RESPONSE OF PLASMA NON-CONJUGATED OESTRADIOL TO MANIPULATED ADRENAL FUNCTION BY ACTH AND DEXAMETHASONE

1979 ◽  
Vol 90 (3) ◽  
pp. 525-533
Author(s):  
G. Reck ◽  
U. Noss ◽  
M. Breckwoldt
Keyword(s):  
Plasma Cortisol ◽  
Maximum Level ◽  
Adrenal Function ◽  
Strongly Correlated ◽  
Acth Secretion ◽  
Time Intervals ◽  
Short Time ◽  
Plasma Oestradiol ◽  
Free Plasma ◽  
Stimulation Of

ABSTRACT The present study is concerned with the regulation of free plasma oestradiol in relation to maternal adrenal function during late human pregnancy. Blood was collected in 9 patients at short time intervals of 30 min from 17 h to 3 h. In order to exclude endogenous ACTH-secretion 5 patients received 12 mg dexamethasone over 48 h. Between 20 h and 2 h 0.25 mg ACTH1-24 (Synacthen°) was infused into the subjects. Nonconjugated oestradiol was determined by radioimmunoassay and total plasma cortisol by protein binding method. During the application of ACTH free oestradiol increased from 21.3 ± 5.7 to 25.5 ± 7.1 ng/ml (P < 0.025) in the patients without dexamethasone. The increase was moderately correlated to rising cortisol (r = 0.58, P < 0.001). Plasma oestradiol reached its maximum level after 90 min, followed by a tendency to decline despite persisting stimulation of maternal adrenals. The patients receiving dexamethasone exhibited during ACTH-infusion a rise of oestradiol from 3.8 ± 1.9 to 7.8 ± 3.1 ng/ml (P < 0.001). Increasing oestradiol was strongly correlated to plasma cortisol (r = 0.67, P < 0.001). The phenomenon of earlier declining oestradiol levels did not occur. These results suggest that maternal adrenals predominantly regulate the formation of free oestradiol. Plasma cortisol indicating maternal precursor production balances the increase of oestradiol by suppressing foetal precursor supply.

CIRCADIAN RHYTHM OF FREE OESTRADIOL IN RELATION TO PLASMA CORTISOL IN LATE HUMAN PREGNANCY

1979 ◽  
Vol 90 (3) ◽  
pp. 519-524 ◽  
Author(s):  
G. Reck ◽  
U. Noss ◽  
M. Breckwoldt
Keyword(s):  
Circadian Rhythm ◽  
Plasma Cortisol ◽  
Life Time ◽  
Early Morning ◽  
Diurnal Variations ◽  
Time Intervals ◽  
Human Pregnancy ◽  
Short Time ◽  
Plasma Oestradiol ◽  
Free Plasma

ABSTRACT The present study investigates the diurnal variations of free plasma oestradiol levels in late human pregnancy. The oestradiol levels are correlated to the maternal adrenal function as reflected by the plasma levels of cortisol. According to the half life time of oestradiol, blood samples were collected at short time intervals of 30 and 60 min, respectively. Three pregnant women volunteered in the study. Free oestradiol was measured by radioimmunoassay and cortisol was quantitated by a protein binding method. All patients exhibited a circadian rhythm for free oestradiol with significantly higher values in the early morning (28.3 ± 7.2 ng/ml) than in the afternoon and early night (21.2 ± 3.6 ng/ml, P < 0.001). The course of oestradiol followed in a moderate but significant correlation plasma cortisol (r = 0.34, P < 0.001). During the period of increasing cortisol the oestradiol levels demonstrated the phenomenon of episodic secretion. The results obtained suggest that the maternal adrenals predominantly regulate the diurnal rhythm of free oestradiol in late human pregnancy.

scholarly journals Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline

1977 ◽  
Vol 162 (3) ◽  
pp. 493-499 ◽  
Author(s):  
R George ◽  
T Ramasarma
Keyword(s):  
Protein Synthesis ◽  
Adrenergic Receptors ◽  
De Novo ◽  
Direct Action ◽  
Time Intervals ◽  
Coa Reductase ◽  
Short Time ◽  
Stimulation Of

1. Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.

Deglutitive inhibition affects both esophageal peristaltic amplitude and shortening

2003 ◽  
Vol 284 (4) ◽  
pp. G575-G582 ◽  
Author(s):  
Guoxiang Shi ◽  
John E. Pandolfino ◽  
Qing Zhang ◽  
Ikuo Hirano ◽  
Raymond J. Joehl ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Longitudinal Muscle ◽  
Short Interval ◽  
Circular Muscle ◽  
Distal Segment ◽  
Esophageal Wall ◽  
Strongly Correlated ◽  
Time Intervals ◽  
Rapid Sequence ◽  
Short Time

Deglutitive inhibition attenuates ongoing esophageal contractions if swallows are separated by short time intervals. This study aimed to determine whether esophageal shortening, mediated by longitudinal muscle, was similarly affected. Eight healthy subjects with two distal esophageal segments demarcated by mucosal clips and manometric recording sites positioned within those segments underwent concurrent manometry and fluoroscopy. Peristaltic amplitude and change in distal segment lengths were quantified during single swallows, paired swallows separated by progressively prolonged intervals, and a series of rapid repetitive swallows. During grouped swallows, deglutitive inhibition with complete attenuation of both the manometric contraction and segment shortening was evident with short-interval swallows and rapid-sequence swallows. No inhibition of either was evident with long-interval pairs. With intermediate interswallow intervals, the occurrence and degree of deglutitive inhibition between peristaltic amplitude and segment shortening were closely correlated. Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other.

Proposal of PV Output Estimate Method in Short Time Intervals

2016 ◽  
Vol 136 (12) ◽  
pp. 891-897 ◽  
Author(s):  
Katsuhiro Matsuda ◽  
Kazuhiro Misawa ◽  
Hirotaka Takahashi ◽  
Kenta Furukawa ◽  
Satoshi Uemura
Keyword(s):  
Time Intervals ◽  
Estimate Method ◽  
Short Time

EVALUATION OF SHORT TIME INTERVALS IN NORMAL AGING AND LATE-LIFE DEPRESSIONS

2020 ◽  
pp. 54-69
Author(s):  
Elena Yu. Balashova ◽  
◽  
Lika I. Mikeladze ◽  
Elena K. Kozlova ◽  
◽  
...  
Keyword(s):  
Late Life ◽  
Normal Aging ◽  
Time Intervals ◽  
Short Time

High Frequency Vibration of Worst Ear Lobule induced short period of Rapid Inhibition of any Cancer Activity including Advanced Terminal Cancers, Most Malignant Brain Tumor "Glioblastoma" as well as Cancer of Lung, Breast & Gastrointestinal Cancers particularly Pancreatic Cancer.

2020 ◽  
Vol 44 (3) ◽  
pp. 241-249
Author(s):  
Yoshiaki Omura
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D3 ◽  
High Frequency ◽  
Optimal Dose ◽  
High Frequency Stimulation ◽  
Frequency Stimulation ◽  
Short Time ◽  
The Brain ◽  
Cancer Activity ◽  
Stimulation Of

While a visiting Professor at the University of Paris, VI (formerly Sorvonne) more than 40 years ago, the Author became very good friends with Dr. Paul Nogier who periodically gave seminars and workshops in Paris. After the author diagnosed his cervical problem & offered him simple help, Dr. Nogier asked the Author to present lectures and demonstrations on the effects of ear stimulation, namely the effects of acupuncture & electrical stimulation of the ear lobules. It is only now, in 2019 that we have discovered 2–5 minute high frequency stimulation of the ear lobule inhibits cancer activity for 1– 4 hours post stimulation. Although the procedure is extremely simple. First take optimal dose of Vitamin D3, which has the most essential 10 unique beneficial factors required for every human cell activity. Next, apply high frequency stimulation to ear lobule while the worst ear lobule is held by all fingers with vibrator directly touching the surface of the worst ear lobule, preferably after patient repeatedly takes optimal dose of Vitamin D3. When the worst ear lobule is held between thumb & index fingers and applying mechanical stimulation of 250 ~ 500 mechanical vibration/second for 2 ~ 5 minutes using an electrical vibrator, there is rapid disappearance of cancer activity in both the brain and rest of the body for short time duration 1 ~ 4 hours. The effect often increases by additional pressure by holding fingers. As of May 2019, the Author found that many people from various regions of the world developed early stages of multiple cancers. For evaluation of this study, U. S. patented Bi-Digital O-Ring Test (BDORT) was used which was developed by the Author while doing his Graduate experimental physics research at Colombia University. BDORT was found to be most essential for determining the beneficial effects as well as harmful effects of any substance or treatment. Using BDORT, Author was the first to recognize severe increasing mid-backache was an early sign of pancreatic cancer of President of New York State Board of Medicine after top pain specialists failed to detect the cause after 3 years of effort, while the BDORT showed early stages of cancer whereas conventional X-Ray of the pancreas did not show any cancer image until 2 months after Author detected with BDORT. For example, the optimal dose of the banana is usually about 2.0 - 2.5 millimeters cross section of the banana. A whole banana is more than 50 ~ 100 times the optimal dose. Any substance eaten in more than 25 times of its optimal dose becomes highly toxic and creates DNA mutations which can cause multiple malignancies in the presence of strong electro-magnetic field. With standard medication given by doctor, patients often become sick and they are unable to reduce body weight, unless medication is reduced or completely stopped. When the amount of zinc is very high, DNA often becomes unstable and multiple cancers can grow rapidly in the presence of strong electromagnetic field. Large amount of Vitamin C from regular orange or orange juice inhibit the most important Vitamin D3 effects. At least 3 kinds of low Vitamin C oranges will not inhibit Vitamin D3. Since B12 particularly methyl cobalamin which is a red small tablet is known to improve brain circulation very significantly we examined its effect within 20 seconds of oral intake we found the following very significant changes. Acetylcholine in both sides of the brain often increases over 4,500 ng. Longevity gene Sirtuin 1 level increases significantly for short time of few hours. Thymosin α1 and Thymosinβ4 both increase to over 1500 ng from 20 ng or less.

scholarly journals Neural Network Approach for Global Solar Irradiance Prediction at Extremely Short-Time-Intervals Using Particle Swarm Optimization Algorithm

Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1213
Author(s):  
Ahmed Aljanad ◽  
Nadia M. L. Tan ◽  
Vassilios G. Agelidis ◽  
Hussain Shareef
Keyword(s):  
Neural Networks ◽  
Particle Swarm Optimization ◽  
Solar Irradiance ◽  
Particle Swarm ◽  
Time Interval ◽  
Time Intervals ◽  
Swarm Optimization ◽  
Backpropagation Neural Networks ◽  
Proposed Model ◽  
Short Time

Hourly global solar irradiance (GSR) data are required for sizing, planning, and modeling of solar photovoltaic farms. However, operating and controlling such farms exposed to varying environmental conditions, such as fast passing clouds, necessitates GSR data to be available for very short time intervals. Classical backpropagation neural networks do not perform satisfactorily when predicting parameters within short intervals. This paper proposes a hybrid backpropagation neural networks based on particle swarm optimization. The particle swarm algorithm is used as an optimization algorithm within the backpropagation neural networks to optimize the number of hidden layers and neurons used and its learning rate. The proposed model can be used as a reliable model in predicting changes in the solar irradiance during short time interval in tropical regions such as Malaysia and other regions. Actual global solar irradiance data of 5-s and 1-min intervals, recorded by weather stations, are applied to train and test the proposed algorithm. Moreover, to ensure the adaptability and robustness of the proposed technique, two different cases are evaluated using 1-day and 3-days profiles, for two different time intervals of 1-min and 5-s each. A set of statistical error indices have been introduced to evaluate the performance of the proposed algorithm. From the results obtained, the 3-days profile’s performance evaluation of the BPNN-PSO are 1.7078 of RMSE, 0.7537 of MAE, 0.0292 of MSE, and 31.4348 of MAPE (%), at 5-s time interval, where the obtained results of 1-min interval are 0.6566 of RMSE, 0.2754 of MAE, 0.0043 of MSE, and 1.4732 of MAPE (%). The results revealed that proposed model outperformed the standalone backpropagation neural networks method in predicting global solar irradiance values for extremely short-time intervals. In addition to that, the proposed model exhibited high level of predictability compared to other existing models.

scholarly journals Optimal Perturbations of an Oceanic Vortex Lens

Fluids ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 63 ◽  
Author(s):  
Thomas Meunier ◽  
Claire Ménesguen ◽  
Xavier Carton ◽  
Sylvie Le Gentil ◽  
Richard Schopp
Keyword(s):  
Normal Mode ◽  
Growth Rates ◽  
Time Interval ◽  
Time Intervals ◽  
Horizontal Structure ◽  
Azimuthal Wave ◽  
Wave Numbers ◽  
Non Linear ◽  
Long Time ◽  
Short Time

The stability properties of a vortex lens are studied in the quasi geostrophic (QG) framework using the generalized stability theory. Optimal perturbations are obtained using a tangent linear QG model and its adjoint. Their fine-scale spatial structures are studied in details. Growth rates of optimal perturbations are shown to be extremely sensitive to the time interval of optimization: The most unstable perturbations are found for time intervals of about 3 days, while the growth rates continuously decrease towards the most unstable normal mode, which is reached after about 170 days. The horizontal structure of the optimal perturbations consists of an intense counter-shear spiralling. It is also extremely sensitive to time interval: for short time intervals, the optimal perturbations are made of a broad spectrum of high azimuthal wave numbers. As the time interval increases, only low azimuthal wave numbers are found. The vertical structures of optimal perturbations exhibit strong layering associated with high vertical wave numbers whatever the time interval. However, the latter parameter plays an important role in the width of the vertical spectrum of the perturbation: short time interval perturbations have a narrow vertical spectrum while long time interval perturbations show a broad range of vertical scales. Optimal perturbations were set as initial perturbations of the vortex lens in a fully non linear QG model. It appears that for short time intervals, the perturbations decay after an initial transient growth, while for longer time intervals, the optimal perturbation keeps on growing, quickly leading to a non-linear regime or exciting lower azimuthal modes, consistent with normal mode instability. Very long time intervals simply behave like the most unstable normal mode. The possible impact of optimal perturbations on layering is also discussed.

An Automatic Paperless Velocity Measuring and Recording System

2014 ◽  
Vol 889-890 ◽  
pp. 745-748
Author(s):  
Jian Sheng Cao ◽  
Wan Jun Zhang ◽  
Xin Hua Zeng
Keyword(s):  
Flow Velocity ◽  
Optical Pulse ◽  
Electric Pulse ◽  
Automatic Monitoring ◽  
Time Intervals ◽  
Stream Flows ◽  
Fluid Flow Velocity ◽  
Photoelectric Sensor ◽  
Velocity Measuring ◽  
Short Time

Automatic monitoring of hydrologic properties such as water velocity at short-time intervals is critical for understanding watershed eco-hydrological processes. This can also be used to study the laws of stream flows and interactions ecological process. The advent of modern electronic technology (and the near-perfection of especially sensor and data collection technologies), has made it possible to use automatic monitoring systems to continuously measure hydrologic properties at short-time intervals. This paper introduces one such paperless flow velocity measuring/recoding system. The system uses a photoelectric sensor that is mainly comprised of photoelectric velocity sensor and pulse recorder. The system uses propellers (with reflective panels and photoemission cells) to transform flow velocities into optical pulse signals. It also uses photosensitive tubes to transform optical pulse signals into electric pulse signals. The electric pulse counts (generated in unit time) are recorded via pulse recorders. This therefore accomplishes automatic monitoring and continuous recording of fluid flow velocity.

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