Premature ovarian failure after childhood cancer and risk of metabolic syndrome – a cross-sectional analysis

2021 ◽  
Author(s):  
Axel Netterlid ◽  
Helena Mörse ◽  
Aleksander Giwercman ◽  
Emir Henic ◽  
Kristina E Akesson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
Fasting Glucose ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovarian Insufficiency ◽  
Cross Sectional ◽  
X Ray ◽  
Sectional Analysis

Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, among them metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since cancer diagnosis of 25 (12 – 41) years. Patients and controls were recruited from the South Medical Region of Sweden. Methods: The study included 167 female CCS, median age 34 (19 – 57) years, diagnosed with childhood cancer at median age 8.4 (0.1 – 17.9) years together with 164 controls, matched for age, sex, ethnicity, residence, and smoking habits. All subjects were examined with fasting glucose, insulin, HbA1c, and lipid profile. Fat mass was calculated with dual-energy X-ray absorptiometry (DXA), questionnaires for medication were obtained. Detailed information of cancer treatment was available. Results: POI was present in 13% (22/167) among CCS (hypothalamic/pituitary cause excluded) and in none among controls. MetS was present in 14% (24/167) among all CCS (p = 0.001), in 23% (5/22) of those with POI (p < 0.001), compared with 4% (6/164) among controls. OR for MetS in all CCS compared with controls was 4.4 (95% CI 1.8, 11.1) (p = 0.002) and among CCS with POI the OR was 7.7 (CI 2.1, 28.1) (p = 0.002). Conclusion: The prevalence of MetS was higher in females treated for childhood cancer compared with controls and the presence of POI significantly increased the risk of developing MetS.

scholarly journals Fat Mass Index Better Identifies Metabolic Syndrome: Insights from Patients in Early Outpatient Cardiac Rehabilitation

2019 ◽  
Vol 8 (12) ◽  
pp. 2147
Author(s):  
Amanda R. Bonikowske ◽  
Maria Irene Barillas Lara ◽  
Katlyn E. Koepp ◽  
Jose R. Medina Inojosa ◽  
Ray W. Squires ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiac Rehabilitation ◽  
Fat Mass ◽  
Cross Sectional Study ◽  
Dual Energy ◽  
Health Record ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fat Mass Index ◽  
X Ray

Body mass index (BMI) does not differentiate fat and lean mass or the distribution of adipose tissue. The purpose of this study was to examine the prevalence of metabolic syndrome (MetS) among patients entering outpatient cardiac rehabilitation (CR) across fat mass index (FMI) categories compared with BMI. This retrospective cross-sectional study evaluated dual-energy x-ray absorptiometry in 483 CR patients from 1 January 2014, through 31 December 2017. Clinical data were extracted from the electronic health record. Patients were grouped by FMI and BMI categories. Mean (SD) age of patients was 64.3 (14) years. The normal FMI category had 15 patients; excess fat, 74; and obese, 384. In contrast, 93, 174, and 216 were in the normal, overweight, and obese BMI categories, respectively. Prevalence of MetS was 0 (0%) in normal, 5 (1%) in excess fat, and 167 (54%) in obese FMI, with 97% in the obese category. MetS prevalence was 4 patients (0.8%) in normal, 39 (8%) in overweight, and 129 (27%) in obese BMI categories, with 75% of MetS in the obese category. FMI more accurately classified CR patients with metabolically abnormal fat (p < 0.001). FMI is a more sensitive index than BMI for metabolically abnormal fat of outpatient CR patients.

Research Protocol: Cross-sectional Study (Survey)—The Fate of Moroccan Childhood Cancer Survivors

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Nadia Benaicha ◽  
Fouzia Msefer Alaoui ◽  
Adil. Najdi ◽  
Karima Elrhazi ◽  
O.D Diakité ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Research Protocol ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association Between Elevation, Health Related Lifestyles and the Metabolic Syndrome Among Ecuadorian Adults: A National Cross-Sectional Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1423-1423
Author(s):  
Christian Juna ◽  
Dongwoo Ham ◽  
Hyojee Joung ◽  
Yoon Hee Cho
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Latin American ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Health Related

Abstract Objectives To examine the associations of elevation, health related lifestyles and Metabolic Syndrome Mets in the Ecuadorian adult population. Methods This cross-sectional study used secondary data from the 2012 Ecuador National Health and Nutrition Survey, a total of 6024 adults (1964 men and 4060 women) aged 20 to 60 years were included in the study. Elevation was obtained by georeferencing techniques, dietary intake was measured using a 24-hour dietary recall method and health related lifestyles through risk factors and physical activity standardized questionnaires. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III and the Latin American Diabetes Association criteria. Multiple logistic regression analysis was used to evaluate the associations between elevation, health related lifestyles and MetS abnormalities. Results Residing at low elevation (0-,2000 masl) showed increased risk of MetS in men (1.42; 95% CI, 1.11–1.81), increased waist circumference in women (1.32; 95% CI, 1.02–1.70) and increased risk of elevated fasting glucose in men (2.08; 95% CI, 1.55–2.79) and women (1.70; 95% CI, 1.38–2.10). Health-related lifestyle factors (alcohol consumption, current smoking, currently working and Estimated Energy Requirement intake) showed increased trend of higher risks of MetS and other components in response to lower elevation. However, only physical activity (Yes vs. No) showed a significant difference, decreased risk of elevated triglycerides in women (0.49; 95% CI, 0.25–0.97). Conclusions Living at low elevation was associated with increased prevalence of MetS in men, increased waist circumference in women and elevated fasting glucose in men and women. Regular physical activity in response to low elevation was associated with decreased risk of elevated triglycerides in women. Funding Sources This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

scholarly journals High impact physical activity and bone health of lower extremities in childhood cancer survivors: A cross‐sectional study of SURfit

2020 ◽  
Vol 147 (7) ◽  
pp. 1845-1854
Author(s):  
Simeon J. Zürcher ◽  
Ruedi Jung ◽  
Sophie Monnerat ◽  
Christina Schindera ◽  
Prisca Eser ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Bone Health ◽  
Lower Extremities ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
High Impact ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Hyperglycemia: the metabolic syndrome component that aggravates erectile dysfunction in Mexican patients

2020 ◽  
Vol 79 (6) ◽  
pp. 1-12
Author(s):  
Alan Espinosa-Marrón ◽  
Christian Anibal Quiñones-Capistrán ◽  
Aquiles Rubio-Blancas ◽  
María Del Pilar Milke-García ◽  
Ricardo Alonso Castillejos-Molina
Keyword(s):  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Metabolic Syndrome Components ◽  
Mexican Patients

  Objectives: To analyze the relationship between erectile dysfunction and metabolic syndrome in a group of Mexican patients, study the influence of other morbidity factors on erectile dysfunction, and define the specific metabolic syndrome components most associated with erectile dysfunction severity. Materials and methods: A descriptive, cross-sectional study was conducted on a group of 86 adult Mexican patients previously diagnosed with erectile dysfunction. Participants were classified as presenting with or not presenting with metabolic syndrome. Anthropometric, biochemical, and clinical parameters were determined and erectile dysfunction severity, alcohol or tobacco consumption, and depressive behavior were identified through validated questionnaires. The results were compared between the two groups. Results: The anthropometric measures, laboratory values, and clinical characteristics were significantly different between the two groups. More patients with severe and moderate erectile dysfunction were identified in the group with metabolic syndrome. Of the metabolic syndrome components, glycated hemoglobin >5.7% and fasting glucose >110 mg/dl were significantly associated with the development of erectile dysfunction. Limitations: The size of our study sample was a limitation, as was the observational and cross-sectional study design. Originality: Our study results suggest that metabolic syndrome contributed to the progression of erectile dysfunction in the Mexican sample analyzed, with hyperglycemia being the most strongly associated factor. Conclusions: Metabolic syndrome components were shown to aggravate erectile dysfunction, particularly the lack of glycemic control. The inclusion of fasting glucose and glycated hemoglobin as complementary biochemical screening in patients with erectile dysfunction should be assessed.

scholarly journals Assessment of Late Effects in Childhood Cancer Survivors: A Cross Sectional Study

2020 ◽  
Author(s):  
Venkata Naga Malleswari Muddana ◽  
Biswajit Dubashi ◽  
S. Nirmala Devi ◽  
Smita Kayal ◽  
Prasanth Ganesan
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Factors affecting weight and body composition in childhood cancer survivors—cross-sectional study

2020 ◽  
Vol 14 ◽  
Author(s):  
Małgorzata Sawicka-Żukowska ◽  
Włodzimierz Łuczyński ◽  
Jakub Dobroch ◽  
Maryna Krawczuk-Rybak
Keyword(s):  
Body Composition ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Affecting
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