scholarly journals Late Retinal Progenitor Cells Show Intrinsic Limitations in the Production of Cell Types and the Kinetics of Opsin Synthesis

2000 ◽  
Vol 20 (6) ◽  
pp. 2247-2254 ◽  
Author(s):  
Michael J. Belliveau ◽  
Tracy L. Young ◽  
Constance L. Cepko
Keyword(s):  
Progenitor Cells ◽  
Cell Types ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor ◽  
Kinetics Of

p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina

Development ◽  
2000 ◽  
Vol 127 (16) ◽  
pp. 3593-3605 ◽  
Author(s):  
M.A. Dyer ◽  
C.L. Cepko
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Kinase Inhibitor ◽  
Retinal Development ◽  
Cell Types ◽  
Cell Cycle Exit ◽  
Retinal Progenitor Cells ◽  
Mouse Development ◽  
Retinal Progenitor ◽  
Cyclin Kinase Inhibitor

A precise balance between proliferation and differentiation must be maintained during retinal development to obtain the correct proportion of each of the seven cell types found in the adult tissue. Cyclin kinase inhibitors can regulate cell cycle exit coincident with induction of differentiation programs during development. We have found that the p57(Kip2) cyclin kinase inhibitor is upregulated during G(1)/G(0) in a subset of retinal progenitor cells exiting the cell cycle between embryonic day 14.5 and 16.5 of mouse development. Retroviral mediated overexpression of p57(Kip2) in embryonic retinal progenitor cells led to premature cell cycle exit. Retinae from mice lacking p57(Kip2) exhibited inappropriate S-phase entry and apoptotic nuclei were found in the region where p57(Kip2) is normally expressed. Apoptosis precisely compensated for the inappropriate proliferation in the p57(Kip2)-deficient retinae to preserve the correct proportion of the major retinal cell types. Postnatally, p57(Kip2) was found to be expressed in a novel subpopulation of amacrine interneurons. At this stage, p57(Kip2)did not regulate proliferation. However, perhaps reflecting its role during this late stage of development, animals lacking p57(Kip2) showed an alteration in amacrine subpopulations. p57(Kip2) is the first gene to be implicated as a regulator of amacrine subtype/subpopulation development. Consequently, we propose that p57(Kip2) has two roles during retinal development, acting first as a cyclin kinase inhibitor in mitotic progenitor cells, and then playing a distinct role in neuronal differentiation.

scholarly journals Pax6 Is Required for Normal Cell-Cycle Exit and the Differentiation Kinetics of Retinal Progenitor Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76489 ◽  
Author(s):  
Chen Farhy ◽  
Michael Elgart ◽  
Zehavit Shapira ◽  
Varda Oron-Karni ◽  
Orly Yaron ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Normal Cell ◽  
Cell Cycle Exit ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor ◽  
Kinetics Of ◽  
Normal Cell Cycle

Different characteristics of rat retinal progenitor cells from different culture periods

2003 ◽  
Vol 341 (3) ◽  
pp. 213-216 ◽  
Author(s):  
Tadamichi Akagi ◽  
Masatoshi Haruta ◽  
Joe Akita ◽  
Akihiro Nishida ◽  
Yoshihito Honda ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor ◽  
Different Characteristics

scholarly journals Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells

2021 ◽  
Vol 62 (3) ◽  
pp. 31
Author(s):  
Lorena Teixeira Frasson ◽  
Barbara Dalmaso ◽  
Priscilla Sayami Akamine ◽  
Edna Teruko Kimura ◽  
Dânia Emi Hamassaki ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Ciliary Epithelium ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor

Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation

2014 ◽  
Vol 14 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Rajiv Dixit ◽  
Nobuhiko Tachibana ◽  
Yacine Touahri ◽  
Dawn Zinyk ◽  
Cairine Logan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Progenitor Cells ◽  
Cellular Differentiation ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor
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