ◽  
Fatimah Nur Fitriani ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Centella Asiatica ◽  
Ethanolic Extracts ◽  
Ulcer Model ◽  
Cox 2 ◽  
Anti Inflammatory

scholarly journals Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3312
Author(s):  
Felipe Leonardo Fagundes ◽  
Quélita Cristina Pereira ◽  
Melina Luzzi Zarricueta ◽  
Raquel de Cássia dos Santos
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Acetic Acid ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Defense Mechanisms ◽  
Ischemia Reperfusion ◽  
Peptic Ulcers ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Peptic ulcer episodes cause damage to the stomach and intestine, with inflammatory cell infiltration and oxidative stress as the main players. In this study, we investigated the potential of anthocyanidin malvidin for preventive and curative peptic ulcer treatment. The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy. Expression levels of oxidative and inflammatory genes were measured to investigate the mechanism of anthocyanin activity. At a dose of 5 mg·kg−1, Malvidin prevented gastric ulcer induction by ethanol, NSAID and repaired the tissue after 6 days of IR. Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanin treatment mitigated the effect of polypharmacy on inflammation and oxidative stress observed in the intestine. Additionally, the compound downregulated cytokine expression and TLR4 and upregulated HMOX-1 and IL-10, exhibiting protective activity in the mouse gut. Malvidin thus prevented gastric and duodenal ulcers due to prominent anti-inflammatory and antioxidative effects on the gastrointestinal tract that were related to gene expression modulation and an increase in endogenous defense mechanisms.

scholarly journals ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY AS WELL AS APOPTOTIC ACTIVITY OF ETHANOLIC EXTRACTS OF CROCUS SATIVUS

2019 ◽  
Author(s):  
B. Arirudran ◽  
P. Priyadharshini ◽  
US Mahadeva Rao
Keyword(s):  
Gene Expression ◽  
Oxidative Burst ◽  
Phagocytic Activity ◽  
Vascular Diseases ◽  
Inflammatory Activity ◽  
Crocus Sativus ◽  
Rt Pcr ◽  
Ethanolic Extracts ◽  
Anti Inflammatory ◽  
Apoptotic Activity

Inflammation is a body reaction which embroils cellular and biochemical responses, which is not only symptom for shared diseases but also known to be an initial phase for certain serious Alzheimer’s, cancer, heart vascular diseases. In order to overcome these drawbacks, there is an urgent need for nutraceuticals with excellent anti-inflammatory response with minimum side effects. Aim: An attempt has been made to evaluate the anti-inflammatory activity along with gene expression analysis on ethanolic extracts of Crocus sativus (CSEE). Dried stigmas of C. sativus were analyzed for anti-inflammatory activity by macrophage scavenging assay. In this study, the phagocytic activity of the extract was tested on oxidative burst reduction of macrophages. RT-PCR was performed to analyze the anti-apoptotic gene expression during cell death, as a result of the compound treatment on cancer cells. The CSEE unveiled high phagocytic activity on the oxidative burst reduction, presenting intracellular killing and the enhancement of lysosomal enzyme activity, showing the active degranulation of macrophages. These findings suggest that C. sativus possessed excellent anti-inflammatory as well as apoptotic activities. Hence it was proposed that C. sativus could be exploited against oxidative stress, anti-inflammatory, cancer and ageing therapy to justify their use in traditional medicine as a nutraceutical.

scholarly journals Evaluation of Therapeutic Efficacy of Stigma and Petal Extracts of Crocus sativus L. on Acetic Acid-Induced Gastric Ulcer in Rats

2021 ◽  
Author(s):  
Mahtab Mohammadifard ◽  
Hossein Javdani ◽  
Ghazaleh Khalili-Tanha ◽  
Ali Farahi ◽  
Mohsen Foadoddini ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Healing Process ◽  
Crocus Sativus ◽  
Gastric Ulcers ◽  
Control Group ◽  
Dependent Manner ◽  
Ulcer Size ◽  
Ethanolic Extracts ◽  
Crocus Sativus L

Saffron (Crocus sativus L.) has long been considered a medicinal plant in Traditional Persian Medicine (TPM) due to its therapeutic properties. Despite this interest, its effects on gastrointestinal disorders have not been completely taken into consideration. Hence, this study aimed to evaluate the pharmacological activity of ethanolic extracts of saffron stigma (SS) and saffron petal (SP) in acetic acid-induced gastric ulcer in rats. The gastric ulcer model was imitated by the serosal application of acetic acid in male Wistar rats. Then, the animals were orally fed with 100 mg/kg and 200 mg/kg of ethanolic extracts of SS or SP, omeprazole (40 mg/kg), or saline for 12 days. The macroscopic and microscopic appearances of gastric ulcers and the levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) in gastric tissues were assessed. The highest anti-ulcer activity was observed in the omeprazole-treated animals with the lowest ulcer size (4.29 ± 1.78 mm2). SS could not reduce gastric ulcer size in rats. Compared to the untreated rats, SP treatment significantly decreased ulcer indices in a dose-dependent manner. The gastric levels of PGE2, VEGF, and MDA were significantly elevated in the untreated animals with gastric ulcers compared to rats in the control group. The SS extract suppressed the elevated PGE2 and VEGF levels at both doses, while SP did not have a significant influence. Both SS and SP treatments significantly ameliorated MDA levels in rats with gastric ulcers. Omeprazole treatment enhanced the PGE2 level and suppressed MDA contents, but it did not influence the VEGF level. In conclusion, our findings demonstrated that the saffron stigma has no significant effects on the gastric ulcer healing process, while its petals accelerate the process. This discrepancy can be attributed to the difference in the main secondary metabolites between saffron stigma and petals.

Matrix Metalloproteinase Gene Expression in Chronic Gastric Ulcer: A Potential Role of Eosinophils in Perforation

1997 ◽  
Vol 25 ◽  
pp. S101-S104 ◽  
Author(s):  
Yoshihide Otani ◽  
Yoshihiko Sakurai ◽  
Kaori Kameyama ◽  
Naoki Igarashi ◽  
Takeyoshi Yokoyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Ulcer ◽  
Matrix Metalloproteinase ◽  
Potential Role ◽  
Chronic Gastric Ulcer
Sign in / Sign up

Export Citation Format

Share Document