scholarly journals Could the Next Antibiotic Emerge from Bacteria?

2019 ◽  
pp. 31-33
Author(s):  
Bichoy Labib
Keyword(s):  
Mechanism Of Action ◽  
Secretion System ◽  
Future Research ◽  
Effector Protein ◽  
Accessory Proteins ◽  
Lethal Effects ◽  
Immunity Protein ◽  
Chaperone Protein ◽  
Bacterial Secretion ◽  
Bacterial Secretion System

An intrinsic bacterial mechanism could play a fundamental role in the future of antibiotics. Using cryo-EM, the structural resolution of the effector protein complexed with its chaperone and other accessory proteins reveals the mechanism of action of type VI bacterial secretion system. The importance of the chaperone protein, used to prime the toxic effector protein, was previously identified. Future research efforts should encompass the immunity protein that may allow bacteria to evade the lethal effects of this mechanism.

scholarly journals Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97367 ◽  
Author(s):  
Chiu-Min Cheng ◽  
Shey-Cherng Tzou ◽  
Ya-Han Zhuang ◽  
Chien-Chiao Huang ◽  
Chien-Han Kao ◽  
...  
Keyword(s):  
Secretion System ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Bacterial Secretion ◽  
Bacterial Secretion System

scholarly journals Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice

2021 ◽  
Author(s):  
Dongrui Zhou ◽  
Na Li ◽  
Fan Yang ◽  
Honglin Zhang ◽  
Zhimao Bai ◽  
...  
Keyword(s):  
Immune Function ◽  
Soil Microbes ◽  
Allergic Diseases ◽  
Short Chain Fatty Acids ◽  
Secretion System ◽  
Total Serum ◽  
Serum Ige ◽  
Bacterial Secretion ◽  
Bacterial Secretion System ◽  
Environmental Microbes

Abstract Background Traditional farm environments provide protection from allergic diseases. In this study, farm environmental factors were classified into three categories: environmental microbes, soil, and organic matter. To explore the impact of soil and environmental microorganisms on gut microbiota and immune function, mice were fed sterilized soil, soil microbes (in lieu of environmental microbes), or non-sterilized soil. Results Metagenomic sequencing results showed that the intake of sterile soil while inhaling a small amount of soil microbes in the air, increased gut microbial diversity and the abundance of type III secretion system (T3SS) genes and decreased total serum IgE levels induced by 2-4-dinitrofluorobenzene. The intake of soil microbes increased the abundance of genes involved in the metabolism of short-chain fatty acids and amino acid biosynthesis. By contrast, the intake of soil increased gut microbial diversity, the abundance of T3SS genes and related infectious elements, and genes associated with the metabolism of short-chain fatty acids and amino acid biosynthesis and decreased serum IgE levels. The immune function was positively and significantly correlated with the bacterial secretion system genes, especially with that of T3SS. Conclusions An important mechanism through which farm environments exert a protective effect against allergic diseases could be by serving as a “prebiotic” promoting the reproduction and growth of some intestinal microorganisms that harbor bacterial secretion system genes, especially those of T3SS, whose abundance was positively and significantly correlated with innate immune function of mice.

scholarly journals SecA—a New Twist in the Tale

2016 ◽  
Vol 199 (2) ◽  
Author(s):  
Ian Collinson
Keyword(s):  
Secretion System ◽  
Protein Export ◽  
Inner Membrane ◽  
Link Type ◽  
Sec System ◽  
Bacterial Secretion ◽  
Bacterial Secretion System ◽  
Timely Reminder

ABSTRACT A paper published in this issue of the Journal of Bacteriology (D. Huber, M. Jamshad, R. Hanmer, D. Schibich, K. Döring, I. Marcomini, G. Kramer, and B. Bukau, J Bacteriol 199:e0622-16, 2017, https://doi.org/10.1128/JB.00622-16 ) provides us with a timely reminder that all is not as clear as we had previously thought in the general bacterial secretion system. The paper describes a new mode of secretion through the Sec system—“uncoupled cotranslocation”—for the passage of proteins across the bacterial inner membrane and suggests that we might rethink the nature and mechanism of the targeting and transport steps toward protein export.

scholarly journals Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Andree Hubber ◽  
Tomoko Kubori ◽  
Cevayir Coban ◽  
Takeshi Matsuzawa ◽  
Michinaga Ogawa ◽  
...  
Keyword(s):  
Secretion System ◽  
Bacterial Secretion ◽  
Bacterial Secretion System

scholarly journals A Widespread Bacterial Secretion System with Diverse Substrates

mBio ◽  
2021 ◽  
Author(s):  
Alex S. Grossman ◽  
Terra J. Mauer ◽  
Katrina T. Forest ◽  
Heidi Goodrich-Blair
Keyword(s):  
Secretion System ◽  
Microbial Colonization ◽  
Secreted Proteins ◽  
Surface Conditions ◽  
Immunological Responses ◽  
Colonization Factors ◽  
Physical And Chemical ◽  
Bacterial Secretion ◽  
Bacterial Secretion System

The microbial constituency of a host-associated microbiome emerges from a complex physical and chemical interplay of microbial colonization factors, host surface conditions, and host immunological responses. To fill unique niches within a host, bacteria encode surface and secreted proteins that enable interactions with and responses to the host and cooccurring microbes.

scholarly journals Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice

2021 ◽  
Author(s):  
Dongrui Zhou ◽  
Na Li ◽  
Fan Yang ◽  
Honglin Zhang ◽  
Zhimao Bai ◽  
...  
Keyword(s):  
Immune Function ◽  
Soil Microbes ◽  
Allergic Diseases ◽  
Short Chain Fatty Acids ◽  
Secretion System ◽  
Total Serum ◽  
Serum Ige ◽  
Bacterial Secretion ◽  
Bacterial Secretion System ◽  
Environmental Microbes

AbstractBackgroundTraditional farm environments provide protection from allergic diseases. In this study, farm environmental factors were classified into three categories: environmental microbes, soil, and organic matter. To explore the impact of soil and environmental microorganisms on gut microbiota and immune function, mice were fed sterilized soil, soil microbes (in lieu of environmental microbes), or non-sterilized soil.ResultsMetagenomic sequencing results showed that the intake of sterile soil while inhaling a small amount of soil microbes in the air, increased gut microbial diversity and the abundance of type III secretion system (T3SS) genes and decreased total serum IgE levels induced by 2-4-dinitrofluorobenzene. The intake of soil microbes increased the abundance of genes involved in the metabolism of short-chain fatty acids and amino acid biosynthesis. By contrast, the intake of soil increased gut microbial diversity, the abundance of T3SS genes and related infectious elements, and genes associated with the metabolism of short-chain fatty acids and amino acid biosynthesis and decreased serum IgE levels. The immune function was positively and significantly correlated with the bacterial secretion system genes, especially with that of T3SS.ConclusionsAn important mechanism through which farm environments exert a protective effect against allergic diseases could be by serving as a “prebiotic” promoting the reproduction and growth of some intestinal microorganisms that harbor bacterial secretion system genes, especially those of T3SS, whose abundance was positively and significantly correlated with innate immune function of mice.

An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenicEscherichia coli

2019 ◽  
Vol 25 (3) ◽  
Author(s):  
Mariano Larzábal ◽  
Hector A. Baldoni ◽  
Fernando D. Suvire ◽  
Lucrecia M. Curto ◽  
Gabriela E. Gomez ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Coiled Coil ◽  
Secretion System ◽  
Inhibitory Mechanism ◽  
Type Three Secretion System ◽  
Type Three Secretion

Empirically Supported Psychological Treatments: EMDR

2012 ◽  
pp. 448-462
Author(s):  
C. Richard Spates ◽  
Sophie Rubin
Keyword(s):  
Mechanism Of Action ◽  
Stress Disorder ◽  
Empirical Studies ◽  
Future Research ◽  
Evidence Based ◽  
Psychological Treatments ◽  
Empirically Supported ◽  
Theoretical Mechanism ◽  
Effectiveness Trials ◽  
Empirical Foundation

In this chapter we review the empirical foundation for Eye Movement Desensitization and Reproessing Therapy (EMDR) for posttraumatic stress disorder. We present a brief description of the therapy, critically review recent primary and meta-analytic investigations concerning its efficacy and effectiveness, offer a summary of recent primary investigations that addressed the mechanism of action for EMDR, and based on this overall review, we suggest limitations with recommendations for future research. Recent empirical investigations of the efficacy of EMDR have improved along a number of important dimensions, and these along with the few completed effectiveness trials, position this therapy among evidence-based frontline interventions for PTSD. What is less thoroughly researched, and thus less well understood, are putative models of its theoretical mechanism of action. In addition to continuing specific improvements in research concerning efficacy and effectiveness, we recommend more and higher quality empirical studies of its mechanism of action.

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