Ultrasensitive estrogen levels at 7 years of age predict earlier thelarche: evidence from girls of the growth and obesity Chilean cohort

ObjectivePrepubertal estradiol equivalents have been inconsistently linked to age at thelarche; elucidating this relationship becomes relevant given the worldwide decline in the age of puberty onset. Thus, our aim is to assess whether prepubertal girls with higher serum levels of estradiol equivalents at age 7 have a greater risk of presenting early thelarche (ET).DesignNested case–control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (∼50% girls) from Santiago, Chile. Girls were defined as cases (ET; n=61) if breast bud appeared prior to 8 years of age; controls (n=91) had thelarche >8 years.MethodsAt 6.7 years, weight, height and waist circumference were measured and a fasting blood sample was obtained for measuring estrogen equivalent (ultrasensitive recombinant cell bioassay), DHEAS, leptin, insulin and IGF1. Beginning at 7 years old, Tanner staging was assessed prospectively twice a year and the appearance of breast bud was assessed by palpation.ResultsMean serum estradiol-equivalent at 6.7 years was 3.9±3.6 pg/ml for cases and 3.6±2.3 pg/ml for controls. Girls with ET had a higher risk of presenting elevated estradiol-equivalent (≥5 pg/ml) at 7 years (OR=2.05, 95% CI: 0.96–4.36) than controls that was borderline significant. However, after adjusting by BMI, insulin and IGF1 at age 7, the association between estradiol-equivalent and ET was significant (OR=2.29 (95% CI: 1.05–5.01)).ConclusionsChilean girls from low to middle socioeconomic status with ET exhibited double the risk of having high levels of estradiol-equivalent at 7 years than girls with a later age of thelarche. Whole-body adiposity and increased adrenal activity did not explain the observed prepubertal estrogen increase.

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Dynamics of soluble syndecan-1 in maternal serum during and after pregnancies complicated by preeclampsia: a nested case control study

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2019-0686 ◽

2019 ◽

Vol 58 (1) ◽

pp. 50-58 ◽

Cited By ~ 2

Author(s):

Lorenz Kuessel ◽

Heinrich Husslein ◽

Eliana Montanari ◽

Michael Kundi ◽

Gottfried Himmler ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Predictive Power ◽

Operating Characteristic ◽

Area Under The Curve ◽

Roc Curves ◽

Serum Levels ◽

Maternal Serum ◽

Nested Case Control ◽

Single Time Point ◽

Control Study

Abstract Background We investigated the dynamics and the predictive value of soluble syndecan-1 (Sdc-1), a biomarker of endothelial dysfunction, in uneventful pregnancies and pregnancies complicated by preeclampsia (PE). Methods Serum levels of Sdc-1 were measured at sequential time points during and after uneventful pregnancies (control, n = 95) and pregnancies developing PE (PE_long, n = 12). Levels were further measured in women with symptomatic PE (PE_state, n = 46) at a single time point. Results Sdc-1 levels increased consistently throughout pregnancy. In the PE_long group Sdc-1 levels were lower at all visits throughout pregnancy, and reached significance in weeks 18–22 (p = 0.019), 23–27 (p = 0.009), 28–32 (p = 0.006) and 33–36 (p = 0.008). After delivery, Sdc-1 levels dropped sharply in all pregnancies but were significantly elevated in the PE_long group. The predictive power of Sdc-1 was evaluated analyzing receiver operating characteristic (ROC) curves. A significant power was reached at weeks 14–17 (area under the curve [AUC] 0.65, p = 0.025), 23–27 (AUC 0.73, p = 0.004) and 33–36 (AUC 0.75, p = 0.013). Conclusions In summary, Sdc-1 levels were lower in women developing PE compared to uneventful pregnancies and Sdc-1 might be useful to predict PE. After delivery, Sdc-1 levels remained higher in women with PE. Additional studies investigating the link between glycocalyx degradation, Sdc-1 levels and placental and endothelial dysfunction in pregnancies affected by PE are warranted.

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Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: Findings from a nested case–control study within the Japan Collaborative Cohort Study

Cancer Epidemiology ◽

10.1016/j.canep.2010.03.017 ◽

2010 ◽

Vol 34 (3) ◽

pp. 279-284 ◽

Cited By ~ 1

Author(s):

Truong-Minh Pham ◽

Yoshihisa Fujino ◽

Kei Nakachi ◽

Koji Suzuki ◽

Yoshinori Ito ◽

...

Keyword(s):

Cohort Study ◽

Growth Factors ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Nested Case Control ◽

Risk Of Cancer ◽

Control Study ◽

Subsequent Risk ◽

Insulin Like Growth Factors

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Adipokines and the risk of active TB: a nested case-control study

The International Journal of Tuberculosis and Lung Disease ◽

10.5588/ijtld.20.0300 ◽

2021 ◽

Vol 25 (1) ◽

pp. 31-35

Author(s):

A. Z. Soh ◽

C. T. Y. Tan ◽

E. Mok ◽

C. B. E. Chee ◽

J-M. Yuan ◽

...

Keyword(s):

Regression Models ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Dependent Manner ◽

Logistic Regression Models ◽

Donated Blood ◽

Nested Case Control ◽

Dose Dependent ◽

Control Study

BACKGROUND: Adipokines are emerging mediators of immune response, and may affect susceptibility to active TB.OBJECTIVE: To examine the associations between adipokines and the risk of active TB.METHODS: In a case-control study nested within a prospective cohort of middle-aged and older adults in Singapore, 280 incident active TB cases who donated blood for research before diagnosis were matched with 280 controls. Serum levels of adiponectin, resistin, leptin and ghrelin were measured. Multivariable logistic regression models were used to compute the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between adipokines and the risk of active TB.RESULTS: Higher levels of leptin and resistin were associated with reduced risk of TB in a dose-dependent manner. Compared to those in the lowest quartile of leptin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.26–0.82; P for trend = 0.009). Similarly, compared to those in the lowest quartile of resistin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.24–0.90; P for trend = 0.03). Adiponectin and ghrelin levels were not associated with TB risk.CONCLUSION: Increased serum levels of leptin and resistin may be associated with reduced susceptibility to active TB infection.

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