scholarly journals High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Group D ◽  
Tsh Levels

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

A CLINICAL STUDY SHOWING ASSOCIATION OF SERUM LIPIDS WITH PRIMARY OPEN ANGLE GLAUCOMA

2021 ◽  
pp. 63-64
Author(s):  
Sudeshna Roy ◽  
Debalina Ghanta
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Open Angle Glaucoma ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Good Control ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Independent Risk Factors ◽  
Total Triglyceride

Introduction: Glaucoma, a multifactorial condition characterized by progressive optic neuropathy and distinctive visual eld loss, has become the most common cause of irreversible blindness worldwide. Many cases have shown progress despite of good control of IOP, strengthening the view that other independent risk factors play role in pathogenesis of glaucoma. Few studies have shown association of serum lipids to glaucoma. The objective of the study is to nd relation between serum lipid and POAG. Materials and Method: The study was conducted on 50 cases of glaucoma and 50 age matched controls. Detailed ophthalmic examinations were performed in all patients. Fasting lipid prole including total cholesterol, triglyceride, Low density lipoprotein(LDL),and high density lipoprotein (HDL) were measured and analyzed between the cases and controls. Result: Level of total cholesterol, total triglyceride, and LDLwere signicantly higher in cases than in contacts with Pvalue <0.05.Level of HDL was lowered in cases than in controls but it was not statistically signicant. Conclusion: Dyslipidemia is an independent risk factor for POAG. High serum Cholesterol, high triglyceride and high serum LDLcorrelate signicantly with POAG.

scholarly journals Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-feverBorrelia

2015 ◽  
Vol 112 (17) ◽  
pp. 5491-5496 ◽  
Author(s):  
Alvaro Toledo ◽  
Javier D. Monzón ◽  
James L. Coleman ◽  
Juan C. Garcia-Monco ◽  
Jorge L. Benach
Keyword(s):  
Lyme Disease ◽  
Serum Cholesterol ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Severe Infection ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Elevated Serum Cholesterol ◽  
Deficient Mice

The Lyme disease (Borrelia burgdorferi) and relapsing-fever (Borrelia hispanica) agents have distinct infection courses, but both require cholesterol for growth. They acquire cholesterol from the environment and process it to form cholesterol glycolipids that are incorporated onto their membranes. To determine whether higher levels of serum cholesterol could enhance the organ burdens ofB. burgdorferiand the spirochetemia ofB. hispanicain laboratory mice, apolipoprotein E (apoE)-deficient and low-density lipoprotein receptor (LDLR)-deficient mice that produce large amounts of serum cholesterol were infected with both spirochetes. Both apoE- and LDLR-deficient mice infected withB. burgdorferihad an increased number of spirochetes in the joints and inflamed ankles compared with the infected wild-type (WT) mice, suggesting that mutations in cholesterol transport that result in high serum cholesterol levels can affect the pathogenicity ofB. burgdorferi. In contrast, elevated serum cholesterol did not lead to an increase in the spirochetemia ofB. hispanica.In the LDLR-deficient mice, the course of infection was indistinguishable from the WT mice. However, infection of apoE-deficient mice withB. hispanicaresulted in a longer spirochetemia and increased mortality. Together, these results argue for the apoE deficiency, and not hypercholesterolemia, as the cause for the increased severity withB. hispanica.Serum hyperlipidemias are common human diseases that could be a risk factor for increased severity in Lyme disease.

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

10.1038/4027 ◽  
1998 ◽  
Vol 4 (12) ◽  
pp. 1434-1437 ◽  
Author(s):  
Matti K. Karvonen ◽  
Ullamari Pesonen ◽  
Markku Koulu ◽  
Leo Niskanen ◽  
Markku Laakso ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Serum Cholesterol ◽  
Signal Peptide ◽  
Ldl Cholesterol ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels

Use of serum cholesterol/triglyceride ratio to discern for which individuals the Friedewald formula can be used confidently

1990 ◽  
Vol 36 (9) ◽  
pp. 1673-1675 ◽  
Author(s):  
M González Estrada ◽  
C R Rodríguez Ferrer ◽  
I R Astarloa ◽  
E M Lahera
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Friedewald Formula ◽  
The Individual ◽  
Low Serum

Abstract The values of low-density lipoprotein cholesterol obtained according to the Friedewald formula (Clin Chem 1972; 18:499-502), or by the De Long transformation (J Am Med Assoc 1986;256:2372-7), were compared with the values obtained when the individual cholesterol/triglyceride ratio of very-low-density lipoprotein was used for estimating the contribution of this lipoprotein to the total cholesterol. We found that these formulas gave the greatest errors for individuals with a low serum cholesterol/triglyceride ratio. We propose criteria for deciding when the numerically calculated value of low-density cholesterol is appropriate, and when it is not.

Hypocholesterolaemia in Cancer and Other Causes of Death in the Mentally Handicapped

1984 ◽  
Vol 145 (1) ◽  
pp. 59-61 ◽  
Author(s):  
J. Jancar ◽  
R. D. Eastham ◽  
G. Carter
Keyword(s):  
Myocardial Infarction ◽  
Serum Cholesterol ◽  
Causes Of Death ◽  
High Serum ◽  
Mentally Handicapped ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Rising Incidence ◽  
The Relationship ◽  
Low Serum

SummarySerum cholesterol levels were estimated in 313 mentally handicapped patients who subsequently died from various causes. Although cholesterol levels in the mentally handicapped are lower than those in the general population, it was found that there was still an association between relatively low serum cholesterol values and mortality due to cancer of the colon. Similarly, patients who died from myocardial infarction had relatively high serum cholesterol levels. The mechanism of the relationship between hypocholesterolaemia and cancer of the colon is unclear, but the increasing longevity of the mentally handicapped is an important factor which has contributed to a rising incidence of cancers, particularly gastrointestinal forms, in this group.

scholarly journals Nutritional status and food consumption in 10–11 year old Dutch boys (Dutch Nutrition Surveillance System)

1991 ◽  
Vol 66 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Geert Van Poppel ◽  
Petra Schneijder ◽  
Michiel R. H. Löwik ◽  
Jaap Schrijver ◽  
Frans J. Kok
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Food Consumption ◽  
Surveillance System ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Cholesterol Levels

As part of the Dutch Nutrition Surveillance System, cardiovascular risk factors and food consumption (24 h recall) as well as haematological, Fe and vitamin status (A, B6, C) were assessed in 126 Dutch boys aged 10–11 years (response 71 %). Body mass index (BMI) and the sum of four skinfolds were strongly associated (r0.85,P< 0.01) and 8% of the boys were overweight (BMI > 20.1 kg/m2). Elevated serum total cholesterol levels (> 4.4 mmol/l) were observed in 38 %; total cholesterol and low-density-lipoprotein-cholesterol levels were strongly associated (r0.88,P< 0.001). Intake of fat was high (38 % of energy) and too much fat was saturated (polyunsaturated: saturated 0.44, guideline: 0.5–1.0), whereas intake of carbohydrate (49% of energy) and dietary fibre was low. About 12% of the boys had insufficient Fe stores (plasma ferritin < 12.0 μg/l) and the mean Fe intake (9.0 mg/d) was below recommended daily allowance (10.0 mg/d). Plasma ferritin was, however, not associated with haematological indices and no frank anaemias were observed. No marginal values were observed for vitamins A, B6and C status. In conclusion, the main nutritional risks in boys aged 10–11 years are cardiovascular risk factors and Fe nutrition.

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