Effects of the nasal passage on forced oscillation lung function measurements

2017 ◽  
Vol 62 (6) ◽  
pp. 635-642 ◽  
Author(s):  
Chuong Ngo ◽  
Karl Krüger ◽  
Thomas Vollmer ◽  
Stefan Winter ◽  
Bernhard Penzlin ◽  
...  

AbstractThe forced oscillation technique (FOT) is a non-invasive pulmonary function test which is based on the measurement of respiratory impedance. Recently, promising results were obtained by the application of FOT on patients with respiratory failure and obstructive sleep apnea (OSA). By using a nasal mask instead of a mouthpiece, the influences of the nasal passage and upper shunt alter the measured mechanical impedance. In this paper, we investigated the effects of the nasal passage and mask on FOT measurements from eight healthy subjects. A method for flow correction has been developed, which contains a pressure-flow characteristics compensation of the undetermined flow leakage at the face-mask interface. Impedance calculation and parameter estimation were performed in the frequency domain using fast Fourier transform (FFT). Average nasal parameters were

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agnieszka Smolinska ◽  
David S. Jessop ◽  
Kirk L. Pappan ◽  
Alexandra De Saedeleer ◽  
Amerjit Kang ◽  
...  

AbstractFace masks and personal respirators are used to curb the transmission of SARS-CoV-2 in respiratory droplets; filters embedded in some personal protective equipment could be used as a non-invasive sample source for applications, including at-home testing, but information is needed about whether filters are suited to capture viral particles for SARS-CoV-2 detection. In this study, we generated inactivated virus-laden aerosols of 0.3–2 microns in diameter (0.9 µm mean diameter by mass) and dispersed the aerosolized viral particles onto electrostatic face mask filters. The limit of detection for inactivated coronaviruses SARS-CoV-2 and HCoV-NL63 extracted from filters was between 10 to 100 copies/filter for both viruses. Testing for SARS-CoV-2, using face mask filters and nasopharyngeal swabs collected from hospitalized COVID-19-patients, showed that filter samples offered reduced sensitivity (8.5% compared to nasopharyngeal swabs). The low concordance of SARS-CoV-2 detection between filters and nasopharyngeal swabs indicated that number of viral particles collected on the face mask filter was below the limit of detection for all patients but those with the highest viral loads. This indicated face masks are unsuitable to replace diagnostic nasopharyngeal swabs in COVID-19 diagnosis. The ability to detect nucleic acids on face mask filters may, however, find other uses worth future investigation.


Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Kate C. Tatham ◽  
Matthew Ko ◽  
Lisa Palozzi ◽  
Stephen E. Lapinsky ◽  
Laurent J. Brochard ◽  
...  

2009 ◽  
Vol 10 (3) ◽  
pp. 337-343 ◽  
Author(s):  
Wolfgang Galetke ◽  
Winfried J. Randerath ◽  
Sven Stieglitz ◽  
Cordula Laumanns ◽  
Norbert Anduleit ◽  
...  

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