scholarly journals Uterine stump leiomyosarcoma after sub-total hysterectomy: a case report

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Haitham Abdel Wahab ◽  
Mohamed Ayaty ◽  
Mohamed Abdallah ◽  
Ahmed Elghandor
Keyword(s):  
Case Report ◽  
Abdominal Circumference ◽  
Ca 125 ◽  
Abdominal Pressure ◽  
Uterine Leiomyosarcoma ◽  
Rare Tumor ◽  
Uterine Sarcomas ◽  
Total Hysterectomy ◽  
Subtotal Hysterectomy ◽  
One Year

Introduction: Uterine sarcomas considered as one of the aggressive tumors of uterine malignancies. It is one of the mesenchymal tumors that originate from smooth muscle of the uterus which is a rare tumor that accounts for 2% to 5% of all uterine malignancies. Very few cases are reported in the literature. Our patient has a unique history of Pelvic-Abdominal swelling reaching xiphisternum level after subtotal hysterectomy one year ago. Abnormal genital bleeding not responding to medical treatment is the usual presentation in uterine sarcoma like in our patient. We report an original case report of an abnormal sequence of this rare tumor arising from the uterine stump after subtotal hysterectomy. Case presentation: A 42-year-old nulliparous woman presented to our gyne-oncology unit in El-Galaa Maternity Teaching Hospital in June 2020 with a significant rapid increase in abdominal circumference, symptoms caused by abdominal pressure (vomiting and constipation) and abnormal genital bleeding after laparotomic sub-total hysterectomy one year ago. Tumor marker CA-125 was raised, LDH was raised and a MRI scan showed a huge mass arising from the pelvis. An exploratory laparotomy was performed and the histopathology report confirmed the diagnosis of uterine leiomyosarcoma weighing around 22kg. Conclusion: Because of their rarity, uterine sarcomas are not suitable for screening. Diagnosis by histopathologic examination and surgery is the only treatment. Pre-operative MRI with contrast for abdomen and pelvis is highly recommended to exclude abdomen metastatic sarcoma if the tumor is confined to the pelvis only.

scholarly journals The Role of Monoclonal Antibody Targeted Therapy in Uterine Sarcomas

2018 ◽  
Vol 69 (11) ◽  
pp. 3315-3319
Author(s):  
Cristian Cirlan ◽  
Cezar Ionut Calin ◽  
Radu Costea ◽  
Adrian Gheorghe Barbilian
Keyword(s):  
Monoclonal Antibody ◽  
Treatment Plan ◽  
Uterine Sarcoma ◽  
Therapeutic Strategies ◽  
The Other ◽  
Uterine Sarcomas ◽  
Total Hysterectomy ◽  
Oncology Treatment ◽  
One Year

The uterine sarcoma is one of the type of neoplasm that affects the abdominopelvine organs. The behaviour of this hystopathological type of cellular line is very aggresive both to the primer organ and also to the nearby organs and to the main filter� organs like the liver and lung, where it develops metastasis. The treatment of this disease is multidisciplinary and it uses many therapeutic strategies depending on staging and the other comorbidities of the pacient. We will present the case of an 81 year old female known with the diagnosis of relapse tumoral abdominopelvin sarcoma developed one year after total hysterectomy surgery with bilateral anexetomie for the uterine sarcoma. Also we will discuss about a series of characteristics of the treatment plan observed at different similar cases. We will evaluate the latest drug lines used in oncology treatment, we will discuss about the therapeutic indications and in the end we will draw conclusions about the therapeutic indications of each case.

scholarly journals Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Seiji Kanayama ◽  
Masako Nakamura ◽  
Hidekazu Oi ◽  
Sumire Sugimoto ◽  
Yoshikazu Sasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Conservative Surgery ◽  
Reproductive Age ◽  
Optimal Management ◽  
Rare Tumor ◽  
Uterine Sarcomas ◽  
Younger Patients ◽  
Younger Women ◽  
The Mean ◽  
Malignancy Potential

Mullerian adenosarcoma (MA) is a rare tumor variant with low malignancy potential and is reported to account for 8% of all uterine sarcomas. Cervical MAs are reported to occur in relatively younger patients with the mean age of 27 years, while those in the uterine corpus generally present in postmenopausal women. Due to the rarity of cervical MAs, optimal management for these patients (especially younger women) is still under exploration. Here, we describe a case of cervical MA in a woman of reproductive age who was treated by fertility-preserving surgery and successfully delivered a child 18 months later.

scholarly journals Fibrous Hamartoma of Infancy in the Scrotum

2019 ◽  
Vol 07 (01) ◽  
pp. e100-e103
Author(s):  
Hrvoje Stepančec ◽  
Zoran Kokot ◽  
Draženko Keretić ◽  
Sandra Radiković ◽  
Donat Grgurović
Keyword(s):  
Case Report ◽  
Clinical Picture ◽  
Benign Tumor ◽  
Male Infant ◽  
Histopathological Analysis ◽  
Rare Tumor ◽  
Diagnostic Challenge ◽  
Fibrous Hamartoma Of Infancy ◽  
One Year

AbstractFibrous hamartoma of infancy is a solid benign tumor of the subcutis, which usually occurs within the first 2 years of life. It predominantly occurs in males, and is clinically presented as a solid, painless, well-limited subcutaneous formation, tending to grow, and in most cases without any symptoms. It occurs in various locations. The aim of this case report was to present a case of a rare tumor of infancy in the scrotal region, in an 8-month-old male infant, with a nonspecific clinical picture, suggestive of a malignant formation, thus presenting a diagnostic challenge for a doctor. The tumor was completely removed. The diagnosis was confirmed by histopathological analysis. One year after the surgical procedure, a follow-up ultrasonography examination showed no relapse.

Cytoreduction as a remedial procedure improves disease-free survival of patients with occult uterine sarcoma undergoing morcellation——a retrospective study

2020 ◽  
Author(s):  
Chao Ding ◽  
Jianqing Zhu
Keyword(s):  
Disease Free Survival ◽  
Endometrial Stromal Sarcoma ◽  
Uterine Sarcoma ◽  
Uterine Leiomyosarcoma ◽  
Uterine Sarcomas ◽  
Free Survival ◽  
Total Hysterectomy ◽  
Stromal Sarcoma ◽  
Significant Difference ◽  
Disease Free

Abstract Background：Tumor morcellation happened to facilitate iatrogenic metastasis for patients with occult uterine sarcoma. The optimal remedial procedure for these patients needed to be established. Methods：Data were retrospectively collected and analyzed from patients with occult uterine sarcoma undergoing morcellation. Results：23 consecutive patients with uterine sarcomas undergoing morcellation were accessed between Jan 2008 and Dec 2018, including 15 patients with uterine leiomyosarcoma and 8 with endometrial stromal sarcoma. Cytoreduction as a remedial procedure was significantly associated with better disease-free survival (P=0.031), and none of 7 patients undergoing cytoreduction suffered recurrence, while total hysterectomy (P=0.194) and adjuvant therapy (P=0.159) had no such benefit. There was no significant difference in disease-free survival between laparoscopic and open surgery (p=0.321). Conclusion：Cytoreduction was considered as the optimal remedial procedure for patients with occult uterine sarcoma undergoing morcellation.

scholarly journals Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature

2020 ◽  
Vol 10 ◽  
Author(s):  
Alessandro Rizzo ◽  
Maria Concetta Nigro ◽  
Vania Ramponi ◽  
Carmine Gallo ◽  
Anna Myriam Perrone ◽  
...  
Keyword(s):  
Case Report ◽  
Uterine Leiomyosarcoma ◽  
Rare Tumor ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Skull Metastasis

scholarly journals Chemoradiotherapy for Inoperable Carotid Body Leiomyosarcoma: A Case Report and Review of Literature

2021 ◽  
Vol 10 ◽  
Author(s):  
Cheng-Sheng Liu ◽  
Jia-Ruey Tsai ◽  
Yi-Tzu Kao ◽  
Long-Sheng Lu ◽  
Yin-Ju Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Carotid Body ◽  
Concurrent Chemoradiotherapy ◽  
Neck Mass ◽  
Definitive Treatment ◽  
Tumor Control ◽  
Rare Tumor ◽  
First Case ◽  
One Year ◽  
Vascular Leiomyosarcoma

Vascular leiomyosarcoma is an extremely rare tumor and is associated with poor prognosis among leiomyosarcoma. Surgical resection remains the main treatment option. But outcome of definitive treatment with chemoradiotherapy in inoperable patients is not clear. Here, we report treatment and outcome of definitive chemoradiotherapy in a case of vascular leiomyosarcoma. A 64-year-old man with the initial presentation of pulsatile right neck mass was diagnosed with right carotid body leiomyosarcoma. He refused surgical intervention due to risk of carotid body injury and ischemic stroke. Successful tumor control was achieved with carboplatin-based concurrent chemoradiotherapy. Investigational liquid biopsy for circulating sarcoma cells was also performed to analyze drug sensitivity profile of this rare tumor. One year after treatment, the disease remained well controlled and there was no evidence of baroreflex failure or treatment-related late toxicities. To our best knowledge, this is the first case report of right carotid body leiomyosarcoma controlled with definitive concurrent chemoradiotherapy. The approach of personalized multi-modality treatment will be a focus of our future investigation.

Cystic struma ovarii, a rare form of ovarian tumor – a case report, and review of the literature

2007 ◽  
Vol 148 (48) ◽  
pp. 2285-2287 ◽  
Author(s):  
Gabriella Östör ◽  
Ildikó Tóth ◽  
Zsuzsanna Hrubyné Tóth ◽  
Sándor Bazsa
Keyword(s):  
Case Report ◽  
Ovarian Tumor ◽  
Ca 125 ◽  
Struma Ovarii ◽  
Review Of The Literature ◽  
Rare Form

Az ovarialis strumák a petefészek-teratomák kevesebb mint 3%-át adják. Megjelenhet bennük a pajzsmirigy szinte minden betegsége, és előfordulhat malignitás is. A szerzők esetében egy 31 éves nő bal oldali petefészekcisztáját távolították el, amely az ovariumcarcinoma klinikai tüneteit mutatta, úgymint nagy hasi térfoglalás, ascites, emelkedett szérum-CA 125-szint. A szövettani diagnózis benignus struma ovarii volt. A posztoperatív pajzsmirigyműködés normális maradt.

scholarly journals Synchronous primary malignancy of ovary and cervix with different histopathology: A rare case report

2016 ◽  
Author(s):  
Alok Tiwari ◽  
Dhananjay Gughe ◽  
Radhika Dureja ◽  
Satinder Kaur
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Contrast Enhancement ◽  
Squamous Cell ◽  
Pap Smear ◽  
Ca 125 ◽  
Post Contrast ◽  
Palpable Mass ◽  
Diffusion Restriction

Concurrent different histopathological types of gynecologic tumors arise rarely. We present ovarian serous and cervical squamous cell carcinoma formed synchronously. A 51-year-old woman with a poor general condition was admitted with gradual distension of abdomen for 1 year with gradual loss of weight and appetite for the last three months and pain in the abdomen and irregular vaginal bleeding for the last two months. There was no family history of malignancy of genital tract, breast or colon. On examination she was cachexic, pale, dehydrated, tachypnoeic and had edema over feet. Per abdomen examination revealed solid, non-mobile palpable mass arising from pelvis. Per vaginal examination revealed large mass in pelvis and uterus can not be felt separately on per speculum examination there was small endocervical erosion, hypertrophied cervix. On per rectal examination bilateral parametria were free. Her tumor marker were evaluated and CA-125 was found to be raised (CA 125: 915.6 u/ml U/mL); rest tumor markers were normal. Cervical punch biopsy was suggestive of moderately differentiated carcinoma and pap smear was also suggestive of cervical cancer. MRI findings revealed a mass of altered signal intensity 2.5 × 1.5 × 2.2 cm with diffusion restriction and post contrast enhancement in the anterior lip of cervix and another large, lobulated predominantly solid mass, hypo intense on T1, intermediate on T2 with diffusion restriction and post contrast enhancement in the right adnexal region abutting the small bowel and sigmoid colon optimal debulking surgery with standard protocol was done. Histopathology report revealed squamous cell carcinoma of cervix, grade III and high grade serous cystadenocarcinoma of ovary. Tumour deposits from ovary were seen on right fallopian tube and right parametrium. Squamous cell carcinoma cervix involved ectocervix, endocervix and infiltrated near full thickness of cervical stroma, endomyometrium, vaginal cuff, paracervical tissue omentum and appendix were free of tumour. Twenty five right pelvic lymphnodes dissected were free of tumour, (00/25). One out of fifteen lymphnode dissected were involved with extra capsular extent, 01/15 and thirteen para aortic lymph node dissected were free of tumor. Immunohistochemistry markers: Ovarian mass-tumour cell expressed ck, vimentin, wt-1 with focal Ck positivity, no expression of ck20, p63, ck5/6 and CEA seen. Cervical tumour-tumour cells expressed ck, ck7, p63 and ck5/6 no expression of ck20, wt-1. Based on our case report we need to keep in mind that even if patient presents with symptoms pertaining to a single malignancy; still the rare possibility of synchronous malignancies should be looked for by doing proper investigations. In our case, patient had symptoms pertaining to ovarian malignancy; whereas cervical malignancy was diagnosed after investigating the patient. Histologic examination should be done properly as the prognosis depends on the malignancies being metastatic or synchronous one appropriate management should be offered in all such cases. Long term follow up of such patients should be maintained to determine the prognosis.

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