Vitamin D metabolites and IL1[beta] RS16944 polymorphism in type 2 diabetes patients: evidence for functional interaction

2017 ◽  
Author(s):  
Nojan Nejatian ◽  
Marissa Penna-Martinez ◽  
Klaus Badenhoop
2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ramu Adela ◽  
Roshan M Borkar ◽  
Murali Mohan Bhandi ◽  
Gayatri Vishwakarma ◽  
P. Naveen Chander Reddy ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2223-PUB
Author(s):  
STEPHEN ATKIN ◽  
ALEXANDRA E. BUTLER

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sandhiya Selvarajan ◽  
Akila Srinivasan ◽  
Deepanjali Surendran ◽  
Jayanthi Mathaiyan ◽  
Sadishkumar Kamalanathan

Abstract Objectives To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Methods In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR). Results About 69.2% of type 2 diabetes patients were found to have vitamin D deficiency. FokI polymorphism showed variations in serum 25 (OH) D levels, with AA and AG genotypes having significantly lower serum 25 (OH) D levels as compared to GG [13.24 (8.4) ng/ml, 15.02 (7.07) ng/ml and 20.67 (13.64) ng/ml respectively]. There was no difference in HbA1c levels with respect to the vitamin D levels and VDR polymorphisms. Conclusions AA and AG genotypes of FokI polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.


2011 ◽  
Vol 5 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Sunil Kumar Kota ◽  
Sruti Jammula ◽  
Siva Krishna Kota ◽  
Prabhas Ranjan Tripathy ◽  
Sandip Panda ◽  
...  

2012 ◽  
Vol 188 (3) ◽  
pp. 1325-1332 ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Omar Al-Attas ◽  
Majed S. Alokail ◽  
Khalid M. Alkharfy ◽  
Hossam M. Draz ◽  
...  

Author(s):  
Sadishkumar Kamalanathan ◽  
Saibal Das ◽  
Akila Srinivasan ◽  
Nishanthi Anandabaskar ◽  
Jayaprakash Sahoo ◽  
...  

2017 ◽  
Vol 18 (7) ◽  
pp. 1532 ◽  
Author(s):  
Alexander Koch ◽  
Georgios Grammatikos ◽  
Sandra Trautmann ◽  
Yannick Schreiber ◽  
Dominique Thomas ◽  
...  

2021 ◽  
Vol 7 (3) ◽  
pp. 79-84
Author(s):  
  Dr. Amal Krishna Paul ◽  
Dr. Arifa Sultana ◽  
Dr. Ismat Ara Begum

Medicine ◽  
2019 ◽  
Vol 98 (14) ◽  
pp. e14970 ◽  
Author(s):  
Zhiwei Hu ◽  
Jin’an Chen ◽  
Xinjuan Sun ◽  
Lei Wang ◽  
Aiping Wang

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