scholarly journals Nanoparticles for the multivalent presentation of a TnThr mimetic and as tool for solid state NMR coating investigation

2019 ◽  
Vol 91 (9) ◽  
pp. 1471-1478 ◽  
Author(s):  
Francesco Papi ◽  
Giulia Targetti ◽  
Linda Cerofolini ◽  
Claudio Luchinat ◽  
Marco Fragai ◽  
...  
Keyword(s):  
Immune Response ◽  
Solid State ◽  
Silica Nanoparticles ◽  
Cancer Immunotherapy ◽  
Solid State Nmr ◽  
Proof Of Concept ◽  
Tnf Α ◽  
Iron Based ◽  
Solid System

Abstract The fully characterization of tumor associated antigens (TAAs) and of tumor associated carbohydrate antigens (TACAs) have opened the avenue of cancer immunotherapy. The intrinsic poor immunogenicity of TACAs, however, spotlighted the importance of multivalent presentation of the antigen(s) to trigger an immune response. Nanoparticles are excellent scaffolds for this purpose. Here we reported on the easy glycosylation of iron-based and biocompatible dextran-based nanoparticles with 1, a mimetic of the TnThr antigen. The multivalent presentation of 1 induced the induction of TNF-α and IL-6/IL10, respectively. The multivalent glycosylation of silica nanoparticles (GSiNPs) was also performed and saccharide loading qualitative assessed by solid state NMR. Our results offer the proof of concept that biomolecules coating can also be investigated on solid system by NMR.

scholarly journals Use of Solid-State NMR Spectroscopy for the Characterization of Molecular Structure and Dynamics in Solid Polymer and Hybrid Electrolytes

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1207
Author(s):  
Gabrielle Foran ◽  
Nina Verdier ◽  
David Lepage ◽  
Cédric Malveau ◽  
Nicolas Dupré ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Pulse Sequence ◽  
Dynamic Properties ◽  
Double Resonance ◽  
Solid Polymer ◽  
Pulse Field ◽  
Solid State Nmr Spectroscopy

Solid-state NMR spectroscopy is an established experimental technique which is used for the characterization of structural and dynamic properties of materials in their native state. Many types of solid-state NMR experiments have been used to characterize both lithium-based and sodium-based solid polymer and polymer–ceramic hybrid electrolyte materials. This review describes several solid-state NMR experiments that are commonly employed in the analysis of these systems: pulse field gradient NMR, electrophoretic NMR, variable temperature T1 relaxation, T2 relaxation and linewidth analysis, exchange spectroscopy, cross polarization, Rotational Echo Double Resonance, and isotope enrichment. In this review, each technique is introduced with a short description of the pulse sequence, and examples of experiments that have been performed in real solid-state polymer and/or hybrid electrolyte systems are provided. The results and conclusions of these experiments are discussed to inform readers of the strengths and weaknesses of each technique when applied to polymer and hybrid electrolyte systems. It is anticipated that this review may be used to aid in the selection of solid-state NMR experiments for the analysis of these systems.

Characterization of some mesogenic alkyl 1-thioglycosides

2002 ◽  
Vol 80 (8) ◽  
pp. 1162-1165 ◽  
Author(s):  
B Henrissat ◽  
G K Hamer ◽  
M G Taylor ◽  
R H Marchessault
Keyword(s):  
Phase Transition ◽  
Liquid Crystal ◽  
Solid State ◽  
Solid State Nmr ◽  
Liquid Crystalline ◽  
Liquid Crystal Phase ◽  
X Ray Diffraction ◽  
X Ray ◽  
Liquid Crystalline Phases

A series of dodecyl 1-thio-β-D-glycosides has been synthesized and characterized (DSC, NMR, CP MAS, X-ray diffraction) as possible new marking materials with liquid-crystalline properties. These compounds undergo solid to liquid crystal phase transitions at various temperatures, which depend on the nature of the carbohydrate part of the structure. Their liquid-crystalline phases show extreme shear thinning behaviour.Key words: liquid crystal, powder X-ray diffraction, phase transition, thioglycoside, solid-state NMR, marking material

Characterization of insoluble calcium alginates by solid-state NMR

2012 ◽  
Vol 87 (1) ◽  
pp. 383-391 ◽  
Author(s):  
Giulia Mollica ◽  
Fabio Ziarelli ◽  
Stéphane Lack ◽  
Florence Brunel ◽  
Stéphane Viel
Keyword(s):  
Solid State ◽  
Solid State Nmr

scholarly journals Characterization of functional groups in estuarine dissolved organic matter by DNP‐enhanced 15N and 13C solid‐state NMR

ChemPhysChem ◽  
2021 ◽  
Author(s):  
Florian Venel ◽  
Hiroki Nagashima ◽  
Andrew G.M. Rankin ◽  
Christelle Anquetil ◽  
Vytautas Klimavicius ◽  
...  
Keyword(s):  
Organic Matter ◽  
Solid State ◽  
Dissolved Organic Matter ◽  
Functional Groups ◽  
Solid State Nmr

scholarly journals Characterization of a brazilian smectite by solid state NMR and X-ray diffraction techniques

1997 ◽  
Vol 8 (6) ◽  
pp. 581-586 ◽  
Author(s):  
Alcides Wagner Serpa Guarino ◽  
Rosane A. S. San Gil ◽  
Helena Polivanov ◽  
Sonia M.C. Menezes
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
X Ray Diffraction ◽  
X Ray
Sign in / Sign up

Export Citation Format

Share Document