scholarly journals Visfatin and 25-Hydroxyvitamin D3 Levels Affect Coronary Collateral Circulation Development in Patients with Chronic Coronary Total Occlusion

2021 ◽  
Author(s):  
Xiaoling Ji
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Collateral Circulation ◽  
Vital Role ◽  
Total Occlusion ◽  
Coronary Collateral Circulation ◽  
Collateral Development ◽  
Coronary Collateral ◽  
The Poor ◽  
Visfatin Level

Background: Coronary collateral circulation (CCC) plays a vital role in the myocardial blood supply, especially forischemic myocardium. Evidence suggests that the visfatin and 25-hydroxyvitamin D3 [25(OH)D3] levels are related to the degree and incidence of vascular stenosis associated with coronary artery disease; however, few studies have evaluated the effect of visfatin and 25(OH)D3 on CCC development in patients with chronic total occlusion (CTO).This study aimed to evaluate the relationship between the serum visfatin and 25(OH)D3 levels and CCC in patients with CTO.Methods: A total of 189 patients with CTO confirmed by coronary angiography were included. CCC was graded from 0 to 3 according to the Rentrop-Cohen classification. Patients with grade 0 or grade 1 collateral development were included in the poor CCC group (n = 82), whereas patients with grade 2 or grade 3 collateral development were included in the good CCC group (n = 107). The serum visfatin and 25(OH)D3 levels were measured by ELISA.Results: The visfatin level was significantly higher in the poor CCC group than in the good CCC group, and the 25(OH)D3 level was significantly lower in the poor CCC group than in the good CCC group (P = 0.000). Correlation analysis showed that the Rentrop grade was negatively correlated with the visfatin level (r = − 0.692, P = 0.000) but positively correlated with the 25(OH)D3 level (r = 0.635, P = 0.000). Logistic regression analysis showed that the visfatin and 25(OH)D3 levels were independent risk factors for CCC (odds ratio 1.597, 95% confidence interval 1.300–1.961, P = 0.000 and odds ratio 0.566, 95% confidence interval 0.444–0.722, P = 0.000, respectively). The visfatin and25(OH)D3 levels can effectively predict the CCC status.Conclusion: Serum visfatin and 25(OH)D3 levels are related to CCC development and are independent predictors of poor CCC.

scholarly journals Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation

2020 ◽  
Author(s):  
Xin Chen ◽  
Yan Lin ◽  
Lihua Tian ◽  
Zhiquan Wang
Keyword(s):  
Roc Curve ◽  
Collateral Circulation ◽  
Total Bilirubin ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Coronary Collateral Circulation ◽  
Ventricular Ejection Fraction ◽  
Ischemia Modified Albumin ◽  
Coronary Collateral ◽  
The Poor

Abstract Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

scholarly journals The Association between Whole Blood Viscosity and Coronary Collateral Circulation in Patients with Chronic Total Occlusion

2016 ◽  
Vol 46 (6) ◽  
pp. 784 ◽  
Author(s):  
Mehmet Serkan Cetin ◽  
Elif Hande Ozcan Cetin ◽  
Kevser Gülcihan Balcı ◽  
Selahattin Aydin ◽  
Emek Ediboglu ◽  
...  
Keyword(s):  
Blood Viscosity ◽  
Whole Blood ◽  
Collateral Circulation ◽  
Chronic Total Occlusion ◽  
Total Occlusion ◽  
Coronary Collateral Circulation ◽  
Whole Blood Viscosity ◽  
Coronary Collateral

scholarly journals Predictors of poorly developed coronary collateral circulation in patients with subclinical hypothyroidism suffered from chronic stable angina

2019 ◽  
Vol 2019 (2) ◽  
Author(s):  
Mohamed Khalfallah ◽  
Enas Draz ◽  
Khaled Shalaby ◽  
Yasser Mostafa Hafez
Keyword(s):  
Coronary Artery ◽  
Subclinical Hypothyroidism ◽  
Stable Angina ◽  
Collateral Circulation ◽  
Chronic Stable Angina ◽  
Multivariate Regression Analysis ◽  
Total Occlusion ◽  
Coronary Collateral Circulation ◽  
Coronary Collaterals ◽  
Coronary Collateral

Background: The development of coronary collaterals is variable among patients with coronary artery disease and remains incompletely understood. We aimed to demonstrate the predictors of poorly developed coronary collateral circulation (CCC) in patients with subclinical hypothyroidism suffered from chronic stable angina.Methods: The study was conducted on 226 patients with subclinical hypothyroidism suffered from chronic stable angina, coronary angiography documented total occlusion at any major coronary artery or coronary artery lumen diameter stenosis ˃90%. Patients were divided into two groups according to grade of CCC, group A: 138 patients with (good collaterals) and group B: 88 patients with (poor collaterals). To classify CCC, we used Rentrop’s classification.Results: Multivariate regression analysis was performed and identified the independent predictors of poor coronary collaterals: N/L ratio (OR 0.413, CI95% 0.172–0.993, p=0.048), and TSH (OR 2.511, CI95% 1.784– 3.534, p=0.001). The ROC analysis provided a cut-off value of >4.6 for N/L ratio, and >9 μIU/mL for TSH to predict poor coronary collaterals.Conclusion: An elevated level of N/L ratio ˃ 4.6 and TSH level ˃ 9 μIU/mL were the independent predictors of poorly developed CCC in patients with subclinical hypothyroidism suffered from chronic stable angina.

scholarly journals Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation

2019 ◽  
Author(s):  
Xin Chen ◽  
Yan Lin ◽  
Lihua Tian ◽  
Zhiquan Wang
Keyword(s):  
Roc Curve ◽  
Collateral Circulation ◽  
Total Bilirubin ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Coronary Collateral Circulation ◽  
Ventricular Ejection Fraction ◽  
Coronary Collateral ◽  
The Poor ◽  
Good Group

Abstract Abstract Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851，P＜0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.

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