PITUITARY-THYROID RESPONSES TO SURGICAL STRESS

1978 ◽  
Vol 88 (3) ◽  
pp. 490-498 ◽  
Author(s):  
Vivian Chan ◽  
Christina Wang ◽  
Rose T. T. Yeung
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Surgical Stress ◽  
Hormone Binding ◽  
Free Triiodothyronine ◽  
Operative Complication ◽  
Reverse Triiodothyronine ◽  
Early Increase ◽  
Total Thyroxine ◽  
Triiodothyronine Concentration

ABSTRACT The effect of surgery on pituitary-thyroid function was studied in 12 euthyroid patients. There was a sharp early increase in total thyroxine level, causing displacement of triiodothyronine from thyroid hormone binding proteins resulting in the elevation of the biologically more potent free triiodothyronine fraction. The serum triiodothyronine concentration fell rapidly during and after the operation, with a concomitant rise in reverse triiodothyronine level. Increased prolactin levels were found during and after surgery. With no post-operative complication, recovery of normal pituitary-thyroid function occurred after 4 to 7 days of convalescence.

scholarly journals Demonstration of reciprocal diurnal variation in human serum T3 and rT3 concentration demonstrated by mass spectrometric analysis and establishment of thyroid hormone reference intervals

2020 ◽  
Vol 11 ◽  
pp. 204201882092268
Author(s):  
Qian Sun ◽  
Lívia Avallone ◽  
Brian Stolze ◽  
Katherine A. Araque ◽  
Yesim Özarda ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Reference Intervals ◽  
Diurnal Fluctuation ◽  
Spectrometric Analysis ◽  
Serum Samples ◽  
Free Triiodothyronine ◽  
Reverse T3 ◽  
Wide Range ◽  
Total Thyroxine

Background: There has been a wide range of reference intervals proposed in previous literature for thyroid hormones due to large between-assay variability of immunoassays, as well as lack of correction for collection time. We provided the diurnal reference intervals for five thyroid hormones, namely total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and reverse T3 (rT3), measured in serum samples of healthy participants using a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method. Methods: Couplet serum samples (a.m. and p.m.) were collected from 110 healthy females and 49 healthy males. Healthy volunteers were recruited from four participating centers between 2016 and 2018. Measurements of thyroid hormones were obtained by LC-MS/MS analysis. Results: Our study revealed significant uptrend in AM to PM FT4 ( p < 0.0001) samples, downtrend in AM to PM TT3 ( p = 0.0004) and FT3 samples ( p < 0.0001), and AM to PM uptrend in rT3 samples ( p < 0.0001). No difference was observed for TT4 between AM and PM. No significant sex differences were seen for any of the five thyroid hormones. Conclusion: When diagnosing thyroid disorders, it is important to have accurate measurement of thyroid hormones, and to acknowledge the diurnal fluctuation found, especially for FT3. Our study highlights the importance of standardization of collection times and implementation of LC-MS/MS in thyroid hormone measurement.

scholarly journals Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Juan Du ◽  
Chunyue Ma ◽  
Runnan Wang ◽  
Lanmei Lin ◽  
Luhui Gao ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Free Triiodothyronine ◽  
Hormone Levels ◽  
Significant Difference ◽  
Total Thyroxine

Objective. The aim of this study was to investigate the relationship between different psoriasis types and thyroid dysfunction. Methods. The data of patients diagnosed with psoriasis between January 2013 and October 2018 who underwent thyroid function tests were collected. Free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) were measured. The thyroid function of patients with psoriasis vulgaris, pustular psoriasis, erythrodermic psoriasis, and psoriatic arthritis was evaluated, and the differences in hormone levels and antibodies in the pituitary-thyroid axis with psoriasis type were analyzed. Results. The data of a total of 468 patients were analyzed in this study. The proportion of normal hormone levels was higher among vulgaris patients ( P < 0.001 ), while the erythrodermic patients were more likely to have decreased FT3 or FT4 but normal TSH ( P < 0.001 ). FT3 levels were lower in pustular patients ( P < 0.05 ), FT4 levels were lower in erythrodermic patients ( P < 0.05 ), and TSH levels were higher in patients with psoriatic arthritis ( P < 0.05 ). TPOAb levels were higher than normal in all patients, but there was no significant difference in the levels of TPOAb and TGAb among 4 types of the patients. Conclusion. Psoriasis is related to thyroid dysfunction, especially in patients with atypical psoriasis types. The possibility of complications should be considered in erythrodermic patients.

scholarly journals Case report: clues to the diagnosis of an unsuspected massive levothyroxine overdose

CJEM ◽  
2015 ◽  
Vol 17 (6) ◽  
pp. 692-698 ◽  
Author(s):  
Kirstie M. Allen ◽  
Veronica B. Crawford ◽  
John V. Conaglen ◽  
Marianne S. Elston
Keyword(s):  
Thyroid Hormone ◽  
Pediatric Population ◽  
Thyroid Stimulating Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Free Triiodothyronine ◽  
History Of ◽  
Symptoms And Signs ◽  
Free Thyroxine Level ◽  
Biochemical Features

AbstractThere is currently little literature pertaining to levothyroxine overdose apart from minor or accidental overdoses in the pediatric population. In particular, there is little information available on how to confidently differentiate levothyroxine overdose from endogenous causes of thyrotoxicosis when there is no history available at the time of assessment.We report a levothyroxine (15,800 mcg) and citalopram (2,460 mg) overdose in a 55-year-old woman presenting with seizure and tachycardia in which the diagnosis was not initially suspected. Clinical data, including a long history of treated hypothyroidism and lack of a goiter; and biochemical findings, such as an incompletely suppressed thyroid-stimulating hormone (TSH) level, despite a markedly elevated free thyroxine level (FT4), a normal sex hormone-binding globulin level at baseline, and an undetectable thyroglobulin, supported the diagnosis of thyrotoxicosis due to a massive exogenous thyroid hormone overdose. Treatment was given to decrease free triiodothyronine (FT3) conversion and increase thyroid hormone clearance with dexamethasone and cholestyramine. The patient made a full recovery.Levothyroxine overdose can result in subtle symptoms and signs clinically, even when in massive quantities. This can make diagnosis challenging. Biochemical features, such as the pattern of thyroid hormone elevation and thyroglobulin levels, help differentiate exogenous thyroid hormone overdose from endogenous causes of thyrotoxicosis.

scholarly journals Total and free iodothyronines profile in the donkey (Equus asinus) over a 12-month period

2012 ◽  
Vol 81 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Esterina Fazio ◽  
Pietro Medica ◽  
Cristina Cravana ◽  
Adriana Ferlazzo
Keyword(s):  
Thyroid Function ◽  
Jugular Vein ◽  
Physiological State ◽  
Reproductive Activity ◽  
Free Triiodothyronine ◽  
Blood Samples ◽  
Hormonal Profile ◽  
Equus Asinus ◽  
Total Triiodothyronine ◽  
Total Thyroxine

Several studies show the correlation between thyroid function and reproductive activity in horses, but no data are available in donkeys. The aim of this study was to determine physiological thyroid changes occurring in 10 pregnant and 14 barren donkeys over a period of 12 months. Blood samples were collected monthly from the jugular vein of pregnant and barren donkeys from June 2008 to June 2009. No significant differences (P < 0.05) in iodothyronine concentrations were observed between pregnant and barren donkeys in the same month. Seasonal total thyroxine (T4) and free triiodothyronine (fT3) patterns remained unmodified, regardless of physiological state, with the lowest T4 levels at September and the highest at February, and the lowest fT3 levels at June and the highest at July, in both pregnant and barren donkeys. Ranges of total triiodothyronine (T3) concentrations in pregnant donkeys over a 12 months period ranged from 1.57 to 2.90 nmol/l, T4 from 31.01 to 63.67 nmol/l, fT3 from 3.15 to 15.52 pmol/l and free thyroxine (fT4) from 22.47 to 33.69 pmol/l. Mean T3 concentrations in barren donkeys over a 12 months period ranged from 1.64 to 3.37 nmol/l, T4 from 42.95 nmol/l and 61.90 nmol/l, fT3 from 3.15 to 11.19 pmol/l and fT4 from 25.46 to 35.06 pmol/l. This is the first study that provided a seasonal thyroid hormonal profile in healthy barren and pregnant donkeys.

Effects of triiodothyronine supplementation following modified Fontan procedure

1997 ◽  
Vol 7 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Richard D. Mainwaring ◽  
John J. Lamberti ◽  
Jerald C. Nelson ◽  
Glenn F. Billman ◽  
Thomas L. Carter ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Clinical Outcome ◽  
Fontan Procedure ◽  
Length Of Hospital Stay ◽  
Free Triiodothyronine ◽  
Low Cardiac Output ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Thyroid Hormone Levels ◽  
Previous Series

AbstractPatients undergoing the modified Fontan procedure may develop low cardiac output postoperatively. Since thyroid hormone has important effects on cardiovascular function, the present study was undertaken to evaluate the influence of triiodothyronine supplementation. Ten consecutive patients under-going the Fontan procedure were administered intravenous triiodothyronine (0.4 mcg per kg) following surgery. Clinical outcome and thyroid hormone profiles were assessed and then compared to a previous series of patients undergoing the Fontan procedure who had not received triiodothyronine supplementation. Both groups initially demonstrated marked decreases in serum free triiodothyronine levels. The group which received triiodothyronine supplementation demonstrated a more rapid return of serum triiodothyronine levels to baseline [259±17 vs 121±15 pg/dl (p<0.05) on the fifth postoperative day and 336±18 vs 178±12 pg/dl (p<0.05) on the eighth day]. In addition, patients receiving supplemental triiodothyronine demonstrated more rapid recovery of total triiodothyronine, free thyroxine, total thyroxine and thyroglobulin levels. The group which received triiodothyronine supplementation had a shorter length of hospital stay [9±2 vs 14±3 (p<0.05)] as compared to patients who did not receive exogenous triiodothyronine. The results of this study demonstrate that triiodothyronine supplementation aids in the recovery of thyroid hormone levels following Fontan procedure. This endocrinologic finding correlated with improved clinical outcome.

scholarly journals Clinical Evaluation of Various Thyroid Hormones on Thyroid Function

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hong Li ◽  
Xiaolan Yuan ◽  
Lu Liu ◽  
Jiaojiao Zhou ◽  
Chunyan Li ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Function ◽  
Pearson Correlation ◽  
Healthy Population ◽  
Healthy Individuals ◽  
Clinical Value ◽  
Free Triiodothyronine ◽  
Important Indicator ◽  
Total Triiodothyronine ◽  
Total Thyroxine

To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P< 0.01), and theR-values were −0.065 and −0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and theR-values were −0.241, −0.225, −0.195, and −0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and theR-values were −0.322, −0.262, −0.179, and −0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.

Effect of Anticonvulsant Dosages of Potassium Bromide on Thyroid Function and Morphology in Dogs

2003 ◽  
Vol 39 (2) ◽  
pp. 193-202 ◽  
Author(s):  
Lisa C. Paull ◽  
J. Catharine R. Scott-Moncrieff ◽  
Dennis B. DeNicola ◽  
Nita Glickman ◽  
Kent R. Refsal ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Function ◽  
Potassium Bromide ◽  
Thyrotropin Releasing Hormone ◽  
Stimulation Test ◽  
Serum Concentrations ◽  
Hormone Stimulation ◽  
Total Thyroxine ◽  
And Control

A placebo-controlled experiment was performed to evaluate the effect of potassium bromide on the canine thyroid gland. Basal total thyroxine, free thyroxine, and basal thyrotropin serum concentrations were evaluated over a 6-month period in potassium bromide-treated and control dogs. A thyrotropin-releasing hormone stimulation test was also performed in all dogs at the beginning and conclusion of the study. Thyroid histopathology was compared between treated and control dogs at the end of the study. No difference was detected in any parameter between the two groups at the end of the study. A decline in thyroid hormone concentrations over the course of the study did occur in both groups of dogs. Potassium bromide does not appear to have a significant effect on canine thyroid function or morphology.

A Study of Thyroid Function in Psychiatric In-patients

1978 ◽  
Vol 133 (3) ◽  
pp. 211-218 ◽  
Author(s):  
D. G. McLarty ◽  
W. A. Ratcliffe ◽  
J. G. Ratcliffe ◽  
J. G. Shimmins ◽  
A. Goldberg
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Age Distribution ◽  
Psychiatric Hospitals ◽  
Primary Hypothyroidism ◽  
Hormone Levels ◽  
Total Thyroxine ◽  
Thyroid Hormone Levels

SummaryThe prevalence of abnormal serum total thyroxine (T4) and triiodothyronine (T3) concentrations were determined in 1,206 in-patients in two associated psychiatric hospitals. The biochemical pattern of primary hypothyroidism occurred in five females and one male (prevalence 0.5 per cent), but in only one patient was the diagnosis clinically obvious. Eight patients (all female) were clinically hyperthyroid (prevalence 0.7 per cent), of whom six were previously undiagnosed. There was no evidence that phenothiazines or benzodiazepine therapy had any significant effect on thyroid hormone levels. The small differences in thyroid hormone levels between psychiatric diagnostic groups could be explained by differences in age distribution.

EFFECT OF CLOMIFENE ON THYROID FUNCTION IN NORMAL MEN

1979 ◽  
Vol 90 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Ulla Feldt-Rasmussen ◽  
Axel P. Lange ◽  
John Date ◽  
Mogens Kern Hansen
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Binding Proteins ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Free Thyroxine Index ◽  
Group 2 ◽  
Uptake Test ◽  
Normal Men ◽  
Group 1

ABSTRACT To study the effect on thyroid function 100 mg of clomifene citrate was given once a day to two groups of healthy male volunteers for 5 and 12 consecutive days, respectively. In both groups serum concentrations of TSH, thyroxine, triiodothyronine, T3 resin uptake test and thyroid hormone binding proteins were measured before, during and after oral administration of clomifene. The effect of clomifene treatment was evaluated in Group 1 by means of serum FSH and LH measurements. Further in Group 2 the serum TSH response to iv TRH (200 μg) was also investigated. The mean per cent elevations in serum concentrations of FSH and LH were 145 and 200, respectively. In Group 1 a small but statistically significant decrease within reference limits in triiodothyronine (P < 0.01) and free thyroxine index (P < 0.02) was found on day 4 of clomifene. On day 5 a slight increase in TSH was observed (P < 0.05). In Group 2 the response of TSH to TRH showed a non-significant increase after 5 days and a significant increase (P < 0.01) after 12 days of clomifene. Eight days after discontinuation of the drug the response was restored to normal. No changes in the thyroid hormone binding proteins in serum could be demonstrated. Though the observed changes were slight, they indicate that clomifene exerts an influence directly on the thyroid function.

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