Existence and immunological significance of circulating Ia+T cells in autoimmune thyroid diseases

1987 ◽  
Vol 115 (2) ◽  
pp. 282-288 ◽  
Author(s):  
Kazuya Zeki ◽  
Takashi Fujihira ◽  
Fumihiko Shirakawa ◽  
Kenichi Watanabe ◽  
Sumiya Eto
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Cytotoxicity Test ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Hla Dr ◽  
Specific Antigens ◽  
Cellular Immune ◽  
Stimulation Of

Abstract. We investigated the percentage of circulating HLA-DR antigen positive (Ia antigen positive: Ia+) T cells and the additive proliferation by non-specific mitogens and thyroid-specific antigens by means of a cytotoxicity test in autoimmune thyroid diseases. Furthermore, we studied the stimulative function of circulating Ia+T cells in autologous mixed lymphocyte reactions. %Ia+T cells were significantly increased in patients with autoimmune thyroid diseases compared with those in normal controls. They were additionally increased by the stimulation of TSH-receptor or thyroid-microsome in patients with Graves' disease, and by the stimulation of thyroglobulin and thyroid-microsome in patients with Hashimoto's thyroiditis. As to the cellular immune function, circulating Ia+T cells stimulated Ia− T cells in autologous MLR in patients with autoimmune thyroid diseases. These data suggest that some of the T cells are already activated in vivo, that the activation of T cells may be by thyroid-specific antigens, and that these activated (Ia+) T cells may be able sequentially to induce the activation of inactivated (Ia−) T cells in autoimmune thyroid diseases.

Apoptosis-induced Decrease of Intrathyroidal CD4+CD25+ Regulatory T Cells in Autoimmune Thyroid Diseases

Thyroid ◽  
2007 ◽  
Vol 17 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Aiko Nakano ◽  
Mikio Watanabe ◽  
Takao Iida ◽  
Shoko Kuroda ◽  
Fumio Matsuzuka ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Defective function of Fas in T cells from paediatric patients with autoimmune thyroid diseases

2003 ◽  
Vol 133 (3) ◽  
pp. 430-437 ◽  
Author(s):  
G. BONA ◽  
S. DEFRANCO ◽  
A. CHIOCCHETTI ◽  
M. INDELICATO ◽  
A. BIAVA ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Paediatric Patients

scholarly journals Stimulation of Dendritic Cells via CD40 Enhances Immune Responses to Mycobacterium tuberculosisInfection

2001 ◽  
Vol 69 (4) ◽  
pp. 2456-2461 ◽  
Author(s):  
Caroline Demangel ◽  
Umaimainthan Palendira ◽  
Carl G. Feng ◽  
Andrew W. Heath ◽  
Andrew G. D. Bean ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Immune Responses ◽  
Protective Efficacy ◽  
Interleukin 12 ◽  
Ifn Γ ◽  
Cellular Immune ◽  
Stimulation Of

ABSTRACT The resolution of pulmonary tuberculosis (TB) critically depends on the development of the Th1 type of immune responses, as exemplified by the exacerbation of TB in IL-12-deficient mice. Therefore, vaccination strategies optimizing IL-12 production by antigen-presenting cells (APC) in response to mycobacteria may have enhanced protective efficacy. Since dendritic cells (DC) are the critical APC for activation of CD4+ and CD8+ T cells, we examined whether stimulation of Mycobacterium bovis bacillus Calmette Guérin (BCG)-infected DC via CD40 increased their ability to generate Th1-oriented cellular immune responses. Incubation of DC with an agonistic anti-CD40 antibody activated CD40 signaling in DC, as shown by increased expression of major histocompatibility complex class II and costimulatory molecules, mRNA production for proinflammatory cytokines and interleukin 12 (IL-12) p40. This activation pattern was maintained when DC were stimulated with anti-CD40 antibody and infected with BCG. Importantly, CD40-stimulated BCG-infected DC displayed increased capacity to release bioactive IL-12 and to activate gamma interferon (IFN-γ) producing T cells in vitro. Moreover, when C57BL/6 mice were immunized with these DC and challenged with aerosol Mycobacterium tuberculosis, increased levels of mRNA for IL-12 p40, IL-18, and IFN-γ were present in the draining mediastinal lymph nodes. However, the mycobacterial burden in the lungs was not reduced compared to that in mice immunized with BCG-infected non-CD40-stimulated DC. Therefore, although the manipulation of DC via CD40 is effective for enhancing immune responses to mycobacteria in vivo, additional strategies are required to increase protection against virulent M. tuberculosis infection.

Decreased proportions of CD4 + IL17+/CD4 + CD25 + CD127− and CD4 + IL17+/CD4 + CD25 + CD127 − FoxP3+ T cells in children with autoimmune thyroid diseases

Autoimmunity ◽  
2016 ◽  
Vol 49 (5) ◽  
pp. 320-328 ◽  
Author(s):  
Artur Bossowski ◽  
Marcin Moniuszko ◽  
Ewelina Idźkowska ◽  
Kamil Grubczak ◽  
Paulina Singh ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Induction of experimental thyroiditis in mice by recombinant interferon γ administration

1990 ◽  
Vol 122 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Yasushi Kawakami ◽  
Nobuaki Kuzuya ◽  
Tsuyoshi Watanabe ◽  
Yasuo Uchiyama ◽  
Kamejirou Yamashita
Keyword(s):  
Interferon Γ ◽  
Thyroid Diseases ◽  
Follicular Cells ◽  
Autoimmune Thyroid Diseases ◽  
Recombinant Interferon ◽  
Thyroglobulin Antibodies ◽  
Autoimmune Thyroid ◽  
Thyroid Glands ◽  
Thyroid Follicular Cells

Abstract. Expression of major histocompatibility complex (MHC) class 2 molecules on the thyroid follicular cells in human autoimmune thyroid diseases has been reported, and is suggested to play a role in the initiation of the autoimmune responses. Interferon γ is known to induce MHC class 2 molecules on cultured thyrocytes. Therefore, we administered recombinant interferon γ to mice to induce MHC class 2 molecule expression in vivo, and investigated the thyroidal changes following MHC class 2 molecule expression. Recombinant interferon γ3 × 105 U, was administered daily, to mice. MHC class 2 molecules, studied by indirect immunohistochemistry, were expressed on the follicular cells on the 2nd to 4th day after the first interferon γ administration and continued thereafter. Serum T4 and T3 concentrations decreased and anti-thyroglobulin antibodies and anti-microsomal antibodies were detected. Lymphocyte infiltrations were observed in the thyroid glands obtained at 28 days, but they were mild. These results suggest that MHC class 2 molecule expression on thyroid follicular cells induces anti-thyroid antibodies and plays an important role in the initiation of autoimmune thyroiditis. However, the progression of the immune response to thyroiditis with lymphocyte infiltration may require some other factor. This new model of autoimmune thyroid disease in mice might be useful to elucidate the pathogenesis of human autoimmune thyroid diseases.

scholarly journals Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Tianyi He ◽  
Ruxing Zhao ◽  
Yiran Lu ◽  
Wenjuan Li ◽  
Xinguo Hou ◽  
...  
Keyword(s):  
T Cells ◽  
Cytotoxic T Cells ◽  
Thyroid Diseases ◽  
Control Group ◽  
Immunomodulatory Effects ◽  
Control Groups ◽  
Autoimmune Thyroid Diseases ◽  
Significant Drop ◽  
Autoimmune Thyroid ◽  
Normal Ranges

Purpose.To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived fromCordyceps sinensis(Berk.) Sacc., on autoimmune thyroid diseases (AITD).Methods.44 Patients with Graves’s disease (GD) and 56 patients with Hashimoto’s thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups. Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment.Results.Significant drop of serum anti-TPO-Ab levels was observed in both GD-Tx and HT-Tx groups. Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T/cytotoxic T cells. There was a significant drop of the helper T/cytotoxic T cells ratio in GD-Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT-Tx was elevated.Conclusion.Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual-directional immunomodulatory effects. And it could significantly reduce the autoantibody levels in both GD and HT.

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