The association between a metabolically healthy overweight/obesity phenotype and markers of inflammation among Chinese children and adolescents aged 10–18 years

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jinyu Zhou ◽  
Ling Bai ◽  
Yangyang Dong ◽  
Rongrong Cai ◽  
Wenqing Ding
Keyword(s):  
Children And Adolescents ◽  
Inflammatory Markers ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Phenotypes ◽  
Tnf Α ◽  
Metabolically Healthy ◽  
Hs Crp ◽  
The Relationship ◽  
Chinese Children And Adolescents

Abstract Objectives The association between metabolically healthy overweight/obesity (MHO) and inflammatory markers remains controversial. The aim of the present study was to describe the prevalence of different metabolic phenotypes and to examine the relationship of different metabolic phenotypes with inflammatory markers among Chinese children and adolescents. Methods The study included 1,125 children and adolescents aged 10–18 years using a cross-sectional survey, and all subjects were classified into four groups based on a combination of BMI and metabolic status. In addition, the inflammatory markers we measured were high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6). Results The prevalence of metabolically healthy with normal-weight (MHNW), MHO, metabolically unhealthy with normal-weight (MUNW), and metabolically unhealthy overweight/obesity (MUO) phenotypes was 38.76, 7.11, 38.67 and 15.47%, respectively. The results of logistic regression analysis showed that the MHO was associated with the z scores of hs-CRP in Chinese children and adolescents (OR=0.57, 95% CI: 0.39–0.83). Meanwhile, multivariate adjusted regression analysis showed that the relationship between hs-CRP and MHO among the overweight/obese was consistent with the results above, but among the normal-weight, only the highest quartile of TNF-α could increase the risk of MUNW (OR=1.65, 95% CI: 1.09–2.52). Conclusions MHO phenotypes were not common in Chinese children and adolescents. Individuals with MHO had a more beneficial hs-CRP profile than those with MUO.

scholarly journals Relationship of Sodium Intake with Overweight/Obesity among Chinese Children and Adolescents: Data from the CNNHS 2010–2012

2021 ◽  
Vol 18 (9) ◽  
pp. 4551
Author(s):  
Kehong Fang ◽  
Yuna He ◽  
Yuehui Fang ◽  
Yiyao Lian
Keyword(s):  
Children And Adolescents ◽  
Abdominal Obesity ◽  
Sodium Intake ◽  
Saturated Fatty Acids ◽  
Positive Association ◽  
Chinese Children ◽  
Weighing Method ◽  
Relationship Of ◽  
The Relationship ◽  
Chinese Children And Adolescents

This study aims to examine association between sodium intake and overweight/obesity among Chinese children and adolescents. Data were obtained from China National Nutrition and Health Surveillance (CNNHS), 2010–2012. All participants recruited in this study aged 7–18 years old and provided complete dietary data on three-day consecutive 24 h dietary recalls combining with the household weighing method. Body Mass Index (BMI) was used to define overweight/obesity, and waist-to-height ratio (WHtR) was used to define abdominal obesity. Sodium intake showed association with risk of overweight/obesity assessed by BMI in the highest tertile group with OR of 1.48 (95%CI 1.13–1.94) and 1.89 (95%CI 1.33–2.67) for WHtR. After adjusted for gender, age, household income, area, energy, carbohydrates, protein, fat, saturated fatty acids, and fiber intake, the relationship between sodium intake and overweight/obesity and abdominal obesity are not changed. The same results were founded in subjects aged 10–18 years old. Our results reveal a positive association between sodium intake and overweight/obesity in Chinese children and adolescents, independent of energy consumption.

scholarly journals The role of the gut microbiota on the metabolic status of obese children

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xin Yuan ◽  
Ruimin Chen ◽  
Kenneth L. McCormick ◽  
Ying Zhang ◽  
Xiangquan Lin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fecal Microbiota ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Status ◽  
Alpha And Beta Diversity ◽  
Metabolically Healthy Obese ◽  
Tnf Α ◽  
Healthy Obese ◽  
Metabolically Healthy

Abstract Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator. Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5–15 years) were divided into three groups: metabolically healthy obese (MHO, n = 42), metabolic unhealthy obese (MUO, n = 23), and healthy normal weight controls (Con, n = 21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p < 0.05). Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

scholarly journals Puberty could regulate the effects of outdoor time on refractive development in Chinese children and adolescents

2020 ◽  
pp. bjophthalmol-2019-315636
Author(s):  
Jingjing Wang ◽  
Tianyu Cheng ◽  
Bo Zhang ◽  
Shuyu Xiong ◽  
Huijuan Zhao ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Axial Length ◽  
Chinese Children ◽  
Related Factors ◽  
Refractive Development ◽  
Significant Difference ◽  
Length Changes ◽  
The Impact ◽  
The Relationship ◽  
Chinese Children And Adolescents

AimTo explore the impact of puberty on refractive development and its interaction with outdoor time in children and adolescents.MethodsIn this 2-year observational study, students aged 7–13 years were selected with cluster sampling. All participants underwent cycloplegic refraction and axial length measurements once every year. Information of related factors was acquired through proper questionnaire or inquiry. The level of testosterone/estradiol was detected from the saliva of the subjects using the ELISA kit. Multiple linear regression and generalised estimating equation (GEE) were used to analyse the relationship among puberty, outdoor activities and refractive indicators.ResultsA total of 776 children and adolescents were included, with an average baseline age of 9.64±1.54 years and 53.6% boys. There were 350 myopes (55.2% of the 634 cyclopleged subjects) at baseline. There was a significant difference in the mean axial length changes and outdoor time among different puberty groups (for axial length: p=0.017, for outdoor time: p=0.015). Myopic parents, less outdoor time and more changes in estradiol were associated with greater changes in axial length and spherical equivalent (SE) (axial length changes: parental myopia β=0.230, outdoor time β=−0.250, changes in estradiol β=0.261; SE changes: parental myopia β=−0.267, outdoor time β=0.256, changes in estradiol β=−0.297). In the GEE model, the interaction between outdoor time and puberty was significantly associated with axial length (p=0.024, β=1.199).ConclusionsThis study implies puberty may play a regulating role on the relationship between outdoor time and refractive development among Chinese children and adolescents, which provides clues for in-depth mechanism interpretation and efficient intervention strategies.

scholarly journals The Role of the Gut Microbiota on the Metabolic Status of Obese Children

2021 ◽  
Author(s):  
Xin Yuan ◽  
Ruimin Chen ◽  
Kenneth L. McCormick ◽  
Ying Zhang ◽  
Xiangquan Lin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fecal Microbiota ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Status ◽  
Alpha And Beta Diversity ◽  
Metabolically Healthy Obese ◽  
Tnf Α ◽  
Healthy Obese ◽  
Metabolically Healthy

Abstract Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obese (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

scholarly journals ASSOCIATION BETWEEN BODY FAT DISTRIBUTION AND BLOOD PRESSURE IN NORMAL-WEIGHT CHINESE CHILDREN AND ADOLESCENTS

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e415
Author(s):  
Rongrong Cai ◽  
Jie Dang ◽  
Yangyang Dong ◽  
Hao Zhang ◽  
Qingmei Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Body Fat ◽  
Fat Distribution ◽  
Normal Weight ◽  
Body Fat Distribution ◽  
Chinese Children ◽  
Chinese Children And Adolescents

scholarly journals Metabolically Healthy Obese Children and the Role of the Gut Microbiota

2020 ◽  
Author(s):  
Xin Yuan ◽  
Ruimin Chen ◽  
Kenneth L. McCormick ◽  
Ying Zhang ◽  
Xiangquan Lin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fecal Microbiota ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Status ◽  
Alpha And Beta Diversity ◽  
Metabolically Healthy Obese ◽  
Tnf Α ◽  
Healthy Obese ◽  
Metabolically Healthy

Abstract Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic status, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6 and TNF-α, and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obesity (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO subgroup, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Dysbiosis of gut microsystem prevails in the MHO cohort, and the abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds. As for a role in the etiology or facilitation of obesity- or perhaps vice versa- this childhood microbial imbalance awaits long-term, longitudinal investigation.

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