Methodological quality of systematic reviews addressing therapeutic hypothermia and/or cooling therapy for traumatic brain injury

IntroductionTraumatic brain injury (TBI) leads to 50 000 deaths, 85 000 disabilities and costs $60 billion each year in the USA. Despite numerous interventions and treatment options, the outcomes of TBI have improved little over the last three decades. In a previous scoping review and expert consultation survey, we identified 13 potentially low-value clinical practices in acute TBI. The objective of this umbrella review is to synthesise the evidence on potentially low-value clinical practices in the care of acute TBI.Methods and analysisUsing umbrella review methodology, we will search Cochrane Central Register of Controlled Trials, Embase, Epistemonikos, International Prospective Register of Systematic Reviews (PROSPERO) and PubMed to identify systematic reviews evaluating the effect of potential intrahospital low-value practices using tailored population, intervention, comparator, outcome and study design questions based on the results of a previous scoping review. We will present data on the methodological quality of these reviews (Assessing the Methodological Quality of Systematic Reviews-2), reported effect sizes and strength of evidence (Grading of Recommendations, Assessment, Development and Evaluation).Ethics and disseminationEthics approval is not required as original data will not be collected. Knowledge users from five healthcare quality organisations and clinical associations are involved in the design and conduct of the study. Results will be disseminated in a peer-reviewed journal, at international scientific meetings and to clinical, healthcare quality and patient–partner associations. This work will support the development of metrics to measure the use of low-value practices, inform policy makers on potential targets for deimplementation and in the long term reduce the use of low-value clinical practices in acute TBI care.PROSPERO registration numberCRD42019132428.

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Poster 89 Clinical Outcomes and Methodological Quality of Complementary and Alternative Medicine Interventions in Traumatic Brain Injury

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2013.08.212 ◽

2013 ◽

Vol 94 (10) ◽

pp. e41-e42

Author(s):

Charles Rhoads ◽

Katherine Crum ◽

Mark A. Hirsch ◽

Jeffrey Eliason ◽

Paras Mehta ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Alternative Medicine ◽

Complementary And Alternative Medicine ◽

Clinical Outcomes ◽

Methodological Quality ◽

Complementary And Alternative

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The currency, completeness and quality of systematic reviews of acute management of moderate to severe traumatic brain injury: A comprehensive evidence map

PLoS ONE ◽

10.1371/journal.pone.0198676 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0198676 ◽

Cited By ~ 4

Author(s):

Anneliese Synnot ◽

Peter Bragge ◽

Carole Lunny ◽

David Menon ◽

Ornella Clavisi ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Systematic Reviews ◽

Severe Traumatic Brain Injury ◽

Acute Management ◽

Evidence Map

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Methodological Quality of Research on Cognitive Rehabilitation After Traumatic Brain Injury

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2009.05.019 ◽

2009 ◽

Vol 90 (11) ◽

pp. S52-S59 ◽

Cited By ~ 26

Author(s):

Keith D. Cicerone ◽

Joanne Azulay ◽

Charlotte Trott

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Rehabilitation ◽

Methodological Quality ◽

Quality Of Research

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A Systematic Review of Upper Limb Rehabilitation for Adults With Traumatic Brain Injury

Brain Impairment ◽

10.1375/brim.9.3.237 ◽

2008 ◽

Vol 9 (3) ◽

pp. 237-246 ◽

Cited By ~ 1

Author(s):

Natasha A. Lannin ◽

Annie McCluskey

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Systematic Reviews ◽

Upper Limb ◽

Methodological Quality ◽

Hand Function ◽

Controlled Trials ◽

Upper Limb Rehabilitation ◽

Evidence Database ◽

Limb Rehabilitation

AbstractObjective:To summarise the effect of upper limb rehabilitation interventions on motor function in adults with traumatic brain injury.Data sources:Databases were last searched on August 2, 2008. Sources included the Cochrane Central Register of Controlled Trials (CENTRAL); Cochrane Database of Systematic Reviews, the Database of Effectiveness Reviews; MEDLINE, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro), Occupational Therapy Systematic Evaluation of Evidence database (OTseeker); Google Scholar; and reference lists of included studies.Review methods:Two reviewers determined whether retrieved abstracts met the inclusion criteria: systematic reviews and randomised controlled trials (RCTs); English language; adult participants; ≥ 50% of study participants with a brain injury; interventions designed to improve upper limb motor function. Included papers were appraised for: study design, participants, therapy approach, therapy protocol (indications, contra-indications, intensity and duration), safety and adverse events, and outcomes. The methodological quality of RCTs was rated using the PEDro scale (1–10 highest). Methodology of systematic reviews was rated using the QUOROM criteria.Results:Of the 333 references identified, six were appraised: three systematic reviews and three RCTs. Methodological quality was high for two RCTs, and moderate for one, based on the PEDro scale score. Interventions included upper limb casting, electrical stimulation, and coordination training using meal preparation tasks (making a sandwich and hot drink). In the latter trial, practice of functional kitchen tasks improved fine motor coordination speed on one of four Jebsen-Taylor hand function subtests by 9.38 seconds (95% CI, 1.1 to 17.7). Remaining trials reported non-significant effects for hand function. Small sample sizes and limited reporting of results reduce the interpretability of two RCTs.Conclusion:No conclusive evidence was found on which to base upper limb motor rehabilitation after brain injury, however, lack of evidence does not equate to evidence of no effect.

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Decompressive Craniectomy is Associated with Improved Quality of Life Up to Ten Years After Rehabilitation from Traumatic Brain Injury

SSRN Electronic Journal ◽

10.2139/ssrn.3377546 ◽

2019 ◽

Author(s):

Katrin Rauen ◽

Lara Reichelt ◽

Philipp Probst ◽

Barbara Schäpers ◽

Friedemann Müller ◽

...

Keyword(s):

Quality Of Life ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Decompressive Craniectomy

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Non-Vitamin K Antagonist Oral Anticoagulants in Pulmonary Embolism: An Overview of Systematic Reviews

Current Pharmaceutical Design ◽

10.2174/1381612826666200506114450 ◽

2020 ◽

Vol 26 (23) ◽

pp. 2686-2691 ◽

Cited By ~ 1

Author(s):

Ioannis Doundoulakis ◽

Christina Antza ◽

Haralambos Karvounis ◽

George Giannakoulas

Keyword(s):

Pulmonary Embolism ◽

Vitamin K ◽

Systematic Reviews ◽

Methodological Quality ◽

Randomized Clinical Trials ◽

Oral Anticoagulants ◽

Vitamin K Antagonist ◽

Language Restriction ◽

Overview Of Systematic Reviews

Background: Anticoagulation in patients with pulmonary embolism. Objective: To identify how non-vitamin K antagonist oral anticoagulants are associated with multiple outcomes in patients with pulmonary embolism. Methods: We performed a systematic search of systematic reviews via multiple electronic databases from inception to August 19th, 2019, without language restriction. Two authors independently extracted data and assessed the methodological quality of the included systematic reviews using the ROBIS tool. Results: We found twelve systematic reviews. Eleven SRs collected their data from randomized clinical trials and one from observational studies. All the included studies were published between 2014 and 2019 in English. The methodological quality of the 12 systematic reviews was low to high. None of the systematic reviews, which are included in our overview of systematic reviews, has evaluated the overall quality of evidence outcome using the Grading of Recommendations Assessments, Development and Evaluation (GRADE) approach. Conclusion: This is the first effort to summarize evidence about non-vitamin K antagonist oral anticoagulants in an overview of systematic reviews focusing exclusively on patients with pulmonary embolism. The evidence suggests that the non-vitamin K antagonist oral anticoagulants seem to be more effective and safer than a dualdrug approach with LMWH- VKA.

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