Effects of Physical Exercise on the Histopathological and Oxidative Stress Parameters in the Myocardial Tissue of Mice Exposed to Straw Cigarette Smoke

Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity is an effective means of reducing acute systemic and low-level inflammation occurring in different pathological conditions and in the recovery phase after disease. As a proof-of-principle, we hypothesized that low-intensity workout performed under modified oxygen supply would elicit a “metabolic exercise” inducing a hormetic response, increasing the metabolic load and oxidative stress with the same overall effect expected after a higher intensity or charge exercise. Herein, we report the effect of a 5-week low-intensity, non-training, exercise program in a group of young healthy subjects in combination with the exposure to hyperoxia (30% and 100% pO2, respectively) or light hypoxia (15% pO2) during workout sessions on several inflammation and oxidative stress parameters, namely hemoglobin (Hb), redox state, nitric oxide metabolite (NOx), inducible nitric oxide synthase (iNOS), inflammatory cytokine expression (TNF-α, interleukin (IL)-6, IL-10), and renal functional biomarkers (creatinine, neopterin, and urates). We confirmed our previous reports demonstrating that intermittent hyperoxia induces the normobaric oxygen paradox (NOP), a response overlapping the exposure to hypoxia. Our data also suggest that the administration of modified air composition is an expedient complement to a light physical exercise program to achieve a significant modulation of inflammatory and immune parameters, including cytokines expression, iNOS activity, and oxidative stress parameters. This strategy can be of pivotal interest in all those conditions characterized by the inability to achieve a sufficient workload intensity, such as severe cardiovascular alterations and articular injuries failing to effectively gain a significant improvement of physical capacity.

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Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration

Metabolic Brain Disease ◽

10.1007/s11011-016-9942-7 ◽

2016 ◽

Vol 32 (2) ◽

pp. 519-528 ◽

Cited By ~ 2

Author(s):

Lara M. Gomes ◽

Milena Carvalho-Silva ◽

Letícia J. Teixeira ◽

Joyce Rebelo ◽

Isabella T. Mota ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Mood Stabilizers ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Behavior and oxidative stress parameters in rats subjected to the animal's models induced by chronic mild stress and 6-hydroxydopamine

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113226 ◽

2021 ◽

Vol 406 ◽

pp. 113226

Author(s):

Talita Tuon ◽

Sandra S. Meirelles ◽

Airam B. de Moura ◽

Thayse Rosa ◽

Laura A. Borba ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Mild Stress ◽

Mild Stress ◽

Oxidative Stress Parameters ◽

6 Hydroxydopamine ◽

And Oxidative Stress ◽

Stress Parameters

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Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination

Neurotoxicity Research ◽

10.1007/s12640-020-00310-0 ◽

2021 ◽

Author(s):

Behnaz Barzegarzadeh ◽

Homeira Hatami ◽

Gholamreza Dehghan ◽

Nazli Khajehnasiri ◽

Mehdi Khoobi ◽

...

Keyword(s):

Oxidative Stress ◽

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Ethidium Bromide ◽

Cognitive Deficits ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2021-0020 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Basiru Olaitan Ajiboye ◽

Babatunji Emmanuel Oyinloye ◽

Jennifer Chidera Awurum ◽

Sunday Amos Onikanni ◽

Adedotun Adefolalu ◽

...

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Protective Role ◽

Diabetic Rats ◽

Gene Expressions ◽

Ki 67 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

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Dopamine Gene Polymorphism, Biochemical and Oxidative Stress Parameters in Geriatric Population with and Without Depression: A Pilot Study

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-020-00928-z ◽

2021 ◽

Author(s):

Raza Abbas Mahdi ◽

Israr Ahmad ◽

Talha Jilani ◽

Jamal Akhtar Ansari ◽

Farzana Mahdi ◽

...

Keyword(s):

Oxidative Stress ◽

Pilot Study ◽

Gene Polymorphism ◽

Geriatric Population ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation, and Oxidative Stress Parameters and Fecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity—PRO-DEMET Randomized Study Protocol

Journal of Clinical Medicine ◽

10.3390/jcm10071342 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1342

Author(s):

Oliwia Gawlik-Kotelnicka ◽

Anna Skowrońska ◽

Aleksandra Margulska ◽

Karolina H. Czarnecka-Chrebelska ◽

Igor Łoniewski ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Study Protocol ◽

Bifidobacterium Longum ◽

White Blood Cells ◽

Fecal Microbiota ◽

Probiotic Supplementation ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.

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