scholarly journals Runt-related transcription factor 3 promoter hypermethylation and gastric cancer risk: A meta-analysis

2018 ◽  
Vol 13 (1) ◽  
pp. 64-70
Author(s):  
Mei Lina ◽  
Wu Changan ◽  
Zhao Qing
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Gene Promoter ◽  
Promoter Hypermethylation ◽  
Cancer Tissue ◽  
Gastric Cancer Risk ◽  
Runx3 Gene ◽  
Gastric Cancer Patients

AbstractObjectiveThe aim of this study was to investigate the correlation between runt-related transcription factor 3 (RUNX3) gene promoter hypermethylation and gastric cancer risk by meta-analysis.MethodsBy searching Medline, PubMed, Embase, Cochrane, Ovid and CNKI electronic databases, the open published studies about the association between RUNX3 gene promoter hypermethylation and gastric cancer risk were screened. The hypermethylation rate in cancer tissue and autologous control tissue (normal gastric tissue of gastric cancer patients) were extracted from each included study. The odds ratio (OR) and corresponding 95% confidence interval (95% CI) of RUNX3 gene promoter hypermethylation in cancer tissue versus autologous control tissue of gastric cancer patients were pooled with random or fixed effect models. The publication bias was evaluated by Begg’s funnel plot and Egger’s line regression test.ResultsFinally, twenty three relevant studies were included in this meta-analysis. The hypermethylation rate in cancer tissue and autologous control tissue of gastric cancer patients were 0.56±0.16 and 0.18±0.22 respectively, which demonstrated a hypermethylation rate in cancer tissue significantly higher than that of autologous controls (P<0.05). A significant positive correlation of hypermethylation rate between cancer tissue and autologous control existed for the included 23 studies(rpearson=0.62, P<0.05). For significant heterogeneity across the studies, the OR was pooled by random effects model. The combined OR was 8.06 with the 95% CI of 5.73~11.32, which indicated the hypermethylation frequency in cancer tissue was higher than that of autologous controls.ConclusionThe RUNX3 gene promoter hypermethylation rate was much higher in cancer tissue than that of normal gastric tissue in patients with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter hypermethylation. Furthermore, RUNX3 gene promoter hypermethylation may be a potential biomarker for gastric cancer diagnosis.

scholarly journals The irreversible HCV-associated risk of gastric cancer following interferon-based therapy: a joint study of hospital-based cases and nationwide population-based cohorts

2019 ◽  
Vol 12 ◽  
pp. 175628481985573 ◽  
Author(s):  
Chun-Wei Chen ◽  
Jur-Shan Cheng ◽  
Tai-Di Chen ◽  
Puo-Hsien Le ◽  
Hsin-Ping Ku ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Population Based ◽  
Hcv Infection ◽  
Research Database ◽  
Gastric Cancer Risk ◽  
Male Sex ◽  
Gastric Cancer Patients

Background: Hepatitis C virus (HCV) infection causes many extrahepatic malignancies; whether it increases gastric cancer risk and the risk reverses after anti-HCV therapy remain elusive. Method: A nationwide population-based cohort study of Taiwan National Health Insurance Research Database (TNHIRD) was conducted. In parallel, the risk factors and HCV-core-protein expressions were surveyed in gastric cancer patients from a tertiary care center. Results: From 2003 to 2012, of 11,712,928 patients, three 1:4:4, propensity-score-matched TNHIRD cohorts including HCV-treated (7545 patients with interferon-based therapy ⩾ 6 months), HCV-untreated ( n = 30,180), and HCV-uninfected cohorts ( n = 30,180) were enrolled. The cumulative incidences of gastric cancer [HCV-treated: 0.452%; 95% confidence interval (CI): 0.149–1.136%; HCV-untreated: 0.472%; 95% CI: 0.274–0.776%; HCV-uninfected: 0.146%; 95% CI 0.071–0.280%] were lowest in HCV-uninfected cohort ( p = 0.0028), but indifferent between treated and untreated cohorts. HCV infection [hazards ratio (HR): 2.364; 95% CI: 1.337–4.181], male sex (HR: 1.823; 95% CI: 1.09–3.05) and age ⩾ 49 years (HR: 3.066; 95% CI: 1.56–6.026) were associated with incident gastric cancers. Among 887 (males: 68.4%; mean age: 66.5 ± 12.9 years, 2008–2018) hospitalized gastric cancer patients, HCV Ab-positive rate was 7.8%. None of the investigated factors exhibited different rates between HCV Ab-positive and Ab-negative patients. No HCV-core-positive cells were demonstrated in gastric cancer tissues. Conclusions: HCV infection, male sex and old age were risk factors for gastric cancer development. HCV-associated gastric cancer risk might be neither reversed by interferon-based therapy, nor associated with in situ HCV-core-related carcinogenesis.

scholarly journals Association between polymorphisms of thymidylate synthase gene 5′- and 3′-UTR and gastric cancer risk: meta-analysis

2016 ◽  
Vol 36 (6) ◽  
Author(s):  
Ao Mo ◽  
Yongliang Zhao ◽  
Yan Shi ◽  
Feng Qian ◽  
Yingxue Hao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Thymidylate Synthase ◽  
Large Scale ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Caucasian Population ◽  
Gastric Cancer Risk ◽  
Increased Risk ◽  
Gastric Cancer Patients

Gastric cancer is the most common cancer and the most frequent cause of cancer death worldwide. Several studies have identified the role of thymidylate synthase (TS) 5′- and 3′-UTR and gastric cancer susceptibility; however, the results still remain inconclusive. The purpose of this meta-analysis was to reinvestigate this correlation. In the present study, online databases were searched to retrieve relevant articles published between January 2000 and 2016. The odds ratio (OR) and 95% confidence interval (CI) were employed to calculate the strength of association. Overall, a total of 13 articles were screened out, including 2382 gastric cancer patients and 3171 healthy controls. We found that polymorphisms of TS 5′-UTR 2R (double repeats)/3R (triple repeats) of a 28-bp sequence (11 articles) and 3′-UTR del6/ins6 (seven articles) were not significantly associated with increased risk of gastric cancer. Subgroup analysis by ethnicity showed that 2R allele and 2R/2R genotype in TS 5′-UTR were associated with gastric cancer susceptibility in Caucasian and African populations; del6 allele, del6/del6 and del6/ins6 genotypes were correlated with gastric cancer in Caucasian population. In conclusion, our result suggested that TS polymorphisms might be the risk factors for gastric cancer risk in Caucasian population, although this association needs further study, and future large-scale researches are still required.

scholarly journals Association of WNT-1 Inducible Signaling Pathway Protein-1 (WISP1) Genetic Polymorphisms with the Risk of Gastric Cancer in Guangxi Chinese

2021 ◽  
Author(s):  
Yanqiong Liu ◽  
Weijuan Qin ◽  
Fuyong Zhang ◽  
Wang Jian ◽  
Xi Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Signaling Pathway ◽  
Dominant Model ◽  
Gastric Cancer Risk ◽  
Chinese Ethnicity ◽  
Gastric Cancer Patients ◽  
First Time ◽  
Normal Controls

Abstract BackgroundTo date, no study has investigated the association of the WNT1 inducible signaling pathway protein-1 (WISP1) polymorphisms with susceptibility to gastric cancer. Therefore, we conducted this study to explore their relation.Methods204 gastric cancer patients and 227 normal controls were enrolled. The WISP1 SNPs rs2929973, rs7843546 and rs10956697 were selected, and their genotypic distributions were determined through PCR-RFLPResultsIn overall, we could not identify a significant association between WISP1 SNP rs2929973, rs7843546 and rs10956697) and gastric cancer risk. However, subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in Han Chinese ethnicity (CT vs. CC: OR= 0.33, 95%CI = 0.14-0.78; TT vs. CC: OR = 0.29, 95%CI = 0.11-0.76; dominant model CT+TT vs. CC: OR = 0.32, 95%CI = 0.14-0.74). In addition, patients with the rs7843546 TT genotype were around one-third as 0.34 likely (OR = 0.34; 95% CI: 0.14-0.84) than those with the CC genotype to develop stage I/II gastric cancer. Furthermore, individuals ≥50 years old who carried the rs10956697 AC genotype represented significantly decreased risk for gastric cancer (AC vs. CC: OR = 0.58, 95%CI = 0.35-0.98). Smokers with the rs10956697 AC and AC+AA genotype were around one-third likely to develop gastric cancer (OR = 0.28, 95% CI= 0.09-0.82 and OR = 0.32, 95% CI = 0.12-0.89, respectively)ConclusionsWISP1 SNPs rs7843546 and rs10956697 polymorphisms were the first time discovered to reduce the susceptibility to gastric cancer in different subgroup in Guangxi Chinese.

A PILOT STUDY OF HER-2/NEU GENE AMPLIFICATION ASSESSED BY FLUORESCENCE IN SITU HYBRIDIZATION (FISH) IN GASTRIC CANCER

2014 ◽  
pp. 15-20
Author(s):  
Van Huy Tran ◽  
Thi Minh Thi Ha ◽  
Trung Nghia Van ◽  
Viet Nhan Nguyen ◽  
Phan Tuong Quynh Le ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cancer Patients ◽  
Gene Amplification ◽  
Cancer Tissue ◽  
Tissue Samples ◽  
Her 2 ◽  
Gastric Cancer Patients

Background: HER-2/neu is a predictive biomarker for treatment of gastric cancer using trastuzumab in combination with chemotherapy. This study aimed to evaluate the status of HER-2/neu gene amplification using fluorescence in situ hybridization (FISH) in gastric cancer. Patients and methods: thirty six gastric cancer patients were assessed HER-2/neu gene amplification by FISH using PathVysionTM HER-2 DNA Probe kit (including HER-2/neu probe and CEP-17 probe) with biopsy and surgical specimens. Results: The HER-2/neu gene amplification was observed in three cases (8.3%), the HER-2/neu gene amplification rate in Lauren’s intestinal-type and diffuse-type were 11.8% and 5.2%, respectively. Conclusion: We applied successfully FISH technique with gastric cancer tissue samples. This technique could be performed as routine test in gastric cancer in order to select patients that benefit from trastuzumab in combination with chemotherapy.

Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

Cytokine ◽  
2012 ◽  
Vol 59 (1) ◽  
pp. 176-183 ◽  
Author(s):  
Wang Junli ◽  
He Wenjun ◽  
Liu Jinxin ◽  
Nong Legen ◽  
Wei Yesheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Gastric Cancer Risk

scholarly journals Alcohol drinking and gastric cancer risk: a meta-analysis of observational studies

Oncotarget ◽  
2017 ◽  
Vol 8 (58) ◽  
pp. 99013-99023 ◽  
Author(s):  
Peng-Liang Wang ◽  
Fang-Tao Xiao ◽  
Bao-Cheng Gong ◽  
Fu-Nan Liu
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Observational Studies ◽  
Meta Analysis ◽  
Gastric Cancer Risk

scholarly journals Association between CHFR gene hypermethylation and gastric cancer risk: a meta-analysis

2016 ◽  
Vol Volume 9 ◽  
pp. 7409-7414 ◽  
Author(s):  
Hua Shi ◽  
Xiaojing Wang ◽  
Jianbo Wang ◽  
Jundi Pan ◽  
Junwei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Gastric Cancer Risk ◽  
Em Gene

Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis

2015 ◽  
Vol 34 (4) ◽  
pp. 620-626 ◽  
Author(s):  
Yihua Wu ◽  
Yao Ye ◽  
Yu Shi ◽  
Peiwei Li ◽  
Jinming Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Vitamin A ◽  
Meta Analysis ◽  
Gastric Cancer Risk

scholarly journals ELISA study of matrix metalloproteinases 2, 7, 9 and their type 2 tissue inhibitor in the tumors of gastric cancer patients: clinical and pathologic correlations

2018 ◽  
Vol 46 (4) ◽  
pp. 323-329
Author(s):  
E. S. Gershtein ◽  
A. A. Ivannikov ◽  
V. L. Chang ◽  
N. A. Ognerubov ◽  
М. M. Davydov ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Matrix Metalloproteinases ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Univariate Analysis ◽  
Gastric Cancer Tissue ◽  
Cancer Tissue ◽  
Gastric Cancer Patients

Background: Over the last 10 years the incidence of gastric cancer has declined significantly. Nevertheless, it remains one of the most prevalent malignancies both in Russia and worldwide. Therefore, the problems of early diagnostics, prognosis and individualized treatment choice are still on the agenda. Much attention is paid to the evaluation of molecular biological characteristics of the tumor, as well as to the development of multiparametric prognostic systems for gastric cancer based on its identified characteristics. An important place among potential tumor biological markers belongs to matrix metalloproteinases (MMPs) involved into all the stages of tumor progression, first of all, into the regulation of invasion and metastasizing.Aim: Comparative quantitative evaluation of some MMP family members (MMP-2, 7, and 9) and one of the tissue MMP inhibitors (TIMP-2) levels in the tumors and adjacent histologically unchanged mucosa in gastric cancer patients, the analysis of their associations with the main clinical and pathological features of the disease and its prognosis.Materials and methods: Sixty six (66) primary gastric cancer patients (32 male and 34 female) aged 24 to 82 years (median, 61 year) were recruited into the study. Twenty two (22) patients were with stage I of the disease, 11 with stage II, 28 with stage III, and 5 with stage IV. The concentrations of the proteins studied were measured in the tumor and unchanged mucosa extracts by standard direct ELISA kits (Quantikine®, R&D Systems, USA).Results: Tumor MMP-2, 7 and 9 levels were significantly increased, compared to those in the adjacent histologically unchanged mucosa, in 80, 70 and 72% of gastric cancer patients, respectively, while the increase of TIMP-2 level found in 61% of the tumors was not statistically significant. Tumor MMP-2 and TIMP-2 content was increasing significantly with higher T index – size and advancement of the primary tumor (p < 0.01 and p < 0.05 respectively). Tumor MMP-2 level was also increasing in parallel with the N index (regional lymph node involvement; p < 0.01); it was significantly higher in the patients with distant metastases than in those without them (p < 0.05). Tumor MMP-9 and MMP-7 concentrations were not significantly associated with the indices of the tumor progression. The patients were followed up for 1 to 85 months (median, 18.3 months). According to the univariate analysis, high (> 32.6 ng/mg protein) MMP-2 and low MMP-7 (< 1.1 ng/mg protein) levels in the gastric cancer tissue represent statistically significant unfavorable prognostic factors for overall survival. Increased TIMP-2 level is associated with a non-significant decrease in the overall survival (p > 0.05), whereas the MMP-9 level was unrelated to the gastric cancer prognosis. Only T index (p = 0.0034) and tumor MMP-7 content (p = 0.026) remained independent prognostic factors in the multivariate regression analysis.Conclusion: The majority of gastric cancer patients demonstrate a significant increase in the expression of three MMP family members, i.e. gelatinases (MMP-2 and 9), and matrilysin (MMP-7), in the tumors, as compared to adjacent histologically unchanged mucosa. Only MMP-2 levels were associated with the disease progression, increasing with higher TNM system indices. High MMP-2 and low MMP-7 content in the gastric cancer tissue are significant unfavorable prognostic factors for the overall survival in the univariate analysis, but only MMP-7 has retained its independent prognostic value in the multivariate assessment.

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