scholarly journals Oral vitamin C restores endothelial function during acute inflammation in young and older adults

2021 ◽  
Vol 9 (21) ◽  
Author(s):  
Elizabeth C. Lefferts ◽  
Brooks A. Hibner ◽  
Wesley K. Lefferts ◽  
Natalia S. Lima ◽  
Tracy Baynard ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin C ◽  
Endothelial Function ◽  
Acute Inflammation ◽  
Oral Vitamin

scholarly journals Despite improving endothelial function oral vitamin C increases phosphocreatine depletion during exercise in patients with chronic heart failure

2002 ◽  
Vol 39 ◽  
pp. 182
Author(s):  
Angus K. Nightingale ◽  
Jenny G. Crilley ◽  
Nicholas C. Pegge ◽  
Rachel C. Field ◽  
Matthias Schmitt ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Vitamin C ◽  
Endothelial Function ◽  
Oral Vitamin

Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes

2002 ◽  
Vol 103 (4) ◽  
pp. 339-344 ◽  
Author(s):  
D. DARKO ◽  
A. DORNHORST ◽  
F.J. KELLY ◽  
J.M. RITTER ◽  
P.J. CHOWIENCZYK
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Blood Flow ◽  
Vitamin C ◽  
Endothelial Function ◽  
Type Ii Diabetes ◽  
Forearm Blood Flow ◽  
Plasma Concentrations ◽  
Type Ii ◽  
Oral Vitamin

Type II diabetes is characterized by increased oxidative stress, endothelial dysfunction and hypertension. We investigated whether short-term treatment with oral vitamin C reduces oxidative stress and improves endothelial function and blood pressure in subjects with Type II diabetes. Subjects (n = 35) received vitamin C (1.5g daily in three doses) or matching placebo for 3 weeks in a randomized, double-blind, parallel-group design. Plasma concentrations of 8-epi-prostaglandin F2α (8-epi-PGF2α), a non-enzymically derived oxidation product of arachidonic acid, were used as a marker of oxidative stress. Endothelial function was assessed by measuring forearm blood flow responses to brachial artery infusion of the endothelium-dependent vasodilator acetylcholine (with nitroprusside as an endothelium-independent control) and by the pulse wave responses to systemic albuterol (endothelium-dependent vasodilator) and glyceryl trinitrate (endothelium-independent vasodilator). Plasma concentrations of vitamin C increased from 58±6 to 122±10μmol/l after vitamin C, but 8-epi-PGF2α levels (baseline, 95±4pg/l; after treatment, 99±5pg/l), blood pressure (baseline, 141±5/80±2mmHg; after treatment, 141±5/81±3mmHg) and endothelial function, as assessed by the systemic vasodilator response to albuterol and by the forearm blood flow response to acetylcholine, were not significantly different from baseline or placebo. Thus treatment with vitamin C (1.5 g daily) for 3 weeks does not significantly improve oxidative stress, blood pressure or endothelial function in patients with Type II diabetes.

scholarly journals Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect

2000 ◽  
Vol 35 (6) ◽  
pp. 1616-1621 ◽  
Author(s):  
Olli T Raitakari ◽  
Mark R Adams ◽  
Robyn J McCredie ◽  
Kaye A Griffiths ◽  
Roland Stocker ◽  
...  
Keyword(s):  
Vitamin C ◽  
Endothelial Function ◽  
Beneficial Effect ◽  
Oral Vitamin ◽  
Short Term

Effect of Oral Vitamin C Supplementation on High-Altitude Hyperuricemia in Young Men Initially Migrating to High Altitude: A Pilot Study

2018 ◽  
Vol 19 (4) ◽  
pp. 373-381
Author(s):  
Hui Peng ◽  
Dongfang Feng ◽  
Yingkai Wang ◽  
Zixi Dong ◽  
Qing Chen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vitamin C ◽  
High Altitude ◽  
Young Men ◽  
Oral Vitamin ◽  
Vitamin C Supplementation

scholarly journals Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure

2021 ◽  
Author(s):  
Daniel H. Craighead ◽  
Thomas C. Heinbockel ◽  
Kaitlin A. Freeberg ◽  
Matthew J. Rossman ◽  
Rachel A. Jackman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Muscle Strength ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Systolic Blood Pressure ◽  
High Resistance ◽  
Maximal Inspiratory Pressure ◽  
No Bioavailability ◽  
Inspiratory Muscle Strength

Background High‐resistance inspiratory muscle strength training (IMST) is a novel, time‐efficient physical training modality. Methods and Results We performed a double‐blind, randomized, sham‐controlled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 50–79 years) with systolic blood pressure ≥120 mm Hg, while also investigating potential mechanisms and long‐lasting effects. Thirty‐six participants completed high‐resistance IMST (75% maximal inspiratory pressure, n=18) or low‐resistance sham training (15% maximal inspiratory pressure, n=18). IMST was safe, well tolerated, and had excellent adherence (≈95% of training sessions completed). Casual systolic blood pressure decreased from 135±2 mm Hg to 126±3 mm Hg ( P <0.01) with IMST, which was ≈75% sustained 6 weeks after IMST ( P <0.01), whereas IMST modestly decreased casual diastolic blood pressure (79±2 mm Hg to 77±2 mm Hg, P =0.03); blood pressure was unaffected by sham training (all P >0.05). Twenty‐four hour systolic blood pressure was lower after IMST versus sham training ( P =0.01). Brachial artery flow‐mediated dilation improved ≈45% with IMST ( P <0.01) but was unchanged with sham training ( P =0.73). Human umbilical vein endothelial cells cultured with subject serum sampled after versus before IMST exhibited increased NO bioavailability, greater endothelial NO synthase activation, and lower reactive oxygen species bioactivity ( P <0.05). IMST decreased C‐reactive protein ( P =0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. Neither IMST nor sham training influenced arterial stiffness ( P >0.05). Conclusions High‐resistance IMST is a safe, highly adherable lifestyle intervention for improving blood pressure and endothelial function in midlife/older adults with above‐normal initial systolic blood pressure. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03266510.

scholarly journals Improvement of Endothelial function by Amlodipine and Vitamin C in Essential Hypertension

2002 ◽  
Vol 17 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Young Keun On ◽  
Cheol Ho Kim ◽  
Dae Won Sohn ◽  
Byung Hee Oh ◽  
Myoung Mook Lee ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Vitamin C ◽  
Endothelial Function

Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation

2006 ◽  
Vol 40 (9) ◽  
pp. 1494-1501 ◽  
Author(s):  
Joseph P. Gaut ◽  
Abderrazzaq Belaaouaj ◽  
Jaeman Byun ◽  
L. Jackson Roberts ◽  
Nobuyo Maeda ◽  
...  
Keyword(s):  
Amino Acids ◽  
Vitamin C ◽  
Acute Inflammation
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