scholarly journals Diurnal rhythm of free estradiol during the menstrual cycle

2003 ◽  
Vol 148 (2) ◽  
pp. 227-232 ◽  
Author(s):  
AM Bao ◽  
RY Liu ◽  
EJ van Someren ◽  
MA Hofman ◽  
YX Cao ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Diurnal Rhythm ◽  
Luteal Phase ◽  
Temporal Organization ◽  
Menstrual Phase ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Reproductive Life ◽  
Periodic Regression ◽  
Free Estradiol

OBJECTIVE: To investigate the diurnal rhythm of estrogens in normally cyclic women during reproductive life. DESIGN: Multiple saliva sampling in normally cyclic healthy women during reproductive life at different phases of their menstrual cycles was carried out. METHODS: Salivary estradiol was measured by radioimmunoassay in samples collected every 2 h for 24 h from 15 normally cyclic healthy women during reproductive life during the menstrual phase, the late follicular/peri-ovulation phase, the early to mid luteal phase and the late luteal phase, respectively, of their menstrual cycles. The levels of salivary estradiol were analyzed by means of periodic regression. RESULTS: A daily biological rhythm of free estradiol was found after quantification with a nonlinear periodic regression model. The observed diurnal free estradiol rhythm consists of two major components: an asymmetrically peaked diurnal cycle and ultradian harmonics in the range of 6 to 12 h. The diurnal and ultradian rhythms were remarkably consistent throughout the menstrual cycle in terms of mesor (24 h mean level), peak width and amplitude. There was a tendency for the 24-h rhythm acrophases to converge in the early morning, while the acrophase of the menstrual phase occurred significantly later than in the late follicular/peri-ovulation phase. CONCLUSIONS: The diurnal rhythm of estradiol has a similar complex temporal organization for different menstrual phases. The menstrual cycle mainly modulates the acrophase of the diurnal rhythm.

Assessment of choroidal vascularity index during the menstrual cycle

2021 ◽  
pp. 112067212110576
Author(s):  
Nazife Aşikgarip ◽  
Emine Temel ◽  
Kemal Örnek
Keyword(s):  
Optical Coherence Tomography ◽  
Menstrual Cycle ◽  
Prospective Study ◽  
Luteal Phase ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Luminal Area ◽  
Choroidal Structure

Purpose To explore the effect of menstrual cycle on choroidal vascularity index (CVI). Methods Thirty six eyes of 36 healthy women were included in this prospective study. The menstrual cycles were regular and ranged from 28 to 30 days in length. Optical coherence tomography images were obtained in 3 different phases of the menstrual cycle. The choroidal thickness (CT), total choroidal area, luminal area, stromal area, and CVI were quantified. Results Mean subfoveal, nasal and temporal CT were significantly changed in mid-luteal phase in comparison to early follicular (p = 0.018, p = 0.006 and p = 0.001, respectively) and ovulatory phases (p = 0.037, p = 0.037, and p = 0.035, respectively). Mean CVI showed a significant change in mid-luteal phase when compared with early follicular (p = 0.001) and ovulatory phases (p = 0.036). Conclusion CVI seemed to be affected in mid-luteal phase of menstrual cycle. This should be considered while analyzing choroidal structure in otherwise healthy women.

Changes in Scores on the Mental Rotations Test during the Menstrual Cycle

1997 ◽  
Vol 84 (3) ◽  
pp. 955-961 ◽  
Author(s):  
M. Suzanne Moody
Keyword(s):  
Menstrual Cycle ◽  
College Women ◽  
Sex Difference ◽  
Educational Psychology ◽  
Luteal Phase ◽  
Female Students ◽  
Menstrual Phase ◽  
Paired Sample ◽  
Menstrual Cycles ◽  
Mental Rotations

The purpose of the study was to examine changes in performance on Vandenberg's Mental Rotations Test during the menstrual cycles of college women. Participants were 12 male and 34 female students recruited from undergraduate educational psychology and nursing classes at a large southeastern university. Each woman was tested once during the menstrual phase and once during the luteal phase of her menstrual cycle. Phases in which the testings occurred were counterbalanced. Men were also tested twice. For all participants, the two testing sessions were held exactly 14 days apart. Women who were contraceptive pill users did not perform significantly differently during either phase from women who were nonusers, and there was no interaction for pill use by phase. Therefore, users and nonusers were combined for a paired-sample t test which indicated that women scored significantly higher during the menstrual phase (Days 2–7) than during the luteal phase (Days 16–22 for 31 women and Days 24–26 for three women with longer cycles). The 12 men scored significantly higher than the 34 women during the initial testing; but not significantly higher than the 17 women who were in the menstrual phase during the first testing. Therefore, that the effect of the phase of menstrual cycle influences the sex difference in performance on the Mental Rotations Test was supported.

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

scholarly journals KLK3 as a possible novel early biomarker of environmental exposure in young women living in Polluted area

2021 ◽  
Author(s):  
Salvatore Raimondo ◽  
Mariacira Gentile ◽  
Giusy Esposito ◽  
Tommaso Gentile ◽  
Ida Ferrara ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Environmental Impact ◽  
Environmental Exposure ◽  
Luteal Phase ◽  
Prostate Gland ◽  
Environmental Pollutants ◽  
Biological Marker ◽  
Mean Values ◽  
Healthy Women ◽  
Early Biomarker

Abstract Background: Kallikrein Related Peptidase 3 (KLK3) is secreted by Skene's glands and, is considered ancestral homologues of the male prostate gland and has long been used as a biological marker of prostate cancer. Recent studies have shown that the synthesis of KLK3 can be induced by steroid hormones in different tissues of women and in the menstrual cycle it seems to follow the cyclic variation of estradiol and progesterone. In addition, some environmental pollutants such as bisphenols, phthalate / DBP (DiButyl Phthalate) affect AR (Androgen Receptors) mediated signalling that directly regulates KLK3 secretion. This suggests that environmental factors may play a role in KLK3 secretion.Methods: 61 healthy women living in a high environmental impact (HEI) area, 58 healthy women living in a low environmental impact (LEI) area were evaluated on possible presence or changes of KLK3 in serum at different phases of the menstrual cycle: blood samples taken in the follicular phase 5th-6th day, ovulatory phase 12th -13th day and luteal phase 19th -20th day of the menstrual cycle. For this aim, an ultra-sensitive kit for KLK3 with a detection limit of 0.001 ng / mL was used.Results KLK 3 values​​showed two opposite peaks, women from HEI had a positive peak in the ovulatory phase with mean value of 9.90 ± 3.21 pg / mL while women from LEI had a negative peak in the ovulatory phase with mean values ​​of 3.07 ± 1.49 pg / mL. Progesterone, showed a correlation with KLK3. Women from HEI had higher KLK3 values on average and no significant changes were evident between the three withdrawals in the different phases of the cycle. In contrast, women from LEI had a statistically significant decrease between the follicular and ovulatory phase (p <0.0001) and a statistically significant increase (p <0.0001) between the ovulatory and luteal phase.Conclusions: The data obtained seem to go beyond the known role of KLK3. The dosage of KLK3 during the various phases of the menstrual cycle, simple to carry out and with low costs, can represent an effective and early biomarker to assess environmental exposure and useful to recognize the risk early and protect female health, not only reproductive.

scholarly journals Menstrual Cycle and Surgical Treatment of Breast Cancer: Findings From the NCCTG N9431 Study

2009 ◽  
Vol 27 (22) ◽  
pp. 3620-3626 ◽  
Author(s):  
Clive S. Grant ◽  
James N. Ingle ◽  
Vera J. Suman ◽  
Daniel A. Dumesic ◽  
D. Lawrence Wickerham ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Adjuvant Radiation ◽  
Menstrual Phase ◽  
Menstrual Cycle Phase ◽  
Hormone Levels ◽  
Menstrual History

Purpose For nearly two decades, multiple retrospective reports, small prospective studies, and meta-analyses have arrived at conflicting results regarding the value of timing surgical intervention for breast cancer on the basis of menstrual cycle phase. We present the results of a multi–cooperative group, prospective, observational trial of menstrual cycle phase and outcome after breast cancer surgery, led by the North Central Cancer Treatment Group (NCCTG) in collaboration with the National Surgical Adjuvant Breast and Bowel Project (NSABP) and the International Breast Cancer Study Group (IBCSG). Patients and Methods Premenopausal women age 18 to 55 years, who were interviewed for menstrual history and who were surgically treated for stages I to II breast cancer, had serum drawn within 1 day of surgery for estradiol, progesterone, and luteinizing hormone levels. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. Disease-free survival (DFS) and overall survival (OS) rates were determined by Kaplan-Meier method and were compared by using the log-rank test and Cox proportional hazard modeling. Results Of 1,118 women initially enrolled, 834 women comprised the study cohort: 230 (28%) in luteal phase; 363 (44%) in follicular phase; and 241 grouped as other. During a median follow-up of 6.6 years, and in analysis that accounted for nodal disease, estrogen receptor status, adjuvant radiation therapy or chemotherapy, neither DFS nor OS differed with respect to menstrual phase. The 5-year DFS rates were 82.7%, 82.1%, and 79.2% for follicular, luteal, or other phases, respectively. Corresponding OS survival rates were 91.9%, 92.2%, and 91.8%, respectively. Conclusion When menstrual cycle phases were strictly defined, neither DFS nor OS differed between women who underwent surgery during the follicular phase versus the luteal phase. Nearly 30% of the patients did not meet criteria for either follicular- or luteal-phase categories.

P–643 Is Euploid blastocyst number higher in luteal versus follicular phase? A case-control study of IVF outcomes of follicular versus luteal phase ovarian stimulation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Biscaro ◽  
A R Lorenzon ◽  
E L Motta ◽  
C Gomes
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Stimulation ◽  
Luteal Phase ◽  
Case Control Study ◽  
Case Control ◽  
Follicular Phase ◽  
Menstrual Cycles ◽  
Ivf Outcomes ◽  
Control Study ◽  
Luteal Phase Ovarian Stimulation

Abstract Study question Is there a difference between IVF outcomes in patients undergoing follicular versus luteal phase ovarian stimulation in different menstrual cycles? Summary answer Number of euploid blastocyst were higher in luteal phase ovarian stimulation IVF cycles. All other outcomes were similar between follicular and luteal phase IVF cycles. What is known already It has been published that human beings can have two or three follicular recruitment waves as observed in animals studies a long time ago. From these findings, several recent studies showed that two egg retrievals at the same menstrual cycle, named as Duo Stim, optimize time and IVF outcomes in women with low ovarian reserve due to more eggs retrieved in a shorter period with consequently higher probability of having good embryos to transfer. However, there is no knowledge about diferences concerning IVF outcomes between folicular and luteal ovarian stimulation, performed at the same women in different menstrual cycles. Study design, size, duration Retrospective, case-control study in a single IVF center. One-hundred-two patients who had two IVF treatments – the first cycle initiating ovarian stimulation at follicular phase (FPS) and the second cycle initiating after a spontaneous ovulation at luteal phase (LPS) – in different menstrual cycles (until 6 months apart) between 2014 and 2020, were included. Statistical analysis was performed with Mann-Whitney test and was considered significant when p ≤ 0.05. Data is represented as mean±SD. Participants/materials, setting, methods Patients underwent two IVF treatments in different menstrual cycles; the FPS IVF treatment was initiating at D2/D3 of menstrual cycle and the LPS treatment started three or four days after spontaneous ovulation, if at least 4 antral follicles were detected. Both IVF treatments were performed with and antagonist protocol and freeze all strategy. The majority of patients presents low ovarian reserve/Ovarian age as primary infertility factor (84.3%). Main results and the role of chance Patient’s mean age was 39.30±3.15 years, BMI (22.66±3.16) and AMH levels (0.85±0.85 ng/mL). Comparison of hormonal levels at the beginning of ovarian stimulation showed differences for FPS vs LPS, as expected: E2 (39.69±31,10 pg/mL vs 177.33±214.26 pg/mL,p&lt; 0.0001) and P4 (0.76±2.47ng/mL vs 3,00±5.00 ng/mL,p&lt; 0.0001). However, E2 and P4 at the day of oocyte maturation trigger were not different between FPS and LPS (1355.24±895.73 pg/mL vs 1133.14±973.01 ng/mL,p=0.0883 and 1.12±1.49 ng/mL vs 2.94±6.51,p=0.0972 respectively). There was no difference for total dose of gonadotrofins (FPS 2786.43±1102.39.01UI vs LPS 2824.12±1188.87UI, p = 0,8578), FSH (FPS 9.50±4.98 vs LPS 11.90±12.99,p=0.7502) and AFC (FPS 7.13±4.25 vs LPS 6.42±4.65,p=0,0944). From 102 patients that started ovarian stimulation, 78 had 1 or more oocyte collect in FPS group and 75 in LPS group: OPU (FPS 4.78±4.93 vs LPS 4.65±5.54,p=0.7889), number of MII (FPS 3.21±3.52 vs LPS 3.40±4.53,p=0.7889). From those, 52 patients performed ICSI in both cycles; fertilization rate 64.9%±28.6% for FPS vs 62.1%±32.4% for LPS,p=0.7899) and blastocyst formation 2.15±2.15 for FPS vs 2.54±2.35,p=0.3496). Data from 25 patients who had embryo biopsy for PGT-A showed similar number of blastocyst biopsed (2.12±1.72 FPS vs 2.48±1.71 LPS,p=0.3101) and a statistically significant difference regarding number of euploid blastocyst (0,20±0,41 FPS vs 0,96±0,93 LPS,p=0,0008). Limitations, reasons for caution This is a retrospective study in a limited number of patients. Therefore, it is not possible to make a definitive conclusion that LPS proportionate higher number of euploid than FPS. More studies are necessary to investigate not only IVF outcomes but also the impact on pregnancy rates. Wider implications of the findings: In our study, LPS protocol after spontaneous ovulation, presents similar IVF outcomes compared to routinely FPS protocol. Intriguingly, the number of euploid blastocyst was significant higher in LPS, which may be further investigated. In this way, LPS is another option of IVF treatment, and may optimize time and treatment results. Trial registration number Not applicable

scholarly journals Aggression predicts Cortisol Awakening Response in healthy young adults

2015 ◽  
Vol 31 (3) ◽  
pp. 1044 ◽  
Author(s):  
Patricia Sariñana-González ◽  
Sara Vitoria-Estruch ◽  
Ángel Romero-Martínez ◽  
Luis Moya-Albiol
Keyword(s):  
Menstrual Cycle ◽  
Physical Aggression ◽  
Luteal Phase ◽  
Verbal Aggression ◽  
Follicular Phase ◽  
Self Report ◽  
Cortisol Awakening Response ◽  
Menstrual Phase ◽  
Free Cortisol ◽  
Do So

Few studies have examined therelationship between the cortisol awakening response (CAR) and aggression inhealthy youth adults. This study analyzes this relationship in 83 women (38 inluteal phase and 45 in follicular phase of menstrual cycle) and 20 men.Salivary-free cortisol measures of the CAR were obtained immediately followingawakening and 30, 45, and 60 minutes afterwards. Additionally, participantscompleted a self-report of aggression. Men presented lower levels of CAR thanwomen in luteal phase. Men were also liable to present more physical aggressionthan women, independently of their menstrual phase. General aggression andspecifically verbal aggression are predictors of CAR in men. In women, verbalaggression predicts CAR during the follicular phase of the menstrual cycle;whereas anger and physical aggression do so during the luteal phase. CAR may beused as a valid marker of proneness to aggression – but must be considered differentlydepending on gender and menstrual cycle of women. This study offers relevantinformation on the hormonal bases of aggression and so contributes to theliterature on alleviating problems related to violence.

scholarly journals Influence of female hormonal fluctuation on maximum occlusal force

2011 ◽  
Vol 22 (6) ◽  
pp. 497-501
Author(s):  
Thaís Marques Simek Vega Gonçalves ◽  
Lucíola Maria Rodrigues de Vasconcelos ◽  
Wander José da Silva ◽  
Altair Antoninha Del Bel Cury ◽  
Renata Cunha Matheus Rodrigues Garcia
Keyword(s):  
Menstrual Cycle ◽  
Test Data ◽  
Oral Contraceptives ◽  
Occlusal Force ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Hormonal Fluctuations ◽  
One Way Anova ◽  
Molar Region ◽  
Hormonal Levels

Hormonal fluctuations during the menstrual cycle may influence on muscular tensions and probably alter occlusal force. The aim of this study was to evaluate whether hormonal levels affect maximum occlusal force (MOF) of healthy women throughout the different phases of the menstrual cycle. Sixty complete dentate subjects who were not under use of oral contraceptives were selected to participate in this study. MOF was bilaterally evaluated on the molar region, during 3 complete menstrual cycles, using 5.65 mm-wide sensors. Measurements were carried out during each of the following menstrual cycle phases: menstrual, follicular, periovulatory and luteal, presumed by ovulation test. Data were analyzed by one-way ANOVA and Tukey-Kramer test (p<0.05). Comparisons among menstrual cycle phases showed no differences on MOF (p=0.27). Under the conditions of this study, it may be concluded that hormonal fluctuations during the menstrual cycle do not affect MOF of a sample of healthy women.

scholarly journals Correlation between endometrial dating of luteal phase days 6 and 10 of the same menstrual cycle

1998 ◽  
Vol 116 (3) ◽  
pp. 1734-1737 ◽  
Author(s):  
Jorge Haddad Filho ◽  
Agnaldo Pereira Cedenho ◽  
Vilmon de Freitas
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Endometrial Thickness ◽  
Human Reproduction ◽  
Progesterone Level ◽  
Ovulatory Cycle ◽  
Plasma Progesterone ◽  
Menstrual Cycles ◽  
Infertile Couples ◽  
Study Setting

CONTEXT: Endometrial maturation, important in the diagnosis of infertile couples, has been evaluated since 1950 using the Noyes criteria. Nevertheless, there is no consensus regarding the most suitable period of the luteal phase for performing the biopsy. OBJETIVE: This study evaluated the correlation between the histological dating of two endometrial biopsies performed in the same menstrual cycle, on luteal phase days six and ten. DESIGN: Prospective study. SETTING: Human Reproduction Division of the Federal University of São Paulo, referral center. PATIENTS:Twenty-five women complaining of infertility had their menstrual cycles monitored by ultrasound and LH plasma levels, to obtain evidence of ovulation. PROCEDURES: Endometrial biopsies were performed on luteal phase days LH+6 and LH+10 (luteal phase day 1 = LH+1 = the day that follows LH peak). Dating was done according to morphometric criteria, in which an endometrium sample is considered out of phase if the minimum maturation delay is one day. On day LH+6, blood was drawn for plasma progesterone level determination. RESULTS: All patients had an ovulatory cycle (mean LH peak: 47.4 U/L; mean follicular diameter on LH peak day: 18.9 mm; mean endometrial thickness on LH peak day: 10.3 mm; mean plasma progesterone level on day LH+6: 14.4 ng/ml). 14 patients had both biopsies in phase; 5 patients had out of phase biopsies only on day LH+6; 3 had out of phase biopsies only on day LH+10 and 3 patients had out of phase biopsies on both days. McNemar's test showed no statistical difference between these data (p>33.36%). CONCLUSIONS: The correlation found between the endometrial datings suggests that biopsies performed on either of these two days are suitable for evaluation of endometrial maturation.

Food craving, mood and the menstrual cycle

1988 ◽  
Vol 18 (4) ◽  
pp. 855-860 ◽  
Author(s):  
John Bancroft ◽  
Ann Cook ◽  
Lynn Williamson
Keyword(s):  
Menstrual Cycle ◽  
Food Craving ◽  
Menstrual Phase ◽  
Mood Change ◽  
Menstrual Cycles ◽  
Sweet Foods ◽  
Retrospective Questionnaire

SynopsisSeventy-six women, with a mean age of 35–7 years, who reported premenstrual craving for sweet foods in a retrospective questionnaire, were assessed prospectively with a pre- and postmenstrual eating questionnaire and daily ratings of craving, mood, irritability and breast tenderness over two menstrual cycles.In 72 % of these women a perimenstrual pattern of food craving was confirmed. In 13 % this craving was confined to the menstrual phase. There was no consistent association between food craving and mood change, either in timing or severity. Women with more severe mood change did not report more severe craving. There was also no association between food craving and cyclical breast tenderness. Perimenstrual food craving, therefore, appears to be a cyclical phenomenon in its own right, of uncertain aetiology and worthy of further study.

Sign in / Sign up

Export Citation Format

Share Document