Chronic oxidative stress promotes H2
            AX
            protein degradation and enhances chemosensitivity in breast cancer patients

Oxidative stress occurs as a result of disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses. Markers of oxidative stress were measured the markers of oxidative stress in breast cancer patients after diagnosis of breast cancer and compared these plasma blood levels controls This study was conducted to three markers of oxidative stress ;these are (SOD) enzyme ,malondialdehyde (MDA)and8-iso-prostaglandinF2α plasma of patients with breast cancer and compare with controls .In this study ; the mean MDA (ng/ml) levels for the breast cancer patients and the controls were55.91±3.31 and40.61±3.76 respectively, while the SOD (pg/ml) levels were1530.37±80.4 and1851.4 9±93.65 respectively and the 8-iso-PGF2α (ng/ml ) levels were 40.16±3.31 and 30.16±2.34 difference of the mean were statistically significant (p value <0.05).

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26P Pre and post chemotherapy circulating oxidative stress parameters in breast cancer patients

Annals of Oncology ◽

10.1093/annonc/mdw573.024 ◽

2016 ◽

Vol 27 (suppl_9) ◽

Author(s):

D. Moslemi ◽

S. Mahjoub ◽

M. Taherkhani ◽

A. Karkhah

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Oxidative Stress Parameters ◽

Stress Parameters

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A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/9441896 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Kaiming Zhang ◽

Liqin Ping ◽

Tian Du ◽

Yan Wang ◽

Ya Sun ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Operable Breast Cancer ◽

Breast Cancer Patients ◽

Training Set ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Validation Set ◽

The Relationship

Background. Breast cancer was associated with imbalance between oxidation and antioxidation. Local oxidative stress in tumors is closely related to the occurrence and development of breast cancer. However, the relationship between systematic oxidative stress and breast cancer remains unclear. This study is aimed at exploring the prognostic value of systematic oxidative stress in patients with operable breast cancer. Methods. A total of 1583 operable female breast cancer patients were randomly assigned into the training set and validation set. The relationship between systematic oxidative stress biomarkers and prognosis were analyzed in the training and validation sets. Results. The systematic oxidative stress score (SOS) was established based on five systematic oxidative stress biomarkers including serum creatinine (CRE), serum albumin (ALB), total bilirubin (TBIL), lactate dehydrogenase (LDH), and blood urea nitrogen (BUN). SOS was an independent prognostic factor for operable breast cancer patients. A nomogram based on SOS and clinical characteristics could accurately predict the prognosis of operable breast cancer patients, and the area under the curve (AUC) of the nomogram was 0.823 in the training set and 0.872 in the validation set, which was much higher than the traditional prognostic indicators. Conclusions. SOS is an independent prognostic indicator for operable breast cancer patients. A prediction model based on SOS could accurately predict the outcome of operable breast cancer patients.

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Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer

Cancers ◽

10.3390/cancers11091255 ◽

2019 ◽

Vol 11 (9) ◽

pp. 1255 ◽

Cited By ~ 14

Author(s):

Patrik Kovács ◽

Tamás Csonka ◽

Tünde Kovács ◽

Zsanett Sári ◽

Gyula Ujlaki ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Cells ◽

Cancer Patients ◽

Breast Cancer Cells ◽

Lithocholic Acid ◽

Constitutive Androstane Receptor ◽

Breast Cancer Patients ◽

Lipid And Protein Oxidation ◽

Oxide Synthase

In breast cancer patients, the diversity of the microbiome decreases, coinciding with decreased production of cytostatic bacterial metabolites like lithocholic acid (LCA). We hypothesized that LCA can modulate oxidative stress to exert cytostatic effects in breast cancer cells. Treatment of breast cancer cells with LCA decreased nuclear factor-2 (NRF2) expression and increased Kelch-like ECH associating protein 1 (KEAP1) expression via activation of Takeda G-protein coupled receptor (TGR5) and constitutive androstane receptor (CAR). Altered NRF2 and KEAP1 expression subsequently led to decreased expression of glutathione peroxidase 3 (GPX3), an antioxidant enzyme, and increased expression of inducible nitric oxide synthase (iNOS). The imbalance between the pro- and antioxidant enzymes increased cytostatic effects via increased levels of lipid and protein oxidation. These effects were reversed by the pharmacological induction of NRF2 with RA839, tBHQ, or by thiol antioxidants. The expression of key components of the LCA-elicited cytostatic pathway (iNOS and 4HNE) gradually decreased as the breast cancer stage advanced. The level of lipid peroxidation in tumors negatively correlated with the mitotic index. The overexpression of iNOS, nNOS, CAR, KEAP1, NOX4, and TGR5 or the downregulation of NRF2 correlated with better survival in breast cancer patients, except for triple negative cases. Taken together, LCA, a metabolite of the gut microbiome, elicits oxidative stress that slows down the proliferation of breast cancer cells. The LCA–oxidative stress protective pathway is lost as breast cancer progresses, and the loss correlates with poor prognosis.

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Oxidative stress induced by early cycles of combination chemotherapy in chemonaive and radionaive breast cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e11561 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e11561-e11561

Author(s):

Victor C. Kok ◽

Wan-Seng Ko ◽

C.H. Guo ◽

P.C. Chen

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Time Course ◽

Connective Tissue Disorder ◽

Tumor Type ◽

Breast Cancer Patients ◽

Exclusion Criteria ◽

Antioxidant Agent ◽

Written Informed Consent

e11561 Background: Chemotherapy-induced oxidative stress (CIOS) can be altered multifactorially in time course of treatment. Initial changes of CIOS in the breast cancer patients are not clear. OBJECTIVES: IRB-approved prospective study of the changes of CIOS in chemo-naïve and radiotherapy-naïve breast cancer patients who undergo chemotherapy(CT) or radiotherapy(RT) in either adjuvant or metastatic settings. Methods: Exclusion criteria: Patient who has prior exposure to CT or RT, active infection, connective tissue disorder, been taking antioxidant agent(s), active hepatitis, liver cirrhosis, renal insufficiency and no written informed consent. Blood samplings were done before CT or RT and day 22 since chemotherapy or day 29 since RT. Serum analyzed for glutathione peroxidase(GSH-Px), glutathione reductase(GR), Vit.E, malondialdehyde (MDA), and trace elements including Zn, Cu, Fe, Se. Results: 10 patients and 10 healthy volunteers were entered. Median age: 47.5 (R: 38~80); Tumor type; infiltrating ductal ca: 8 pts; lobular ca: 1; mucinous: 1. Stage: IIA: 4 pts; IIB: 1; IIIA: 3; IIIB: 0; IIIC: 1; Relapsed: 1. ECOG 0/1: 9/1 pts; Regimens: FEC: 5 pts, CAF: 1, EC: 2, CMF: 1; RT: 1. After 1 cycle of CT or 28 days of RT: GSH-Px was significantly increased (P=0.0003); GR increased (P=0.0002); Vit. E increased (1-sided P=0.028); MDA decreased (P=0.0073) and Zn decreased (P=0.0162). Contrary to some oncologists initial expectations, the early changes after chemotherapy or radiotherapy are elevation of body's antioxidative capacity. Conclusions: Spontaneous counterbalance of CIOS after initial cycles of chemotherapy is suggested from this study.

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