scholarly journals Relationship between growth hormone deficiency and oxidative stress in patients with heart failure: Preliminary data.

2014 ◽  
Author(s):  
Antonio Mancini ◽  
Sebastiano Raimondo ◽  
Chantal Di Segni ◽  
Giovanni Gadotti ◽  
Francesco Leo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Preliminary Data ◽  
Hormone Deficiency ◽  
Patients With Heart Failure ◽  
And Oxidative Stress

scholarly journals Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0248971
Author(s):  
Antonio Mancini ◽  
Francesco Guidi ◽  
Carmine Bruno ◽  
Flavia Angelini ◽  
Edoardo Vergani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Hormone ◽  
Pilot Study ◽  
Oxidative Damage ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Serum Samples ◽  
Adult Growth ◽  
Significant Difference ◽  
Thymidine Glycol

Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage analysing the production of thymidine-glycol in lymphocytes and its correlation with plasma antioxidant levels, evaluated as Total Antioxidant Capacity (TAC). GHD was diagnosed using GHRH 50μg iv+arginine 0,5 g/Kg test, with peak GH response <9 μg/L when BMI was <30 kg/m2 or <4 μg/L when BMI was >30 kg/m2. Three groups were identified: total GHD (n = 16), partial GHD (n = 11), and controls (n = 12). Thymidine-glycol, TAC and IGF-1 have been determined respectively in lymphocytes, plasma and serum samples. When considering thymidine-glycol, we found a significant difference between total vs partial GHD and controls. Unexpectedly thymidine-glycol was lower in total GHD, also accompanied with a significant increase in plasmatic TAC. Our results showed that in adult GHD condition, the production of antioxidant species, in response to increased oxidative stress, could exert a protective effect on thymidine-glycol formation, and consequently on DNA intracellular damages. This pilot study could be inserted in the complex scenario of oxidative damage of GHD, a subtle, yet poorly defined condition, worthy of further insights.

scholarly journals Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction

2009 ◽  
Vol 94 (9) ◽  
pp. 3329-3336 ◽  
Author(s):  
Antonio Cittadini ◽  
Lavinia Saldamarco ◽  
Alberto Maria Marra ◽  
Michele Arcopinto ◽  
Guido Carlomagno ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Hormone ◽  
Chronic Heart Failure ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Beneficial Effects

scholarly journals Evaluation of oxidative stress effects on different macromolecules in adult growth hormone deficiency

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236357
Author(s):  
Antonio Mancini ◽  
Carmine Bruno ◽  
Edoardo Vergani ◽  
Francesco Guidi ◽  
Flavia Angelini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Adult Growth Hormone Deficiency ◽  
Stress Effects ◽  
Adult Growth
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