Optical coherence tomography in diagnosing inflammatory diseases of ENT

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Alina Meller ◽  
Maria Shakhova ◽  
Yuriy Rilkin ◽  
Alexey Novozhilov ◽  
Mikhail Kirillin ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Optical Coherence Tomography ◽  
Inflammatory Diseases ◽  
Differential Diagnostics ◽  
Atrophic Rhinitis ◽  
Optical Coherence ◽  
Tympanic Cavity ◽  
Inflammatory Processes ◽  
Two Stages ◽  
Nose And Throat

AbstractThe object of the study was to demonstrate the abilities of optical coherence tomography (OCT) technique in diagnostics of inflammatory processes in ear, nose, and throat (ENT). When used in diagnostics of the nose and pharynx, OCT facilitates differential diagnostics of rhinitis enabling differentiation between the normal state, two stages of allergic rhinitis, vasomotor and atrophic rhinitis and diagnostics of pharyngitis. This paper also demonstrates the ability of OCT to monitor changes in pharynx induced by cryotherapy. In diagnostics of the tympanic cavity the ability of OCT to differentiate between different stages of chronic otitis and retraction of the tympanic membrane is demonstrated. Finally a correlation is discussed between morphologic alterations induced by inflammatory processes and changes in diagnostic OCT images.

scholarly journals Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Eduardo Morizot ◽  
Camila Schiavo Froner
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Inflammatory Diseases ◽  
Clinical Findings ◽  
Optical Coherence ◽  
Retrospective Case ◽  
Multifocal Choroiditis ◽  
White Dot Syndrome ◽  
Contralateral Eye ◽  
The Right

Abstract Purpose To report a case of multifocal choroiditis (MC) that has relapsed as choroidal neovascularization in the contralateral eye followed by a mixed aspect of multiple evanescent white dot syndrome (MEWDS) and MC. Methods Retrospective case report and literature review. The clinical findings were documented by fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography (OCT-A). Results The authors describe the case of a 39-year-old woman with prior ocular history of presumed MEWDS in her left eye, which developed into MC 7 years later in the same eye and 11 years later in the right eye, starting as choroidal neovascularization and developing into MEWDS. OCT-A showed neovessel in a supposedly active MC area outside the macular region in right and left eyes. OCT showed increased choroidal thickness in both eyes and a choroidal neovascularization in the right eye, treated using anti- VEGF therapy. Conclusion This case corroborates the proximity of some inflammatory diseases such as MC and MEWDS. OCT-A has opened new horizons for the better understanding of some retinal diseases by providing more thorough and promising morphological analyses using enhanced tools.

scholarly journals The modern view of treatment of allergic rhinitis and it’s combination with bronchial asthma

2021 ◽  
pp. 92-98
Author(s):  
D. S. Smirnov ◽  
O. M. Kurbacheva
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Inflammatory Diseases ◽  
Nasal Congestion ◽  
Combined Therapy ◽  
Correct Diagnosis ◽  
Economic Problem ◽  
Atrophic Rhinitis ◽  
Significant Treatment ◽  
Adequate Treatment

In recent years, there has been a significant increase in the prevalence of diseases of the nose and paranasal sinuses. Inflammatory diseases of the mucous membrane nasal cavities (rhinitis) are most commonly characterized as a syndrome in which the patient experiences some combination of persistent nasal symptoms, including rhinorrhea, sneezing, nasal congestion, itching and burning in the nasal cavity. Among the chronic forms of rhinitis, allergic rhinitis occupies a large place along with vasomotor, infectious, hypertrophic, catarrhal and atrophic rhinitis. Allergic rhinitis is a significant social and medico-economic problem, since it significantly reduces the quality of life of patients and requires significant treatment costs. This nosology is found in the practice of doctors of all specialties, however, the correct diagnosis and the appointment of adequate therapy can take many months and years. Currently, the concept of “common airways” is widely discussed, which demonstrates the close relationship between allergic rhinitis and bronchial asthma and proves that the inflammatory response can be supported and enhanced by interrelated mechanisms. Therefore, patients with allergic rhinitis should be examined for the presence of bronchial asthma. In turn, patients with bronchial asthma need to diagnose allergic rhinitis, and treatment should be aimed at suppressing allergic inflammation in both the upper and lower respiratory tract. This article discusses modern diagnostic and therapeutic approaches to patients with these diseases, which make it possible to efficiently and timely identify allergic rhinitis and initiate appropriate adequate treatment. The article also discusses the feasibility of using combined therapy with levocetirizine and montelukast in the above nosologies.

scholarly journals Small choroidal melanoma and pseudomelanomas: methods of differential diagnostics (literature review). Part 3

2020 ◽  
Vol 13 (4) ◽  
pp. 91-98
Author(s):  
E. B. Myakoshina
Keyword(s):  
Optical Coherence Tomography ◽  
Literature Review ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Choroidal Melanoma ◽  
Metastatic Carcinoma ◽  
Age Related Macular Degeneration ◽  
Differential Diagnostics ◽  
Optical Coherence ◽  
Age Related

The third part of literature review (see first part in ROJ 2019; 12 (4): 99–108, second part in ROJ 2020; 13 (2): 88–98) discusses the features characteristic of small uveal melanoma and pseudomelanomas (choroidal nevus, circumscribed choroidal hemangioma, melanocytoma, choroidal metastatic carcinoma, congenital hypertrophy of retinal pigment epithelium, late-stage age-related macular degeneration, focal retinochoroiditis, organized subretinal hemorrhage, retinal hemangioma) which were revealed by optical coherence tomography and optical coherence tomography-angiography. The need for further comparative studies aimed at defining differential diagnostic is emphasized.

scholarly journals Clinicopathology of non-infectious choroiditis: evolution of its appraisal during the last 2–3 decades from “white dot syndromes” to precise classification

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carl P. Herbort ◽  
Piergiorgio Neri ◽  
Ioannis Papasavvas
Keyword(s):  
Optical Coherence Tomography ◽  
Inflammatory Diseases ◽  
Phenomenological Approach ◽  
Diagnostic Techniques ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
White Dot Syndromes ◽  
Choroidal Imaging ◽  
Imaging Optical Coherence Tomography

AbstractChoroidal imaging investigation techniques were very limited until 2–3 decades ago.Fluorescein angiography (FA) was not suited for the analysis of the choroidal compartment and B-scan ultrasonography did not provide enough accuracy. It was on this background that a purely phenomenological approach was attempted to classify these choroiditis diseases by regrouping them under the vague potpourri term of “white dot syndromes”. With the availability of precise investigational modalities of choroidal inflammation or choroiditis-induced lesions, such as indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT) and enhanced depth imaging optical coherence tomography (EDI-OCT) it became possible to better classify these diseases based on clinico-pathological mechanisms rather than on purely phenomenological observation.Recently OCT-angiography has implemented the armamentarium of diagnostic techniques possibly also contributing to the classification of choroidal inflammatory diseases.Based on pioneering pragmatism, the aim of this article was to give a clear classification of non-infectious choroiditis. Thanks to new imaging investigations of the choroid, it is now possible to classify and understand the diverse clinicopathological mechanisms in the group of non-infectious choroiditis entities.

Machine learning aided automated differential diagnostics of chronic rhinitis based on optical coherence tomography

2020 ◽  
Vol 17 (11) ◽  
pp. 115608
Author(s):  
Nikita Soloviev ◽  
Aleksandr Khilov ◽  
Maria Shakhova ◽  
Alina Meller ◽  
Valeriya Perekatova ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optical Coherence Tomography ◽  
Differential Diagnostics ◽  
Optical Coherence ◽  
Chronic Rhinitis

scholarly journals Differential diagnosis algorithms of сentral serous chorioretinopathy and adult-onset vitelliform dystrophies

2020 ◽  
Vol 13 (4) ◽  
pp. 35-46
Author(s):  
Nataliia V. Matcko ◽  
Marina V. Gatsu
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Differential Diagnosis ◽  
Roc Curve ◽  
Differential Diagnostics ◽  
Disease Detection ◽  
Optical Coherence ◽  
Adult Onset ◽  
Area Under Roc Curve ◽  
Sd Oct

Purpose.To optimize the differential diagnosis of chronic central serous chorioretinopathy (CSCR) and of adult-onset vitelliform dystrophies (VD). Research objectives. On the multimodal diagnosis basis, to investigate signs characteristic for VD and chronic CSCR using mathematic modeling, to elaborate algorithms of their differential diagnosis in settings of differently equipped clinics. Materials and methods.61 patient (90 eyes) with long-term neuroepithelial detachments (NEDs) were included in the study. In all patients, the disease history was collected, including the family history; all patients underwent a standard ophthalmologic examination: visual acuity testing including best corrected visual acuity (BCVA), biomicroophthalmoscopy, fundus photography, spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT-A), short-wavelength autofluorescence (SW-AF), fluorescein angiography (FA), indocyanine green angiography (ICGA). Patients were divided into two groups: with vitelliform dystrophies 30 patients (30 eyes), and with CSCR 31 patients (31 eyes). To estimate the probability of disease detection, binary logistic regression method was used. Results.Diagnostic predictors found in both groups were scrutinized; mathematical models for estimating the probability of disease detection were obtained. Differential diagnostics algorithms have been developed taking into account the resulting formulas for calculating the probability of disease detection, including criteria of different examination combinations: SD-OCT (area under ROC curve 0.946); BAF (area under ROC curve 0.955), SD-OCT and SW-AF (area under ROC curve 0.980); SW-AF, FA and ICGA (area under ROC curve 0.989). Conclusion.The obtained models make it possible to carry out differential diagnosis of vitelliform dystrophies and chronic CSCR in settings of differently equipped clinics.

scholarly journals Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

2016 ◽  
Vol 2 (1) ◽  
pp. 443-447 ◽  
Author(s):  
Lars Kirsten ◽  
Simon Baumgärtner ◽  
Mikael Timo Erkkilä ◽  
Jonas Golde ◽  
Max Kemper ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Tympanic Membrane ◽  
Middle Ear ◽  
Ex Vivo ◽  
Oscillation Amplitude ◽  
Indirect Detection ◽  
Optical Coherence ◽  
Tympanic Cavity ◽  
Promising Tool ◽  
Doppler Oct

AbstractThe treatment of otitis media requires classifying the effusion in the tympanic cavity for choosing appropriate therapeutic strategies. Otoscopic examination of the middle ear depends on the expertise of the physician and is often hampered in case of inflammatory alterations of the tympanic membrane. In otologic research, optical coherence tomography is an innovative non-invasive imaging technique utilized for visualizing the tympanic membrane. This ex vivo study presents the possibility of OCT and Doppler-OCT for the detection of effusions in the tympanic cavity. Structural OCT imaging allows the direct visualization of scattering fluids behind the tympanic membrane. In addition, the measurement of the reduced oscillation amplitude by means of Doppler-OCT permits the indirect detection of scattering and transparent fluids.

scholarly journals Multimodal imaging supporting the pathophysiology of white dot syndromes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ilaria Testi ◽  
Rocco Luigi Modugno ◽  
Carlos Pavesio
Keyword(s):  
Optical Coherence Tomography ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
New Technologies ◽  
Inflammatory Diseases ◽  
Optical Coherence ◽  
Outer Retina ◽  
Ocular Imaging ◽  
White Dot Syndromes

AbstractWhite dot syndromes (WDS) represent a heterogeneous group of inflammatory diseases, primarily affecting the outer retina, choriocapillaris and choroid. Recent advances in the field of ocular imaging and development of new technologies, including optical coherence tomography angiography (OCT-A), have allowed a better characterization of the morphology of these conditions. This review will analyse the WDS from an imaging-based perspective, providing a better understanding of the pathophysiology underlying these disorders.

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