Synthesis and characterization of hyperbranched poly (sulfone-amine) modified β-cyclodextrin

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Liang Chen ◽  
Peng He ◽  
Zhifeng Jia ◽  
Xinyuan Zhu ◽  
Deyue Yan
Keyword(s):  
Drug Delivery ◽  
Low Cost ◽  
Food Additives ◽  
Synthesis And Characterization ◽  
Good Solubility ◽  
Low Viscosity ◽  
Hyperbranched Poly ◽  
Potential Applications ◽  
Inclusion Ability

AbstractAn economical strategy to prepare hyperbranched poly(sulfone-amine) modified β-cyclodextrins (HPSA-m-CDs) from natural β-cyclodextrin (β-CD) and other commercially available materials has been reported. The final product has many good properties of hyperbranched poly(sulfone-amine)s (good solubility, low viscosity etc.), while its inclusion ability can also be well kept. It is a feasible approach to prepare functionalized modified cyclodextrin at very low cost, and may have potential applications in the fields of catalysis, drug delivery, food additives, etc.

scholarly journals Synthesis and Characterization of Super Paramagnetic Magnetite Nanoparticles for Drug Delivery Application

2018 ◽  
Vol 7 (2.19) ◽  
pp. 87
Author(s):  
D BALAJ ◽  
C SARALA RUBI ◽  
N G. RENGANATHAN
Keyword(s):  
Drug Delivery ◽  
Magnetite Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Biomedical Application ◽  
Synthesis And Characterization ◽  
Xrd Pattern ◽  
Magnetite Fe3o4 ◽  
Tumor Hyperthermia ◽  
Potential Applications

Attractive nanoparticles have been broadly considered on account of their potential applications as complexity operators in attractive reverberation imaging (MRI) of tumors, cell and DNA partition, attractively guided medication conveyance, tumor hyperthermia. Among the attractive oxides, magnetite nanoparticles are most appropriate because of their low danger and great attractive properties which may be used in drug delivery. Magnetite nanoparticles were synthesized using FeCl3 and FeSO4 as precursors and characterized for size and shape using non-contact AFM.  The formation of magnetite was confirmed by XRD pattern. The elemental composition of the obtained phase was determined using EDAX. In this work, we are aiming to develop drug loaded biopolymer Magnetite nanoparticles for biomedical application. Our main objective is to synthesize and characterize Magnetite (Fe3O4) nanoparticles.  

Synthesis and characterization of a porphyrin-crown ether conjugate as a potential intermediate for drug delivery application

2020 ◽  
pp. A-G
Author(s):  
Maher Fathalla
Keyword(s):  
Mass Spectrometry ◽  
Drug Delivery ◽  
High Resolution Mass Spectrometry ◽  
Mesoporous Silica Nanoparticles ◽  
Synthesis And Characterization ◽  
Delivery Vehicle ◽  
Potential Applications ◽  
Resolution Mass ◽  
C Nmr

The development of synthetic strategies for functional building units plays a central role in supramolecular chemistry. Both porphyrin and crown ethers have attracted the attention of researchers worldwide owing to their unique properties. It is envisioned that the integration of the two molecules will result in hybrid materials with potential applications in many fields. In the present study, a new porphyrin derivative 3 appended with four 18-crown-6 (18C6) ether moieties was synthesized through the Suzuki-Miyaura coupling of boronic ester porphyrin 1 and 4-bromobenzo-18-crown-6 2 in 80% yield. Porphyrin 3 was fully characterized by 1H/[Formula: see text]C NMR spectroscopy and high resolution mass spectrometry. The tendency of the 18C6 to form host-guest complexes with ammonium cations was exploited to assemble cation responsive hybrid material of porphyrin 3 and ammonium immobilized mesoporous silica nanoparticles (MSNs). Furthermore, the potential application of the 3/MSNs conjugate as a cation-responsive drug delivery vehicle was investigated in solution by UV-vis and fluorescence spectroscopies.

scholarly journals Synthesis and Characterization of Novel Castor Oil-Based Polyol for Potential Applications in Coatings

2019 ◽  
Vol 7 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Azam Sardari ◽  
Ali Asghar Sabbagh Alvani ◽  
Seyed Reza Ghaffarian
Keyword(s):  
Castor Oil ◽  
Synthesis And Characterization ◽  
Potential Applications

scholarly journals Focused ultrasound in neuro-oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation

2021 ◽  
Author(s):  
Emily C. Whipple ◽  
Camille A. Favero ◽  
Neal F. Kassell
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Focused Ultrasound ◽  
Clinical Evidence ◽  
Neurological Injury ◽  
High Concentration ◽  
Potential Applications ◽  
Tumor Agent

Abstract Introduction Intra-arterial (lA) delivery of therapeutic agents across the blood-brain barrier (BBB) is an evolving strategy which enables the distribution of high concentration therapeutics through a targeted vascular territory, while potentially limiting systemic toxicity. Studies have demonstrated lA methods to be safe and efficacious for a variety of therapeutics. However, further characterization of the clinical efficacy of lA therapy for the treatment of brain tumors and refinement of its potential applications are necessary. Methods We have reviewed the preclinical and clinical evidence supporting superselective intraarterial cerebral infusion (SSJACI) with BBB disruption for the treatment of brain tumors. In addition, we review ongoing clinical trials expanding the applicability and investigating the efficacy of lA therapy for the treatment of brain tumors. Results Trends in recent studies have embraced the use of SSIACI and less neurotoxic chemotherapies. The majority of trials continue to use mannitol as the preferred method of hyperosmolar BBB disruption. Recent preclinical and preliminary human investigations into the lA delivery of Bevacizumab have demonstrated its safety and efficacy as an anti-tumor agent both alone and in combination with chemotherapy. Conclusion lA drug delivery may significantly affect the way treatment are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of lA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, lA therapy may offer significant benefits for the treatment of brain tumors.

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