New Isoflavonoid from Dipterix odorata

2003 ◽  
Vol 58 (12) ◽  
pp. 1206-1209 ◽  
Author(s):  
Maria P. Socorro ◽  
Angelo C. Pinto ◽  
Carlos R. Kaiser
Keyword(s):  
Spectral Data ◽  
Methanol Extract ◽  
2D Nmr

The isoflavonol 7,8,3’-trihydroxy-6,4’-dimethoxy-isoflavone (1) was isolated from the methanol extract of the bark of the trunk of Dipterix odorata. The structure was determined from spectral data and with aid of his acetylation to obtain 1a as a strategy to help the assignments of the 2D NMR experiments.

scholarly journals A HOPANE TRITERPENOID FROM THE MYCELIUM OF Isaria japonica IN VIETNAM

2017 ◽  
Vol 55 (5) ◽  
pp. 535
Author(s):  
Nguyen Ngoc Tuan ◽  
Tran Thi Kim Anh ◽  
Ping-Chung Kuo ◽  
Tran Dinh Thang
Keyword(s):  
Spectral Data ◽  
13C Nmr ◽  
Methanol Extract ◽  
2D Nmr ◽  
1H And 13C Nmr ◽  
Nmr Techniques ◽  
First Time

A hopane triterpenoid (11b, 22-dihydroxyhopane) was isolated from the methanol extract of the mycelium of Isaria japonica in Vietnam. The structure of this compound was elucidated using a combination of 1D and 2D NMR techniques (1H-, 13C-NMR, COSY, HSQC and HMBC). In the study, we reported the comprehensive 1H- and 13C-NMR spectral data of 11b, 22-dihydroxyhopane for the first time.

scholarly journals Isolation of lupeol from the stem bark of Leptadenia hastata (Pers.) Decne

2020 ◽  
Vol 24 (10) ◽  
pp. 1835-1838
Author(s):  
M.M. Mailafiya ◽  
U.U. Pateh ◽  
H.S. Hassan ◽  
M.I. Sule ◽  
A.H. Bila ◽  
...  
Keyword(s):  
Spectral Data ◽  
Column Chromatography ◽  
Methanol Extract ◽  
2D Nmr ◽  
Stem Bark ◽  
Hexane Fraction ◽  
Solid Substance ◽  
Phytochemical Screening ◽  
Nmr Data ◽  
Crude Methanol Extract

Dried stem bark powder of Leptadania hastata was subjected to maceration with methanol to afford crude methanol extract, which was partitioned with n-hexane, ethylacetate, chloroform and n- butanol to afford different their respective fractions. Extensive phytochemical screening of the n-hexane fraction using column chromatography resulted to the isolation of a white solid substance. The substance was identified as of lupeol using IR, 1D – NMR, 2D – NMR data and by comparison with reference spectral data. Keywords: Leptadenia hastata, Isolation, Lupeol, 1D – NMR, 2D – NMR

scholarly journals Flavonoid Glycosides and their p-Coumaroyl Esters from Campylospermum calanthum Leaves

2012 ◽  
Vol 67 (5-6) ◽  
pp. 233-243 ◽  
Author(s):  
Savio S. Elo Manga ◽  
Anastasie E. Tih ◽  
Bintou Abderamane ◽  
Raphael T. Ghogomu ◽  
Alain Blond ◽  
...  
Keyword(s):  
Spectral Data ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Flavonoid Aglycones ◽  
New Compounds ◽  
Related Compounds ◽  
Chemical Evidence

Six new compounds, comprising three flavonoid glycosides and their respective coumaroyl esters, have been isolated and characterized from the methanol extract of the leaves of Campylospermum calanthum, along with three known flavonoid aglycones, 7-O-methyl apigenin (1), 7-O-methyl luteolin (2), and 7-O-methyl quercetin (3). Their structures were elucidated based on chemical evidence as well as spectroscopic analysis including 1D and 2D NMR (1H-1H COSY, HSQC, HMBC, and NOESY) spectroscopy and by comparing their spectral data with those reported for related compounds

New flavonoid C–O–C dimers and other chemical constituents from Garcinia brevipedicellata stem heartwood

2016 ◽  
Vol 71 (7-8) ◽  
pp. 233-241 ◽  
Author(s):  
Bintou Abderamane ◽  
Anastasie E. Tih ◽  
Raphael T. Ghogomu ◽  
Alain Blond ◽  
Bernard Bodo
Keyword(s):  
Spectral Data ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Related Compounds

Abstract The methanol extract of the stem heartwood of Garcinia brevipedicellata has furnished three new flavonoid C–O–C dimers, brevipedicilones A (6), B (8) and C (10), along with five previously reported flavonoid dimers, viz. amentoflavone (1), 4″′-O-methylamentoflavone (2), robustaflavone (3), 4′-O-methyl robustaflavone (4) and tetrahinokiflavone (5). The new structures, which are composed of flavanone–flavanonol or flavanonol–flavanonol sub-units, were established based on spectroscopic analysis including 1D and 2D NMR (1H-1H COSY, HSQC, HMBC, and NOESY) spectroscopy, and by comparing their spectral data with those reported for related compounds.

(–)-6α-Hydroxy polyanthellin A — A novel antifouling diterpenoid from the Indian soft coral Cladiella krempfi (Hickson)

2011 ◽  
Vol 89 (1) ◽  
pp. 57-60 ◽  
Author(s):  
V. P. Limna Mol ◽  
T. V. Raveendran ◽  
P. S. Parameswaran ◽  
R. J. Kunnath ◽  
P. R. Rajamohanan
Keyword(s):  
Spectral Data ◽  
Mass Spectra ◽  
Soft Coral ◽  
Methanol Extract ◽  
2D Nmr ◽  
Balanus Amphitrite ◽  
Therapeutic Ratio

Bioassay-guided purification of methanol extract of the soft coral Cladiella krempfi (Octocorallia: Alcynocea) yielded a novel eunicellin-type diterpenoid, (–)-6α-hydroxy polyanthellin A (1), active against the cyprids of the fouling barnacle, Balanus amphitrite (EC50 9.02 µg/mL; LC50 36 µg/mL; and therapeutic ratio = 4). The structure of compound 1 was determined from its spectral data, including IR, NMR (1D and 2D NMR), and mass spectra.

Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

2019 ◽  
Vol 16 (6) ◽  
pp. 474-477 ◽  
Author(s):  
Pham Van Khang ◽  
Nguyen Thi Hien Lan ◽  
Le Quang Truong ◽  
Mai Thi Minh Chau ◽  
Mai Xuan Truong ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Spectral Data ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Ic50 Values ◽  
Nmr Techniques ◽  
Inhibitory Activities ◽  
Anemarrhena Asphodeloides

In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

scholarly journals Chemical Constituents of the Marine Sponge Aaptos aaptos (Schmidt, 1864) and Their Cytotoxic Activity

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199334
Author(s):  
Do Thi Trang ◽  
Bui Huu Tai ◽  
Dan Thuy Hang ◽  
Pham Hai Yen ◽  
Phan Thi Thanh Huong ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Absolute Configuration ◽  
Marine Sponge ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Extensive Analysis ◽  
First Time ◽  
Tddft Method ◽  
Mcf 7

Seven compounds (1-7) were isolated from the marine sponge Aaptos aaptos living in the Vietnamese sea. Their structures were determined as 2 hours, 5 H,7 H,9 H-9 S-hydroxy-imidazo[1,5- α]pyridine-1,3-dione (1), 3-([9-methylhexadecyl]oxy)propane-1,2-diol 2, 2,3-dihydro-2,3-dioxoaaptamine (3), indol-3-aldehyde (4), methyl indole-3-carboxylate (5) 4-hydroxy-5-(indole-3-yl)−5-oxo-pentan-2-one (6), and thymidine (7) by extensive analysis of HR-ESI-MS, 1D, and 2D NMR spectral data, as well as by comparison of the spectral data with those reported in the literature. In addition, the absolute configuration of 1 was determined from the experimental ECD spectrum and comparison of this with the theoretical ECD calculations using the TDDFT method. Compounds 1 and 2 were isolated from nature for the first time. Compound 3 induced cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values of 41.27 ± 2.63, 40.70 ± 2.65, 34.31 ± 3.43, and 36.63 ± 1.40 µM, respectively.

Rarely Occurring Natural Products Isolated from Vincetoxicum stocksii

2019 ◽  
Vol 41 (4) ◽  
pp. 695-695
Author(s):  
Saima Khan Saima Khan ◽  
Muhammad Imran Tousif Muhammad Imran Tousif ◽  
Naheed Raiz Naheed Raiz ◽  
Mamona Nazir Mamona Nazir ◽  
Mahreen Mukhtar Mahreen Mukhtar ◽  
...  
Keyword(s):  
Natural Products ◽  
Methanol Extract ◽  
High Resolution Mass Spectrometry ◽  
Ethyl Acetate Fraction ◽  
2D Nmr ◽  
Ethyl Carbamate ◽  
Carbamic Acid ◽  
Nmr Analysis ◽  
Nmr Techniques ◽  
Resolution Mass

Silica gel column chromatography of the ethyl acetate fraction of methanol extract of Vincetoxicum stocksii resulted in the separation of three new rarely occurring natural products; [4-(4-(methoxycarbonyl)benzyl)phenyl] carbamic acid (1), bis[di-p-phenylmethane]ethyl carbamate (2), methyl 2-hydroxy-3-(2-hydroxy-5-(3-methylbut-2-enyl)phenyl)-2-(4-hydroxyphenyl) propanoate, stocksiloate(3), along with five known compounds; 1-(4-hydroxy-3-methoxyphenyl)-1,2,3,-propanetriol (4), feruloyl-6-O-β-D-glucopyranoside (5), 4-hydroxy-3,5-dimethoxybenzoic acid (6), apocynin (7) and vincetomine (8). The structures of compounds 1 and 2 were established with help of 1D, 2D-NMR techniques and high resolution mass spectrometry, whereas, compound 3 could only be characterized tentatively by 1D, 2D-NMR techniques. Compounds 1 is new compound while 2 is synthetically known but never been reported from natural source. The known compounds were identified due to 1D NMR analysis and in comparison with the literature values. Compounds 1-3 were found inactive in an anti-urease assay.

scholarly journals Isolation of Stigmasterol and ?-Sitosterol from the dichloromethane extract of Rubus suavissimus

2012 ◽  
Vol 1 (9) ◽  
pp. 239-242 ◽  
Author(s):  
Venkata Sai Prakash Chaturvedula ◽  
Indra Prakash
Keyword(s):  
Spectral Data ◽  
Aqueous Extract ◽  
Pharmaceutical Journal ◽  
2D Nmr

Purification of the dichloromethane (CH2Cl2) fraction of the aqueous extract of Rubus suavissimus resulted in the isolation of two sterols namely stigmasterol and ?-sitosterol. The structures of the isolated compounds were characterized on the basis of extensive spectral data (1D and 2D NMR; and MS) and in comparison with their literature data.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11613 International Current Pharmaceutical Journal 2012, 1(9): 239-242 

scholarly journals Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Manne Sumalatha ◽  
Rachakunta Munikishore ◽  
Aluru Rammohan ◽  
Duvvuru Gunasekar ◽  
Kotha Anil Kumar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Methanol Extract ◽  
2D Nmr ◽  
Docking Studies ◽  
Selective Inhibitor ◽  
Pueraria Tuberosa ◽  
Nmr Techniques ◽  
Cox 2 ◽  
Plant Sources ◽  
Cox 1

Bioassay-guided fraction of the methanol extract of the roots of Pueraria tuberose DC yielded puerarin, an isoflavone C-glycoside (PT-1), isoorientin, a flavone C-glycoside (PT-2) and mangiferin, a xanthone C-glycoside (PT-3). The extracts and the isolated compounds were screened for potent antiinflammatory components inhibiting the cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-LOX), the target enzymes of inflammation, by employing spectroscopic/polorographic methods. Among these, isoorientin was found to be a potent inhibitorof COX-2with an IC50 value of 39 μM. Docking studies were carried out to understand the interactions of isorientin (PT-2) with COX-2. The structures of the isolates were determined by mass spectrometry and 2D-NMR techniques including HSQC, HMBC, NOESY and 1H-1H COSY experiments. Although isoorientin and mangiferin have been reported from several plant sources, this is the first report of their isolation from a Pueraria species.

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