Cytochalasin P1, a new cytochalasin from the marine-derived fungus Xylaria sp. SOF11

2017 ◽  
Vol 72 (3-4) ◽  
pp. 129-132 ◽  
Author(s):  
Ziming Chen ◽  
Yuchan Chen ◽  
Hongbo Huang ◽  
Hongyan Yang ◽  
Weimin Zhang ◽  
...  
Keyword(s):  
South China Sea ◽  
Tumor Cell ◽  
Cell Lines ◽  
South China ◽  
The South China Sea ◽  
Tumor Cell Lines ◽  
The South ◽  
China Sea ◽  
Data Analyses ◽  
Mcf 7

Abstract A new cytochalasin, named cytochalasin P1 (1), together with four known analogs (2–5) was isolated from marine-derived fungus Xylaria sp. SOF11 from the South China Sea. The structure of the new compound was elucidated on the basis of MS and NMR (1H, 13C, HSQC, HMBC, and NOESY) data analyses. Compounds 1–5 were tested for their cytotoxicities against four tumor cell lines (SF-268, MCF-7, NCI-H460, and HepG-2). Compounds 1–5 showed significant cytotoxicity against two tumor cell lines MCF-7 and SF-268, with the IC50 values varying between 0.33 and 4.17 μM.

Steroids from the South China Sea Gorgonian Coral Muricella flexuosa

2011 ◽  
Vol 66 (6) ◽  
pp. 635-640
Author(s):  
Ping Wang ◽  
Shu-Hua Qi ◽  
Kai-Sheng Liu ◽  
Li-Si Huang ◽  
Fei He ◽  
...  
Keyword(s):  
South China Sea ◽  
Cell Lines ◽  
Cancer Cell ◽  
South China ◽  
2D Nmr ◽  
The South China Sea ◽  
The South ◽  
Gorgonian Coral ◽  
China Sea ◽  
Spectroscopic Analyses

Four new steroidal glycosides and a new steriod linked with a 4-hydroxyphenylmethylene group, namely muricellasteroids A- E (1 - 5), together with one known steroidal glycoside analog, 22α,2ʹ,3ʹ,4ʹ-O-tetraacetyl-27-O-[β -D-arabino-pyranosyl-oxy]-20β -hydroxy-cholest-4- ene-3-one (6), were isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian coral Muricella flexuosa. The structures of 1 - 5 were established by means of 1D- and 2D-NMR and other spectroscopic analyses. Compounds 1 - 3 and 5 - 6 showed moderate cytotoxicity against A375, K562, and A549 cancer cell lines.

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