scholarly journals DERMOSCOPY OF THE MONTH Nevi with Site-Related Atypia

2017 ◽  
Vol 9 (4) ◽  
pp. 169-173
Author(s):  
Tanja Tirnanić ◽  
Dimitrije Brašanac ◽  
Lidija Kandolf Sekulović
Keyword(s):  
Histological Features ◽  
Melanocytic Nevi ◽  
Pigmented Lesions ◽  
Anatomic Locations ◽  
Benign Nevi ◽  
Present Site

Abstract The term “nevi of special sites” refers to melanocytic nevi of specific anatomic locations including the breast, axillae, umbilicus, genitalia, flexural areas, acral surfaces, ear, scalp and the conjunctiva. Nevi from these anatomic sites display sometimes dermoscopic and histological features of melanoma, resulting in unnecessarily high rates of excisions and re-excisions. Some authors have categorized nevi excised in the axillary, breast, umbilical and perineal areas as the nevi of the milk line. Two patients, a 32-year-old female and 23-year-old male with breast and periumbilical pigmented lesions, presented to our Department during 2017. Dermoscopy revealed features that were highly specific for melanoma. Excisional biopsies were done and histopathology revealed benign nevi with present site-related atypia. Irregular blotches, non-uniform radial streaks, blue-gray veil, and regression are the most specific features of melanoma of the breast and flexural areas. Excision is always recommended in pigmented lesions on the breast and flexural areas, which exhibit these features. However, larger studies are needed to define specific criteria required to distinguish special-site nevi from melanoma.

Management and Dermoscopy of Fast-Growing Nevi in Pregnancy: Case Report and Literature Review

2006 ◽  
Vol 10 (5) ◽  
pp. 249-252 ◽  
Author(s):  
Anna Zampetti ◽  
Claudio Feliciani ◽  
Francesco Landi ◽  
M.L. Capaldo ◽  
M. Rotoli ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Rapid Evolution ◽  
Melanocytic Lesion ◽  
Melanocytic Nevi ◽  
Fast Growing ◽  
Pigmented Lesions ◽  
Melanocytic Lesions ◽  
Treatment Measures ◽  
In Pregnancy

Background: The relationship between pregnancy and a change in melanocytic nevi is still controversial. Moreover, management of the rapid evolution of a nevus in an unauspicious melanocytic lesion can be a clinical challenge in pregnancy. Methods: This article examines a case of a fast-growing deep penetrating nevus in a pregnant woman and provides a literature review of articles relative to pregnancy and nevi change, the management of fast-growing pigmented lesions, and the role and usefulness of dermoscopy in these cases. Results: Recent studies have documented that pregnancy is not associated with any significant change in the size of melanocytic nevi. The management of fast-growing melanocytic lesions during this period compulsorily leans toward excision. Dermoscopy can be useful, providing clinicohistopathologic correlations and a better assignment of the lesion. Conclusion: This case report and review provide important management considerations for nevi during pregnancy. Early intervention with aggressive treatment measures is the best management for fast-growing lesions, and epiluminescence dermoscopy can assist the management, although still remaining a second-level examination, useful for documentation and for a better classification of the lesion.

scholarly journals Melanocortin-1 receptor (MC1R) genotypes do not correlate with size in two cohorts of medium-to-giant congenital melanocytic nevi

2020 ◽  
Author(s):  
Neus Calbet-Llopart ◽  
Mirella Pascini-Garrigos ◽  
Gemma Tell-Martí ◽  
Miriam Potrony ◽  
Vanessa Martins da Silva ◽  
...  
Keyword(s):  
Epidemiological Studies ◽  
Compound Heterozygous ◽  
Control Analysis ◽  
Large Set ◽  
Adult Size ◽  
Loss Of Function ◽  
Melanocytic Nevi ◽  
Pigmented Lesions ◽  
Congenital Melanocytic Nevi

ABSTRACTCongenital melanocytic nevi (CMN) are cutaneous malformations whose prevalence is inversely correlated with projected adult size. CMN are caused by somatic mutations, but epidemiological studies suggest that germline genetic factors may influence CMN development. In CMN patients from the U.K., genetic variants in the MC1R gene, such as p.V92M and loss-of-function variants, have been previously associated with larger CMN. We analyzed the association of MC1R variants with CMN characteristics in 113 medium-to-giant CMN patients from Spain and from a distinct cohort of 53 patients from France, Norway, Canada and the U.S. These cohorts were similar at the clinical and phenotypical level, except for the number of nevi per patient. We found that the p.V92M or loss-of-function MC1R variants either alone or in combination did not correlate with CMN size, in contrast to the U.K. CMN patients. An additional case-control analysis with 259 unaffected Spanish individuals, showed a higher frequency of MC1R compound heterozygous or homozygous variant genotypes in Spanish CMN patients compared to the control population (15.9% vs. 9.3%; P=0.075). Altogether, this study suggests that MC1R variants are not associated with CMN size in these non-U.K. cohorts. Additional studies are required to define the potential role of MC1R as a risk factor in CMN development.SIGNIFICANCECongenital melanocytic nevi (CMN) are common pigmented lesions that originate during prenatal life, without clear evidence of a genetic predisposition. To date, limited data exist regarding the role of the MC1R gene, a key regulator of human pigmentation, in the development of the class of rarer CMN that are greater than 10 cm diameter at projected adult size and associated with increased morbidity or mortality risks. This study provides data from a large set of such CMN patients to support the hypothesis that MC1R could be involved in the development of these types of lesions, but at the same time discounting its influence on the size of CMN across distinct populations. Improving our understanding of genetic susceptibility to rare types of CMN is necessary to determine whether routine germline genotyping is relevant in clinical practice.

Histological features and outcome of inverted type-A melanocytic nevi

2018 ◽  
Vol 45 (4) ◽  
pp. 254-262 ◽  
Author(s):  
Soheil S. Dadras ◽  
Jun Lu ◽  
Artur Zembowicz ◽  
Thomas J. Flotte ◽  
Martin C. Mihm
Keyword(s):  
Type A ◽  
Histological Features ◽  
Melanocytic Nevi

scholarly journals Correlation between dermoscopic and histopathological diagnoses of atypical nevi in a dermatology outpatient clinic of the Medical School of São José do Rio Preto, SP, Brazil

2013 ◽  
Vol 88 (2) ◽  
pp. 199-203 ◽  
Author(s):  
João Roberto Antonio ◽  
Rosa Maria Cordeiro Soubhia ◽  
Solange Corrêa Garcia Pires D'Avila ◽  
Adriana Cristina Caldas ◽  
Lívia Arroyo Trídico ◽  
...  
Keyword(s):  
Outpatient Clinic ◽  
Skin Lesions ◽  
Histopathological Diagnosis ◽  
Melanocytic Nevi ◽  
Pigmented Lesions ◽  
Highly Sensitive ◽  
Advanced Stages ◽  
Malignant Lesions ◽  
Atypical Nevi

BACKGROUND: The incidence of cutaneous melanoma is increasing worldwide. Since it is an aggressive neoplasm, it is difficult to treat in advanced stages; early diagnosis is important to heal the patient. Melanocytic nevi are benign pigmented skin lesions while atypical nevi are associated with the risk of developing melanoma because they have a different histological pattern than common nevi. Thus, the clinical diagnosis of pigmented lesions is of great importance to differentiate benign, atypical and malignant lesions. Dermoscopy appeared as an auxiliary test in vivo, playing an important role in the diagnosis of pigmented lesions, because it allows the visualization of structures located below the stratum corneum. It shows a new morphological dimension of these lesions to the dermatologist and allows greater diagnostic accuracy. However, histopathology is considered the gold standard for the diagnosis. OBJECTIVES: To establish the sensitivity and specificity of dermoscopy in the diagnosis of pigmented lesions suspected of malignancy (atypical nevi), comparing both the dermatoscopic with the histopathological diagnosis, at the Dermatology Service of the outpatient clinic of Hospital de Base, São José do Rio Preto, SP. METHODS: Analysis of melanocytic nevi by dermoscopy and subsequent biopsy on suspicion of atypia or if the patient so desires, for subsequent histopathological diagnosis. RESULTS: Sensitivity: 93%. Specificity: 42%. CONCLUSIONS: Dermoscopy is a highly sensitive method for the diagnosis of atypical melanocytic nevi. Despite the low specificity with many false positive diagnoses, the method is effective for scanning lesions with suspected features of malignancy.

scholarly journals Congenital melanocytic nevus of the oral mucosa: report of a rare pigmented lesion and review of the literature

2011 ◽  
Vol 1 (1) ◽  
pp. 17 ◽  
Author(s):  
Melanie Louise Gilbert ◽  
Weddad Hanna ◽  
Danny Ghazarian ◽  
Dean Dover ◽  
Hagen Benjamin Edward Klieb
Keyword(s):  
Oral Mucosa ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Review Of The Literature ◽  
Melanocytic Nevi ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Congenital Melanocytic Nevi

Oral pigmented lesions are uncommon and congenital melanocytic nevi are especially rare. We report a case of a patient with multiple congenital melanocytic nevi including a palatal lesion. This is reported to add to the scant literature that exists on this subject. Prognosis and management are discussed.

Histopathological Features of Acral Melanocytic Nevi in Children: Study of 21 Cases

1998 ◽  
Vol 1 (5) ◽  
pp. 388-392 ◽  
Author(s):  
Margaret J. Evans ◽  
Elizabeth S. Gray ◽  
Karen Blessing
Keyword(s):  
Single Cell ◽  
Histological Examination ◽  
The State ◽  
Cell Infiltration ◽  
Anatomical Location ◽  
Cytological Atypia ◽  
Melanocytic Nevi ◽  
Melanocytic Lesions ◽  
Anatomic Subsite ◽  
Benign Nevi

Benign melanocytic lesions in children may give cause for some concern histologically. This is because they represent a specific entity, or they reflect the state of evolution of the lesion or the anatomical location. This latter phenomenon has been poorly documented in children. In this study, we address the problem of atypical features frequently seen in benign nevi from acral sites in a group of patients aged 18 years or less. Twenty-one cases (12 female, 9 male) were identified from the Department of Pathology files during the years 1975–1988. All were Caucasian. Histological examination revealed that 6 cases were congenital and 15 were aquired; of these, 19 cases (90%) had a junctional component and all of these exhibited architecture atypia in the form of either lentiginous proliferation (84%) or confluence of junctional nests (84%). Forty-two percent (8/19) showed a mixture of both. Thirty-seven percent (7/19) exhibited transepidermal elimination of melanocytic nests, with 13/19 (68%) showing single cell infiltration of the epidermis. Atypical size, shape, and location of the junctional nests were present in 10/19 cases (53%). Within this group there appears to be no relationship between the age of the patient and the degree of architectural atypia. Mild cytological atypia was common. This report stresses the importance of anatomic subsite in the assessment of melanocytic lesions in children as well as in adults.

Eruptive Melanocytic Nevi Induced by Interferon for Nodal Metastatic Melanoma: Case Report and Review of the Literature

2013 ◽  
Vol 17 (6) ◽  
pp. 410-413 ◽  
Author(s):  
Thomas G. Salopek ◽  
Muhammad N. Mahmood
Keyword(s):  
Nodal Metastasis ◽  
Chemotherapeutic Agents ◽  
High Dose ◽  
Melanocytic Nevi ◽  
Dysplastic Nevi ◽  
Pigmented Lesions ◽  
Paraneoplastic Disorder ◽  
Possible Cause ◽  
High Dose Interferon ◽  
Melanoma Case

Background: The rapid appearance of multiple new melanocytic nevi is known as eruptive nevi and has been well documented to occur with certain medications, in particular chemotherapeutic agents. Methods: We report a case of a woman with melanoma complicated by nodal metastasis who developed multiple melanocytic nevi while on high-dose interferon. Results: Serial photographs confirmed that the pigmented lesions were of new onset, whereas histology documented that the lesions were dysplastic nevi. A survey of the literature documented numerous causes of eruptive nevi, which we review. To date, interferon has not been linked to eruptive nevi. Conclusions: The phenomenon of eruptive nevi has been attributed to medications, bullous dermatoses, immunosuppression, and systemic conditions and is possibly a paraneoplastic disorder. Interferon appears to be another possible cause of this disorder.

scholarly journals Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012 ◽  
Vol 1 (4) ◽  
pp. 195-202 ◽  
Author(s):  
Jillian F. Rork ◽  
Elena B. Hawryluk ◽  
Marilyn G. Liang
Keyword(s):  
Pediatric Population ◽  
Melanocytic Nevi ◽  
Pigmented Lesions

scholarly journals Association of giant congenital melanocytic nevus, halo nevus and vitiligo in a 75-year-old patient

2012 ◽  
Vol 87 (2) ◽  
pp. 288-291 ◽  
Author(s):  
Marina Leite da Silveira ◽  
Flávia Regina Ferreira ◽  
Marcia Lanzoni Alvarenga ◽  
Samuel Henrique Mandelbaum
Keyword(s):  
Normal Skin ◽  
Rare Condition ◽  
Melanocytic Nevus ◽  
Malignant Degeneration ◽  
Congenital Melanocytic Nevus ◽  
Triple Combination ◽  
Histological Features ◽  
Melanocytic Nevi ◽  
Lower Back ◽  
Giant Congenital Melanocytic Nevus

A giant congenital melanocytic nevus represents a rare condition. The halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of halo nevus and giant congenital melanocytic nevus is rare and the association of both with vitiligo even more rare. A 75-yearold woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic halo of onset three years ago. The histological features were consistent with congenital melanocytic nevus and halo nevus, respectively. After two years the patient developed achromic areas in normal skin, histologically consistent with vitiligo. The authors emphasize the rarity of this triple combination, the patient's age and the absence of malignant degeneration to date.

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