Paraoxonase 2 Cys311Ser polymorphism and its association with the systolic blood pressure values in asymptomatic dyslipidemic individuals: a pilot study

2015 ◽  
Vol 39 (4) ◽  
Author(s):  
Dalibor Novotny ◽  
David Karasek ◽  
Helena Vaverkova ◽  
Margita Bartkova ◽  
Veronika Kubickova
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Adhesion Molecule ◽  
Apolipoprotein A1 ◽  
Lower Systolic Blood Pressure ◽  
Reactive Protein ◽  
Hemostatic Markers ◽  
Cell Adhesion Molecule 1 ◽  
Relationship Of ◽  
The Relationship

AbstractThe study aimed to evaluate the relationship of paraoxonase 2 (Two hundred and sixty-four individuals were included in the study. The laboratory parameters were assessed by routine kit methods, while methods based on polymerase chain reaction were used for311 SS homozygous individuals had significantly lower systolic blood pressure values (SBP, p<0.01), C-reactive protein, and apolipoprotein A1 levels (p<0.05), as compared with C allele carriers. The analysis revealed no differences in the levels of endothelial/hemostatic markers, except for the increased adhesion molecule [soluble vascular cell adhesion molecule 1 (sVCAM-1)] concentrations in 311S/E2 carriers (p<0.05).The presence of the

scholarly journals HUBUNGAN INDEKSMASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH LAKI-LAKI DEWASA

2018 ◽  
Vol 9 (2) ◽  
pp. 193-199
Author(s):  
Tamariani Manullang
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Study Design ◽  
Computer Software ◽  
Adult Males ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

Prevalence of hypertension in adult males was highest in PuskesmasBasuki Rahmat (16.2%) as many as 648 cases of hypertension patients which hasincreased compared to 2012 by 12% in cases of hypertension totaled 482 patients((Dinkes Kota, 2013). This study aims to determine the relationship of body massindex (BMI) and waist circumference (WC) with systolic blood pressure (BP) in adultmales in Puskesmas Basuki Rahmat Bengkulu City in 2015. The study design wasdescriptive analytic with cross sectional approach. Study location was in PuskesmasBasuki Rahmat City of Bengkulu. Samples were selected using purposive samplingtotalling 68 people. Criterias sample were being adult males who occupied inPuskesmas Basuki Rahmat City of Bengkulu, aged ≥ 18 years, agreed to beinterviewed,and able to communicate actively. Data were obtained include BMI, WCand systolic BP adult males and processed using computer software with pearsoncorrelation analysis.The results showed that there was relationship between BMI andsystolic BP (p = 0.0005; r = 0.395); between WC and systolic BP (p = 0.004 and r =0.347) in adult males. This study concluded that there was relationship between BMIand WC with systolic BP in adult males in Puskesmas Basuki Rahmat Bengkulu Cityin 2015.

Relationship of Age and Blood Pressure to Baroreflex Sensitivity and Arterial Compliance in Man

1976 ◽  
Vol 51 (s3) ◽  
pp. 357s-360s ◽  
Author(s):  
O. S. Randall ◽  
M. D. Esler ◽  
G. F. Bulloch ◽  
A. S. Maisel ◽  
C. N. Ellis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Negative Correlation ◽  
Baroreflex Sensitivity ◽  
Arterial Compliance ◽  
Significant Negative Correlation ◽  
Arterial Distensibility ◽  
Blood Pressures ◽  
Relationship Of ◽  
The Relationship

1. The relationship between baroreflex sensitivity (BRS) and arterial compliance index (ACI) has been investigated (a) in paired subjects matched in one instance for systolic blood pressure with differing ages, and (b) in another instance matched for age with differing systolic blood pressures. 2. There was a significant negative correlation between BRS and age and between ACI and age in the twelve systolic blood pressure-matched subjects. 3. A significant negative correlation of systolic blood pressure with both BRS and ACI was observed in the fourteen age-matched subjects. 4. Both BRS and ACI appear to decrease with increasing age and systolic blood pressure. This decrease in BRS is probably due at least in part to the observed reduction in arterial distensibility.

scholarly journals 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium in Apoe−/− Mice

Endocrinology ◽  
2011 ◽  
Vol 152 (1) ◽  
pp. 236-246 ◽  
Author(s):  
Graeme A. Deuchar ◽  
Danielle McLean ◽  
Patrick W. F. Hadoke ◽  
David G. Brownstein ◽  
David J. Webb ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cell Adhesion ◽  
Systolic Blood Pressure ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Hydroxysteroid Dehydrogenase ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Cell Adhesion Molecule 1

Abstract Mineralocorticoid receptor (MR) activation is proinflammatory and proatherogenic. Antagonism of MR improves survival in humans with congestive heart failure caused by atherosclerotic disease. In animal models, activation of MR exacerbates atherosclerosis. The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) prevents inappropriate activation of the MR by inactivating glucocorticoids in mineralocorticoid-target tissues. To determine whether glucocorticoid-mediated activation of MR increases atheromatous plaque formation, we generated Apoe−/−/11β-HSD2−/− double-knockout (E/b2) mice. On chow diet, E/b2 mice developed atherosclerotic lesions by 3 months of age, whereas Apolipoprotein E (Apoe−/−) mice remained lesion free. Brachiocephalic plaques in 3-month-old E/b2 mice showed increased macrophage and lipid content and reduced collagen content compared with similar sized brachiocephalic plaques in 6-month-old Apoe−/− mice. Crucially, treatment of E/b2 mice with eplerenone, an MR antagonist, reduced plaque development and macrophage infiltration while increasing collagen and smooth muscle cell content without any effect on systolic blood pressure. In contrast, reduction of systolic blood pressure in E/b2 mice using the epithelial sodium channel blocker amiloride produced a less-profound atheroprotective effect. Vascular cell adhesion molecule 1 expression was increased in the endothelium of E/b2 mice compared with Apoe−/− mice. Similarly, aldosterone increased vascular cell adhesion molecule 1 expression in mouse aortic endothelial cells, an effect mimicked by corticosterone only in the presence of an 11β-HSD2 inhibitor. Thus, loss of 11β-HSD2 leads to striking atherogenesis associated with activation of MR, stimulating proinflammatory processes in the endothelium of E/b2 mice.

scholarly journals Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study

2015 ◽  
Vol 72 (1) ◽  
pp. 89-94 ◽  
Author(s):  
B. Gwen Windham ◽  
Michael E. Griswold ◽  
Seth Lirette ◽  
Anna Kucharska-Newton ◽  
Randi E. Foraker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Functional Status ◽  
Late Life ◽  
Relationship Of ◽  
Aric Study ◽  
The Relationship

Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study

2002 ◽  
Vol 103 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Johannes HULTHE ◽  
John WIKSTRAND ◽  
Lillemor MATTSSON-HULTÉN ◽  
Björn FAGERBERG
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Reactive Protein ◽  
Tnf Α ◽  
Old Men ◽  
Cell Adhesion Molecule 1 ◽  
The Relationship

There is a lack of data on circulating levels of cell-adhesion molecules in relation to subclinical atherosclerosis measured in both the carotid and femoral arteries in humans. The aim of the present study was to investigate the relationship between clinically silent atherosclerosis and cell-adhesion molecules, and to explore the relationship between these molecules, C-reactive protein and the inflammatory cytokines interleukin-6, tumour necrosis factor-α (TNF-α), soluble TNF-α receptor p55 and soluble TNF-α receptor p75. The study group (n = 391) consisted of clinically healthy 58-year-old men recruited from the general population. The results showed a positive trend between levels of soluble intercellular cell-adhesion molecule 1 (sICAM-1) and plaque occurrence in the carotid and femoral arteries (P = 0.008), and also a univariate correlation between sICAM-1 levels and the composite variable of carotid and femoral intima-media thickness (P<0.001). When adjusted for other risk factors, the relationship between sICAM-1 and intima-media thickness no longer reached statistical significance. The level of sICAM-1 was associated with those of the pro-inflammatory cytokine TNF-α, its two soluble receptors, and also interleukin-6 and C-reactive protein. Levels of soluble E-selectin and vascular cell-adhesion molecule 1 (VCAM-1) showed weak or no association with subclinical atherosclerosis and inflammatory variables. Thus, in clinically healthy middle-aged men, levels of sICAM-1, but not of soluble VCAM-1 or E-selectin, were associated with both subclinical atherosclerosis and inflammatory variables.

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