Antimicrobial Activity of Quaternary Ammonium Salts of Some Saturated Heterocycloalkyl Amines [1]

1979 ◽  
Vol 34 (5-6) ◽  
pp. 485-486 ◽  
Author(s):  
Ivan Lacko ◽  
Ferdinand Devínsky ◽  
Ľudovít Krasnec ◽  
Dušan Mlynarčik
Keyword(s):  
Antimicrobial Activity ◽  
Quaternary Ammonium ◽  
Alkyl Chain ◽  
Heterocyclic Ring ◽  
Substantial Effect ◽  
Quaternary Ammonium Salts ◽  
Heterocyclic Amines ◽  
Ammonium Salts ◽  
Activity Change ◽  
Inhibition Concentration

Abstract N,N-Dialkyl Ammonium Salts of Saturated Heterocyclic Amines, Antimicrobial Activity Antimicrobial activity of N-alkyl-N-dodecylpiperidinium bromides and N-ethyl-N-dodecylheterocycloalkyl ammonium bromides (pyrrolidine, morpholine, perhydroazepine) deter­ mined on grampositive and gramnegative bacteria, yeasts and moulds, presented as minimum inhibition concentration (MIC). Comparison of the effect of change of structure: lenghtening of alkyl chain, change of heterocyclic ring. Change in the lenght of alkyl chain markedly affects the antimicrobial activity, change of heterocyclic ring has no substantial effect. The most active compounds were N-heptyl-and N-hexyl-N-dodecylpiperidinium bromides.

scholarly journals Biological Activity of Quaternary Ammonium Salts and Their Derivatives

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 459 ◽  
Author(s):  
Dobrawa Kwaśniewska ◽  
Ying-Lien Chen ◽  
Daria Wieczorek
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Food Spoilage ◽  
Biocidal Activity ◽  
Positive Role ◽  
Current State ◽  
Potential Use

Besides their positive role, microorganisms are related to a number of undesirable effects, including many diseases, biodeterioration and food spoilage, so when their presence is undesired, they must be controlled. Numerous biocides limiting the development of microorganisms have been proposed, however, in this paper the biocidal and inhibitory activity of quaternary ammonium salts (QASs) and their zwitterionic derivatives is addressed. This paper presents the current state of knowledge about the biocidal activity of QAS and their derivatives. Moreover, the known mechanisms of antimicrobial activity and the problem of emerging resistance to QAS are discussed. The latest trends in the study of surfactants and their potential use are also presented.

Enantiomerically pure quaternary ammonium salts with a chiral alkyl chain N(CH3)(n-C3H7)2(sec-C4H9)I: Synthesis and physical studies

Chirality ◽  
2008 ◽  
Vol 20 (10) ◽  
pp. 1085-1091 ◽  
Author(s):  
Ruxandra Gheorghe ◽  
Lise-Marie Chamoreau ◽  
Josef Kapitan ◽  
Nikolaï S. Ovanesyan ◽  
Sergei M. Aldoshin ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Alkyl Chain ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Enantiomerically Pure

The influence of cation and anion structure of new quaternary ammonium salts on adsorption and leaching

Holzforschung ◽  
2005 ◽  
Vol 59 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Jadwiga Zabielska-Matejuk
Keyword(s):  
Scots Pine ◽  
Quaternary Ammonium ◽  
Chemical Structure ◽  
Alkyl Chain ◽  
Chloride Ion ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Physical Processes ◽  
Water Leaching ◽  
Pine Wood

Abstract This study examined the effect of cation and anion chemical structure of new quaternary ammonium and imidazolium compounds (QAC, bis-QAC, IC, bis-IC) on the adsorption onto Scots pine wood (Pinus sylvestris L.) and resistance to water leaching. The group of copper (II) modified QACs, containing copper-chloro-acetate complexes in the anion structure, was also examined. The length of alkyl hydrophobic substituents in the cation structure significantly influences adsorption. The adsorption characteristics were statistically related to the alkyl chain length of new quaternary ammonium salts (quantitative correlations between CMC and adsorption values). Bis-ICs adsorb onto Scots pine wood with the greatest difficulty and the slowest and are also leached to the greatest degree. A varied adsorption of chloride ion cations and a several times higher leaching of chlorides than cations of the examined salts from the saturated wood were observed. The anion modification of bis-QAC and bis-IC of copper-chloro-acetate complexes causes decreased adsorption and resistance to the leaching of these salts. As a result of the performed regression analysis of Langmuir and Freundlich adsorption isotherms, it was found that the adsorption of the examined compounds onto wood was governed by both chemical and physical processes. New quaternary ammonium and imidazolium compounds represent potential wood preservatives.

ChemInform Abstract: Antimicrobial Agents. Part 6. Synthesis and Antimicrobial Activity of Some New Benzofuran Quaternary Ammonium Salts.

ChemInform ◽  
2010 ◽  
Vol 22 (31) ◽  
pp. no-no
Author(s):  
C. V. R. SASTRY ◽  
O. P. BANSAL ◽  
B. LAL ◽  
S. C. CHATURVEDI ◽  
J. S. SRINIVAS ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts

Safety Assessment of Trimoniums as Used in Cosmetics

2012 ◽  
Vol 31 (6_suppl) ◽  
pp. 296S-341S ◽  
Author(s):  
Lillian C. Becker ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Safety Assessment ◽  
Alkyl Chain ◽  
Expert Panel ◽  
Safety Data ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Entire Group ◽  
Product Usage ◽  
Cosmetic Product

Quaternary ammonium salts, including alkyl chain, alkanol, and polymer derivatives (trimoniums) are used in cosmetics mainly as surfactant-cleansing agents, hair-conditioning agents, and antistatic agents.  The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the trimomiums.  The available data on many of the trimoniums are sufficient, however, and similar structural activity relationships, functions in cosmetics, and cosmetic product usage supported extending these data to the entire group.  These ingredients were determined to be safe in the present practices of use and concentration when formulated to be nonirritating.

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