Apoptosis-induced Decrease of Intrathyroidal CD4+CD25+ Regulatory T Cells in Autoimmune Thyroid Diseases

Thyroid ◽  
2007 ◽  
Vol 17 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Aiko Nakano ◽  
Mikio Watanabe ◽  
Takao Iida ◽  
Shoko Kuroda ◽  
Fumio Matsuzuka ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Existence and immunological significance of circulating Ia+T cells in autoimmune thyroid diseases

1987 ◽  
Vol 115 (2) ◽  
pp. 282-288 ◽  
Author(s):  
Kazuya Zeki ◽  
Takashi Fujihira ◽  
Fumihiko Shirakawa ◽  
Kenichi Watanabe ◽  
Sumiya Eto
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Cytotoxicity Test ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Hla Dr ◽  
Specific Antigens ◽  
Cellular Immune ◽  
Stimulation Of

Abstract. We investigated the percentage of circulating HLA-DR antigen positive (Ia antigen positive: Ia+) T cells and the additive proliferation by non-specific mitogens and thyroid-specific antigens by means of a cytotoxicity test in autoimmune thyroid diseases. Furthermore, we studied the stimulative function of circulating Ia+T cells in autologous mixed lymphocyte reactions. %Ia+T cells were significantly increased in patients with autoimmune thyroid diseases compared with those in normal controls. They were additionally increased by the stimulation of TSH-receptor or thyroid-microsome in patients with Graves' disease, and by the stimulation of thyroglobulin and thyroid-microsome in patients with Hashimoto's thyroiditis. As to the cellular immune function, circulating Ia+T cells stimulated Ia− T cells in autologous MLR in patients with autoimmune thyroid diseases. These data suggest that some of the T cells are already activated in vivo, that the activation of T cells may be by thyroid-specific antigens, and that these activated (Ia+) T cells may be able sequentially to induce the activation of inactivated (Ia−) T cells in autoimmune thyroid diseases.

scholarly journals Defective function of Fas in T cells from paediatric patients with autoimmune thyroid diseases

2003 ◽  
Vol 133 (3) ◽  
pp. 430-437 ◽  
Author(s):  
G. BONA ◽  
S. DEFRANCO ◽  
A. CHIOCCHETTI ◽  
M. INDELICATO ◽  
A. BIAVA ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Paediatric Patients

Decreased proportions of CD4 + IL17+/CD4 + CD25 + CD127− and CD4 + IL17+/CD4 + CD25 + CD127 − FoxP3+ T cells in children with autoimmune thyroid diseases

Autoimmunity ◽  
2016 ◽  
Vol 49 (5) ◽  
pp. 320-328 ◽  
Author(s):  
Artur Bossowski ◽  
Marcin Moniuszko ◽  
Ewelina Idźkowska ◽  
Kamil Grubczak ◽  
Paulina Singh ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Tianyi He ◽  
Ruxing Zhao ◽  
Yiran Lu ◽  
Wenjuan Li ◽  
Xinguo Hou ◽  
...  
Keyword(s):  
T Cells ◽  
Cytotoxic T Cells ◽  
Thyroid Diseases ◽  
Control Group ◽  
Immunomodulatory Effects ◽  
Control Groups ◽  
Autoimmune Thyroid Diseases ◽  
Significant Drop ◽  
Autoimmune Thyroid ◽  
Normal Ranges

Purpose.To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived fromCordyceps sinensis(Berk.) Sacc., on autoimmune thyroid diseases (AITD).Methods.44 Patients with Graves’s disease (GD) and 56 patients with Hashimoto’s thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups. Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment.Results.Significant drop of serum anti-TPO-Ab levels was observed in both GD-Tx and HT-Tx groups. Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T/cytotoxic T cells. There was a significant drop of the helper T/cytotoxic T cells ratio in GD-Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT-Tx was elevated.Conclusion.Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual-directional immunomodulatory effects. And it could significantly reduce the autoantibody levels in both GD and HT.

scholarly journals Elevated thyroglobulin level is associated with dysfunction of regulatory T cells in patients with thyroid nodules

2019 ◽  
Vol 8 (4) ◽  
pp. 309-317
Author(s):  
Yun Hu ◽  
Na Li ◽  
Peng Jiang ◽  
Liang Cheng ◽  
Bo Ding ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Peripheral Blood ◽  
Thyroid Nodules ◽  
Inhibitory Effect ◽  
High Concentration ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Objective Thyroid nodules are usually accompanied by elevated thyroglobulin (Tg) level and autoimmune thyroid diseases (AITDs). However, the relationship between Tg and AITDs is not fully understood. Dysfunction of regulatory T cells (Tregs) plays an important role in the development of AITDs. We aimed to evaluate the effects of Tg on the function of Tregs in patients with thyroid nodules. Methods Tg levels and the functions of Tregs in peripheral blood and thyroid tissues of patients with thyroid nodules from Nanjing First Hospital were evaluated. The effects of Tg on the function of Tregs from healthy donors were also assessed in vitro. The function of Tregs was defined as an inhibitory effect of Tregs on the effector T cell (CD4+ CD25− T cell) proliferation rate. Results The level of Tg in peripheral blood correlated negatively with the inhibitory function of Tregs (R = 0.398, P = 0.03), and Tregs function declined significantly in the high Tg group (Tg >77 μg/L) compared with the normal Tg group (11.4 ± 3.9% vs 27.5 ± 3.5%, P < 0.05). Compared with peripheral blood, the function of Tregs in thyroid declined significantly (P < 0.01), but the proportion of FOXP3+ Tregs in thyroid increased (P < 0.01). High concentration of Tg (100 μg/mL) inhibited the function of Tregs and downregulated FOXP3, TGF-β and IL-10 mRNA expression in Tregs in vitro. Conclusions Elevated Tg level could impair the function of Tregs, which might increase the risk of AITDs in patient with thyroid nodules.

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