scholarly journals The Role of the Renal Dopaminergic and the Prostaglandin Systems in Renal Uric Acid Metabolism in Patients with Essential Hypertension

1991 ◽  
Vol 67 (11) ◽  
pp. 1271-1281
Author(s):  
Naotoshi SATOH ◽  
Kenjiro KIKUCHI ◽  
Tohru HASEGAWA ◽  
Hiroaki KOMURA ◽  
Shin-ichiro SUZUKI ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Acid Metabolism

503-P: Inhibition of Glucose Transporter 9 Increases Serum Uric Acid Level but Attenuates Renal Albumin Excretion in Streptozotocin-Induced Diabetic Rats: A Role of Hepatic Uric Acid Metabolism

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 503-P
Author(s):  
CHUPING CHEN ◽  
JIANMIN RAN ◽  
RUYI ZHANG ◽  
GUANGSHU CHEN ◽  
PING ZHU ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Glucose Transporter ◽  
Acid Metabolism ◽  
Serum Uric Acid Level ◽  
Diabetic Rats ◽  
Glucose Transporter 9

scholarly journals The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage

2005 ◽  
Vol 19 (3) ◽  
pp. 211-217 ◽  
Author(s):  
C Tsioufis ◽  
D Chatzis ◽  
E Vezali ◽  
K Dimitriadis ◽  
D Antoniadis ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

Uric acid metabolism in dalmatians and other dogs. Role of the liver

1972 ◽  
Vol 129 (3) ◽  
pp. 492-496 ◽  
Author(s):  
G. Kuster
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension

1999 ◽  
Vol 17 (7) ◽  
pp. 1033-1039 ◽  
Author(s):  
Juan G. Puig ◽  
Felicitas Mateos ◽  
Antonio Buño ◽  
Rafael Ortega ◽  
Felipe Rodriguez ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Acid Metabolism

Effects of azelnidipine on uric acid metabolism in patients with essential hypertension

2014 ◽  
Vol 36 (7) ◽  
pp. 447-453 ◽  
Author(s):  
Satoshi Miyazaki ◽  
Toshihiro Hamada ◽  
Shigemasa Hirata ◽  
Akira Ohtahara ◽  
Einosuke Mizuta ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Acid Metabolism

scholarly journals Effects of Irbesartan on Uric Acid Metabolism in Patients with Treated Essential Hypertension

2018 ◽  
Vol 2 (1) ◽  
pp. 11-19
Author(s):  
Satoshi Miyazaki ◽  
Tetsushi Sakuragi ◽  
Toshihiro Hamada ◽  
Shinobu Sugihara ◽  
Daeho Park ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Acid Metabolism

scholarly journals The Effect Of Uric Acid Metabolism Disorders On The Cardiovascular System In Children With Pyelonephritis

2021 ◽  
Vol 03 (01) ◽  
pp. 167-170
Author(s):  
Rajabova N.T. ◽  
◽  
Ismailova Z.A. ◽  
Klicheva T.A. ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Uric Acid ◽  
Inverse Relationship ◽  
Acid Metabolism ◽  
Recent Literature ◽  
Pediatric Practice ◽  
Therapeutic Practice

Both nephrologists [Vasilyeva M.P. et al., 2015; Mukhin N.A. et al., 2015], and cardiologists [Кuo-ChengLue.a.,2014 ] recognized the fact that most of the currently known risk factors for cardiovascular disease (hypertension, obesity, diabetes mellitus, dyslipoproteinemia, microalbuminuria, etc.) are also risk factors for chronic kidney disease (ChKD). An inverse relationship, i.e. the influence of renal pathology on the frequency of cardiovascular disease detection has been established [Galushkin A.A. et al., 2013]. This fact is especially relevant in disorders of uric acid (UA) metabolism, as the recent literature data indicate a significant role of UA in the development of cardiovascular diseases. However, these issues are intensively studied in therapeutic practice, but they are certainly relevant for pediatric practice [M.S.Ignatova, 2011; VyalkovaA.A.,2012].

Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid

2021 ◽  
Author(s):  
Jing Liu ◽  
Yang Fan ◽  
Hang Yu ◽  
Tong Xu ◽  
Chunze Zhang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Bile Acid ◽  
Liver Injury ◽  
Liver Diseases ◽  
Acid Metabolism ◽  
Glutathione Depletion ◽  
Bile Acid Metabolism ◽  
New Perspective ◽  
Cholestatic Liver Injury

Abstract Cholestasis is one of the most severe manifestations of liver injury and has limited therapeutic options. Allopurinol (AP), an inhibitor of uric acid (UA) synthesis, was reported to prevent liver damage in several liver diseases. However, whether AP protects against intrahepatic cholestatic liver injury and what is the role of UA in the pathogenesis of cholestasis remain unknown. In this study, we reported that AP attenuated liver injury in a mouse model of intrahepatic cholestasis induced by alpha-naphthylisothiocyanate (ANIT). AP showed no significant effect on glutathione depletion, inflammation, or bile acid metabolism in livers of ANIT-treated mice. Instead, AP significantly improved fatty acid β-oxidation in livers of ANIT-treated mice, which was associated with activation of PPARα. The protective effect of AP on cholestatic liver injury was not attributable to the depletion of UA, because both exogenous and endogenous UA prevented liver injury in ANIT-treated mice via inhibition of NF-kB-mediated inflammation. In conclusion, the present study provides a new perspective for the therapeutic use of AP and the role of UA in cholestatic liver injury.

Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases

2020 ◽  
Vol 20 (18) ◽  
pp. 1857-1866
Author(s):  
Dan Wu ◽  
Wenji Zhang ◽  
Xingfei Lai ◽  
Qiuhua Li ◽  
Lingli Sun ◽  
...  
Keyword(s):  
Uric Acid ◽  
Acid Metabolism ◽  
Inflammatory Reactions ◽  
Metabolism Disorder ◽  
Uric Acid Transporters ◽  
Uric Acid Secretion ◽  
High Uric Acid ◽  
Urate Crystals

Uric acid is the end product of purine metabolism in humans. High uric acid levels form sodium urate crystals that trigger biological processes, which lead to the development of several diseases, including diabetes, hyperuricemia, gout, inflammatory disease, kidney disease, cardiovascular disease and hypertension. Catechins have been suggested to be beneficial for the regulation of uric acid metabolic disorders due to their powerful antioxidant and anti-inflammatory properties. To identify an effective and safe natural substance that can decrease levels of serum uric acid to improve uric acid metabolism disorders. A search was performed on PubMed, Web of Science and Google Scholar to identify comprehensive studies that presented summarized data on the use of catechins in lowering uric acid levels in diseases. This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in the liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine. Additionally, Catechins were also found to prevent monosodium urate-induced inflammatory reactions. In vivo, catechins can be used to decrease high uric acid levels that result from hyperuricemia and related diseases. Catechins can be used to maintain the balance of uric acid metabolism.

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