scholarly journals Acute fasting diminishes the circadian rhythm of biochemical markers of bone resorption

1999 ◽  
pp. 332-337 ◽  
Author(s):  
A Schlemmer ◽  
C Hassager
Keyword(s):  
Circadian Rhythm ◽  
Bone Resorption ◽  
Bone Turnover ◽  
Food Consumption ◽  
Biochemical Markers ◽  
Calcium Absorption ◽  
Control Period ◽  
Circadian Variation ◽  
Fasting Period ◽  
Markers Of Bone Turnover

OBJECTIVE: Biochemical markers of bone turnover exhibit circadian rhythms with the peak during the night/early morning and the nadir in the late afternoon. The nocturnal increase in bone resorption could theoretically be caused by the absence of food consumption which brings about a decrease in net calcium absorption and an increase in parathyroid hormone (PTH), followed by increased bone resorption in response to the body's demand for calcium. The aim of the present study was to assess the influence of a 33-h fast on the circadian variation in biochemical markers of bone turnover. DESIGN: Eleven healthy premenopausal women (age: 24+/-5 years) participated in a randomised, cross-over study consisting of two periods: either 33h of fasting (fasting) followed 1 week later by a 33-h period with regular meals eaten at 0800-0830h, 1130-1230h and 1800-1900h (control) or vice versa. METHODS: Urinary CrossLaps (U-CL/Cr) corrected with creatinine, as a marker of bone resorption; serum osteocalcin (sOC) as a marker of bone formation; serum intact PTH (iPTH); serum phosphate; and serum calcium corrected with albumin. RESULTS: Both the fasting and the control periods showed a significant circadian rhythm in U-CL/Cr (P<0.001), but the decrease was significantly less pronounced in the morning hours during the fasting period. Fasting resulted in a significant decrease in serum iPTH (throughout the study period) as compared with the control period (P<0.05-0.001). No change was observed in sOC by fasting. CONCLUSION: Food consumption has a small influence on the circadian variation in bone resorption, independent of PTH. The fall in iPTH during fasting may be secondary to an increased bone resorption produced by fasting.

Physical activity increases bone formation and decreases bone resorption as assessed by biochemical markers of bone turnover

1996 ◽  
Vol 6 (S1) ◽  
pp. 250-250
Author(s):  
HW Woitge ◽  
M Müller ◽  
P Bärtsch ◽  
B Friedmann ◽  
MJ Seibel ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Markers Of Bone Turnover

scholarly journals Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

2019 ◽  
Vol 70 (2) ◽  
pp. 623-626
Author(s):  
Luana Andreea Macovei ◽  
Alexandra Burlui ◽  
Elena Rezus
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Corticosteroid Treatment ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Bone Formation Marker ◽  
Markers Of Bone Turnover

Osteocalcin and deoxypyridinoline levels were measured in 55 RA patients during and after glucocorticoid therapy with prednisone, methylprednisolone and cortisone. A decrease of 27% of the bone resorption marker deoxypyridinoline (from 10.13 to 7.4) and an increase of 23% of the bone formation marker osteocalcin (from 16.3 to 20.1) were also clinically confirmed by the presence of osteoporosis in 74% of patients receiving corticosteroid treatment as compared with only 31% in the control group.

Biochemical Markers of Bone Turnover and Fracture Prediction

2003 ◽  
Vol 9 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Rosemary A Hannon ◽  
Richard Eastell
Keyword(s):  
Bone Mineral Density ◽  
Bone Resorption ◽  
Bone Turnover ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Risk Of Fracture ◽  
Increased Risk ◽  
Markers Of Bone Turnover

Low bone mineral density is a strong risk factor for fractures in the older woman. Biochemical markers of bone turnover may predict fracture risk independently of bone mineral density. High levels of bone resorption markers are associated with increased risk of fracture in both retrospective and prospective studies, although the evidence for bone formation markers and fracture risk is equivocal. For example, the risk of fracture is increased up to two-fold in women with elevated levels of several markers of bone resorption. Prediction models have been developed to predict the 10–year risk of fracture using bone mineral density and biochemical markers of bone turnover and these could prove very useful in clinical practice.

Risk Assessment for Osteoporosis II: Biochemical Markers of Bone Turnover: Bone Resorption Indices

2000 ◽  
Vol 20 (3) ◽  
pp. 503-526 ◽  
Author(s):  
Henning W. Woitge ◽  
Markus J. Seibel
Keyword(s):  
Risk Assessment ◽  
Bone Resorption ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Markers Of Bone Turnover

scholarly journals Bone markers and osteoporosis

2004 ◽  
Vol 23 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Kaya Emerk
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Alcohol Intake ◽  
Bone Markers ◽  
Bone Alkaline Phosphatase ◽  
Low Concentrations ◽  
Trabecular Microstructure ◽  
Markers Of Bone Turnover

Diagnosis of a given disease is often the first step to a successful therapy. The use of biochemical markers of bone turnover in osteoporosis is becoming more important due to their capacity to give early information. Many of the new markers are proteins, peptides, or other large biomolecules, usually present at very low concentrations. Bone is a living, growing tissue that turns over at a rate of about 10% a year. It is lergely made up of collagen, that gives the bone its tensile strength and framework, and calcium phosphate, mineralized complex that hardens the framework. After age 24, bone resorption slowly begins to happen faster than bone formation. Bone loss is most rapid in women in the first few year after menopause but continues into the postmenopausal years. Loss although much slowly, also happens in men. In addition to bone porosity, the bone strength is determined by the trabecular microstructure in wich osteoclastic, and osteoblastic activities play an important role. Osteoporosis develops when bone resorption occurs too rapidly and bone formation fails to keep up. Risk factors for osteoporosis involves age, gender, ethnicity, use of certain drugs, exercise, smoking Vit D deficiency, Ca intake, sex hormones, alcohol intake etc. Mineralization markers are serum osteocalcin, bone alkaline phosphatase, serum prokollagen I extention peptides. Markers for the resorption of bone on the other hand are urine N-telopeptide crosslinks, urine deoxy-piridinoline, urine hydroxyproline, tartarate dependent acid phosphatase and Catepsin K. Biochemical markers of bone turnover should be used with BMD for diagnosis.

Biochemical markers of bone turnover in patients with metastatic bone disease

1995 ◽  
Vol 41 (10) ◽  
pp. 1489-1494 ◽  
Author(s):  
L M Demers ◽  
L Costa ◽  
V M Chinchilli ◽  
L Gaydos ◽  
E Curley ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Turnover ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Bone Disease ◽  
Biochemical Markers ◽  
Clinical Evidence ◽  
Metastatic Bone Disease ◽  
Z Score ◽  
Markers Of Bone Turnover

Abstract Several biochemical markers of bone formation and bone resorption have recently been developed. These markers have been evaluated for clinical utility in patients with metabolic bone disease, including Paget disease and osteoporosis, and for their potential use in cancer patients whose disease has metastasized to bone. We have evaluated seven markers of bone turnover in the plasma and urine of 94 patients with newly diagnosed or progressive malignancy with and without clinical evidence of bone metastases. As determined by a positive bone scan and (or) bone survey, 30 patients had metastases to bone; 51 patients had metastatic cancer without overt bony involvement; and 13 patients had local disease without bone metastases. To evaluate the predictive value of these markers in the metastatic population, we utilized a "Z-score" and logistic regression analysis to distinguish patients with documented bone metastatic disease from those patients without clinical evidence of bone metastases. The higher the Z-score, the better the marker predicts the presence of bone metastases. With this statistical approach, urine N-telopeptide measurements had the highest Z-score and the most significant association with the probability of bone metastases. Urine deoxypyridinoline was the second most predictive marker of bone metastases. Thus, biochemical markers of bone resorption might be of use to predict the presence of bone metastases in cancer patients and to monitor the efficacy of antiresorptive therapy in patients treated for metastatic bone disease.

scholarly journals Early Changes in Biochemical Markers of Bone Turnover Predict the Long-Term Response to Alendronate Therapy in Representative Elderly Women: A Randomized Clinical Trial

1998 ◽  
Vol 13 (9) ◽  
pp. 1431-1438 ◽  
Author(s):  
Susan L. Greenspan ◽  
Robert A. Parker ◽  
Lauren Ferguson ◽  
Harold N. Rosen ◽  
Lauri Maitland-Ramsey ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Turnover ◽  
Randomized Clinical Trial ◽  
Biochemical Markers ◽  
Elderly Women ◽  
Markers Of Bone Turnover ◽  
Term Response
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