High carbohydrate high fat diet causes arterial hypertension and histological changes in the aortic wall in aged rats: The involvement of connective tissue growth factors and fibronectin

ABSTRACT Biochemical and histological changes in the aortic wall of rabbits were demonstrated following injection of epinephrine and l-thyroxine during 2 weeks. The widespread gross and microscopic changes were accompanied by an increase in hexosamine content and uptake of 35S labeled sodium sulphate, and an increased calcium content, whereas the collagen content, assessed by determination of hydroxyproline, was reduced. Comparison with the effect of epinephrine injections alone showed that thyroxine intensified the damaging effect of epinephrine on the vessel wall and induced more pronounced mucopolysaccharide changes in the aortic wall, presumably acting as a link in the healing processes.

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Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats

Lipids in Health and Disease ◽

10.1186/s12944-017-0539-x ◽

2017 ◽

Vol 16 (1) ◽

Cited By ~ 16

Author(s):

Md Mizanur Rahman ◽

Mohammad Nazmul Alam ◽

Anayt Ulla ◽

Farzana Akther Sumi ◽

Nusrat Subhan ◽

...

Keyword(s):

Oxidative Stress ◽

Glucose Intolerance ◽

High Fat Diet ◽

High Fat ◽

High Carbohydrate ◽

Obese Rats ◽

And Oxidative Stress

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Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalectomy

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1987.253.2.e149 ◽

1987 ◽

Vol 253 (2) ◽

pp. E149-E157

Author(s):

H. K. Kim ◽

D. R. Romsos

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

High Fat Diet ◽

High Fat ◽

Adipose Tissue Metabolism ◽

High Carbohydrate ◽

Bat Mitochondria ◽

Norepinephrine Turnover ◽

Brown Adipose ◽

Thermogenic Capacity

Adrenalectomy prevents development of obesity in ob/ob mice fed high-carbohydrate stock diets partly by stimulating the low thermogenic capacity of their brown adipose tissue (BAT). Adrenalectomy, however, fails to prevent development of obesity in ob/ob mice fed a high-fat diet. Effects of adrenalectomy on BAT metabolism in ob/ob mice fed a high-fat diet were thus examined. ob/ob mice fed the high-fat diet developed gross obesity despite normal BAT metabolism, as assessed by rates of norepinephrine turnover in BAT, GDP binding to BAT mitochondria, and GDP-inhibitable, chloride-induced mitochondrial swelling. Adrenalectomy failed to arrest the development of obesity or to influence BAT metabolism in ob/ob mice fed the high-fat diet. Development of obesity in ob/ob mice fed a high-fat diet is not associated with low thermogenic capacity of BAT or with adrenal secretions, as it is in ob/ob mice fed high-carbohydrate stock diets.

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Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet

Nutrients ◽

10.3390/nu7085292 ◽

2015 ◽

Vol 7 (8) ◽

pp. 6313-6329 ◽

Cited By ~ 38

Author(s):

Kampeebhorn Boonloh ◽

Veerapol Kukongviriyapan ◽

Bunkerd Kongyingyoes ◽

Upa Kukongviriyapan ◽

Supawan Thawornchinsombut ◽

...

Keyword(s):

Gene Expression ◽

Insulin Resistance ◽

Rice Bran ◽

High Fat Diet ◽

Inflammatory Cytokine ◽

Cytokine Gene Expression ◽

Cytokine Gene ◽

High Fat ◽

High Carbohydrate ◽

Improve Insulin Resistance

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Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00190.2001 ◽

2002 ◽

Vol 282 (2) ◽

pp. R366-R371 ◽

Cited By ~ 33

Author(s):

K. E. Castiglione ◽

N. W. Read ◽

S. J. French

Keyword(s):

Gastric Emptying ◽

Dietary Intake ◽

Test Meal ◽

High Fat Diet ◽

Lag Phase ◽

High Fat ◽

Free Living ◽

Gastric Emptying Rate ◽

High Carbohydrate ◽

Before And After

Previous work has shown that the gastric emptying rate in animals and humans can adapt due to previous dietary intake. The present study investigated whether adaptation in gastric emptying rate due to consumption of a high-fat diet (HFD) is nutrient specific in humans. Gastric emptying of high-fat and high-carbohydrate test meals was measured (using gamma scintigraphy) before and after consumption of an HFD for 14 days in eight free-living male volunteers. Visual analog ratings of appetite were recorded throughout each test. There was no effect of HFD on any parameters of gastric emptying rate (lag phase, half-emptying time, and linear emptying rate) measured for carbohydrate test meals. HFD led to an acceleration of the linear emptying rate of the high-fat test meal (0.36 vs. 0.47%/min; P < 0.05). All meals reduced appetite ratings, but there were no differences between tests. These results support our previous findings of accelerated gastric emptying of high-fat test meals following an HFD and show that these changes appear to be nutrient specific, confirming recent studies in rats.

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Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation

British Journal Of Nutrition ◽

10.1079/bjn19850143 ◽

1985 ◽

Vol 54 (3) ◽

pp. 567-575 ◽

Cited By ~ 3

Author(s):

H. C. Mehta ◽

A. S. Saini ◽

Harjit Singh ◽

P. S. Dhatt

Keyword(s):

Total Energy ◽

High Fat Diet ◽

High Protein Diet ◽

High Carbohydrate Diet ◽

High Protein ◽

Protein Diet ◽

Duodenal Juice ◽

High Fat ◽

Carbohydrate Diet ◽

High Carbohydrate

1. Sixty marasmic children were investigated for the absorption of xylose, proteins and fats. Their duodenal juice samples were also analysed for bile salts and microflora.2. The marasmic children were then studied in three groups of twenty by allocating them to three different dietary schedules: a high-protein diet (30% of the total energy from protein), a high-fat diet (40% of the total energy from fat) and a high-carbohydrate diet (70% of the total energy from carbohydrate) for 2 weeks and the previous measurements repeated.3. Whereas the high-fat diet resulted in improved fat absorption, along with an increase in total and conjugated bile acids, and the high-carbohydrate diet led to improved xylose absorption, the diet rich in protein resulted in an improvement in the absorption of all three dietary ingredients. It appears that a high-protein diet improves the overall absorption process by improving the intestinal environment as a whole, while high-carbohydrate and high-fat diets bring about adaptive changes related to the respective absorptive processes.

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