scholarly journals Recreational Drugs: a New Health Hazard for Patients with Concomitant Chronic Liver Diseases

2014 ◽  
Vol 23 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Giovanni Tarantino ◽  
Vincenzo Citro ◽  
Carmine Finelli
Keyword(s):  
Liver Diseases ◽  
Hepatic Injury ◽  
Health Hazard ◽  
Short Review ◽  
The Other ◽  
Rapid Progression ◽  
Recreational Drugs ◽  
Chronic Liver Diseases ◽  
Raising Awareness

Our purpose in this article is to review the effects of recreational drugs, used either on their own but principally combined with alcohol consumption, in determining hepatic injury or influencing the evolution of some chronic diseases of the liver, specifically HCV infection and NAFLD. A deleterious role of daily use of recreational drugs, in particularly cannabis, has been shown to demonstrate clearly a rapid progression of fibrosis and steatosis, leading to a major severity in patients with chronic hepatitis C. On the other hand, the effects of the misuse of these substances on NAFLD, the main obesity-related comorbidity, leading to addiction, is still to be elucidated even though some clues to the recreational drugs hepatotoxicity  are  already present in the literature. This short review aims at raising awareness about this topic.

Homeostatic Role of Autophagy in Hepatocytes

2018 ◽  
Vol 38 (04) ◽  
pp. 308-319 ◽  
Author(s):  
Bilon Khambu ◽  
Shengmin Yan ◽  
Nazmul Huda ◽  
Gang Liu ◽  
Xiao-Ming Yin
Keyword(s):  
Direct Effect ◽  
Liver Diseases ◽  
Metabolic Regulation ◽  
Molecular Mechanisms ◽  
Nutrient Supply ◽  
The Other ◽  
Chronic Liver Diseases ◽  
Physiological Processes ◽  
Abnormal Accumulation

AbstractAutophagy actively participates in the physiological process of the liver. While the direct effect of autophagy may be limited to the sequestration and degradation of a selective cargo, its overall impact can be broad, affecting many more physiological processes regulated by the particular cargo. This review will discuss two aspects of the importance of autophagy in the liver: metabolic regulation in response to feeding and starvation, and pathological consequences in the absence of autophagy. These two aspects illustrate the homeostatic functions of autophagy in the liver, one in a more direct fashion, regulating the cellular nutrient supply, and the other in a more indirect fashion, controlling the pathological signaling triggered by the abnormal accumulation of cargos. Remarkably, the hepatic pathology in autophagy-deficient livers does not seem different from that presented in other chronic liver diseases. Autophagy deficiency can be a model for the study of the relevant molecular mechanisms.

Role of scavenger receptors in the pathophysiology of chronic liver diseases

2013 ◽  
Author(s):  
Carolina Armengol ◽  
Ramon Bartoli ◽  
Lucia Sanjurjo ◽  
Isabel Serra ◽  
Nuria Amezaga ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Chronic Liver ◽  
Scavenger Receptors ◽  
Chronic Liver Diseases

scholarly journals The Role of the Gut Microbiome in Liver Cirrhosis Treatment

2020 ◽  
Vol 22 (1) ◽  
pp. 199
Author(s):  
Na Young Lee ◽  
Ki Tae Suk
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Chronic Liver ◽  
Chronic Liver Diseases

Liver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing cholangitis and Wilson’s disease can also lead to cirrhosis. Moreover, alcohol can cause cirrhosis on its own and exacerbate chronic liver disease of other causes. The treatment of cirrhosis can be divided into addressing the cause of cirrhosis and reversing liver fibrosis. To this date, there is still no clear consensus on the treatment of cirrhosis. Recently, there has been a lot of interest in potential treatments that modulate the gut microbiota and gut-liver axis for the treatment of cirrhosis. According to recent studies, modulation of the gut microbiome by probiotics ameliorates the progression of liver disease. The precise mechanism for relieving cirrhosis via gut microbial modulation has not been identified. This paper summarizes the role and effects of the gut microbiome in cirrhosis based on experimental and clinical studies on absorbable antibiotics, probiotics, prebiotics, and synbiotics. Moreover, it provides evidence of a relationship between the gut microbiome and liver fibrosis.

Total Productive Maintenance: Competing or Complementary to other Initiatives?

2013 ◽  
Vol 315 ◽  
pp. 472-476
Author(s):  
Adnan Hj. Bakri ◽  
Abdul Rahman Abdul Rahim ◽  
Noordin Mohd Yusof
Keyword(s):  
Large Scale ◽  
Manufacturing Industry ◽  
Short Review ◽  
The Other ◽  
Total Quality ◽  
Total Productive Maintenance ◽  
Quality Initiatives ◽  
Practical Applications ◽  
Manufacturing Organization

The objective of this short review paper is to examine the practical applications of Total Productive Maintenance (TPM) in the manufacturing industry. In this short review, an attempt was made to critically discuss the previous literatures related to TPM with the other established quality initiatives in the manufacturing, such as Total Quality Management (TQM) and Just-In-Time practice (JIT). This literature review-based research revealed an important research gaps related to TPM. The significance role of TPM as an important complementary to either TQM or JIT initiative is observed not been well addressed in the available literatures. Most of the researches available investigate these initiatives separately, focuses on the other element rather than addressing on the significant role of TPM as one of the main thrust. The separate implementation of such quality initiatives in the manufacturing organization means the requirement of large scale human, financial and technical resources as well the associated problems of running competing project in the company. The outcomes from this review justify the needs of further research in the area of TPM integration with other available initiatives, to further enhance its methodology aimed at solidifying its philosophy towards more realistic practical applications.

The Role of Oxidative Stress in Chronic Liver Diseases

2020 ◽  
pp. 13-25
Author(s):  
Devaraj Ezhilarasan ◽  
Shanmugam Rajeshkumar ◽  
Thangavelu Lakshmi
Keyword(s):  
Oxidative Stress ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Mitochondrial Roles and Cytoprotection in Chronic Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Davide Degli Esposti ◽  
Jocelyne Hamelin ◽  
Nelly Bosselut ◽  
Raphaël Saffroy ◽  
Mylène Sebagh ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Hepatic Metabolism ◽  
Chronic Liver ◽  
Oxygen Species ◽  
Organelle Biogenesis ◽  
Chronic Liver Diseases ◽  
Chronic Liver Injury ◽  
Promising Therapeutic Target ◽  
Apoptosis And Necrosis

The liver is one of the richest organs in terms of number and density of mitochondria. Most chronic liver diseases are associated with the accumulation of damaged mitochondria. Hepatic mitochondria have unique features compared to other organs' mitochondria, since they are the hub that integrates hepatic metabolism of carbohydrates, lipids and proteins. Mitochondria are also essential in hepatocyte survival as mediator of apoptosis and necrosis. Hepatocytes have developed different mechanisms to keep mitochondrial integrity or to prevent the effects of mitochondrial lesions, in particular regulating organelle biogenesis and degradation. In this paper, we will focus on the role of mitochondria in liver physiology, such as hepatic metabolism, reactive oxygen species homeostasis and cell survival. We will also focus on chronic liver pathologies, especially those linked to alcohol, virus, drugs or metabolic syndrome and we will discuss how mitochondria could provide a promising therapeutic target in these contexts.

Media and Elections: An Overview and Its Importance

2017 ◽  
Vol 12 (01) ◽  
Author(s):  
Anamika Srivastava
Keyword(s):  
Public Participation ◽  
The Other ◽  
Indirect Communication ◽  
Prominent Feature ◽  
Raising Awareness ◽  
Democratic Rights ◽  
The Media ◽  
Democratic Nation ◽  
The Voice

The election has always been the prominent feature of a nation. It’s a remarkable process to choose a leader or a party to whom or which public want to see at the position of power. It’s a medium of indirect communication and the voice of democratic nation. It’s a medium through which mass speaks out. Election provides ways to the citizens to choose their representatives which based on the policies of state to adapt and follow in governance. On the other hand, Media is the most effective and influential tool for disseminating information. It provides its availability in every convenient manner. The media plays an indispensable role in the proper functioning of a democracy. During elections, Media have the various roles in scrutinizing the electoral process itself, electoral management, in order to evaluate the fairness of the process, its efficiency, and its probity. Media enables the full public participation. The paper looks into the very implementation part of Media during election. It deeply looks into the role of Media in keeping abreast to the citizens and raising awareness. The paper also looks the discussion of the media’s functions within electoral contexts, watchdog role and educating voters on how to exercise their democratic rights.

scholarly journals Dysregulation of redox pathways in liver fibrosis

2016 ◽  
Vol 311 (4) ◽  
pp. G667-G674 ◽  
Author(s):  
Natalie J. Torok
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Liver Diseases ◽  
Oxygen Species ◽  
Chronic Liver Diseases ◽  
Cell Fate Decisions ◽  
Novel Treatment ◽  
Antioxidant Mechanisms ◽  
Precise Role

Reactive oxygen species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of oxidative radicals drives a fibrogenic response that is a common feature of disease progression. Despite our understanding the biology of the main prooxidant enzymes, their targets, and antioxidant mechanisms in the liver, there is still lack of knowledge concerning their precise role in the pathogenesis of fibrosis. This review will examine the role of physiological redox signaling in the liver, provide an overview on recent advances in prooxidant and antioxidant pathways that are dysregulated during fibrosis, and highlight possible novel treatment targets.

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