scholarly journals Densin-180 Forms a Ternary Complex with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin

2001 ◽  
Vol 21 (2) ◽  
pp. 423-433 ◽  
Author(s):  
Randall S. Walikonis ◽  
Asako Oguni ◽  
Eugenia M. Khorosheva ◽  
Chung-Jiuan Jeng ◽  
Franklin J. Asuncion ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Ternary Complex ◽  
Dependent Protein Kinase ◽  
Α Subunit ◽  
Protein Kinase Ii ◽  
Dependent Protein

Expression of a catalytically active polypeptide of calmodulin-dependent protein kinase II α subunit in Escherichia coli

1990 ◽  
Vol 170 (2) ◽  
pp. 705-712 ◽  
Author(s):  
Shunji Ohsako ◽  
Atsuko Watanabe ◽  
Shun-ichi Sekihara ◽  
Atsushi Ikai ◽  
Takashi Yamauchi
Keyword(s):  
Escherichia Coli ◽  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Α Subunit ◽  
Protein Kinase Ii ◽  
Catalytically Active ◽  
Dependent Protein

Cell-specific localization of the α-subunit of calcium/calmodulin-dependent protein kinase II in Purkinje cells in rodent cerebellum

1988 ◽  
Vol 4 (3) ◽  
pp. 233-242 ◽  
Author(s):  
S.Ivar Walaas ◽  
Yvonne Lai ◽  
Fred S. Gorelick ◽  
Pietro DeCamilli ◽  
Milena Moretti ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Purkinje Cells ◽  
Dependent Protein Kinase ◽  
Α Subunit ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Specific Localization ◽  
Dependent Protein

Scutellarin Mitigates Cancer-Induced Bone Pain by Suppressing CaMKII/CREB Pathway in Rat Models

2019 ◽  
Vol 17 (3) ◽  
pp. 249-253
Author(s):  
Liu Chenglong ◽  
Liu Haihua ◽  
Zhang Fei ◽  
Zheng Jie ◽  
Wei Fang
Keyword(s):  
Protein Kinase ◽  
Bone Pain ◽  
Binding Protein ◽  
Camp Response Element Binding ◽  
Camp Response Element ◽  
Dependent Protein Kinase ◽  
Response Element ◽  
Protein Kinase Ii ◽  
Element Binding Protein ◽  
Dependent Protein

Cancer-induced bone pain is a severe and complex pain caused by metastases to bone in cancer patients. The aim of this study was to investigate the analgesic effect of scutellarin on cancer-induced bone pain in rat models by intrathecal injection of Walker 256 carcinoma cells. Mechanical allodynia was determined by paw withdrawal threshold in response to mechanical stimulus, and thermal hyperalgesia was indicated by paw withdrawal latency in response to noxious thermal stimulus. The paw withdrawal threshold and paw withdrawal latencies were significantly decreased after inoculation of tumor cells, whereas administration of scutellarin significantly attenuated tumor cell inoculation-induced mechanical and heat hyperalgesia. Tumor cell inoculation-induced tumor growth was also significantly abrogated by scutellarin. Ca2+/calmodulin-dependent protein kinase II is a multifunctional kinase with up-regulated activity in bone pain models. The activation of Ca2+/calmodulin-dependent protein kinase II triggers phosphorylation of cAMP-response element binding protein. Scutellarin significantly reduced the expression of phosphorylated-Ca2+/calmodulin-dependent protein kinase II and phosphorylated-cAMP-response element binding protein in cancer-induced bone pain rats. Collectively, our study demonstrated that scutellarin attenuated tumor cell inoculation-induced bone pain by down-regulating the expression of phosphorylated-Ca2+/calmodulin-dependent protein kinase II and phosphorylated-cAMP-response element binding protein. The suppressive effect of scutellarin on phosphorylated-Ca2+/calmodulin-dependent protein kinase II/phosphorylated-cAMP-response element binding protein activation may serve as a novel therapeutic strategy for CIBP management.

Calcium/Calmodulin-Dependent Protein Kinase II Involvement in Release of Gonadotropin-Releasing Hormone

1998 ◽  
Vol 67 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Wendy W. Waters ◽  
Pat L. Chen ◽  
Newell H. McArthur ◽  
Pete A. Moreno ◽  
Paul G. Harms
Keyword(s):  
Protein Kinase ◽  
Gonadotropin Releasing Hormone ◽  
Dependent Protein Kinase ◽  
Releasing Hormone ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein
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