scholarly journals Mass spectrometry methods measured androgen and estrogen concentrations during pregnancy and in newborns of mothers with polycystic ovary syndrome

2016 ◽  
Vol 174 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Mirte R Caanen ◽  
Esther A Kuijper ◽  
Peter G Hompes ◽  
Mark M Kushnir ◽  
Alan L Rockwood ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Polycystic Ovary Syndrome ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Polycystic Ovary ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Causative Role ◽  
Ovary Syndrome

ObjectiveLittle is known about the aetiology of polycystic ovary syndrome (PCOS). Some suggest that elevated maternal androgens during gestation play a causative role. This implies placental passage of androgens during pregnancy. The aim of this study is to compare androgen and estrogen concentrations in maternal serum during pregnancy and in umbilical cord blood, between mothers with PCOS and their offspring compared to controls.DesignProspective case–control study.MethodsMaternal blood samples were collected around 20 weeks of gestation and at delivery. Umbilical cord blood was also taken at delivery. Androgens (testosterone (T), androstenedione (ADION), dehydroepiandrostenedione (DHEA)) and estrogens (estrone (E1), estradiol (E2), estriol (E3)) were measured using the liquid chromatography tandem mass spectrometry (LC-MS/MS) methods.ResultsAt 20 weeks of gestation: T (P=0.019) and ADION (P=0.034) were higher in the PCOS mothers (pregnant with a girl), whereas DHEA, E1, E2, and E3were not different. Maternal concentration at birth: T (P=0.004) and ADION (P=0.009) were also higher in the subgroup of PCOS mothers that were pregnant with a girl compared to the girl pregnancy controls. DHEA, E1, E2and E3were not different. In umbilical cord blood, no differences were found for T, ADION, DHEA, E2, E3, and AMH between the PCOS mothers and the controls respectively. E1was lower in girls from PCOS mothers (P=0.007).ConclusionsDespite elevated maternal androgen concentrations during pregnancy in PCOS mothers, offspring showed no signs of elevated androgen concentrations in cord blood at birth using the latest highly specific LC-MS/MS methods.

scholarly journals Comparison of the umbilical cord Blood’s anti-Mullerian hormone level in the newborns of mothers with polycystic ovary syndrome (PCOS) and healthy mothers

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Faezeh Tadaion Far ◽  
Shahideh Jahanian Sadatmahalleh ◽  
Saeideh Ziaei ◽  
Anoshirvan Kazemnejad
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Polycystic Ovary ◽  
Clinical Findings ◽  
Control Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Significant Difference

Abstract Background Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases. At present, the cause of the disease is not fully understood, but many studies have shown that PCOS is associated with genetic and environmental factors. The present study aimed to assess the umbilical cord blood’s Anti-mullerian hormone (AMH) level in the newborns of mothers suffering from PCOS comparing to healthy mothers. Methods This prospective cohort study was conducted on 120 pregnant women with PCOS, who were selected through Rotterdam criteria, and 60 healthy pregnant women as the control group. The subjects in each group were divided into obese and non-obese mothers according to their body mass index (BMI) before pregnancy. The cord blood samples were collected from the offsprings on the time of childbirth. Finally, the circulating concentrations of AMH in both sexes of the newborns were determined by specific assays. Results The research results showed that the blood level of AMH was higher in the neonates of obese mothers with PCOS comparing to the controls (P < 0.001). Mean AMH level was higher in male neonates born from non-obese PCOS mothers than in the controls (P < 0.001); however, there was not a significant difference in the level of AMH in female neonates between these two groups (P = 0.264). Also the level of the above biomarker was higher in both sexes of the neonates belonging to obese PCOS mothers compared with the neonates born from non-obese PCOS mothers (P < 0.001). Conclusion(s) It can be said that the cord blood AMH level of neonates from obese women with PCOS is higher than that in the newborns of non-obese PCOS mothers. Further longitudinal studies are needed to confirm the clinical findings of the present research.

scholarly journals Resistin in pregnancy: analysis of determinants in pairs of umbilical cord blood and maternal serum

Cytokine X ◽  
2021 ◽  
pp. 100052
Author(s):  
Anne FLOECK ◽  
Nina FERRARI ◽  
Christine JOISTEN ◽  
Maria T. PUTH ◽  
Brigitte STRIZEK ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Serum ◽  
In Pregnancy

Infants of Women With Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels

2010 ◽  
Vol 65 (9) ◽  
pp. 572-574
Author(s):  
Helen Anderson ◽  
Naomi Fogel ◽  
Stefan K. Grebe ◽  
Ravinder J. Singh ◽  
Robert L. Taylor ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cord Blood ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Estradiol Levels

Polycystic ovary syndrome in Indian women: a mass spectrometry based serum metabolomics approach

Metabolomics ◽  
2017 ◽  
Vol 13 (10) ◽  
Author(s):  
Sourav RoyChoudhury ◽  
Tushar H. More ◽  
Ratna Chattopadhyay ◽  
Indrani Lodh ◽  
Chaitali Datta Ray ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Indian Women ◽  
Serum Metabolomics

scholarly journals Infants of Women with Polycystic Ovary Syndrome have Lower Cord Blood Androstenedione and Estradiol Levels

Endocrinology ◽  
2010 ◽  
Vol 151 (4) ◽  
pp. 1971-1972
Author(s):  
Helen Anderson ◽  
Naomi Fogel ◽  
Stefan K. Grebe ◽  
Ravinder J. Singh ◽  
Robert L. Taylor ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cord Blood ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Estradiol Levels

scholarly journals Infants of Women with Polycystic Ovary Syndrome have Lower Cord Blood Androstenedione and Estradiol Levels

2010 ◽  
Vol 31 (2) ◽  
pp. 255-256
Author(s):  
Helen Anderson ◽  
Naomi Fogel ◽  
Stefan K. Grebe ◽  
Ravinder J. Singh ◽  
Robert L. Taylor ◽  
...  
Keyword(s):  
Birth Weight ◽  
Polycystic Ovary Syndrome ◽  
Cord Blood ◽  
Gestational Age ◽  
Polycystic Ovary ◽  
Large For Gestational Age ◽  
Control Group ◽  
Ovary Syndrome ◽  
17 Hydroxyprogesterone ◽  
Androgen Levels

ABSTRACT Context Prenatal androgen excess can cause a phenocopy of polycystic ovary syndrome (PCOS) in mammals. Retrospective studies have suggested that girls at risk for PCOS have low birth weight and prospective studies have suggested an increased prevalence of small for gestational age offspring in women with PCOS. Objective To determine whether infants of women with PCOS have reduced birth weight or increased intrauterine androgen levels. Design Prospective case-control study. Participants Thirty-nine PCOS and 31 control women and their infants. Main outcome measures Birth weight and mixed cord blood testosterone, androstenedione (A), dehydroepiandrosterone, 17-hydroxyprogesterone, estradiol (E2), and dihydrotestosterone levels. Results Mean birth weight did not differ but there was a significant increase in the prevalence of large for gestational age infants in the PCOS group. Cord blood E2 and A levels were lower (p &lt; 0.05) but testosterone:E2 ratios did not differ in female PCOS compared to control offspring. There was no difference in E2 and A levels in the male PCOS and control offspring. There was no difference in 17-hydroxyprogesterone or in other androgen levels in either male or female PCOS offspring compared to their respective control group. Conclusion Infants of women with PCOS were more likely to be large for gestational age. Female offspring of affected women have lower cord blood A levels; other cord blood androgen levels do not differ compared to female control offspring. Cord blood E2 levels are also significantly decreased in PCOS, without any difference in the testosterone:E2 ratio, suggesting decreased fetal or placental production of steroids.

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