scholarly journals Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum

2019 ◽  
Vol 32 (12) ◽  
pp. 1403-1406
Author(s):  
Ulkem Colak ◽  
Gul Y. Mutlu ◽  
Banu O. Sozmen ◽  
Esra B. Yucel ◽  
Hulya Kayserili ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Xeroderma Pigmentosum ◽  
Rare Condition ◽  
Skin Carcinoma ◽  
Pediatric Case ◽  
Dihydroxyvitamin D ◽  
Parathyroid Hormone Related Protein ◽  
Severe Hypercalcemia ◽  
Osteolytic Metastases ◽  
Squamous Cell Skin Carcinoma

Abstract Malignancy-induced hypercalcemia is a very rare condition in children whereas it is more common among adult patients with malignancy. The mechanisms of malignancy-induced hypercalcemia include the over-secretion of parathyroid hormone-related protein (PTHrP), osteolytic metastases and the over-production of 1,25-dihydroxyvitamin D (calcitriol). Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases. Herein, we report calcitriol-mediated severe hypercalcemia in a 5-year-old boy with squamous cell skin carcinoma arising in the background of xeroderma pigmentosum (XP) which responded well to zoledronate treatment. To the best of our knowledge, this is the first pediatric case of malignancy-induced hypercalcemia which is mediated by calcitriol in squamous cell skin carcinoma.

scholarly journals Giant locally advanced and metastatic squamous cell skin carcinoma of head and neck region: case report

2020 ◽  
Vol 25 (1) ◽  
pp. 20-22
Author(s):  
Jan Stuk ◽  
Jaroslav Vanasek ◽  
Karel Odrazka ◽  
Martin Dolezel ◽  
Iveta Kolarova ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Region ◽  
Skin Carcinoma ◽  
Head And Neck Region ◽  
Squamous Cell Skin Carcinoma

Unusual behaviour of an unusual tumour: calcitriol-induced hypercalcaemia in metastatic oesophageal neuroendocrine carcinoma

2020 ◽  
Vol 13 (8) ◽  
pp. e235209
Author(s):  
Filip Ionescu ◽  
Ioana Petrescu ◽  
Maria Marin
Keyword(s):  
Parathyroid Hormone ◽  
Serum Calcium ◽  
Neuroendocrine Carcinoma ◽  
Solid Tumours ◽  
Related Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Parathyroid Hormone Related Protein ◽  
Solid Malignancies ◽  
Osteolytic Metastases

Hypercalcaemia in malignancy is most commonly caused by paraneoplastic secretion of parathyroid hormone-related protein or osteolytic metastases. Very rarely (<1% of cases), the mechanism behind increased serum calcium is increased production of calcitriol (1,25-dihydroxyvitamin D) and even rarer is the occurrence of this phenomenon in solid malignancies, with few such instances reported in the literature. We present a case of a neuroendocrine malignancy originating in the oesophagus associated with calcitriol-induced hypercalcaemia, a phenomenon that has not been previously described. We review the pathophysiology of calcitriol-induced hypercalcaemia and previously reported cases of solid tumours with this presentation.

EP-1366: 'Intraoperative-like' single dose X-ray radiotherapy in squamous cell skin carcinoma in elderly patients

2014 ◽  
Vol 111 ◽  
pp. S110
Author(s):  
K. Majercakova ◽  
J. Isern Verdum ◽  
M. Alegre ◽  
J.R. Garcés ◽  
J. Craven-Bartle
Keyword(s):  
Single Dose ◽  
Elderly Patients ◽  
Squamous Cell ◽  
Skin Carcinoma ◽  
X Ray ◽  
Squamous Cell Skin Carcinoma

scholarly journals Nonmelanoma skin cancer in the population of the city of Belgrade in the period 1999-2011

2015 ◽  
Vol 143 (5-6) ◽  
pp. 290-295 ◽  
Author(s):  
Goran Videnovic ◽  
Dragan Miljus ◽  
Danijela Ilic ◽  
Dragan Krasic ◽  
Snezana Zivkovic
Keyword(s):  
Skin Cancer ◽  
Incidence Rate ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Skin Carcinoma ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers ◽  
The City ◽  
Squamous Cell Skin Carcinoma

Introduction. Nonmelanoma skin cancers in the literature are mainly related to basal cell and squamous cell skin carcinoma. Objective. The aim of the study was to determine the trend in the incidence of histological types of nonmelanoma skin cancers in the population of the city of Belgrade from 1999 to 2011. Methods. From the Serbian National Cancer Registry we extracted all recorded cases of skin cancer in Belgrade from January 1st 1999 to December 31st 2011. Incidence rates were standardized by the method of direct standardization with the world population as the standard population. Trends and annual percentage change (APC) of incidence rate were calculated by performing joinpoint regression analyses. Results. Incidence rate of nonmelanoma skin cancer showed significantly increasing trend between 1999 and 2006 with APC of 8.6% (95% CI: 5.6-11.7), basal cell carcinoma increased with APC of 8.4% (95% CI: 5.2-11.6) and squamous cell skin carcinoma with APC of 9.33% (95% CI: 5.7-13.1). The incidence increased with age for both men and women, especially after the age of 60. Conclusion. Our results showed a continuously increasing incidence trend of both basal cell and squamous cell skin carcinomas in the population of the city of Belgrade between 1999 and 2011. Adequate primary and secondary prevention would certainly be successful in reducing this type of cancer in the future.

scholarly journals Immunotherapy in Squamous Cell Skin Carcinoma: A Game Changer?

2017 ◽  
Vol 130 (5) ◽  
pp. e207-e208 ◽  
Author(s):  
Sravanthi Ravulapati ◽  
Cerena Leung ◽  
Nishant Poddar ◽  
Yifan Tu
Keyword(s):  
Squamous Cell ◽  
Skin Carcinoma ◽  
Squamous Cell Skin Carcinoma ◽  
Game Changer
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