Effects of Feed Powder Quantity and Compression Pressure on the Tensile Strength of Eurycoma longifolia Jack Tablets Using Different Binders

2013 ◽  
Vol 9 (2) ◽  
pp. 155-161
Author(s):  
Aziana Azlin Abdul Hamid ◽  
Yus Aniza Yusof ◽  
Nyuk L. Chin ◽  
Suhaila Mohamed ◽  
Faiqa Salleh
Keyword(s):  
Tensile Strength ◽  
Binary Mixtures ◽  
Linear Trend ◽  
Direct Compression ◽  
Compression Pressure ◽  
Eurycoma Longifolia ◽  
Compression Properties ◽  
Compression Speed ◽  
Eurycoma Longifolia Jack ◽  
Diametral Compression Test

AbstractThis study investigated the direct compression properties of Eurycoma longifolia Jack tablets using binary mixtures such as microcrystalline cellulose (mcc) and κ-carrageenan (carr). The mixtures were compacted to various compression pressures ranging from 7.5 to 74 MPa at a constant compression speed of 5 mm/min. The tensile strengths of the tablets were determined by a diametral compression test. A linear relationship between the tensile strength and the compression pressure was observed under the conditions of the test; hence, the slopes of the data were obtained by fitting linear trend lines. This paper shows that binary mixtures of 30% mcc and 70% Eurycoma longifolia Jack give the highest values for constant (a slope) compared with the other binary mixtures of both binders. Thus, this approach can be used to develop formulations for Eurycoma longifolia Jack tablets.

scholarly journals Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

2021 ◽  
Vol 4 (4) ◽  
pp. 333-344
Author(s):  
Johnson Ajeh Isaac ◽  
Kokonne Elizabeth Ekere ◽  
Ekeh Ezekiel ◽  
Isa Hayatu Galadima ◽  
Rashida Abdulahi ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Andrographis Paniculata ◽  
Wet Granulation ◽  
Direct Compression ◽  
Maize Starch ◽  
Compression Pressure ◽  
Compression Properties ◽  
Moringa Oleifera Leaves ◽  
Density Values ◽  
Compaction Properties

Traditionally, the leafy part of Andrographis paniculata and Moringa oleifera have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of A. paniculata and M. oleifera were produced by compressing powders and granules at various compression pressure. Results show that M. oleifera met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression.

scholarly journals Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1486
Author(s):  
Martin Dominik ◽  
Barbora Vraníková ◽  
Petra Svačinová ◽  
Jan Elbl ◽  
Sylvie Pavloková ◽  
...  
Keyword(s):  
Mechanical Resistance ◽  
Direct Compression ◽  
Preparation Technique ◽  
Flow Properties ◽  
Compression Pressure ◽  
Compression Properties ◽  
Novel Approach ◽  
Ejection Force ◽  
Orally Disintegrating Tablets ◽  
Consolidation Behavior

The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs—Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®—were investigated using different methods, including granulometry, powder rheometry, and tablet compaction under three pressures. Due to the similar composition and the same preparation technique (spray drying), the properties of CPEs and their compacts were generally comparable. The most pronounced differences were observed in flowability, undissolved fraction after 3 min and 24 h, energy of plastic deformation (E2), ejection force, consolidation behavior, and compact friability. Cellactose® 80 exhibited the most pronounced consolidation behavior, the lowest values of ejection force, and high friability of compacts. CombiLac® showed excellent flow properties but insufficient friability, except for compacts prepared at the highest compression pressure (182 MPa). MicroceLac® 100 displayed the poorest flow properties, lower ejection forces, and the best mechanical resistance of compacts. StarLac® showed excellent flow properties, the lowest amounts of undissolved fraction, the highest ejection force values, and the worst compact mechanical resistance. The obtained results revealed that higher compression pressures need to be used or further excipients have to be added to all tested materials in order to improve the friability and tensile strength of formed tablets, except for MicroceLac® 100.

scholarly journals Evaluation of Binders in Twin-Screw Wet Granulation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Claudia Köster ◽  
Sebastian Pohl ◽  
Peter Kleinebudde
Keyword(s):  
Molecular Weight ◽  
Tensile Strength ◽  
Wet Granulation ◽  
Compression Pressure ◽  
Demineralized Water ◽  
Twin Screw

The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL-SFP, HPC SSL, and HPC SL-FP) were evaluated regarding their suitability in twin-screw wet granulation. Six mixtures of lactose and binder as well as lactose without binder were twin-screw granulated with demineralized water at different barrel fill levels and subsequently tableted. A screening run with HPC SSL determined the amount of water as an influential parameter for oversized agglomerates. Subsequent examination of different binders, especially Kollidon 30 and Kollidon VA64 resulted in large granules. All binders, except Pharmacoat 606, led to a reduction of fines compared to granulation without a binder. The molecular weight of applied hyproloses did not appear as influential. Tableting required an upstream sieving step to remove overlarge granules. Tableting was possible for all formulations at sufficient compression pressure. Most binders resulted in comparable tensile strengths, while Pharmacoat 606 led to lower and lactose without a binder to the lowest tensile strength. Tablets without a binder disintegrated easily, whereas binder containing tablets of sufficient tensile strength often nearly failed or failed the disintegration test. Especially tablets containing Pharmacoat 606 and HPC SL-FP disintegrated too slowly.

Review: Etnotaksonomi dan bioekologi tumbuhan pasak bumi (Eurycoma longifolia Jack.)

2021 ◽  
Vol 11 (2) ◽  
pp. 177-178
Author(s):  
Syafitri Hidayati ◽  
Ervizal A.M. Zuhud ◽  
Ivan Khofian Adiyaksa ◽  
Primadhika Al Manar
Keyword(s):  
Literature Review ◽  
Southeast Asia ◽  
Tropical Forest ◽  
Human Health ◽  
Natural Regeneration ◽  
Literature Study ◽  
High Rainfall ◽  
Eurycoma Longifolia ◽  
Economical Benefit ◽  
Eurycoma Longifolia Jack

Eurycoma longifolia (EL) is a species that have economical benefit as medicinal ingredients for human health. This species grows in tropical forest areas with high rainfall. Research on the ecology of EL has been done a lot, but research related to ethnotaxonomic, bioecology that includes morphology, ecology, and the association of EL with other plants hasn’t been done much. This study aim to analyze the bioecology of EL plant. The method is literature study, which is looking for literature on the results of research that has been carried out related to EL. The results showed that EL has long been known by the communities of Indonesia and other countries in Southeast Asia with several local names. This plant is also associated with other plants around where it grows, one of which is kempas (Koompassia malaccensis). Based on the results of literature review, research on natural regeneration of EL hasn’t been done much. Therefore, there is a need for research related to the natural regeneration of EL. In addition, it is necessary to conduct research related to the characteristics of the place to grow for optimal cultivation of EL. Thus, the preservation of EL in the future can be maintained.

scholarly journals Studies on the Tensile Strength of Dental Amalgams by the Application of Diametral Compression Test

1970 ◽  
Vol 12 (1) ◽  
pp. 9-24
Author(s):  
Kazuo NAGAI ◽  
Masayoshi OHASHI ◽  
Hiroyoshi HABU ◽  
Masahiro UEMURA ◽  
Fujio KORENAGA ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Compression Test ◽  
Diametral Compression ◽  
Dental Amalgams ◽  
Diametral Compression Test
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