scholarly journals The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process

2016 ◽  
Vol 66 (2) ◽  
pp. 207-218 ◽  
Author(s):  
Narges Poursina ◽  
Alireza Vatanara ◽  
Mohammad Reza Rouini ◽  
Kambiz Gilani ◽  
Abdolhossein Rouholamini Najafabadi
Keyword(s):  
Salmon Calcitonin ◽  
Freeze Drying ◽  
Tween 80 ◽  
Drying Process ◽  
Dry Powders ◽  
Aerosol Performance ◽  
Inhalation Delivery ◽  
Spray Freeze Drying ◽  
The Stability ◽  
Structurally Stable

Abstract Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).

scholarly journals Post-Processing Techniques for the Improvement of Liposome Stability

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1023
Author(s):  
Ji Young Yu ◽  
Piyanan Chuesiang ◽  
Gye Hwa Shin ◽  
Hyun Jin Park
Keyword(s):  
Freeze Drying ◽  
Protective Agent ◽  
Post Processing ◽  
Additional Process ◽  
Spray Freeze Drying ◽  
The Stability ◽  
Processing Techniques ◽  
The Impact ◽  
Self Aggregation ◽  
Liposome Stability

Liposomes have been utilized as a drug delivery system to increase the bioavailability of drugs and to control the rate of drug release at the target site of action. However, the occurrence of self-aggregation, coalescence, flocculation and the precipitation of aqueous liposomes during formulation or storage can cause degradation of the vesicle structure, leading to the decomposition of liposomes. To increase the stability of liposomes, post-processing techniques have been applied as an additional process to liposomes after formulation to remove water and generate dry liposome particles with a higher stability and greater accessibility for drug administration in comparison with aqueous liposomes. This review covers the effect of these techniques including freeze drying, spray drying and spray freeze drying on the stability, physicochemical properties and drug encapsulation efficiency of dry liposomes. The parameters affecting the properties of liposomes during the drying process are also highlighted in this review. In addition, the impact of using a protective agent to overcome such limitations of each process is thoroughly discussed through various studies.

scholarly journals Stability of pseudorabies virus during freeze-drying and storage: effect of suspending media

1976 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
E M Scott ◽  
W Woodside
Keyword(s):  
Freeze Drying ◽  
Pseudorabies Virus ◽  
Storage Effect ◽  
Drying Process ◽  
Sodium Glutamate ◽  
Degree Of Protection ◽  
The Stability ◽  
Subsequent Storage ◽  
And Storage ◽  
Lactalbumin Hydrolysate

The effect of suspending media on the stability of pseudorabies virus upon freeze-drying and subsequent storage was studied. A variety of media was tested, including: sodium glutamate; sucrose; lactose; lactalbumin hydrolysate; peptone; a combination of sucrose, dextran, and glutamate; and various combinations of sucrose, glutamate, and potassium phosphates. Suspending media containing glutamate, either alone or in combination with sucrose and either dextran or phosphates, afforded the greatest degree of protection during the freeze-drying process and upon storage. Some possible functions of these additives in preventing injury to the virus during freezing and drying have been suggested.

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

2019 ◽  
Vol 560 ◽  
pp. 144-154 ◽  
Author(s):  
Qiuying Liao ◽  
Long Yip ◽  
Michael Y.T. Chow ◽  
Shing Fung Chow ◽  
Hak-Kim Chan ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Pulmonary Delivery ◽  
Lung Deposition ◽  
Dry Powders ◽  
Spray Freeze Drying

scholarly journals Trehalose and Tween 80 Improve the Stability of Marine Lysozyme During Freeze-Drying

2009 ◽  
Vol 23 (3) ◽  
pp. 1351-1354 ◽  
Author(s):  
C. Ji ◽  
M. Sun ◽  
J. Yu ◽  
Y. Wang ◽  
Y. Zheng ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Tween 80 ◽  
The Stability

Innovative synthesis of nanostructured composite materials by a spray-freeze drying process: Efficient catalysts and photocatalysts preparation

2019 ◽  
Vol 334 ◽  
pp. 193-202 ◽  
Author(s):  
Alice Lolli ◽  
Magda Blosi ◽  
Simona Ortelli ◽  
Anna Luisa Costa ◽  
Ilaria Zanoni ◽  
...  
Keyword(s):  
Composite Materials ◽  
Freeze Drying ◽  
Drying Process ◽  
Nanostructured Composite ◽  
Spray Freeze Drying

Effect of Cryoprotectant and Freeze-Drying Process on the Stability of W/O/W Emulsions

2007 ◽  
Vol 25 (5) ◽  
pp. 809-819 ◽  
Author(s):  
M. J. Choi ◽  
S. Briançon ◽  
D. Bazile ◽  
A. Royere ◽  
S. G. Min ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Drying Process ◽  
The Stability

Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying

2017 ◽  
Vol 305 ◽  
pp. 63-70 ◽  
Author(s):  
Tiantian Ye ◽  
Jiaqi Yu ◽  
Qiuhua Luo ◽  
Shujun Wang ◽  
Hak-Kim Chan
Keyword(s):  
Freeze Drying ◽  
Dry Powders ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Preparation and Characterization of n-HA/Chitosan Scaffold Prepared by a New Method of Emulsion-Foaming/Freeze-Drying Process

2007 ◽  
Vol 544-545 ◽  
pp. 789-792 ◽  
Author(s):  
Li Zhang ◽  
Yu Bao Li ◽  
Pu Jiang Shi ◽  
Yi Zuo ◽  
Lan Wu
Keyword(s):  
Compressive Strength ◽  
Freeze Drying ◽  
Cell Attachment ◽  
Composite Scaffold ◽  
Testing Machine ◽  
Calculated Data ◽  
Tween 80 ◽  
New Method ◽  
High Porosity ◽  
Drying Process

A novel nano-hydroxyapatite/chitosan (n-HA/CS) composite scaffold with high porosity was developed by a new method of emulsion-foaming/freeze-drying process and was characterized by means of infrared spectroscopy (IR), scanning electronic microscopy (SEM) and universal material testing machine. In addition, the porosity and density of the scaffold were also calculated. IR result shows that the characteristic absorption peaks belonging to both CS and HA are present in their composite, and the slight band-shifts and peak-decrease suggest that some interactions have taken place between the two phases of CS and n-HA in the composite. SEM photo displays that, with the dosage increase of Tween-80, the prepared scaffold shows highly porous and interconnected structure, in which macropores and micropores coexist. The calculated data demonstrate that the porosity of the scaffold is proportional to the content of the emulsifier, while the compressive strength is inversely. When 15wt% emulsifier used, the porosity of the scaffold can be up to 90% and the density is 0.453g/cm3, while the corresponding compressive strength is about 2.4MPa. The newly developed n-HA/CS composite scaffolds may serve as a good 3-D substrate for cell attachment and migration in bone tissue engineering.

Microstructure of spray freezing dried powders affected by the presence of inert particles

2020 ◽  
Vol 16 (7) ◽  
Author(s):  
Fan Zhang ◽  
Linsong Wang ◽  
Xiaoyu Ma ◽  
Qing Xu ◽  
Wei Tian ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Great Influence ◽  
Freezing Process ◽  
Drying Time ◽  
Dry Powders ◽  
Spray Freezing ◽  
Spray Freeze Drying ◽  
The Difference ◽  
Droplet Morphology ◽  
Drying Chamber

AbstractSpray freeze-drying is a process to directly produce high quality powders with short drying time. The difference of microstructures has a great influence on the physical properties of powders. However, during the spray freeze-drying process, the freezing degree of droplets in the drying chamber will change the product structure and affect the powder quality. In this study, the surface structure and morphology of dry powders were observed using scanning electron microscopy. The formation mechanism of droplet morphology during spray freeze-drying was analyzed. The results show that the rapid freezing process can produce finer microstructures.

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