scholarly journals A novel estimate of endothelial cell autophagic flux is associated with greater vascular endothelial function and reduced oxidative stress in healthy middle‐aged/older adults (855.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Anna Boekel ◽  
Jessica Santos‐Parker ◽  
Thomas LaRocca ◽  
Douglas Seals ◽  
Rachelle Kaplon
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Endothelial Cell ◽  
Endothelial Function ◽  
Autophagic Flux ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged

scholarly journals Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Aging ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 187-208 ◽  
Author(s):  
Jessica R. Santos-Parker ◽  
Talia R. Strahler ◽  
Candace J. Bassett ◽  
Nina Z. Bispham ◽  
Michel B. Chonchol ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Older Adults ◽  
Endothelial Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Nitric Oxide Bioavailability

scholarly journals Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults

2014 ◽  
Vol 116 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Rachelle E. Kaplon ◽  
Lindsey B. Gano ◽  
Douglas R. Seals
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Nadph Oxidase ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Antioxidant Vitamin ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
And Oxidative Stress

We tested the hypothesis that vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. In 127 men and women aged 48–77 yr, brachial artery flow-mediated dilation (FMD) was positively related to dietary niacin intake [%change (Δ): r = 0.20, P < 0.05; mmΔ: r = 0.25, P < 0.01]. In subjects with above-average dietary niacin intake (≥22 mg/day, NHANES III), FMD was 25% greater than in subjects with below-average intake ( P < 0.05). Stepwise linear regression revealed that dietary niacin intake (above vs. below average) was an independent predictor of FMD (%Δ: β = 1.8; mmΔ: β = 0.05, both P < 0.05). Plasma oxidized low-density lipoprotein, a marker of systemic oxidative stress, was inversely related to niacin intake ( r = −0.23, P < 0.05) and was lower in subjects with above- vs. below-average niacin intake (48 ± 2 vs. 57 ± 2 mg/dl, P < 0.01). Intravenous infusion of the antioxidant vitamin C improved brachial FMD in subjects with below-average niacin intake ( P < 0.001, n = 33), but not above-average ( P > 0.05, n = 20). In endothelial cells sampled from the brachial artery of a subgroup, dietary niacin intake was inversely related to nitrotyrosine, a marker of peroxynitrite-mediated oxidative damage ( r = −0.30, P < 0.05, n = 55), and expression of the prooxidant enzyme, NADPH oxidase ( r = −0.44, P < 0.01, n = 37), and these markers were lower in subjects with above- vs. below-average niacin intake [nitrotyrosine: 0.39 ± 0.05 vs. 0.56 ± 0.07; NADPH oxidase: 0.38 ± 0.05 vs. 0.53 ± 0.05 (ratio to human umbilical vein endothelial cell control), both P < 0.05]. Our findings support the hypothesis that higher dietary niacin intake is associated with greater vascular endothelial function related to lower systemic and vascular oxidative stress among healthy middle-aged and older adults.

scholarly journals The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials

2020 ◽  
Vol 17 (16) ◽  
pp. 5643 ◽  
Author(s):  
Michitaka Kato ◽  
Fumi Nihei Green ◽  
Kazuki Hotta ◽  
Toshiya Tsukamoto ◽  
Yasunari Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Stretching Exercises

Background: Aerobic exercise is known to reduce arterial stiffness; however, high-intensity resistance exercise is associated with increased arterial stiffness. Stretching exercises are another exercise modality, and their effect on arterial stiffness remains unclear. The purpose of this study was to determine whether stretching exercises reduce arterial stiffness in middle-aged and older adults, performing the first meta-analysis of currently available studies. Methods: We searched the literature for randomized controlled trials (RCTs) and non-RCTs published up to January 2020 describing middle-aged and older adults who participated in a stretching intervention vs. controls without exercise training. The primary and secondary outcomes were changes in arterial stiffness and vascular endothelial function and hemodynamic status. Pooled mean differences (MDs) and standard MDs (SMDs) with 95% confidence intervals (CIs) between the intervention and control groups were calculated using a random effects model. Results: We identified 69 trials and, after an assessment of relevance, eight trials, including a combined total of 213 subjects, were analyzed. Muscle stretching exercises were shown to significantly reduce arterial stiffness and improve vascular endothelial function (SMD: −1.00, 95% CI: −1.57 to −0.44, p = 0.0004; SMD: 1.15, 95% CI: 0.26 to 2.03, p = 0.01, respectively). Resting heart rate (HR) and diastolic blood pressure (DBP) decreased significantly after stretching exercise intervention (MD: −0.95 beats/min, 95% CI: −1.67 to −0.23 beats/min, p = 0.009; MD: −2.72 mm Hg, 95% CI: −4.01 to −1.43 mm Hg, p < 0.0001, respectively) Conclusions: Our analyses suggest that stretching exercises reduce arterial stiffness, HR, and DBP, and improve vascular endothelial function in middle-aged and older adults.

scholarly journals Sodium Nitrite Supplementation Improves Vascular Endothelial Function but not Motor or Cognitive Function in Middle‐Aged and Older Adults

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Kayla A. Woodward ◽  
Jessica R. Santos‐Parker ◽  
Kara L. Lubieniecki ◽  
Erzsebet Nagy ◽  
Nathan S. Bryan ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Endothelial Function ◽  
Sodium Nitrite ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged

scholarly journals Mineralocorticoid receptors modulate vascular endothelial function in human obesity

2013 ◽  
Vol 125 (11) ◽  
pp. 513-520 ◽  
Author(s):  
Moon-Hyon Hwang ◽  
Jeung-Ki Yoo ◽  
Meredith Luttrell ◽  
Han-Kyul Kim ◽  
Thomas H. Meade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Endothelial Function ◽  
Body Fat ◽  
Dependent Manner ◽  
Vascular Endothelial ◽  
Mineralocorticoid Receptors ◽  
Vascular Endothelial Function ◽  
Human Obesity

Obesity increases linearly with age and is associated with impaired vascular endothelial function and increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to impaired vascular endothelial function in cardiovascular disease; however, their role in uncomplicated human obesity is unknown. Because plasma aldosterone levels are elevated in obesity and adipocytes may be a source of aldosterone, we hypothesized that MRs modulate vascular endothelial function in older adults in an adiposity-dependent manner. To test this hypothesis, we administered MR blockade (eplerenone; 100 mg/day) for 1 month in a balanced randomized double-blind placebo-controlled cross-over study to 22 older adults (ten men, 55–79 years) varying widely in adiposity [BMI (body mass index): 20–45 kg/m2], but who were free from overt cardiovascular disease. We evaluated vascular endothelial function [brachial artery FMD (flow-mediated dilation)] via ultrasonography) and oxidative stress (plasma F2-isoprostanes and vascular endothelial cell protein expression of nitrotyrosine and NADPH oxidase p47phox) during placebo and MR blockade. In the whole group, oxidative stress (P>0.05) and FMD did not change with MR blockade (6.39±0.67 compared with 6.23±0.73%; P=0.7). However, individual improvements in FMD in response to eplerenone were associated with higher total body fat (BMI: r=0.45, P=0.02; and dual-energy X-ray absorptiometry-derived percentage body fat: r=0.50, P=0.009) and abdominal fat (total: r=0.61, P=0.005; visceral: r=0.67, P=0.002; and subcutaneous: r=0.48, P=0.03). In addition, greater improvements in FMD with eplerenone were related to higher baseline fasting glucose (r=0.53, P=0.01). MRs influence vascular endothelial function in an adiposity-dependent manner in healthy older adults.

scholarly journals Evaluating the Impact of an Aronia Berry Dietary Supplement on Vascular Endothelial Function and the Gut Microbiota in Healthy Middle-Aged/Older Adults: Study Protocol

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1744-1744
Author(s):  
Allegra Vazquez ◽  
Emily Woolf ◽  
Kiri Michell ◽  
Lauren Grabos ◽  
Roxy Trotter ◽  
...  
Keyword(s):  
Older Adults ◽  
Gut Microbiota ◽  
Endothelial Function ◽  
Postmenopausal Women ◽  
Dietary Supplement ◽  
Outcome Measures ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Full Spectrum

Abstract Objectives Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, an initiating step in the development of atherosclerosis. The gut microbiota has emerged as an important regulator of cardiovascular health. Aronia berries are rich in polyphenols such as anthocyanins, proanthocyanidins, and phenolic acids. These compounds, and metabolites resulting from gut microbial and phase II metabolism, have been shown to improve endothelial function. The primary objective of this study is to assess the dose-dependent efficacy of an aronia berry full spectrum dietary supplement to improve vascular endothelial function in middle-aged/older men and postmenopausal women. A secondary goal is to determine whether aronia full spectrum modulation of the gut microbiota is associated with improvements in vascular endothelial function. Methods Healthy men and postmenopausal women (n = 28) aged 45–75 years are being recruited for this randomized, double-blind, placebo-controlled, crossover trial. In random order, participants take a placebo, 500 mg aronia full spectrum, or 1000 mg aronia full spectrum daily for a 6-week period. Each treatment period is separated by a 6-week washout period. The primary outcome is reactive hyperemia index (RHI), a validated measure of vascular endothelial function assessed using peripheral arterial tonometry. Secondary outcome measures include analysis of the gut microbiota in stool samples, hemodynamic parameters including blood pressure and augmentation index, arterial stiffness, and blood biomarkers of cardiovascular and metabolic health including blood lipids, hemoglobin a1c, oxidized LDL, and adhesion molecules. Other outcome measures will include plasma, fecal, and urine polyphenol metabolites. Gut microbial populations will be statistically compared with RHI. Results To date, a total of 22 individuals (11 men/11 women) have been enrolled in the trial and randomized to their intervention order. Of these, 3 have completed the study, 1 was lost to follow-up, and 18 are currently enrolled. Conclusions We hypothesize that this aronia berry dietary supplement will dose-dependently improve vascular endothelial function in healthy middle-aged/older adults, and that improvements will be linked to modulation of the gut microbiota. Funding Sources Naturex.

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