scholarly journals Effects Of Rose-Hip And Grapeseed Dietary Supplementation On Serum Oxidative Stress Parameters In Dogs Before And After Physical Exercise

2015 ◽  
Vol 65 (3) ◽  
pp. 404-416 ◽  
Author(s):  
Kukovska Valentina ◽  
Celeska Irena ◽  
Ruškovska Tatjana ◽  
Valčić Olivera
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Statistical Significance ◽  
Dietary Supplementation ◽  
Oxidative Stress Parameters ◽  
Before And After ◽  
Antioxidative Effects ◽  
Dietary Regime ◽  
Rose Hip ◽  
Stress Parameters

AbstractThe aim of this study was to evaluate the effects of 60 days of rose-hip and grapeseed dietary supplementation of a balanced home-cooked diet on serum oxidative stress parameters: ROMs, MDA and FRAP in army service dogs before and after regular physical exercise. The dogs were fed a balanced cooked diet as instructed by army standards until the initial blood sampling in June. Thereon the dogs were randomly allotted to 4 groups according to the dietary regime: dogs maintained on a balanced cooked diet according to army standards, branded dry dog food, cooked diet with added 500 mg rose-hip extract, and cooked diet with added 100 mg grapeseed extract for a 60 day period from June to September after which all 4 groups were fed the standard cooked meal diet. Sampling was performed at the beginning of the experiment (June), 60 days from the start of the treatment (September) and finally 60 days after the end of supplementation (November). Statistical analysis of the results included descriptive statistical parameters: mean (M), standard deviation (SD), and variation coefficient (CV%). In order to test the statistical significance of the differences between treatments a multifactor variance test (ANOVA) was performed for ROM, MDA and FRAP and the combined effects of diet, exercise and time period were observed. The initial (in June) increase in MDA and ROMs after exercise indicates the presence of oxidative stress 30 minutes after exercise. However, the antioxidative effects of rose-hip and grapeseed extracts are not conclusive, as multifactor ANOVA testing of time, diet, and exercise factors did not reveal for MDA statistically significant differences either at 60 days of supplementation nor 60 days after withdrawal of the supplements. Only one distinct exception was recorded for the prolonged antioxidative effects reflected in significantly decreased (p<0.01) ROMs before and after exercise in dogs fed the branded dry food 60 days after the end of such dietary regime (November). FRAP values tend to be higher (p>0.05) after exercise compared to before exercise in all experimental groups in November, indicating on a possible redistribution and upregulation of endogenous antioxidants during the experiment.

scholarly journals Alfacalcidol modulates oxidative stress parameters in the peripheral blood of patients with active rheumatoid arthritis

2016 ◽  
Vol 81 (10) ◽  
pp. 1127-1139 ◽  
Author(s):  
Tatjana Zivanovic-Radnic ◽  
Katarina Simic-Pasalic ◽  
Mirjana Sefik-Bukilica ◽  
Sonja Misirlic-Dencic ◽  
Andjelka Isakovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Das28 Score ◽  
Sod Activity ◽  
Oxidative Stress Parameters ◽  
Before And After ◽  
Significant Clinical Improvement ◽  
Membrane Depolarisation ◽  
O2 Production ◽  
Gpx Activity ◽  
Stress Parameters

Hormone D and its analogues display immunomodulatory activities providing a beneficial effect in immunoinflammatory diseases. The aim of this study was to assess the effect of alfacalcidol treatment on superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activity and glutathione (GSH) and malondialdehyde (MDA) levels in patients with active RA. Sixteen patients with active RA and twenty controls were enrolled in the study. Blood samples were taken before and after 12 weeks of alfacalcidol therapy (2 ?g/day). Oxidative stress parameters were determined spectrophotometrically and by flow cytometry assessment. Disease activity was assessed using DAS28 score. The results revealed that alfacalcidol treatment, significantly (p = 0.04) reduced SOD activity and CAT activity (p = 0.001) in RA patients. The activity of GPx was significantly lower in RA patients before treatment, compared to controls (p = 0.04). After therapy, GPx activity was restored to control levels, and GSH levels were significantly reduced (p = 0.01). MDA levels in patients at the beginning of the study protocol, remained significantly elevated compared to controls (p = 0.01). Alfacalcidol treatment decreased MDA levels in patients (p = 0.19). Furthermore, 12-weeks alfacalcidol therapy, changed the response of RA patients? PBMC to stimulation preventing the O2 - production and mitochondrial membrane depolarisation. After alfacalcidol treatment, significant clinical improvement was observed.

Effects of palygorskite dietary supplementation on back fat mobilization, leptin levels and oxidative stress parameters in sows

2016 ◽  
Vol 132-133 ◽  
pp. 535-541 ◽  
Author(s):  
Georgios A. Papadopoulos ◽  
Vasileios Kanoulas ◽  
Georgios Arsenos ◽  
Geert P.J. Janssens ◽  
Johan Buyse ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dietary Supplementation ◽  
Oxidative Stress Parameters ◽  
Fat Mobilization ◽  
And Oxidative Stress ◽  
Stress Parameters

Physical Exercise Prevents the Exacerbation of Oxidative Stress Parameters in Chronic Kidney Disease

2010 ◽  
Vol 20 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Bárbara L.P. Coelho ◽  
Luís G.C. Rocha ◽  
Karoline S. Scarabelot ◽  
Débora L. Scheffer ◽  
Merieli M. Ronsani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Physical Exercise ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Evaluation of oxidative stress parameters in dogs with brachycephalic obstructive airway syndrome before and after surgery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Vladimira Erjavec ◽  
Tomaž Vovk ◽  
Alenka Nemec Svete
Keyword(s):  
Oxidative Stress ◽  
Clinical Signs ◽  
Respiratory Disorder ◽  
Lipid Peroxidation Product ◽  
Sod Activity ◽  
Oxidative Stress Parameters ◽  
Before And After ◽  
Status Assessment ◽  
Grade 3 ◽  
Stress Parameters

Abstract Introduction Canine brachycephalic obstructive airway syndrome (BOAS) is a conformation-related respiratory disorder of dog breeds having congenitally flattened facial and skull anatomy. The aim of the study was to determine oxidative stress parameters, the lipid peroxidation product malondialdehyde, and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase in BOAS patients before and after surgical treatment and in healthy brachycephalic dogs. Material and Methods Nine healthy brachycephalic dogs that had not undergone surgery and 39 BOAS patients were included in the study. The BOAS patients were classified as grade 1 (5/34), grade 2 (16/34), and grade 3 (13/34) based on the decrease in the radius of the airway in the larynx. In BOAS patients, oxidative stress parameters were determined before and two weeks after surgery, while in control dogs, blood samples were collected only on inclusion to the study. Results All BOAS patients showed various degrees of improvement in clinical signs after surgery. Significantly lower (P < 0.05) SOD activity was found in grade 2 and 3 BOAS patients than in grade 1 patients. Two weeks after surgery, a significant (P < 0.05) increase in SOD activity in grade 2 and 3 patients was observed. Conclusion Antioxidant enzyme SOD may play an important role in BOAS and can be used as a biomarker of antioxidant status assessment in BOAS patients.

scholarly journals Hypoxic and Hyperoxic Breathing as a Complement to Low-Intensity Physical Exercise Programs: A Proof-of-Principle Study

2021 ◽  
Vol 22 (17) ◽  
pp. 9600
Author(s):  
Costantino Balestra ◽  
Kate Lambrechts ◽  
Simona Mrakic-Sposta ◽  
Alessandra Vezzoli ◽  
Morgan Levenez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Physical Exercise ◽  
Ischemia Reperfusion ◽  
Exercise Program ◽  
Low Intensity ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Proof Of Principle ◽  
Stress Parameters

Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity is an effective means of reducing acute systemic and low-level inflammation occurring in different pathological conditions and in the recovery phase after disease. As a proof-of-principle, we hypothesized that low-intensity workout performed under modified oxygen supply would elicit a “metabolic exercise” inducing a hormetic response, increasing the metabolic load and oxidative stress with the same overall effect expected after a higher intensity or charge exercise. Herein, we report the effect of a 5-week low-intensity, non-training, exercise program in a group of young healthy subjects in combination with the exposure to hyperoxia (30% and 100% pO2, respectively) or light hypoxia (15% pO2) during workout sessions on several inflammation and oxidative stress parameters, namely hemoglobin (Hb), redox state, nitric oxide metabolite (NOx), inducible nitric oxide synthase (iNOS), inflammatory cytokine expression (TNF-α, interleukin (IL)-6, IL-10), and renal functional biomarkers (creatinine, neopterin, and urates). We confirmed our previous reports demonstrating that intermittent hyperoxia induces the normobaric oxygen paradox (NOP), a response overlapping the exposure to hypoxia. Our data also suggest that the administration of modified air composition is an expedient complement to a light physical exercise program to achieve a significant modulation of inflammatory and immune parameters, including cytokines expression, iNOS activity, and oxidative stress parameters. This strategy can be of pivotal interest in all those conditions characterized by the inability to achieve a sufficient workload intensity, such as severe cardiovascular alterations and articular injuries failing to effectively gain a significant improvement of physical capacity.

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