The pathogenic role of Blastocystis isolated from patients with irritable bowel syndrome and colitis from Iasi, Romania

2014 ◽  
Vol 60 (1) ◽  
Author(s):  
Doina S. Matiut ◽  
Lucian Hritcu
Keyword(s):  
Irritable Bowel Syndrome ◽  
Chronic Diarrhea ◽  
Clinical Manifestations ◽  
Total Serum ◽  
Pathogenic Potential ◽  
Ige Antibody ◽  
Etiologic Agents ◽  
Serum Iga ◽  
Irritable Bowel ◽  
Antibody Levels

AbstractBlastocystis is a common parasite and regarded as one of the etiologic agents of irritable bowel syndrome, colitis and chronic diarrhea. Our study was undertaken in order to identify different subtypes of Blastocystis isolated in patients with irritable bowel syndrome and colitis, as well as with chronic diarrhea and to evaluate their pathogenic potential. Seventy-three subjects (10 asymptomatic infected subjects, 49 subjects harboring Blastocystis or associated with other etiologic agents like bacteria, yeasts, protozoa, helminthes and 14 subjects with unknown etiologic agents) were investigated by in vitro parasitological and bacteriological stool samples followed by PCR subtyping of Blastocystis using STS primers, immunological markers (total serum IgA and IgE antibody levels), Helicobacter pylori antigen rapid test and fecal occult blood test. Also, among 49 subjects, there were 12 subjects harboring Blastocystis as the single etiologic agent. Subtyping proved that only three subtypes of Blastocystis were identified as following: subtype II (66.66%) in single infected subjects, subtype I (16.66%) in mixed infection with subtype II and subtype IV (8.33%) in single infected subjects. Total serum IgA and IgE antibody levels were in normal range. Subtype II was the most frequent subtype followed by subtype I and subtype IV of Blastocystis isolates in patients with irritable bowel syndrome, colitis, and chronic diarrhea as well as in asymptomatic infected group. Our results suggest that the severity of clinical manifestations depend on factors involving the host and possible parasitic density and not necessarily by isolated subtype.

Benign Chronic Diarrhea of Infancy

1981 ◽  
Vol 3 (5) ◽  
pp. 153-158
Author(s):  
W. Allan Walker
Keyword(s):  
Irritable Bowel Syndrome ◽  
Chronic Diarrhea ◽  
Spontaneous Resolution ◽  
Gastrointestinal Problems ◽  
High Incidence ◽  
Bowel Movements ◽  
Separate Clinical Entity ◽  
Irritable Bowel ◽  
Classic Paper ◽  
Referral Practice

Chronic nonspecific diarrhea of infancy (CNSD) or irritable bowel syndrome represents one of the most common gastrointestinal problems confronted by practicing pediatricias. In the subspecialty setting of the pediatric gastroenterologist, this entity comprised almost 35% of the outpatient referral practice. CNSD, originally thought to be part of the celiac syndrome, was described as a separate clinical entity by Cohlan in 1956.1 Since that time in the classic paper on this subject, Davidson and Wasserman2 have described consistent diagnostic criteria further characterizing CNSD as a recognizable syndrome. The onset of symptoms occurs classically between 6 and 30 months of age with the development of three to six loose stools with mucous per day, with no associated malabsorption or growth and development abnormalities (to be discussed in detail below). Whereas spontaneous resolution of CNSD is anticipated by 39 months of age, longitudinal observations indicate that these patients have a high incidence of functional bowel complaints during adolescence and beyond suggesting a continuum with "irritable bowel syndrome" of adulthood.3 From the standpoint of the child, this "complaint" all too frequently becomes the "problem" when the frequency and/or consistency of the bowel movements impair training or become intolerable to the parents.

Irritable Bowel Syndrome with Diarrhea

2018 ◽  
Author(s):  
Judy Nee ◽  
Jacqueline L. Wolf
Keyword(s):  
Irritable Bowel Syndrome ◽  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Treatment Modalities ◽  
Dietary Advice ◽  
Emerging Therapies ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal condition characterized by abdominal pain and alteration in bowel habits without an organic cause. One of the subcategories of this disorder is IBS with diarrhea (IBS-D). Clinically, patients who present with more than 3 months of abdominal pain or discomfort associated with an increase in stool frequency and/or loose stool form are defined as having IBS-D. This review addresses IBS-D, detailing the epidemiology, etiology and genetics, pathophysiology and pathogenesis, diagnosis, clinical manifestations and physical examination findings, differential diagnosis, treatment, emerging therapies, complications, and prognosis. Figures show potential mechanisms and pathophysiology of IBS, IBS-D suspected by clinical assessment and Rome III criteria, pharmacologic and nonpharmacologic treatment options, potential mechanisms of action of probiotics, and potential treatment modalities. Tables list the Rome criteria for IBS, alarm signs and symptoms suggestive of alternative diagnoses, IBS criteria, differential diagnosis of IBS-D, dietary advice options for IBS-D, and alternative and emerging therapies in IBS-D. This review contains 5 figures, 6 tables and 42 references KEYWORDS: IBS-D, eluxadoline, rifaximin, probiotics, bloating, antidepressants, bile acid malabsorption, microscopic colitis, celiac

Relation between frequency of asthma and IgE antibody levels against Dermatophagoides farinae and total serum IgE levels in schoolchildren

1988 ◽  
Vol 82 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Masanao Shibasaki ◽  
Kimio Tajima ◽  
Akihiro Morikawa ◽  
Masato Mitsuhashi ◽  
Ryo Sumazaki ◽  
...  
Keyword(s):  
Total Serum ◽  
Dermatophagoides Farinae ◽  
Serum Ige ◽  
Ige Antibody ◽  
Antibody Levels

scholarly journals Research Progress in Fecal Microbiota Transplantation as Treatment for Irritable Bowel Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yao Wang ◽  
Fengling Zheng ◽  
Shan Liu ◽  
Huanhuan Luo
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Large Scale ◽  
Fecal Microbiota Transplantation ◽  
Clinical Manifestations ◽  
Fecal Microbiota ◽  
Research Progress ◽  
Future Research ◽  
Intestinal Microbes ◽  
Irritable Bowel

Irritable bowel syndrome is a functional disorder characterized by abdominal pain or discomfort associated with altered bowel habits. Due to the uncertainty of the pathogenesis of IBS and the diversity of its clinical manifestations, IBS cannot be completely cured. Increasing evidence suggests the key role of altered intestinal microbiota in the pathogenesis of IBS. Therefore, attention is being shifted to adjusting the changes in intestinal microbiota to control IBS symptoms. Fecal microbiota transplantation (FMT), antibiotics, probiotics, and synbiotics are currently often employed as treatment for IBS. And FMT is the most significant therapeutic efficacy with the least number of side effects. FMT provides a creative way to restore the abnormal gut microbiome in patients with IBS. But although current clinical studies confirm the effectiveness of FMT in the treatment of IBS, they are short-term studies of small samples, and there is still a lack of large-scale long-term studies. In this paper, we review the intestinal microbiota changes of IBS, the common methods of treating IBS with intestinal microbes, and the research status of FMT for the treatment of IBS. Finally, we put forward some opinions on the future research direction of FMT treatment of IBS.

Significantly Increased IgG2 Subclass Antibody Levels to Blastocystis hominis in Patients with Irritable Bowel Syndrome

1997 ◽  
Vol 56 (3) ◽  
pp. 301-306 ◽  
Author(s):  
Rabia Hussain ◽  
Wasim Jaferi ◽  
Ashfaq Ahmed ◽  
Sarwar Zuberi ◽  
Viqar Zaman ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Blastocystis Hominis ◽  
Irritable Bowel ◽  
Antibody Levels

scholarly journals Actual issues of diagnosis and treatment of irritable bowel syndrome

2019 ◽  
pp. 110-116
Author(s):  
D. I. Trukhan ◽  
V. V. Goloshubina ◽  
D. S. Ivanova
Keyword(s):  
Irritable Bowel Syndrome ◽  
Diagnostic Criteria ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Bifidobacterium Infantis ◽  
Rome Criteria ◽  
International Consensus ◽  
Incorrect Diagnosis ◽  
Irritable Bowel ◽  
Number Of Publications

The problem of irritable bowel syndrome (IBS) remains relevant for practice internist and gastroenterologist, as evidenced by the large number of publications in recent years on this issue, affecting various aspects of the pathogenesis, clinical manifestations, diagnosis and treatment of IBS. The article describes the evolution of diagnostic criteria for IBS as part of an international consensus «Rome criteria». Lack of effect of the treatment of IBS ex juvantibus often not a consequence of an incorrect diagnosis, and due to the presence in the patient’s intestinal disorders microbiocenosis. In this situation, it is expedient to correct the microbial landscape of the intestine with the use of probiotic agents. Efficacy in reducing the symptoms of irritable bowel syndrome has reliably demonstrated specific strains of probiotics, such as Bifidobacterium infantis 35624.

IBS‑like syndromes in clinic of internal diseases: current state of problem

2021 ◽  
Vol 1 (6) ◽  
pp. 36-40
Author(s):  
A. M. Osadchuk ◽  
I. D. Loranskaya ◽  
M. A. Osadchuk
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Manifestations ◽  
Optimal Management ◽  
Lactase Deficiency ◽  
Results Of Treatment ◽  
Current State ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
Long Term Preservation

IBS-like syndromes are one of the most important problems in gastroenterology. The clinical picture is identical to that of irritable bowel syndrome can be associated with inflammatory bowel disease, colorectal cancer, celiac disease, food allergy, lactase deficiency enteropathy, non-celiac sensitivity, gluten and other diseases. In this regard, irritable bowel syndrome is a diagnosis of exclusion and always requires a rather complex differential diagnosis to establish the true cause of the disease, conduct adequate therapy and achieve a stable remission. The purpose of the review was to obtain scientific knowledge about IBS-like syndromes and to develop optimal management tactics for these patients. The review demonstrates that the clinical manifestations of IBS are largely nonspecific due to the frequent transition of one form of the disease to another, which creates certain difficulties in making a diagnosis. Timely diagnosis of IBS-like syndromes, often superimposed on the already existing IBS pathology, significantly improves the results of treatment of patients with intestinal symptoms and ensures long-term preservation of remission of the disease.

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