VASCULAR CONNECTIVE TISSUE UNDER THE INFLUENCE OF THYROXINE

1961 ◽  
Vol 36 (2) ◽  
pp. 197-211 ◽  
Author(s):  
lb Lorenzen
Keyword(s):  
Connective Tissue ◽  
Vessel Wall ◽  
Aortic Wall ◽  
Calcium Content ◽  
Sodium Sulphate ◽  
Collagen Content ◽  
Histological Changes ◽  
Hexosamine Content ◽  
Healing Processes

ABSTRACT Biochemical and histological changes in the aortic wall of rabbits were demonstrated following injection of epinephrine and l-thyroxine during 2 weeks. The widespread gross and microscopic changes were accompanied by an increase in hexosamine content and uptake of 35S labeled sodium sulphate, and an increased calcium content, whereas the collagen content, assessed by determination of hydroxyproline, was reduced. Comparison with the effect of epinephrine injections alone showed that thyroxine intensified the damaging effect of epinephrine on the vessel wall and induced more pronounced mucopolysaccharide changes in the aortic wall, presumably acting as a link in the healing processes.

MINERALIZATION OF AORTIC WALL - PIXE STUDIES

1992 ◽  
Vol 02 (04) ◽  
pp. 551-567 ◽  
Author(s):  
E. ROKITA
Keyword(s):  
Mathematical Description ◽  
Vessel Wall ◽  
Aortic Wall ◽  
Mineralization Process ◽  
Tissue Samples ◽  
Animal Material ◽  
The Mean ◽  
Pixe Method ◽  
Human Autopsy

The application of PIXE and micro-PIXE methods for the description of human aortic wall mineralization including its dynamics is presented. The data was collected both from human autopsy samples and from animal material. The mean concentrations of P, S, Cl, K, Ca, Fe, Cu, Zn, Br, Sr and Pb were determined in tissue samples and in the aortic wall sections. On the basis of PIXE results the following conclusion may be drawn: the concentrations of Ca, Zn, Sr and Pb increase while that of S, Cl and K contents decrease when the mineralization of the vessel wall (determined histochemically) develops. The micro-PIXE method enabled: (1) the determination of the elemental composition of both inorganic and organic materials in the sample, (2) the identification of different Ca—P compounds on the basis of the Ca/P ratio, (3) the investigations of the involvement of other elements in the development of mineralization process (4) the determination of the deposit radii on the basis of Ca concentration and (5) the generalized analysis on the inorganic deposit growth using mathematical description.

Changes in the biomechanical properties of skin and aorta induced by corticotrophin treatment

1980 ◽  
Vol 94 (1) ◽  
pp. 132-137 ◽  
Author(s):  
H. Oxlund
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Connective Tissue ◽  
Thoracic Aorta ◽  
Aortic Wall ◽  
Biomechanical Properties ◽  
Elastic Stiffness ◽  
Collagen Content ◽  
Dorsal Skin ◽  
Biophysical Properties

Abstract. The work presented here is an investigation of the effect of elevated levels of corticosteroids on the biophysical properties of skin, aorta and muscle tendon. Rats were given corticotrophin injections for 10, 30 and 60 days to elevate the level of plasma endogenous corticosteroids. The corticotrophin treatments did not change the water or collagen content of specimens from dorsal skin, thoracic aorta and peroneal muscle tendons, tested mechanically. Changes became evident after longer treatment times. For both skin and aorta, the tensile strength, elastic stiffness and failure energy were increased after 60 days of treatment. The corticotrophin treatment did not influence the mechanical properties of muscle tendons. Complete reversibility of changes in the mechanical properties induced by 30 days of corticotrophin treatment was found after an additional period of 30 days of saline injections. This study indicates that an increased level of plasma corticosteroids elicited by corticotrophin treatment may increase the stiffness of the connective tissue of the organism. In the aorta this results in loss of capacitive function with increased haemodynamic strain on the aortic wall.

VASCULAR CONNECTIVE TISSUE UNDER THE INFLUENCE OF THYROXINE

1961 ◽  
Vol 37 (2) ◽  
pp. 191-198 ◽  
Author(s):  
lb Lorenzen
Keyword(s):  
Connective Tissue ◽  
Microscopic Examination ◽  
Aortic Wall ◽  
Physiological Saline ◽  
Vascular Wall ◽  
Treated Group ◽  
Microscopic Appearance ◽  
Clear Cut ◽  
Hexosamine Content

ABSTRACT Aortae were studied in three groups of rabbits: First group: Injected with epinephrine for two weeks and with 1-thyroxine for another two weeks. Second group: Injected with epinephrine for two weeks and with physiological saline for another two weeks. Third group: Untreated controls. The aortae were assessed by gross and microscopic examination, and the content of water, hexosamine, hydroxyproline and calcium as well as the in vivo uptake of 35S sulphate determined. The alterations in the epinephrine-thyroxine-treated group were not so pronounced as previously observed after simultaneous injections of epinephrine plus 1-thyroxine. But the thyroxine injections in this group brought about a clear-cut increase in hexosamine content and 35S sulphate uptake as compared with the untreated controls. This presumably indicates that owing to the thyroxine treatment the vascular wall was still exposed to damage despite the discontinuation of the epinephrine injections. In contradistinction, the epinephrine-saline-treated rabbits did not differ significantly from the controls as regards biochemical changes in the aortic wall two weeks after discontinuation of epinephrine. When the microscopic appearance were also considered, this was interpreted as a sign of cessation of the injuries to the vascular wall and of healing.

VASCULAR CONNECTIVE TISSUE UNDER THE INFLUENCE OF THYROXINE

1961 ◽  
Vol 37 (2) ◽  
pp. 183-190 ◽  
Author(s):  
lb Lorenzen
Keyword(s):  
Aortic Valve ◽  
Connective Tissue ◽  
Abdominal Aorta ◽  
Aortic Wall ◽  
Physiological Saline ◽  
Clear Cut ◽  
Reparative Process ◽  
Hexosamine Content

ABSTRACT Male albino rabbits were injected with 1-thyroxine and physiological saline for 2 weeks. The resulting changes in the aortic wall were assessed grossly and microscopically and also by analysis of hexosamine, hydroxyproline, water, and calcium. Furthermore, the in vivo uptake of 35S sulphate was determined. Despite insignificant gross and microscopic changes, there was a clear-cut increase in hexosamine content and uptake of 35S sulphate, most pronounced in the first part of the aorta, from the aortic valve to the first intercostal arteries, and in the abdominal aorta. These changes were of the same nature as those seen following injections of epinephrine and of epinephrine plus 1-thyroxine. The lesions of the aortic wall might be due to thyroxine induced sensitization to endogenous epinephrine, and the accumulation of mucopolysaccharide probably indicates a reparative process.

THE HEXOSAMINE CONTENT OF THE ORBIT IN RELATION TO ANTI-THYROTROPHIN ANTIBODY TITRES IN SERA OF THYROTROPHIN-TREATED RABBITS WITH AND WITHOUT CORTISONE ADMINISTRATION

1962 ◽  
Vol 41 (3) ◽  
pp. 474-480 ◽  
Author(s):  
Otto Wegelius ◽  
E. J. Jokinen
Keyword(s):  
Connective Tissue ◽  
Guinea Pigs ◽  
Antibody Formation ◽  
Direct Proof ◽  
Significant Rise ◽  
Extraocular Muscles ◽  
Concomitant Treatment ◽  
Antibody Titres ◽  
Hexosamine Content ◽  
Synergetic Action

ABSTRACT In all previous investigations on experimental exophthalmos, heterologous thyrotrophic pituitary extracts have been used. These protein hormones stimulate antihormone formation in the test animals. Cortisone has been reported to effectively block antibody formation. In addition, it has been shown to potentiate TSH-induced exophthalmos in guinea-pigs. With rabbits as test animals, the hexosamine content of the orbital tissues was determined and used as an index of exophthalmos development and at the same time the antibody titres in the sera were followed. TSH injections for six weeks led to a highly significant accumulation of hexosamine in the retrobulbar connective tissue and in the extraocular muscles, i. e. an increase of up to 400% as compared with the control animals. At the same time a significant rise in antihormonal titres was detectable in the sera. Concomitant treatment with cortisone brought about an equal or higher accumulation of hexosamine but significantly lower antibody titres. The known opposite peripheral actions of TSH and cortisone can be reconciled with the synergy in producing experimental exophthalmos by attributing the synergetic action of cortisone to the blocking of antihormone formation. If less antihormones are produced, the effect of TSH is enhanced. Our experiments do not provide direct proof for this hypothesis. High hexosamine values in the orbit and low antihormone titres in the serum are, however, concomitant phenomena.

Features of phosphorus-calcium metabolism in children with neurogenic disorders of urination

2020 ◽  
Vol 24 (1) ◽  
pp. 45-50
Author(s):  
Yu. F. Lobanov ◽  
D. Y. Latyshev ◽  
Ya. F. Zverev ◽  
N. A. Tekuteva ◽  
N. M. Mikheeva
Keyword(s):  
Connective Tissue ◽  
Calcium Metabolism ◽  
Point System ◽  
Industry Standards ◽  
Muscular Dysfunction ◽  
Connective Tissue Dysplasia ◽  
Calcium And Phosphorus ◽  
Comparison Of The Results ◽  
Neurogenic Disorders

THE AIM: To study the characteristics of phosphorus-calcium metabolism in patients with neurogenic disorders of urination, taking into account the severity of the manifestations of connective tissue dysplasia. PATIENTS AND METHODS. The study included 90 children, including 60 children with neuro-muscular dysfunction of the bladder (NMDB) and 30 children with enuresis from the age of 5 to 15 years. The diagnosis was established based on a comprehensive examination and according to industry standards. Connective tissue dysplasia was diagnosed in children with the detection of 6 or more small external or visceral manifestations involving 3 or more organs from different systems. Assessment of the severity (severity) of connective tissue dysplasia was carried out according to the point system proposed by T.I. Kadurina et al. Each group was divided into subgroups depending on the severity of the manifestations of connective tissue dysplasia. The determination of the level of calcium and phosphorus in the blood and urine, as well as the calculation of the calcium-creatinine coefficient followed by a comparison of the results in these groups and subgroups. To assess the significance of differences, the Mann-Whitney test was calculated, p <0.05 was considered significant. RESULTS. he level of calcium and phosphorus in the urine was slightly higher in children with enuresis, especially in the morning portion of urine, where the concentration of calcium was 26% higher than in patients with NMDB. At the same time, the value of calcium /creatinine coefficient was significantly higher in the group of patients with enuresis and was 2 times higher than the normative indicators, which indicates the importance of hypercalciuria in the development of enuresis. СONCLUSION. According to the obtained data, the severity of calciuria, determined by the value of the calcium-creatinine coefficient, is significantly higher in patients with enuresis than with NMDB.

RATIONAL PROCESS PARAMETERS OF CHOPPED SEMI-FINISHED PRODUCTS PRODUCTION USING EMULSIONS FROM COLLAGENCONTAINING RAW MATERIALS

2020 ◽  
pp. 199-213
Author(s):  
I. Kaltovich
Keyword(s):  
Heat Treatment ◽  
Weight Loss ◽  
Connective Tissue ◽  
Raw Materials ◽  
Steam Treatment ◽  
Point System ◽  
Technological Parameters ◽  
Genus Lactobacillus ◽  
Rational Process

The article presents the results of research on the determination of rational technological parameters for the production of chopped semi-products using emulsions from collagen-containing raw materials fermented by bacteria of the genus Lactobacillus. Water dosages are installed in the composition of chopped semi-finished products: 12% – with emulsions from pork skin and tails and 11% - with emulsion from connective tissue. Duration of ingredients mixing (5 minutes), sequence of raw materials laying during manufacture of articles, as well as duration of heat treatment of chopped semiproducts is determined: 25 minutes – during steaming (t = 95–100 °С), 20 minutes – during baking (t = 180 °C), 15 minutes – during frying (t = 110 °C), while recommended methods of bringing semifinished products to culinary readiness are steam treatment and baking, which allow for improved functional and technological (TUS – 79.3-81.8%, weight loss during heat treatment – 5.1–7.9%), structural and mechanical (PNS - 1413.9–1470.4 Pa) and organoleptic indicators (juiciness, appearance, consistency, taste, smell) of these products (9 points according to the 9-point system).

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