Muscle Rad Expression and Human Metabolism: Potential Role of the Novel Ras-Related GTPase in Energy Expenditure and Body Composition

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 444-450 ◽  
Author(s):  
W. T. Garvey ◽  
L. Maianu ◽  
A. Kennedy ◽  
P. Wallace ◽  
E. Ganaway ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Potential Role ◽  
The Novel ◽  
Human Metabolism

Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 444-450 ◽  
Author(s):  
W. T. Garvey ◽  
L. Maianu ◽  
A. Kennedy ◽  
P. Wallace ◽  
E. Ganaway ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Potential Role ◽  
The Novel ◽  
Human Metabolism

scholarly journals Gut microbiota influence in type 2 diabetes mellitus (T2DM)

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
A. L. Cunningham ◽  
J. W. Stephens ◽  
D. A. Harris
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gut Microbiota ◽  
Potential Role ◽  
Evidence Base ◽  
Human Metabolism ◽  
Altered Glucose

AbstractA strong and expanding evidence base supports the influence of gut microbiota in human metabolism. Altered glucose homeostasis is associated with altered gut microbiota, and is clearly associated with the development of type 2 diabetes mellitus (T2DM) and associated complications. Understanding the causal association between gut microbiota and metabolic risk has the potential role of identifying susceptible individuals to allow early targeted intervention.

The potential role of androgens as early determinants of body composition and metabolic health.

2021 ◽  
Author(s):  
Thiberiu Banica ◽  
Charlotte Verroken ◽  
Zmierczak Hans-Georg ◽  
Stefan Goemaere ◽  
Guy T’Sjoen ◽  
...  
Keyword(s):  
Body Composition ◽  
Potential Role ◽  
Metabolic Health

scholarly journals Body composition and resting energy expenditure in humans: role of fat, fat-free mass and extracellular fluid

2000 ◽  
Vol 24 (9) ◽  
pp. 1153-1157 ◽  
Author(s):  
S Nielsen ◽  
DD Hensrud ◽  
S Romanski ◽  
JA Levine ◽  
B Burguera ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Extracellular Fluid ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Resting Energy

scholarly journals Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis

2018 ◽  
Author(s):  
Jin Li ◽  
Peng Yu
Keyword(s):  
Alternative Splicing ◽  
Computational Analysis ◽  
Potential Role ◽  
Exon Skipping ◽  
Chronic Inflammatory Disease ◽  
Splicing Factors ◽  
The Novel ◽  
Rna Seq ◽  
Genome Wide

AbstractPsoriasis is a chronic inflammatory disease that affects the skin, nails, and joints. For understanding the mechanism of psoriasis, though, alternative splicing analysis has received relatively little attention in the field. Here, we developed and applied several computational analysis methods to study psoriasis. Using psoriasis mouse and human datasets, our differential alternative splicing analyses detected hundreds of differential alternative splicing changes. Our analysis of conservation revealed many exon-skipping events conserved between mice and humans. In addition, our splicing signature comparison analysis using the psoriasis datasets and our curated splicing factor perturbation RNA-Seq database, SFMetaDB, identified nine candidate splicing factors that may be important in regulating splicing in the psoriasis mouse model dataset. Three of the nine splicing factors were confirmed upon analyzing the human data. Our computational methods have generated predictions for the potential role of splicing in psoriasis. Future experiments on the novel candidates predicted by our computational analysis are expected to provide a better understanding of the molecular mechanism of psoriasis and to pave the way for new therapeutic treatments.

scholarly journals Detection of single nucleotide polymorphisms at major prolificacy genes in the Mehraban sheep and association with litter size

2018 ◽  
Vol 18 (3) ◽  
pp. 685-698 ◽  
Author(s):  
Reza Talebi ◽  
Ahmad Ahmadi ◽  
Fazlollah Afraz ◽  
Julien Sarry ◽  
Florent Woloszyn ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Litter Size ◽  
Potential Role ◽  
Chromosome 6 ◽  
The Novel ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Hardy Weinberg Equilibrium ◽  
Gdf9 Gene

Abstract The present study aimed to investigate the presence of polymorphisms at four known genes controlling ovine prolificacy i.e. BMP15, GDF9, BMPR1B and B4GALNT2 in a sample of 115 Iranian Mehraban ewes and their association with litter size (LS) and lambs’ birth weight (BW) traits. Using Sanger sequencing of exons and polymorphism specific genotyping, ten SNPs (Single Nucleotide Polymorphisms) were observed in only two genes, GDF9 and BMPR1B. Seven SNPs were found in the GDF9 gene on the chromosome 5. Among them, six were already described in the coding sequence, and a new one (g.41840985C>T) was found in the 3’UTR. In the BMPR1B gene on the chromosome 6, three novel SNPs were detected in the exon 7 (g.29382184G>A; g.29382337G>A and g.29382340G>A). Allelic frequencies were established for six SNPs among the ten identified and they were in Hardy-Weinberg equilibrium. A significant association was found between the novel SNPs found in the exon 7 of BMPR1B and LS. Present results indicate the potential role of the BMPR1B locus in controlling prolificacy of Mehraban sheep and provide genetic markers for further exploitation in selection to improve reproductive efficiency.

The Role Of Spasticity In Body Composition And Energy Expenditure After Spinal Cord Injury

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S328
Author(s):  
Ashraf S. Gorgey ◽  
Anthony E. Chiodo ◽  
David R. Gater
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Body Composition ◽  
Energy Expenditure ◽  
Cord Injury

scholarly journals Three New Orbivirus Species Isolated from Farmed White-Tailed Deer (Odocoileus virginianus) in the United States

Viruses ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 13 ◽  
Author(s):  
Mohammad Shamim Ahasan ◽  
Kuttichantran Subramaniam ◽  
Juan M. Campos Krauer ◽  
Katherine A. Sayler ◽  
Julia C. Loeb ◽  
...  
Keyword(s):  
United States ◽  
Potential Role ◽  
Genetic Relatedness ◽  
Phylogenetic Analyses ◽  
The United States ◽  
Hemorrhagic Disease ◽  
The Novel ◽  
Viral Pathogens ◽  
Gene Coding

We report the detection and gene coding sequences of three novel Orbivirus species found in six dead farmed white-tailed deer in the United States. Phylogenetic analyses indicate that the new orbiviruses are genetically closely related to the Guangxi, Mobuck, Peruvian horse sickness, and Yunnan orbiviruses, which are thought to be solely borne by mosquitos. However, four of the six viruses analyzed in this work were found as co-infecting agents along with a known cervid pathogen, epizootic hemorrhagic disease virus-2 (EHDV-2), raising questions as to whether the new viruses are primary pathogens or secondary pathogens that exacerbate EHDV-2 infections. Moreover, EHDV-2 is known to be a Culicoides-borne virus, raising additional questions as to whether Culicoides species can also serve as vectors for the novel orbiviruses, if mosquitoes can vector EHDV-2, or whether the deer were infected through separate bites by the insects. Our findings expand knowledge of the possible viral pathogens of deer in the United States. Moreover, due to the close genetic relatedness of the three new orbiviruses to viruses that are primary pathogens of cattle and horses, our findings also underscore a crucial need for additional research on the potential role of the three new orbiviruses as pathogens of other animals.

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