scholarly journals Psychological morbidity and impaired quality of life in patients with stable treatment for primary adrenal insufficiency: cross-sectional study and review of the literature

2014 ◽  
Vol 171 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Jitske Tiemensma ◽  
Cornelie D Andela ◽  
Ad A Kaptein ◽  
Johannes A Romijn ◽  
Roos C van der Mast ◽  
...  

ContextA high prevalence of psychological morbidity and maladaptive personality as well as impaired quality of life (QoL) is observed in patients with and without hydrocortisone dependency following (cured) Cushing's syndrome. However, it is currently unclear whether a similar pattern is present in patients with chronic glucocorticoid replacement for primary adrenal insufficiency (PAI).ObjectiveTo evaluate psychological functioning, personality traits, and QoL in patients with PAI.Design and subjectsA cross-sectional study including 54 patients with stable treatment for PAI and 54 healthy matched controls. Both patients and controls completed questionnaires on psychological functioning (Apathy Scale, Irritability Scale, Mood and Anxiety Symptoms Questionnaire short form, and Hospital Anxiety and Depression Scale), personality traits (Dimensional Assessment of Personality Pathology short form), and QoL (Multidimensional Fatigue Inventory, Short Form 36, EuroQoL-5D, Nottingham Health Profile, and Physical Symptom Checklist).ResultsPatients with PAI suffered from more psychological morbidity (i.e. irritability and somatic arousal) and QoL impairments compared with controls (allP<0.01). There were no differences regarding maladaptive personality traits between patients and controls. However, there was a strong and consistent positive association between the daily hydrocortisone dose and prevalence of maladaptive personality traits (i.e. identity problems, cognitive distortion, compulsivity, restricted expression, callousness, oppositionality, rejection, conduct problems, social avoidance, narcissism, and insecure attachment, allP<0.05). There was also a strong relation between the mean daily hydrocortisone dose and both psychological morbidity (i.e. depression,P<0.05) and QoL impairments (i.e. general health perception, several measures of physical functioning, and vitality, allP<0.05).ConclusionPatients on stable glucocorticoid replacement therapy for PAI report psychological morbidity and impaired QoL. Psychological morbidity, impaired QoL, and maladaptive personality traits were all associated with higher dosages of hydrocortisone.

2022 ◽  
Author(s):  
MING YI ◽  
Jing LI ◽  
Gang LIU ◽  
Weixi ZHANG ◽  
Ying WANG ◽  
...  

Abstract Background Facial appearance and expressions influence social interaction. However, few studies have reported on the stigma associated with spasms from facial dystonia. This study investigated the stigma and quality of life for these patients. Methods This cross-sectional study included 90 patients with facial dystonia (hemifacial spasm [HFS], blepharospasm [BSP], and blepharospasm-oromandibular dystonia [BOD]; 30 patients per group) and 30 individuals without dystonia (control group) from October 2019 to November 2020. All participants underwent stigma, quality of life, and mental health evaluations using seven questions related to stigma, the 36-item Short Form Health Survey, the 14-item version of the Hamilton Anxiety Scale (HAMA), and the 24-item version of the Hamilton Depression Scale. Results Nineteen patients (21.11%) felt stigmatized. Patients with BPS and HFS had more difficulty finding a job and were more susceptible to discrimination than healthy individuals. The role-physical and social function scores were significantly lower in the dystonia groups than in the control group. The vitality score of the BPS group and the mental health scores in the BPS and BOD groups were significantly less than those of the control group. The HAMA scores in the BPS and BOD groups were significantly higher than in the control group. Regression analysis demonstrated that the disease course influenced depression. Conclusion Enacted stigma from a negative public attitude may be the main factor triggering stigma in patients with facial dystonia, with detrimental effects on psychosocial outcomes, including social rights, quality of life, and mood.


2020 ◽  
Author(s):  
Myung Kyung Lee ◽  
Woo Jin CHUNG

Abstract Background: Previous studies have not considered a broad range of symptoms and the association with healthy behavior and quality of life of patients with liver cirrhosis. Objectives: The purposes of the study were to examine the association of symptom with adopting exercise and consuming fruits and vegetables, and to identify factors associated with quality of life in patients with liver cirrhosis.Methods: This cross-sectional study enrolled 91 consecutive patients with liver cirrhosis in one tertiary general hospital in South Korea between February 2016 and January 2017. Each study participant completed a self-administered questionnaire that measured symptom, stage-of-change in performing exercise and consumption of fruits and vegetables, and the Korean version of the 36-item Short-Form Health Survey. Multivariate logistic regression analysis and multiple regression models was used respectively to examine the association of each symptom with engaging in exercise and increasing consumption of fruits and vegetables and to evaluate factors affecting quality of life.Results: Experiencing nausea was associated with increased intensity of exercise but experiencing shortness of breath was associated with decreased intensity of exercise. Experiencing right upper quadrant pain was associated with increased consumption of fruits and vegetables and muscle cramps, anorexia, right upper quadrant pain and body pain, itching, ascites or edema, bruising, and change in appearance negatively affected quality of life.Conclusions: The results suggest that the types of symptoms experienced by a patient with liver cirrhosis hinder or promote the patient’s adoption of exercise and dietary behavior. Experiencing symptoms may negatively affect quality of life. Caregivers should provide supportive care to patients with liver cirrhosis, which includes assessing and managing symptoms to improve quality of life.


2020 ◽  
Author(s):  
Luke Sy-Cherng Woon ◽  
Paula Junggar Gosse ◽  
Emily Samantha Kaunismaa ◽  
Roslyn Laurie Mainland ◽  
Arun Ravindran ◽  
...  

Abstract Background: Diabetes mellitus is highly prevalent in the elderly population, with a significant impact on quality of life. This study aimed to explore the relationship between personality traits and quality of life in an elderly population with diabetes. Methods: A cross-sectional study was conducted at the Universiti Kebangsaan Malaysia Medical Center. Outpatients above 60 years old with a diagnosis of type 1 or type 2 diabetes mellitus were recruited. Sociodemographic and clinical information were obtained. Quality of life was assessed using the WHO Quality of Life-BREF questionnaire and personality traits were assessed using the Big Five Inventory questionnaire. Depression and anxiety were measured with Beck Depression Inventory and Generalized Anxiety Disorder 7-item scale respectively and controlled for in statistical analyses. Results: There were 170 study participants (median age=69.0 years; IQR: 65.0-73.0; 51.2% male). In stepwise linear regression models, higher conscientiousness scores (β=0.156; p=0.044) and lower neuroticism scores (β=-0.176; p=0.028) were associated with greater quality of life in the physical health domain. Higher extraversion scores (β=0.209; p=0.001) and higher conscientiousness scores (β=0.248; p<0.001) were associated with greater quality of life in the psychological health domain. Higher agreeableness scores (β=0.286; p<0.001) were associated with greater quality of life in the social relationship domain. Finally, higher agreeableness scores (β=0.327; p<0.001) and lower neuroticism scores (β=-0.223; p=0.001) were associated with greater quality of life in the environment domain. Conclusions: Personality traits were closely associated with all domains of quality of life among elderly patients with diabetes mellitus. Premorbid personality may have important role in moderating the impact of diabetes mellitus on the lives of elderly patients.


2019 ◽  
Vol 47 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Wallis Bavière ◽  
Xavier Deprez ◽  
Eric Houvenagel ◽  
Peggy Philippe ◽  
Valerie Deken ◽  
...  

Objective.In psoriatic arthritis (PsA), comorbidities add to the burden of disease, which may lead to poorer quality of life. The purpose of this study was to evaluate the relationship between comorbidities and quality of life (QOL).Methods.Patients from a multicentric, cross-sectional study on comorbidities in PsA were included in the analysis. Data on comorbidities were collected and were subsequently used to compute the modified Rheumatic Disease Comorbidity Index (mRDCI). The Medical Outcomes Study Short Form-36 questionnaire physical (PCS) and mental component summary (MCS) scales were used to assess QOL.Results.In total, 124 recruited patients fulfilled the ClASsification for Psoriatic ARthritis criteria (CASPAR): 62.1% were male; mean age and mean disease duration were 52.6 ± 12.6 years and 11.3 ± 9.6 years, respectively. The number of comorbid conditions was 2.0 ± 1.3, with 30.6% of the sample having currently or a history of 3 or more comorbidities. In the multivariate linear regression analysis, only anxiety remained significantly related to mental health (p < 0.0001). Anxiety alone accounted for 28.7% of the variance in MCS scores. Moreover, MCS was also significantly associated with the mRDCI score, which explained 4.9% of the variance in MCS [β = −1.56 (standard error 0.64), R2 = 0.049, p = 0.0167]. In contrast, PCS was not significantly associated either with type or number of comorbidities.Conclusion.In this study, the type of comorbidity appeared to have a greater effect than the number of comorbidities. Indeed, anxiety in PsA was independently associated with QOL and would thus be an important factor to take into account in daily clinical practice.


2021 ◽  
Vol 16 (1) ◽  
pp. 50-68
Author(s):  
Luke Sy-Cherng Woon ◽  

While diabetes mellitus is highly prevalent in the elderly population with significant impact on quality of life (QOL), we yet to know much about how personality traits affect QOL in this patient population. A cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Centre with the aim to determine the relationship between personality traits and QOL among the elderly (aged ≥60 years) with diabetes mellitus. Sociodemographic and clinical information were obtained. QOL was assessed using the WHO Quality of Life-BREF (WHOQOLBREF) questionnaire and personality traits were assessed using the Big Five Inventory (BFI) questionnaire. Depression and anxiety were measured with Beck Depression Inventory-II (BDI-II) and Generalized Anxiety Disorder 7-item (GAD-7) scale, respectively, and controlled for in all analyses. There were in total 170 study participants (median age=69.0 years; IQR: 65.0-73.0; 51.2% male). In stepwise linear regression models, higher conscientiousness scores (β=0.156; P=0.044) and lower neuroticism scores (β=-0.176; P=0.028) were associated with greater QOL in the physical health domain. Higher extraversion scores (β=0.209; P=0.001) and higher conscientiousness scores (β=0.248; P<0.001) were associated with greater QOL in the psychological health domain. Higher agreeableness scores (β=0.286; P<0.001) were associated with greater QOL in the social relationship domain. Finally, higher agreeableness scores (β=0.327; P<0.001) and lower neuroticism scores (β=-0.223; P=0.001) were associated with greater QOL in the environment domain. Personality traits were closely associated with all domains of QOL among elderly patients with diabetes mellitus. Premorbid personality may have important role in moderating the impact of diabetes mellitus on the lives of elderly patients.


2021 ◽  
Author(s):  
Marzieh Kafeshani ◽  
Awat Feizi ◽  
Ahmad Esmaillzadeh ◽  
Ammar Hassanzadeh Keshteli ◽  
Hamidreza Roohafza ◽  
...  

Abstract BackgroundThe eating speed has been hypothesized to be associated with energy intake and weight control. Recently, the effects of some factors on eating rate were investigated, however; studies about the impacts of psychological factors in this field are rare. One of these possible factors is personality traits. This study aimed to assess the relationship between personality traits and eating speed. MethodsThis cross-sectional study was performed among 4763 adults in 2011. Personality trait was assessed by using the Big Five Personality Inventory Short Form. The eating speed was evaluated using a pretested questionnaire and latent class analysis (LCA) was applied to categorize participants according to the eating speed. Multiple binary logistic regression analysis was used for data analyses. ResultsWe found that the higher levels of neuroticism (quartile 4) were associated significantly with lower odds of normal eating speed (OR: 0.43; 95% CI: 0.31, 0.60; P<0.001) but higher levels of other personality traits were statistically significantly associated with higher odds of normal eating speed. ConclusionsThe current study showed significant associations between personality traits and eating speed; accordingly, it provides primary evidence about the potential value of personality traits for managing the eating rate. Further prospective observational and interventional studies are recommended.


2021 ◽  
Author(s):  
Marzieh Kafeshani ◽  
Awat Feizi ◽  
Ahmad Esmaillzadeh ◽  
Ammar Keshteli ◽  
Hamidreza Roohafza ◽  
...  

Abstract The eating speed has been hypothesized to be associated with energy intake and weight control. Recently, the effects of some factors on eating rate were investigated, however; studies about the impacts of psychological factors in this field are rare. One of these possible factors is personality traits. This study aimed to assess the relationship between personality traits and eating speed. This cross-sectional study was performed among 4763 adults in 2011. Personality trait was assessed by using the Big Five Personality Inventory Short Form. The eating speed was evaluated using a pretested questionnaire and latent class analysis (LCA) was applied to categorize participants according to the eating speed. Multiple binary logistic regression analysis was used for data analyses. We found that the higher levels of neuroticism (quartile 4) were associated significantly with lower odds of normal eating speed (OR: 0.43; 95% CI: 0.31, 0.60; P<0.001) but higher levels of other personality traits were statistically significantly associated with higher odds of normal eating speed. The current study showed significant associations between personality traits and eating speed; accordingly, it provides primary evidence about the potential value of personality traits for managing the eating rate. Further prospective observational and interventional studies are recommended.


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