When locoregional recurrences (LRR) in papillary thyroid carcinoma (PTC) can be repeatedly eliminated by ultrasound-guided percutaneous ethanol ablation (UPEA) and appropriate use of dermatologic surgery, cervical skin metastases (SM) in low risk PTC (LRPTC) can be associated with an excellent long-term prognosis

2018 ◽  
Author(s):  
Nicole Iniguez-Ariza ◽  
Jerry Brewer ◽  
Ian Hay ◽  
Robert Lee
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Low Risk ◽  
Dermatologic Surgery ◽  
Papillary Thyroid ◽  
Ultrasound Guided ◽  
Appropriate Use ◽  
Ethanol Ablation ◽  
Long Term Prognosis

scholarly journals Low-risk papillary thyroid carcinoma

2019 ◽  
Vol 98 (6) ◽  
pp. 403-407
Author(s):  
Caio Nassuo Furukawa ◽  
Leonardo André Hage Fabri ◽  
Flávio Carneiro Hojaij
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Active Surveillance ◽  
Hormone Replacement ◽  
Good Alternative ◽  
Low Risk ◽  
Papillary Thyroid ◽  
Risk Patients ◽  
Immediate Surgery

Introduction: A epidemic increase in the incidence of papillary thyroid carcinoma (PTC) has been happening within the last 25 years. The majority of those tumors are low-risk, and some studies reported low progression rates of low-risk PTC. It suggests that immediate surgery may not be the best option, specially when considering the intrinsic risk to a thyroidectomy and inconvenience of lifelong hormone replacement. In this systematic review we compare the outcomes of active surveillance for the primary management of low-risk PTC. Methods: The review was conducted based on three studies selected from specific databases. These studies followed up low-risk patients nonoperatively and surgery was performed if needed. Results: All studies reported low percentages of tumor growth and metastatic disease during active surveillance. Furthermore, no significant differences between immediate surgery and late rescue surgery were reported, and active surveillance appears to be cheaper than the tradicional conduct. Conclusions: Active surveillance seems to be a good alternative for low-risk PTC management, yet, more long-term and bigger research is still needed, specially outside of a japanese population.

scholarly journals Long-Term Efficacy of Ethanol Ablation as Treatment of Metastatic Lymph Nodes from Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Pål Stefan Frich ◽  
Eva Sigstad ◽  
Audun Elnæs Berstad ◽  
Kristin Fagerlid Holgersen ◽  
Trond Harder Paulsen ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Papillary Thyroid ◽  
Ethanol Ablation ◽  
Metastatic Lymph Nodes ◽  
Term Efficacy ◽  
Metastatic Lymph

Abstract Context Ethanol ablation (EA) is considered an alternative to surgery for metastatic lymph nodes from papillary thyroid carcinoma (PTC) in selected patients. Objective The aim of this study was to evaluate the long-term efficacy and safety of this particular treatment. Design and setting Adult patients with PTC who had received EA in lymph node metastasis at a tertiary referral center, and were included in a published study from 2011, were invited to participate in this follow-up study. Methods Radiologic- and medical history were reviewed. Ultrasound examination of the neck was performed by radiologists, and clinical examination was performed by an endocrine surgeon. Response was reported according to predefined criteria for satisfactory EA-treatment. Adverse events associated with EA were evaluated. Cause of death was reported for deceased patients. Results From the 2011-study 51 of 63 patients were included. Forty-four patients were reexamined (67/109 lesions) and 7 patients were deceased. Median follow-up time from primary surgery was 14.5 years. Median follow-up from the latest performed EA in the 2011 study was 11.3 years. Local control was permanently achieved in most patients (80 %). Recurrence within an ablated node was registered in 13 metastases in 10 patients. Seven of these patients also had recurrent disease elsewhere in the neck. No major side effects were reported. Conclusion EA is a minimally invasive procedure with a low risk of complications. Our data suggest that EA is a safe and efficient treatment, providing excellent results for a large group of patients also in the long term.

scholarly journals Macrofollicular Variant of Papillary Thyroid Carcinoma: Its Clinicopathological Features and Long-Term Prognosis

2009 ◽  
Vol 56 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Mitsuhiro FUKUSHIMA ◽  
Yasuhiro ITO ◽  
Mitsuyoshi HIROKAWA ◽  
Kaoru KOBAYASHI ◽  
Akihiro MIYA ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Long Term Prognosis

Papillary Thyroid Carcinoma: How Radical Lymphadenectomy Should be Performed?

Swiss Surgery ◽  
2003 ◽  
Vol 9 (2) ◽  
pp. 63-68
Author(s):  
Schweizer ◽  
Seifert ◽  
Gemsenjäger
Keyword(s):  
High Risk ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Low Risk ◽  
Papillary Thyroid ◽  
Sentinel Nodes ◽  
Fand Sich ◽  
Radical Lymphadenectomy ◽  
N Status

Fragestellung: Die Bedeutung von Lymphknotenbefall bei papillärem Schilddrüsenkarzinom und die optimale Lymphknotenchirurgie werden kontrovers beurteilt. Methodik: Retrospektive Langzeitstudie eines Operateurs (n = 159), prospektive Dokumentation, Nachkontrolle 1-27 (x = 8) Jahre, Untersuchung mit Bezug auf Lymphknotenbefall. Resultate: Staging. Bei 42 Patienten wurde wegen makroskopischem Lymphknotenbefall (cN1) eine therapeutische Lymphadenektomie durchgeführt, mit pN1 Status bei 41 (98%) Patienten. Unter 117 Patienten ohne Anhalt für Lymphknotenbefall (cN0) fand sich okkulter Befall bei 5/29 (17%) Patienten mit elektiver (prophylaktischer) Lymphadenektomie, und bei 2/88 (2.3%) Patienten ohne Lymphadenektomie (metachroner Befall) (p < 0.005). Lymphknotenrezidive traten (1-5 Jahre nach kurativer Primärtherapie) bei 5/42 (12%) pN1 und bei 3/114 (2.6%) cN0, pN0 Tumoren auf (p = 0009). Das 20-Jahres-Überleben war bei TNM I + II (low risk) Patienten 100%, d.h. unabhängig vom N Status; pN1 vs. pN0, cN0 beeinflusste das Überleben ungünstig bei high risk (>= 45-jährige) Patienten (50% vs. 86%; p = 0.03). Diskussion: Der makroskopische intraoperative Lymphknotenbefund (cN) hat Bedeutung: - Befall ist meistens richtig positiv (pN1) und erfordert eine ausreichend radikale, d.h. systematische, kompartiment-orientierte Lymphadenektomie (Mikrodissektion) zur Verhütung von - kurablem oder gefährlichem - Rezidiv. - Okkulter Befall bei unauffälligen Lymphknoten führt selten zum klinischen Rezidiv und beeinflusst das Überleben nicht. Wir empfehlen eine weniger radikale (sampling), nur zentrale prophylaktische Lymphadenektomie, ohne Risiko von chirurgischer Morbidität. Ein empfindlicherer Nachweis von okkultem Befund (Immunhistochemie, Schnellschnitt von sampling Gewebe oder sentinel nodes) erscheint nicht rational. Bei pN0, cN0 Befund kommen Verzicht auf 131I Prophylaxe und eine weniger intensive Nachsorge in Frage.

scholarly journals Long-term survival in a patient with brain metastases of papillary thyroid carcinoma

2016 ◽  
pp. bcr2015213824
Author(s):  
Daniela Guelho ◽  
Cristina Ribeiro ◽  
Miguel Melo ◽  
Francisco Carrilho
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Brain Metastases ◽  
Papillary Thyroid ◽  
Term Survival ◽  
Long Term Survival
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