scholarly journals Asymmetric Mannich Reaction: Synthesis of Novel Chiral 5-(substituted aryl)-1,3,4-Thiadiazole Derivatives with Anti-Plant-Virus Potency

2019 ◽  
Vol 25 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Song Bai ◽  
Yunying Zhu ◽  
Qin Wu
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Mannich Reaction ◽  
Plant Virus ◽  
Enantiomeric Excess ◽  
Cinchona Alkaloid ◽  
Reaction Synthesis ◽  
Thiadiazole Derivatives

AbstractA series of novel chiral 5-(substituted aryl)-1,3,4-thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess (ee)). The bioassay results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV).

Plant virus hybrid materials based on tobacco mosaic virus and small organic cross-linkers

2018 ◽  
Vol 7 (3) ◽  
pp. 187-193
Author(s):  
Esra Icik ◽  
Sabine Eiben ◽  
Nicole Schädel ◽  
Julia Kupka ◽  
Maike Martini ◽  
...  
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Hybrid Materials ◽  
Plant Virus

scholarly journals Inhibitory Effect of Osthole from Cnidium monnieri on Tobacco Mosaic Virus (TMV) Infection in Nicotiana glutinosa

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 65 ◽  
Author(s):  
Ya-Han Chen ◽  
Dong-Sheng Guo ◽  
Mei-Huan Lu ◽  
Jian-Ying Yue ◽  
Yan Liu ◽  
...  
Keyword(s):  
Coat Protein ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Virus ◽  
Inhibitory Effect ◽  
Nicotiana Glutinosa ◽  
1H And 13C Nmr ◽  
Virus Activity ◽  
Viral Particles ◽  
Coumarin Compound

The coumarin compound of osthole was extracted from Cnidium monnieri and identified by LC-MS and 1H- and 13C-NMR. Osthole was tested for anti-virus activity against tobacco mosaic virus (TMV) using the half-leaf method. The results showed that stronger antiviral activity on TMV infection appeared in Nicotiana glutinosa than that of eugenol and ningnanmycin, with inhibitory, protective, and curative effects of 72.57%, 70.26%, and 61.97%, respectively. Through observation of the TMV particles, we found that osthole could directly affect the viral particles. Correspondingly, the level of coat protein detected by Western blot was significantly reduced when the concentrations of osthole increased in tested plants compared to that of the control. These results suggest that osthole has anti-TMV activity and may be used as a biological reagent to control the plant virus in the half-leaf method.

scholarly journals S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE−/− mice

2019 ◽  
Vol 7 (11) ◽  
pp. 1842-1846 ◽  
Author(s):  
Jooneon Park ◽  
Huiyun Gao ◽  
Yunmei Wang ◽  
He Hu ◽  
Daniel I. Simon ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Virus ◽  
High Specificity ◽  
Diagnostic Strategy ◽  
High Risk Factors ◽  
Atherosclerotic Lesions

TMV-based plant virus nanoparticles targeting S100A9 exhibited high specificity to atherosclerotic lesions in ApoE−/− mice, which provides a new diagnostic strategy for atherosclerosis with high risk factors.

Dielectrophoretic investigation of plant virus particles: Cow Pea Mosaic Virus and Tobacco Mosaic Virus

2006 ◽  
Vol 27 (20) ◽  
pp. 3939-3948 ◽  
Author(s):  
Irina Ermolina ◽  
Joel Milner ◽  
Hywel Morgan
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Virus ◽  
Virus Particles

THE ELECTROPHORETIC ANALYSIS OF PLANT VIRUS PREPARATIONS

1959 ◽  
Vol 37 (1) ◽  
pp. 119-126 ◽  
Author(s):  
P. M. Townsley
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Extracts ◽  
Plant Virus ◽  
Potato Virus X ◽  
Electrophoretic Analysis ◽  
Agar Gel ◽  
Zone Electrophoresis ◽  
Staining Methods ◽  
Protein Staining

Zone electrophoresis in agar gel has been used for separating tobacco mosaic virus and potato virus X from crude plant extracts and reaction mixtures. The viruses were located within the gel by autoradiographic, serological, and protein-staining methods.

THE ELECTROPHORETIC ANALYSIS OF PLANT VIRUS PREPARATIONS

1959 ◽  
Vol 37 (1) ◽  
pp. 119-126 ◽  
Author(s):  
P. M. Townsley
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Extracts ◽  
Plant Virus ◽  
Potato Virus X ◽  
Electrophoretic Analysis ◽  
Agar Gel ◽  
Zone Electrophoresis ◽  
Staining Methods ◽  
Protein Staining

Zone electrophoresis in agar gel has been used for separating tobacco mosaic virus and potato virus X from crude plant extracts and reaction mixtures. The viruses were located within the gel by autoradiographic, serological, and protein-staining methods.

scholarly journals ELECTRON MICROSCOPY OF STRUCTURAL DETAIL IN FROZEN BIOLOGICAL SPECIMENS

1957 ◽  
Vol 3 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Russell L. Steere
Keyword(s):  
Electron Microscopy ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Internal Structure ◽  
Plant Virus ◽  
Yellow Mosaic Virus ◽  
Turnip Yellow Mosaic Virus ◽  
Structural Detail ◽  
Hexagonal Packing

A procedure is described whereby preshadowed replicas can be obtained from frozen biological specimens which have been cut and then etched by sublimation of the ice from their surfaces. Electron micrographs showing details of the internal structure of plant virus crystals are presented to demonstrate the values of the procedure. Crystals of purified tobacco ringspot virus and squash mosaic virus and some portions of turnip yellow mosaic virus crystals have been shown to exhibit hexagonal packing. Sections through in situ crystals of tobacco mosaic virus show the rods to be parallel within each layer and arranged in a square net as viewed end on. Individual rods in each layer of the latter measure 300 mµ in length and are somewhat tilted with respect to the rods of adjacent layers. This results in the formation of a herring-bone appearance when a crystal is cut perpendicular to its hexagonal face. It is suggested that the procedure outlined here might well serve to supplement other procedures for the preparation of many cytological specimens for electron microscopy.

scholarly journals Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60621 ◽  
Author(s):  
Ruolan Liu ◽  
Radhika A. Vaishnav ◽  
Andrew M. Roberts ◽  
Robert P. Friedland
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Plant Virus
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