scholarly journals The Cost-Effective Laboratory: Implementation of Economic Evaluation of Laboratory Testing

2017 ◽  
Vol 36 (3) ◽  
pp. 238-242
Author(s):  
Natasa Bogavac-Stanojevic ◽  
Zorana Jelic-Ivanovic
Keyword(s):  
Clinical Practice ◽  
Laboratory Test ◽  
Laboratory Testing ◽  
Laboratory Tests ◽  
Clinical Decision Making ◽  
Economic Value ◽  
Cost Effective ◽  
The Other ◽  
Total Hospital Cost ◽  
Other Hand

SummaryLaboratory testing as a part of laboratoryin vitrodiagnostic (IVD) has become required tool in clinical practice for diagnosing, monitoring and prognosis of diseases, as well as for prediction of treatment response. The number of IVD tests available in laboratory practice has increased over the past decades and is likely to further increase in the future. Consequently, there is growing concern about the overutilization of laboratory tests and rising costs for laboratory testing. It is estimated that IVD accounts for between 1.4 and 2.3% of total healthcare expenditure and less than 5% of total hospital cost (Lewin Group report). These costs are rather low when compared to pharmaceuticals and medical aids which account for 15 and 5%, respectively. On the other hand, IVD tests play an important role in clinical practice, as they influence from 60% to 70% of clinical decision-making. Unfortunately, constant increases in healthcare spending are not directly related to healthcare benefit. Since healthcare resources are limited, health payers are interested whether the benefits of IVD tests are actually worth their cost. Many articles have introduced frameworks to assess the economic value of IVD tests. The most appropriate tool for quantitative assessment of their economic value is cost-effectiveness (CEA) and cost-utility (CUA) analysis. The both analysis determine cost in terms of effectiveness or utilities (combine quantity and quality of life) of new laboratory test against its alternative. On the other hand, some investigators recommended calculation of laboratory test value as product of two ratios: Laboratory test value = (Technical accuracy/Turnaround time) × (Utility/Costs). Recently, some researches used multicriteria decision analysis which allows comparison of diagnostic strategies in terms of benefits, opportunities, costs and risks. All analyses are constructed to identify laboratory test that produce the greatest healthcare benefit with the resources available. Without solid evidence that certain laboratory tests are cost-effective, laboratory services cannot be improved. Consequently, simple policy measures such as cost cutting may be imposed upon many laboratories while patients will have limited access to laboratory service.

Radioimmunszintigraphie mit SPECT: Methodik, Probleme und klinische Erfahrungen

1987 ◽  
Vol 26 (05) ◽  
pp. 202-205 ◽  
Author(s):  
J. Fass ◽  
S. Truong ◽  
U. Büll ◽  
V. Schumpelick ◽  
R. Bares
Keyword(s):  
Clinical Practice ◽  
The Other ◽  
Whole Body ◽  
Blood Clearance ◽  
Planar Scintigraphy ◽  
Gastrointestinal Carcinomas ◽  
Body Regions ◽  
Other Hand ◽  
Body Retention ◽  
Klinische Erfahrungen

Radioimmunoscintigraphy (RIS) with 111ln- and 131 I-labelled monoclonal anti bodies (MAbs) against CEA and/or CA 19-9 was performed in 83 patients with various gastrointestinal carcinomas. A total of 276 body regions could be examined. The results of planar scintigraphy and SPECT were compared intraindividually. Using 111 In-labelled MAbs the sensitivity of RIS was significantly improved by SPECT (88.9 vs. 52.4% with planar scintigraphy, p <0.01). For131 l-labelled MAbs the effect was smaller (83.9 vs. 65.6% with planar scintigraphy, n.s.). This finding can be explained by different kinetics and biodistribution of the used MAb preparations.111 In-labelled MAbs with long whole-body retention and rapid blood clearance reveal ideal qualities for SPECT; on the other hand, the short whole-body retention of131 l-labelled MAbs leads to small count rates and therefore long counting times that make delayed SPECT unsuitable in clinical practice

scholarly journals Erythroderma caused by vancomycin in children: concentration and speed of infusion

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
José F. Luna Álvarez ◽  
Mónica Gómez Vázquez ◽  
Ana L. Moreno González ◽  
Aldo Melchor Hernández ◽  
Marco A. Escamilla-Acosta ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Clinical Practice ◽  
Retrospective Study ◽  
Clinical Characteristics ◽  
Male Gender ◽  
The Other ◽  
Paediatric Hospital ◽  
Other Hand ◽  
Red Man Syndrome ◽  
Main Factors

Vancomycin is an antibiotic glycopeptide that was isolated of the Streptomyces orientalis. It was introduced in the clinical practice for treatment of infections caused by staphylococcus in which other antibiotics were proving to be ineffective. In this retrospective study, we determine its prescription, clinical characteristics as well as the factors that favor the apparition of the erythroderma or red-man syndrome in a paediatric hospital. Forty patients to which physicians administer vancomycin and presented erythroderma were evaluated. Male gender was more predominated, with a total of 25 cases (62.5 %). The average age was of 12 ± 6 years. We identified two main factors that are directly related to the appearance of erythroderma. On one hand, the "concentration of the drug", which is related to the dilution that it is realized when a dose of vancomycin is going to be administered to the patient and on the other hand the “time or speed of infusion”. In the present study, it was found a low incident of this adverse reaction and few cases of complications.

scholarly journals Kajian Valuasi Ekonomi Objek Wisata Sekar Langit Kabupaten Magelang dengan Pendekatan Travel Cost Method

2019 ◽  
Vol 3 (2) ◽  
pp. 221-229
Author(s):  
Rr Retno Retno Sugiharti ◽  
Fitrah Sari Islami ◽  
Yulida Army Nurcahaya
Keyword(s):  
Economic Value ◽  
Travel Cost ◽  
The Other ◽  
Travel Cost Method ◽  
Tourist Attraction ◽  
Regional Government ◽  
Tourist Attractions ◽  
Other Hand ◽  
Regional Topography ◽  
Tourism Potential

Abstrak Kabupaten Magelang yang berada di lereng gunung dengan topografi wilayah yang bervariasi memiliki potensi pariwisata lokasi yang sangat besar. Namun sayangnya objek-objek wisata di Kabupaten Magelang rata-rata belum dikelola dengan baik. Melalui penelitian ini, ingin mengkaji salah satu objek wisata di Kabupaten Magelang yaitu Air Terjut Sekar Langit. Dengan pertumbungan jumlah kunjungan yang positif menunjukkan bahwa objek ini memiliki potensi untuk berkembang bila dikelola dengan baik. Menggunakan travel cost method, penelitian itu bertujuan untuk mengetahui  nilai ekonomi dari objek wisata Air Terjun Sekar Langit sehingga dalam jangka Panjang dapat digunakan sebagai pertimbangan Pemerintah dan Dinas terkait untuk mengelola sekaligus tetap melestarikan sumber daya alam yang ada di Air Terjun Sekar Langit, serta sebagai referensi untuk pengambilan kebijakan. Abstract Magelang Regency is on a mountainside with varied regional topography which has a very large tourism potential location. But unfortunately, tourist attractions in Magelang regency on average have not been managed well. Through this research, we want to examine one of the tourist attractions in Magelang Regency, which is the Waterfall of Sekar Langit. With the growth in the number of positive visits shows that this object has the potential to develop if managed properly. Using the Travel Cost Method, this study aims to analyze the economic value of the Sekar Langit Waterfall attraction. With the hope that the results of this study can be used as consideration for the Regional Government and related agencies to manage, but on the other hand the natural preservation of the Sekar Langit tourist attraction is maintained.  

Truncation of the Secondary Concentrator (CPC) as Means to Cost Effective Beam-Down System

2010 ◽  
Vol 132 (3) ◽  
Author(s):  
Akiba Segal ◽  
Michael Epstein
Keyword(s):  
Focal Point ◽  
Cost Effective ◽  
The Other ◽  
Substantial Decrease ◽  
Optical Performance ◽  
Compound Parabolic Concentrator ◽  
Other Hand ◽  
Solar Plant ◽  
Effective Design ◽  
Effective Beam

A central solar plant based on beam-down optics is composed of a field of heliostats, a tower reflector (hyperboloid mirror), and a ground receiver interfaced at its aperture with one or a cluster of secondary concentrators (compound parabolic concentrator). In previous publications, a method was presented, illustrating the correlation between the tower reflector position and its size on one hand and the geometry, dimensions, and reflective area of the secondary concentrator on the other hand, both related to the heliostat field reflective area. Obviously, when one wishes to reduce the size of a tower reflector by locating it closer to the upper focal point, the image created at the lower focus will be broader, resulting in a larger secondary ground concentrator. The present paper describes a method for substantial decrease in the dimensions of the ground secondary concentrator cluster (and, implicitly, the concentrator's area) via truncation and some geometrical corrections without significant sacrifice of the optical performance. This offers a method for cost effective design of future central solar plants, utilizing the beam-down optics.

scholarly journals Abundance of Mosquito Larvae at Jagannath University and Dhaka University Campus of Dhaka, Bangladesh

2021 ◽  
Vol 49 (2) ◽  
pp. 321-329
Author(s):  
Farzana Islam ◽  
Homaira Prithul
Keyword(s):  
Public Universities ◽  
Cost Effective ◽  
The Other ◽  
Mosquito Larvae ◽  
Dhaka City ◽  
University Campus ◽  
Other Hand

A year-round survey on the abundance of mosquito larvae was conducted at Jagannath University - and Dhaka University - Campus from October 2018 to September 2019. A number of total 4415 mosquito larvae were collected of which 3086 were identified as Culex and 1329 were Aedes. Only 3 species belonging to 2 genera were identified in this study. At Jagannath University campus, highest number of Culex larvae was recorded in the month of August which was 167 (10.9%) and the lowest number was recorded in February which was 66 (4.3%), on the other hand, highest number of Aedes larvae was recorded in the month of July which was 137 (23.8%) and the lowest number was found in December which was 9 (1.6%). At Dhaka University campus, the highest number of Culex larvae was found in the month of April, which was 179 (11.5%) and the lowest number was found in June, which was 66 (4.3%), on the other hand, the highest number of Aedes larvae was found in the month of June which was 200 (26.5%) and lowest number was found in February which was 8 (1.06%). This study could be helpful in launching larvicidal programs in a more cost-effective way at these two urban public universities of Dhaka city. Bangladesh J. Zool. 49 (2): 321-329, 2021

Pre- and post-conditioning of the heart: an overview of cardioprotective signaling pathways

2020 ◽  
Vol 19 ◽  
Author(s):  
Denise Coutinho de Miranda ◽  
Gabriela de Oliveira Faria ◽  
Milla Marques Hermidorff ◽  
Fernanda Cacilda dos Santos Silva ◽  
Leonardo Vinícius Monteiro de Assis ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Signaling Pathways ◽  
Exponential Growth ◽  
Comprehensive Evaluation ◽  
Therapeutic Agents ◽  
The Other ◽  
Other Hand ◽  
The Future

: Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre- and post-conditioning is promising.

A multifunctional, modified rigid neuroendoscopic system: clinical experience with 83 procedures

2003 ◽  
Vol 99 (2) ◽  
pp. 421-425 ◽  
Author(s):  
Ajay Bakshi ◽  
Rana Patir ◽  
Asha Bakshi ◽  
Ajit Kumar Banerji
Keyword(s):  
Balloon Catheter ◽  
Cost Effective ◽  
The Other ◽  
Clinical Testing ◽  
Content Type ◽  
Irrigation Channel ◽  
Area Of Interest ◽  
Outer Sheath ◽  
Other Hand ◽  
Fine Print

✓ The authors combined a monopolar electrode and a suction/irrigation channel with a 0°, 4-mm Hopkins rigid telescope into a single multifunctional unit. This three-in-one instrument is inserted through a lightweight 7.5-mm outer sheath, which is fixed separately. A fourth instrument (for example, a balloon catheter or a biopsy forceps) can be introduced and manipulated independently with the other hand. All endoscopic procedures were performed with a trephine to create a 15-mm craniotomy. After opening the dura mater, ventricles were tapped with a brain needle, which was followed by the insertion of the rigid scope for visualization. The telescope was then withdrawn momentarily; the outer sheath was introduced into the ventricle and fixed over the area of interest. The definitive procedure was then performed with ease by using the multifunctional three-inone instrument in one hand and a fourth instrument in the other hand. This novel neuroendoscopic system has been used in clinical testing at the Vidyasagar Institute of Mental Health and Neurosciences since May 1998. Thus far, 83 neuroendoscopic procedures have been successfully performed with the aid of this instrumentation system, which has proven to be safe, versatile, and cost-effective, allowing a greater degree of freedom for the neurosurgeon.

Truncation of the Secondary Concentrator (CPC) as Means to Cost Effective Beam-Down System

2009 ◽  
Author(s):  
Akiba Segal ◽  
Michael Epstein
Keyword(s):  
Focal Point ◽  
Cost Effective ◽  
The Other ◽  
Substantial Decrease ◽  
Optical Performance ◽  
Other Hand ◽  
Solar Plant ◽  
Effective Design ◽  
Effective Beam

A central solar plant based on beam-down optics is composed of a field of heliostats, a tower reflector (hyperboloid mirror) and a ground receiver interfaced at its aperture with one or a cluster of secondary concentrators (CPC). In previous publications a method was presented illustrating the correlation between the tower reflector position and its size on one hand and the geometry, dimensions and reflective area of the secondary concentrator on the other hand, both related to the heliostat field reflective area. Obviously, when one wishes to reduce the size of a tower reflector by locating it closer to the upper focal point, the image created at the lower focus will be broader, resulting in a larger secondary ground concentrator. The present paper describes a method for substantial decrease of the dimensions of the ground secondary concentrator cluster (and, implicitly, the concentrator’s area) via truncation and some geometrical corrections without significant sacrifice of the optical performance. This offers a method for cost effective design of future central solar plants utilizing the beam-down optics.

scholarly journals A Unified FPGA Virtualization Framework for General-Purpose Deep Neural Networks in the Cloud

2022 ◽  
Vol 15 (3) ◽  
pp. 1-31
Author(s):  
Shulin Zeng ◽  
Guohao Dai ◽  
Hanbo Sun ◽  
Jun Liu ◽  
Shiyao Li ◽  
...  
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
High Performance ◽  
Deep Neural Networks ◽  
Cost Effective ◽  
General Purpose ◽  
The Other ◽  
Private Cloud ◽  
Single Task ◽  
Other Hand

INFerence-as-a-Service (INFaaS) has become a primary workload in the cloud. However, existing FPGA-based Deep Neural Network (DNN) accelerators are mainly optimized for the fastest speed of a single task, while the multi-tenancy of INFaaS has not been explored yet. As the demand for INFaaS keeps growing, simply increasing the number of FPGA-based DNN accelerators is not cost-effective, while merely sharing these single-task optimized DNN accelerators in a time-division multiplexing way could lead to poor isolation and high-performance loss for INFaaS. On the other hand, current cloud-based DNN accelerators have excessive compilation overhead, especially when scaling out to multi-FPGA systems for multi-tenant sharing, leading to unacceptable compilation costs for both offline deployment and online reconfiguration. Therefore, it is far from providing efficient and flexible FPGA virtualization for public and private cloud scenarios. Aiming to solve these problems, we propose a unified virtualization framework for general-purpose deep neural networks in the cloud, enabling multi-tenant sharing for both the Convolution Neural Network (CNN), and the Recurrent Neural Network (RNN) accelerators on a single FPGA. The isolation is enabled by introducing a two-level instruction dispatch module and a multi-core based hardware resources pool. Such designs provide isolated and runtime-programmable hardware resources, which further leads to performance isolation for multi-tenant sharing. On the other hand, to overcome the heavy re-compilation overheads, a tiling-based instruction frame package design and a two-stage static-dynamic compilation, are proposed. Only the lightweight runtime information is re-compiled with ∼1 ms overhead, thus guaranteeing the private cloud’s performance. Finally, the extensive experimental results show that the proposed virtualized solutions achieve up to 3.12× and 6.18× higher throughput in the private cloud compared with the static CNN and RNN baseline designs, respectively.

Volunteer Clouds

2016 ◽  
pp. 314-355
Author(s):  
Attila Csaba Marosi ◽  
Péter Kacsuk
Keyword(s):  
Cloud Computing ◽  
Cost Effective ◽  
The Other ◽  
Volunteer Computing ◽  
Evolutionary Stage ◽  
Research Areas ◽  
Other Hand ◽  
Service Environments ◽  
Different Levels ◽  
Homogeneous Environment

Cloud Computing (CC) offers simple and cost effective outsourcing in dynamic service environments and allows the construction of service-based applications extensible with the latest achievements of diverse research areas. CC is built using dedicated and reliable resources and provides uniform seemingly unlimited capacities. Volunteer Computing (VC) on the other hand uses volatile, heterogeneous and unreliable resources. This chapter per the authors makes an attempt starting from a definition for Cloud Computing to identify the required steps and formulate a definition for what can be considered as the next evolutionary stage for Volunteer Computing: Volunteer Clouds (VCl). There are many idiosyncrasies of VC to overcome (e.g., volatility, heterogeneity, reliability, responsiveness, scalability, etc.). Heterogeneity exists in VC at different levels. The vision of CC promises to provide a homogeneous environment. The goal of this chapter per the authors is to identify methods and propose solutions that tackle the heterogeneities and thus, make a step towards Volunteer Clouds.

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