The potential role of androgens as early determinants of body composition and metabolic health.

2021 ◽  
Author(s):  
Thiberiu Banica ◽  
Charlotte Verroken ◽  
Zmierczak Hans-Georg ◽  
Stefan Goemaere ◽  
Guy T’Sjoen ◽  
...  
Keyword(s):  
Body Composition ◽  
Potential Role ◽  
Metabolic Health

scholarly journals Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1940
Author(s):  
Anh N. Nguyen ◽  
Susana Santos ◽  
Kim V. E. Braun ◽  
Trudy Voortman
Keyword(s):  
Early Childhood ◽  
Body Composition ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Metabolic Health ◽  
Carbohydrate Intake ◽  
Fat Free Mass ◽  
Total Carbohydrate ◽  
Blood Concentrations

High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participating in a population-based cohort in the Netherlands. Intake of total carbohydrate, monosaccharides and disaccharides, and polysaccharides at age 1 year was assessed with a food-frequency questionnaire. We repeatedly measured children’s height and weight to calculate BMI between their ages of 1 and 10 years. At ages 6 and 10 years, fat and fat-free mass were measured with dual-energy X-ray-absorptiometry and blood concentrations of triglycerides, cholesterol, and insulin were obtained. For all outcomes, we calculated age and sexspecific SD-scores. In multivariable-adjusted linear mixed models, we found no associations of intake of carbohydrates or its subtypes with children’s BMI or body composition. A higher intake of monosaccharides and disaccharides was associated with higher triglyceride concentrations (0.02 SDS per 10 g/day, 95% CI: 0.01, 0.04). Higher monosaccharide and disaccharide intake was also associated with lower HDL-cholesterol (−0.03 SDS, 95% CI: −0.04; −0.01), especially when it replaced polysaccharides. Overall, our findings suggest associations of higher monosaccharide and disaccharide intake in early childhood with higher triglyceride and lower HDL-cholesterol concentrations, but do not support associations with body composition.

Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 444-450 ◽  
Author(s):  
W. T. Garvey ◽  
L. Maianu ◽  
A. Kennedy ◽  
P. Wallace ◽  
E. Ganaway ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Potential Role ◽  
The Novel ◽  
Human Metabolism

Muscle Rad Expression and Human Metabolism: Potential Role of the Novel Ras-Related GTPase in Energy Expenditure and Body Composition

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 444-450 ◽  
Author(s):  
W. T. Garvey ◽  
L. Maianu ◽  
A. Kennedy ◽  
P. Wallace ◽  
E. Ganaway ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Potential Role ◽  
The Novel ◽  
Human Metabolism

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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