Dietary intervention modulates the expression of the splicing machinery in patients at high-risk of type 2 diabetes development: clinical implications

2018 ◽  
Author(s):  
Rio-Moreno Mercedes del ◽  
Emilia Alors-Perez ◽  
Antonio Camargo ◽  
Javier Delgado-Lista ◽  
Juan L. Lopez-Canovas ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Dietary Intervention ◽  
Clinical Implications ◽  
Diabetes Development ◽  
Splicing Machinery

scholarly journals A Web-Based Dietary Intervention for People with Type 2 Diabetes: Development, Implementation, and Evaluation

2014 ◽  
Vol 22 (3) ◽  
pp. 365-373 ◽  
Author(s):  
Amutha Ramadas ◽  
Carina Ka Yee Chan ◽  
Brian Oldenburg ◽  
Zanariah Hussien ◽  
Kia Fatt Quek
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intervention ◽  
Web Based ◽  
Diabetes Development

scholarly journals Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3528
Author(s):  
Mercedes del Río-Moreno ◽  
Raúl M. Luque ◽  
Oriol A. Rangel-Zúñiga ◽  
Emilia Alors-Pérez ◽  
Juan F. Alcalá-Diaz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intervention ◽  
Mononuclear Cells ◽  
Dietary Interventions ◽  
Peripheral Blood Mononuclear ◽  
Major Health Problem ◽  
Cardiovascular Patients ◽  
Fat Diets ◽  
Splicing Machinery

Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Thus, the aim of this work was to evaluate the influence of 3-year dietary intervention in the expression pattern of the splicing machinery components in peripheral blood mononuclear cells (PBMCs) from patients within the CORDIOPREV study. Expression of splicing machinery components was determined in PBMCs, at baseline and after 3 years of follow-up, from all patients who developed T2DM (Incident-T2DM, n = 107) and 108 randomly selected non-T2DM subjects, who were randomly enrolled in two healthy dietary patterns (Mediterranean or low-fat diets). Dietary intervention modulated the expression of key splicing machinery components (i.e., up-regulation of SPFQ/RMB45/RNU6, etc., down-regulation of RNU2/SRSF6) after three years, independently of the type of healthy diet. Some of these changes (SPFQ/RMB45/SRSF6) were associated with key clinical features and were differentially induced in Incident-T2DM patients and non-T2DM subjects. This study reveals that splicing machinery can be modulated by long-term dietary intervention, and could become a valuable tool to screen the progression of T2DM.

scholarly journals New Sub-Phenotyping of Subjects at High Risk of Type 2 Diabetes: What Are the Potential Clinical Implications?

2021 ◽  
Author(s):  
Djordje S. Popovic ◽  
Manfredi Rizzo ◽  
Edita Stokic ◽  
Nikolaos Papanas
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Clinical Implications

Identification of a spliceosome-associated fingerprint with potential to predict development of type 2 diabetes in high-risk patients

2016 ◽  
Author(s):  
Raul M. Luque ◽  
Manuel D. Gahete ◽  
Mercedes del Rio-Moreno ◽  
Sergio Pedraza-Arevalo ◽  
Antonio Camargo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
High Risk Patients ◽  
Risk Patients

2-OR: Impact of N Terminal Pro B-Type Natriuretic Peptide and High Sensitivity Cardiac Troponin on the Prediction of Death and Cardiovascular Events in High-Risk Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2-OR
Author(s):  
MARCUS V.B. MALACHIAS ◽  
PARDEEP JHUND ◽  
BRIAN CLAGGETT ◽  
MAGNUS O. WIJKMAN ◽  
RHONDA BENTLEY-LEWIS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Cardiovascular Events ◽  
High Sensitivity ◽  
High Risk Patients ◽  
Risk Patients
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